• 대한치과의사협회지
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• 제40권7호통권398호
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• pp.512-515
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• 2002

• 대한약침학회지
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• 제13권4호
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• pp.109-118
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• 2010

Objectives : This pilot study is designed to reveal the effect of Carthami-semen acupuncture treatment on chronic daily headache. Methods : 1. All the voluntary subjects were diagnosed as CDH. 2. Carthami-semen acupuncture is applied 2 times a week for 4 weeks. 3. The patients were assessed by Headache impairment test score(HIT), Short Form 36 (SF-36) Health Survey, and Headache Free Days(HFD) before and after 4 weeks treatment, and two weeks the treatment finished. Results : The result were as follows ; 1. HIT score decreased from $65.3{\pm}5.5$ to $53.1{\pm}9.4$, and furthermore declined to $49.5{\pm}8.0$ after 2 weeks the treatment finished. 2. HFD increased from 19.1% to 31.5% during the treatment time. Moreover it showed continuous effectiveness after 2 weeks the treatment finished. 3. SF-36 showed significant improvement on all of the QOL items. Conclusions : This pilot study suggests that Carthami-semen acupuncture treatment has an effect on the CDH patients.

• Genomics & Informatics
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• 제9권3호
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• pp.102-113
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• 2011

C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation of blood pressure. The current study aim is to determine the blood pressure association of the genes regulated by CSK down-regulation. The CSK mRNA expression was downregulated in vascular smooth muscle cells using small interfering RNA (siRNA). CSK mRNA levels fell by 90% in cells that were treated with CSK siRNA; the RNA from these cells was examined by microarray using the Illumina HumanRef-8 v3 platform, which comprises 24,526 reference mRNA probes. On treatment with CSK siRNA, 19 genes were downregulated by more than 2-fold and 13 genes were upregulated by more than 2-fold. Three (CANX, SLC30A7, and HMOX1) of them revealed more than 3 fold differential expression. Interestingly, the HMOX1 SNPs were associated with diastolic blood pressure in the 7551 Koreans using Korea Association REsource data, and the result was supported by the other reports that HMOX1 linked to blood vessel maintenance. Among the remaining 29 differentially expressed genes, seven (SSBP1, CDH2, YWHAE, ME2, PFTK1, G3BP2, and TUFT1) revealed association with both systolic and diastolic blood pressures. The CDH2 gene was linked to blood pressures. Conclusively, we identified 32 differentially expressed genes which were regulated by CSK reduction, and two (HOMX1 and CDH2) of them might influence the blood pressure regulation through CSK pathway.

• Advances in pediatric surgery
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• 제7권1호
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• pp.21-25
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• 2001

Congenital diaphragmatic hernia (CDH) in the past was considered a surgical emergency requiring immediate operation. Several groups now advocate preoperative stabilization and delayed surgery. The treatment strategy for CDH in this institution is delayed surgery after preoperative stabilization. The aim of this study was to evaluate the results of delayed surgery. A retrospective review of 16 neonates with CDH was performed. Surfactant. conventional mechanical ventilation. high frequency oscillation. and nitric oxide were utilized for preoperative stabilization as necessary. The difference in outcome between two groups differentiated by the duration of the preoperative stabilization periods with mechanical ventilation (${\leq}$ 8 hours and > 8 hours) was determined. Chi-square test was used to analyze the data. There were 7 right-sided hernias and 9 left. The average duration of stabilization was 32.4 hours. Hepatic herniation through the defect was found in 6 cases and all died. The most common postoperative complication was pneumothorax. The mortality rate of the right side hernia was higher than the left (85.7% vs. 33.3%. p=0.036). Mortality rate of the group (N=8) whose preoperative stabilization period was 8 hours or less was better than that (N=6) whose preoperative stabilization period was more than 8 hours (25.0% vs. 83.3%. p=0.031). The overall mortality rate was 56.3%. The better prognosis was noticed in left side hernia. no liver herniation, or shorter preoperative stabilization period.

