Browse > Article

Effective Factors on Association between Liver/kidney Function and Blood-Cd Level in the Korean Urban People  

김호현 (연세대학교 환경공해연구소)
임영욱 (서남대학교 환경보건학과)
임종한 (인하대학교 산업의학과)
양지연 (연세대학교 환경공해연구소)
신동천 (연세대학교 환경공해연구소)
Publication Information
Environmental Analysis Health and Toxicology / v.18, no.1, 2003 , pp. 33-44 More about this Journal
Abstract
The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20∼75 years) at 4 survey sites throughout seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 $\mu\textrm{g}$/1, It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.
Keywords
Cadmium; Liver and kidney function; Environmental factors;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Cikrt M, Tichy M, Blaha K, Bittnerova D, Havrdova J, Lepsi P, Sperlingova I, Nemecek and Herber RF M. The study of exposure to cadmium in the general population. II. morbidity studies, Pollut J Occup Environ Health 1992; 5: 345-356
2 Emara M, Abdel-Samie F. Cadmium. Egypt J Occup Med 1991; 15(1): 65-74
3 Ikeda M, Watanabe T, Koizumi A, Fujita H, Nakatsuka H and Kasahara M. Dietary intake of lead among Japanese farmers, Arch. Environ. Health 1989; 44: 23-29   DOI   ScienceOn
4 Moon C-S, Zhang Z-W, Shimbo S, Watanabe T, Moon DH, Lee C-U, Lee B-K, Ahn K-D, Lee S-H, Ikeda M. Dietary intake of cadmium and lead among general population in Korea, Environ Res 1995; 71: 46-54   DOI   ScienceOn
5 Moyer TP. Toxic metals: cadmium. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd Philadelphia: WB Saunders, 1999; 988
6 Nomiyama K, Nomiyama H. New concept on the mechanism of kidney dysfunction after cadmium exposure. 2. Chronic experiments (in Japanese), Jpn J Hyg 1993; 48:127
7 Toda K, Mori Y, Koike S, Ohmori K, Yamaga S. Chronic renal dysfunction in workers exposured to cadmium oxide fumes (in Japanese with English abstract), Sanyo Igaku: 1984; 26: 212-213   DOI
8 World Health Organization (WHO). Air quality guidelines for Europe. Copenhagen: WHO, Regional Office for Europe, 1987
9 Dell'Omo M, Muzi G, Piccinini R et al. Blood cadmium concentrations in the general population of Umbria, central Italy. Sci Total Environ 1999; 226(1): 57-64   DOI   ScienceOn
10 식약청 독성연구소 내분비계 장애물질의 위해성평가(III) 2002
11 CHAN- SEOK MOON et al. Dietary Intake of Cadmium and Lead among the General Population in Korea, Environment Research 1995; 71: 46-54   DOI   ScienceOn
12 Buchet JP, Lauwerys R, Vandevoorde A and Pycke JM. Oral daily intake of cadmium, lead, manganese, copper, chromium, mercury, calcium, zinc and arsenie in Belgium: Aduplicate meal study, Food Chem Toxical 1983; 21, 19-24   DOI   ScienceOn
13 Onodera M, Hosoda K, Ohmae K, Sakurai H Liver dysfunction after occupational exposure to cadmium (in Japanese), Sangyo Igaku 1996; 38: S493
14 Suzuki Y. Cadmium metabolism and toxicity in rats after long-term subcutaneous administration, J Toxicol Environ Health 1980; 6: 469-482   DOI   PUBMED   ScienceOn
15 Chlopicka J, Zachwieja Z, Zagrodzki P, Frydrych J, Slota P, Krosniak M. Lead and cadmium on the hair and blood of children from a highly industrial area on poland, BioI Trace Elem Res 1998; 62(3): 229-234   DOI   ScienceOn
16 Lauwerys RR, Hoet P. Cadmium. In: Lauwerys RR, Hoet P, editers. Industrial Chemical Exposure: Guidelines for Biological Monitoring, 2nd ed. Boca Raton: Lewis Publishers, 1993; 32-38
17 Weigel HJ, Elmadfa I, Jager HJ. The effect of low dose of dietary cadmium oxide on the disposition of trace elements (zinc, copper, iron), hematological parameters, and liver function in rats, Arch Environ Contam Toxicol 1984; 13: 289-296   DOI   ScienceOn
18 Friberg L, Kjellstrom T, Nordberg GF. Cadmium. In: Friberg L, Nordberg GF, Vouk VR, editors. Handbook on the Toxicology of metals, vol. 2. Amsterdam: Elsevier, 1986; 130-184
19 Itokawa Y, Abe T, Tanaka S. Bone changes in experimental chronic cadmium poisoning. Radiological and biological approaches, Arch Environ Health 1973; 26: 241-244   DOI
