• Title/Summary/Keyword: CD44

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Effective Factors on Association between Liver/kidney Function and Blood-Cd Level in the Korean Urban People (도시거주자의 혈중 카드뮴 농도와 간 및 신장 기능과의 상관성 평가)

  • 김호현;임영욱;임종한;양지연;신동천
    • Environmental Analysis Health and Toxicology
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    • v.18 no.1
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    • pp.33-44
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    • 2003
  • The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20∼75 years) at 4 survey sites throughout seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 $\mu\textrm{g}$/1, It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.

Electrical and Optical Properties of CdS Films prepared by Electrodeposition (전착법으로 제조한 CdS 막의 전기 및 광학적 특성)

  • 권오균;임호빈
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1990.10a
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    • pp.39-44
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    • 1990
  • Polycrystalline CdS films were grown on glass substrate with conducting indium tin oxide(ITO) by electrodeposition. The average size of the plate-shape grains o the CdS films was from 0.3um to 0.05um, and the adhesion to ITO was excellent. The optical band gap of the electrodeposited CdS films was in the range from 2.51eV to 2.68 eV. The optical transmittance was 80% and the electrical resistivity varied from 10$^3$ to 10$\^$5/$\Omega$-cm depending on the deposition condition.

Effect of Cadmium-contaminated Brown Rice Diet on Accumulation of Heavy Metal in Rats (카드뮴 오염 현미 섭취에 의한 랫드의 체내 중금속 축적)

  • Kim, Jae-Young;Im, Hyo-Bin;Kim, Seong-Jo;Baek, Seung-Hwa
    • Journal of Food Hygiene and Safety
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    • v.27 no.2
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    • pp.133-140
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    • 2012
  • Movement and accumulation of cadmium in male Sprague-Dawley rats, fed with brown rice from nearby Janghang smeltery area were investigated. The rat fed with five different cadmium level diets made with Cd-polluted during 12 weeks. The brown rice-polluted with 0.87 ppm Cd (PBR) was sampled from products in the Janghang smeltery area. Diets of brown rice group were brown rice (BR, 0.002 ppm Cd), each 50% of BR and PBR (BR+PBR 50%, 0.44 ppm Cd) and PBR (PBR 100%, 0.87 ppm Cd). To compare with BR+PBR 50%, the another group diet composed the feed (FE, 0.002 Cd ppm) and each 50% of FE and PBR (FE+PBR 50%, 0.44 ppm Cd). Accumulation of Cd, Zn and Cu in blood, liver and kidney rats was measured by GF-AAS. The weight gain in BR groups and FE groups were different 0.22-0.26 and 1.08-1.26 g/day, respectively. Daily intake cadmium was 10.77 and 22.36 ${\mu}g/rat$ in BR+PBR 50% and PBR 100%, and 8.83 ${\mu}g/rat$ in FE+PBR 50%. Cadmium contents in diets were higher, and total intake of the heavy metals was more increased on the whole. Weights of liver and kidney in FE+PBR 50% group was 2.64 and 2.27 folds higher than those in BR+PBR 50% group. Cadmium contents in blood were increased with intake of BR diet, but Zn and Cu were decreased with them. In the diet groups with the same Cd concentration, Cd content of FE+PBR 50% was higher 1.27 times than that of BR+PBR 50%. In the diet group of BR, BR+PBR 50%, and PBR 100%, the increase of Cd concentration was significantly different to the increase of Cd content in the livers. In the same condition of Cd concentration, Cd contents were higher in the BR+PBR 50% group. In the diet groups of BR, BR+PBR 50%, and PBR 100%, the increase of Cd content in the kidneys led to the increase of Zn and Cu contents. In the same condition of Cd concentration, the diet group with the addition of BR was shown to be 3.11 times higher than with the addition of FE. In view of the results so far achieved, It was closely related with Cd, Zn, and Cu content.