• International Journal of Oral Biology
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• 제31권2호
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• pp.27-32
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• 2006

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline mutations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast cancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma(SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign epithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

• Current Research on Agriculture and Life Sciences
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• 제5권
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• pp.68-74
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• 1987

A. calcoaceticus C10은 CL 배지에서 ${\varepsilon}$-caprolactone 및 succinate에 의해 생육에 아무 영향도 받지 않았으나 adipate와 xylose에 의해서 균의 생육도가 증가하였다. 특히 이 균이 탄소원으로 이용할 수 없는 포도당에 의해서도 생육도가 증가하였으며 6시간 배양 후 0.2%의 포도당을 첨가한 경우에는 16시간 후 CL 배지에서 생육한 것보다 약 2배의 생육도를 냐타내었다. A. calcoacelicus C10이 생산하는 cyclohexanol dehydrogenase(CDH)는 ${\varepsilon}$-caprolactone, succinate, xylose 및 포도당에 의해 이화물 억제를 받지 않았으나 사이클로헥사놀 대사경로의 최종생산물인 adipate에 의하여 생합성 억제를 받았다. CL 배지에 0.1%의 adipate를 첨가한 배지에서는 CDH가 다소 유도되었으나 0.2%의 adipate를 첨가한 배지에서는 CDH가 거의 유도되지 않아 0.5%의 adipate를 첨가한 것과 비슷한 억제효과를 나타내었다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 추계학술발표대회
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• pp.232-235
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• 2021

동형암호는 서버에 암호화된 데이터를 통해 연산할 수 있다는 장점으로 대용량의 데이터를 암호화하여 처리하는 시스템에 사용될 수 있어 주목된다. 동형암호의 방법 중 효율성과 실용성을 지니는 장점으로 인해 연구되고 있는 Bilinear Pairing을 사용하는 서명 및 인증 방법들은 DDH와 CDH 문제에 기반을 둔 방법으로, 많은 연구가 진행되어 왔다. 본 논문은 동형암호에서 사용되는 Bilinear Pairing의 핵심인 GDH 그룹과 타원곡선암호, Weil Pairing, SDH 문제를 기반으로 하는 서명 방식과 그룹 서명 방식, 랜덤오라클을 제외한 서명을 소개한다.

• 정보보호학회논문지
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• 제15권1호
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• pp.41-55
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• 2005

그룹키 통의 프로토콜은 일련의 그룹을 형성하는 다수의 통신 참여자들이 공개된 통신망을 통해 안전하고 효율적인 방법으로 그룹의 세션키를 설정하기 위한 목적으로 설계된다. 본 논문에서는 유료 방송 시스템과 같은 그룹중심의 응용이나 서비스에 적합한 ID 기반의 2 라운드의 그룹키 동의 프로토콜을 제안하고, 이의 안전성을 CDH 가정과 BDDH 가정에 기반하여 랜덤 오라클 모델에서 증명한다. 제안하는 프로토콜은 Nam이 제안한 3 라운드 그룹키 동의 프로토콜을 기초로 설계된 것으로, 개인식별정보에 기반한 암호 시스템을 사용하여 키 관리 절차를 보다 간단히 하였으며, 새로운 인증 메카니즘을 사용하여 키 전송 메시지들의 길이를 줄이고 결합적 단순성을 제공하였다. 또한 제안하는 프로토콜은 전송되는 메시지들에 대한 인증을 묶음(batch) 기법을 사용하여 검증하도록 설계하여 효율성을 더욱 개선 시 켰다.

• ETRI Journal
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• 제38권2호
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• pp.397-404
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• 2016

In group-oriented applications, it is often required to verify a group of signatures/messages. The individual verification of signed messages in such applications comes at a high cost in terms of computations and time. To improve computational efficiency and to speed up the verification process, a batch verification technique is a good alternative to individual verification. Such a technique is useful in many real-world applications, such as mail servers, e-commerce, banking transactions, and so on. In this work, we propose a new, efficient identity-based signature (IDS) scheme supporting batch verifications. We prove that the proposed IDS scheme and its various types of batch verifications is tightly related to the Computational Diffie.Hellman problem under a random oracle paradigm. We compare the efficiency of the proposed scheme with related schemes that support batch verifications.

• Advances in pediatric surgery
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• 제2권2호
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• pp.129-132
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• 1996

This is a case report of a sliding hiatal hernia with severe gastroesophageal reflux(GER) after repair of congenital diaphragmatic hernia(CDH). It was not possible to determine whether the hiatal hernia is a de novo lesion which was missed at the original operation or a consequence of overzealous repair of the Bochdalek defect at the expense of weakening of the diaphragmatic crura. This case demonstrates that a sliding hiatal hernia can be a cause of severe gastroesophageal reflux that should be managed surgically.