20 Zhang Z-W, Shimbo S, Ochi N, Eguchi M, Watanabe T, Moon C-S, Ikeda M. Determination of lead and cadmium in food and blood by inductively coupled plasma mass spectrometry: a comparison with graphite furnace atomic absorption spectrometry, Sci. Total Environ 1997a; 205: 179-187   DOI   ScienceOn
21 FDA. Guidance Document for Cadmium in Shellfish, Center for Food Safety and Applied Nutrition, United Ststes Food and Drug Administration, Washington, D.C. 1993; 202-204
22 Nakamura K, Nishiyama S, Takata T, Suzuki E, Sugiura Y, Kobayashi T, Chao B-Y. Effects of zinc on cadmium induced alterations in hepatic funcyions and blood glucose of rats. Environ Res 1983: 30: 175-181   DOI   ScienceOn
23 Ikeda M, Zhang ZW, Higashikawa K et al. Background exposure of general women populations in Japan to cadmium in the environment and possible health effects. Toxicol Lett 1999; 108(2/3): 161-166   DOI   ScienceOn
24 Chia SE, Chan OY, Sam CT, Heng BH. Blood cadmium levels on non -occupationally exposed adult subjects in Singapore. Sci Total Environ 1994; 145(1/2): 119-123   DOI   ScienceOn
25 Goering PL, Waalkes MP, Klaassen CD. Toxicology of cadmium, In Toxicology of Metals : Biochemical Aspects, ed, Goyer RA, Cherian MG. Berlin, Springer-Verlag, 1995; 189-214
26 Herber RFM, Chiristensen JM, Sabbioni E. Critical evaluation and review of cadmium concentrations in blood for use in occup Environ Health 1997; 69: 372-378
27 Jin T, Lu J, Nordberg M. Toxicokinetics and biochemistry of cadmium with special emphasis on the role of metallothionein. Neurotoxicology 1998; 19(4/5): 529-535
28 Osfor MM, Dessouky SA, Sayed A, Higazy RA. Relationship between environmental pollution in Manzala lake and health profile of fishermen, Nahrung 1998; 42(1): 42-45   DOI   ScienceOn
29 Krachler M, Rossipal E, Micetic-Turk D. Trace element transfer from the mother to the newborn: investigation on triplets of colostrum, maternal and umbilical cord sera, eur J Clin Nutr 1999; 53(6): 486-494   DOI   ScienceOn
30 Vahter M. Berglund M. Lind B. Jorhem L. Siorach S, Friberg L. Personal monitoring of lead and cadmium exposure-a Swedish study with special reference to methodological aspects, Scand J Work Environ Health 1991; 17: 65-74   DOI
31 박정덕, 박찬병, 최병선, 강은용, 홍연표, 장임원, 천병렬, 예민해, 폐광지역 주민의 뇨 중 카드륨 농도와 신기능평가, 예방의학회지 1998; 31(3)
32 Ikeda M, Moon CS, Zhang ZW, Iguchi H, Watanable T, Iwami O, Imai Y and Shimbo S. Urinary ${\alpha}_1-microglobulin,\;{\beta}_2-microglobulin$, and RBP levels in general populations in Japan with references to cadmium in urine, blood and 24-hour food dupkicates, Environ Res 1995; 70: 35-46   DOI   ScienceOn
33 Ellis KJ, Cohn SH and Smith TJ. Cadmium inhalation exposure estimates: their significance with respect to kidney and liver cadmium burden, J. Toxicol Environ. Health 1985; 15: 173-87   DOI   ScienceOn
34 Muller M and Anke M. Distribution of cadmium in the food chain (soil-plant-human) of a cadmium exposured area and the health risk of the general population, Sci. Total Environ 1994; 156: 151-158   DOI   ScienceOn
35 IPCS. International Programme on Chemical Safety (IPCS): Cadmium. Geneva, Switzerland: World Health Organization, 1992
36 Lopez-Artigue M, Soria ML, Camean A and Repett M. Cadmium in the diet of the local population of Seville (Spain), Bull Environ Contam. Toxieol 1993; 50: 417-424
37 Sato S, Okabe M, Emoto T, Kurasaki M, Kojima Y. Restriction of cadmium transfer to eggs from laying hens exposed to cadmium, J Toxicol Environ Health 1997; 51(1): 15-22   DOI   PUBMED   ScienceOn
38 Zang ZW, Watanabe T, Shimbo S, Higashikawa K, Ikeda M. Lead and cadmium contents in cereals and pulses in north-eastern Chine. Sci Total Environ 1998b; 220 (2/3): 137-145   DOI   PUBMED   ScienceOn
39 Dudley RE, Svoboda DJ, Klassen CD. Acute exposure to cadmium causes severe liver injury in rats, Toxicol Appl Pharmacol 1982; 55: 302-313