Optimization of Encapsulation Conditions for Fermented Red Ginseng Extracts by Using Cyclodextrin (Cyclodextrin을 이용한 발효홍삼농축액 최적 포접 조건)

  • Shin, Myung-Gon;Lee, Gyu-Hee
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.11
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    • pp.1708-1714
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    • 2015
  • Fermented red ginseng concentrate is known as a healthy food source, whereas it has off-flavor such as bitterness and sour flavor based on fermentation. ${\beta}$- and ${\gamma}$-cyclodextrin (CD) were used to encapsulate the off-flavor of fermented red ginseng concentrate by using response surface methodology design on ${\beta}$- and ${\gamma}-CD$ combination. The reducing effects were analyzed by sensory evaluation for bitter and sour tastes, ginsenoside Rb1, and total acidity. The optimized mixing ratio of ${\beta}$- and ${\gamma}-CD$ for reducing bitterness was the least expected value of 2.07 at ${\beta}-CD$ 3.74% versus the soluble solid content of fermented red ginseng concentrate and the ${\gamma}-CD$ 20.63% mixture. The encapsulation effects of ginsenoside Rb1 were the most expected value of 96.75% at ${\beta}-CD$ 3.47% and ${\gamma}-CD$ 19.89% mixture. The encapsulation effects of sour taste were the least expected value of 5.63 at ${\beta}-CD$ 9.34% and ${\gamma}-CD$ 9.96% mixture. The encapsulation effects of lactic acid were the most expected value of 67.73% at ${\beta}-CD$ 16.0% and ${\gamma}-CD$ 13.18% mixture. Based on encapsulation and each optimized combination, the most effective entrapping ${\beta}$-and ${\gamma}-CD$ combination ratio was ${\beta}-CD$ 10% and ${\gamma}-CD$ 13%.

An Implementation of an ARM Platform based MP3 Sound Enhancement System (ARM 플랫폼 기반의 MP3 오디오 음질 향상 시스템 구현)

  • Oh, Sang-Hun;Park, Kyu-Sik
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.44 no.1
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    • pp.70-75
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    • 2007
  • In order to mitigate the problems in storage space and network bandwidth for the full CD quality audio with 44.1 kHz sampling rate, current existing digital audio is always restricted by sampling rate and bandwidth. This kind of restriction normally can be resolved by using low bit rate audio codec such as MP3, OGG, and AAC. However it suffers a major problem such as a loss of high frequency fidelity. This high frequency loss will reproduce only the band-limited low-frequency part of audio in the standard CD-quality audio. In general, the high frequency contents of audio have lots of information such as localization and ambient information, and bright nature of audio. The purpose of this paper is to implement on ARM platform system that can effectively estimate and compensate the missing high frequency contents of MP3 audio. From the experimental results with spectrum analysis and listening test, we confirm the superiority of the proposed algorithms for MP3 audio quality enhancement.

Elevated Circulating CD19+ Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer

  • Yu, Qi-Ming;Yu, Chuan-Ding;Ling, Zhi-Qiang
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2219-2224
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    • 2012
  • Background: Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients. Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases. Methods: A retrospective study on a prevalent cohort of 846 GC patients hospitalized at Hospital from Aug 2006 to Jul 2010 was conducted. We calculated the patient's disease free survival (DFS) after first hospital admission, and hazard ratios (HR) from the Cox proportional hazards model. Results: Our findings indicated a significantly decreased percentage of CD3+, and CD8+ cells, a significantly increased proportion of $CD4^+$, $CD19^+$, $CD44^+$, $CD25^+$, NK cells, and an increased $CD4^+/CD8^+$ ratio in GC patients as compared with healthy controls (all P < 0.05). Alteration of lymphocyte subsets was positively correlated with sex, age, smoking, tumor stage and distant metastasis of GC patients (all P<0.05). Follow-up analysis indicated significantly higher DFS for patients with high circulating $CD19^+$ lymphocytes compared to those with low $CD19^+$ lymphocytes (P=0.037), with $CD19^+$ showing an important cutoff of $7.91{\pm}2.98%$ Conclusion: Circulating lymphocyte subsets in GC patients are significantly changed, and elevated CD19+ cells may predict a favorable survival.

Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System

  • Yoo, Hyun Jung;Kim, Na Young;Kim, Ji Hyung
    • Molecules and Cells
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    • v.44 no.5
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    • pp.310-317
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    • 2021
  • Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A' pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Its ligands originate from self or foreign sources. There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind to both the CD1a surface and the antigen or to only CD1a itself, which activates the T cell, or they are unable to bind because of bulky motifs protruding from the antigen-binding groove, which might inhibit autoreactive T-cell activation. Recently, several studies have shown that by producing TH2 or TH17 cytokines, CD1a-restricted T cells contribute to inflammatory skin disorders, including atopic dermatitis, psoriasis, allergic contact dermatitis, and wasp/bee venom allergy. They may also participate in other diseases, including pulmonary disorders and cancer, because CD1a-expressing dendritic cells are also located in non-skin tissues. In this mini-review, we discuss the current knowledge regarding the biology of CD1a-reactive T cells and their potential roles in disease.