• Title/Summary/Keyword: CCR4

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Efficiency Analysis of ASEAN Ports Using DEA & Shannon's Entropy (DEA결합모형을 활용한 아세안(ASEAN)지역 항만의 효율성 분석)

  • Park, Seonyoul;Kim, Sangyoul;Park, Ho
    • Journal of Korea Port Economic Association
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    • v.33 no.4
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    • pp.1-16
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    • 2017
  • The total container throughput of ASEAN is expected to increase continuously with economic development. However, ASEAN port infrastructure is insufficient to handle the increasing trade volume. According to the World Economic Forum, ASEAN ports except Singapore and Malaysia are ranked in low. Participation in ASEAN port development projects can lead an increase in trade efficiency with S. Korea by improving the port infrastructure of ASEAN countries. In addition, the S. Korean port-related industry can be energized through entering ASEAN port development projects. This study, which measures the efficiency of ASEAN ports, can be used as a basic guideline for the development and the planning of the ports. This study used Data Envelopment Analysis(DEA) and Shannon's Entropy model together to measure ASEAN ports' efficiency. After measuring each DEA (CCR, I-BCC, O-BCC, SBM) weight, the efficiency of ASEAN ports is measured as reflecting each DEA weight. As a result, the ports of Singapore and Malaysia, the major ports in the world, have the highest efficiency. Further, Vietnamese ports need to raise efficiency along with increasing container throughput. Leam Chabang (Thailand), Ho Chi Minh City (Vietnam), and Tanjung Priok (Indonesia) exhibit a negative correlation between container throughput and efficiency; therefore, the ports need to improve so as to maintain competitiveness. Lastly, Cambodia, Myanmar, and Brunei, which do not have active economic development, need to improve their ports for economic development.

A Study on the Efficiency and Determinants of Static and Dynamic in Korean property casualty insurance Company (국내 손해보험회사의 효율성 및 결정요인에 대한 Static and Dynamic 분석)

  • Kim, Tae-Hyuk;Park, Chun-Gwang;Kim, Byeong-Chul
    • The Korean Journal of Financial Management
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    • v.25 no.4
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    • pp.183-212
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    • 2008
  • The purpose of this paper is to analyze the efficiency change and determinants of the korean non-life insurance companies. we use DEA (Data Envelopment Analysis) model to measure company efficiency change and use GLS, Tobit model, FIixed effect model, Random effect model, GMM to measure efficiency determinants. we utilize ten non-life insurance companies in korea and the panel data for five from 2001 to 2005. The empirical results show the following findings. First, technical efficiency shows that approximately 15.5% of inefficiency exists on the non-life insurance companies and it reveals that the cause for technical inefficiency is due to scale inefficiency. Second, Dea Window results show that the stable dissimilarity by standard deviation, LDP of CCR. Third, the results of efficiency determinants show that increase efficiency is depend on the premium income and real estates.

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An Analysis of Efficiency in Major University Hospitals in Domestically Capital Area Through DEA Analysis (DEA분석을 통한 국내 수도권 주요 대학병원의 효율성 분석)

  • Park, Byeong-Tae;Lee, Dong-Hyeon
    • Korea Journal of Hospital Management
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    • v.16 no.4
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    • pp.35-66
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    • 2011
  • This study analyzed efficiency by utilizing DEA analytical technique centering on materials for 2009 of 20 major university hospitals in capital area. Input variables were utilized professor & full-time doctor, resident, nurse & number of bed hospitals. Output variables were analyzed by dividing number of annual outpatients & number of annual inpatients, and annually total outpatient profit & inpatient profit into a model of the standard for number of patients and the standard for medical profit. DEA analysis was elicited efficiency score by applying CCR, BCC, BFG, scale profit, and SE model. Through t-test after eliciting efficiency score, the implications were suggested by comparing efficiency between DMU in Seoul and DMU in capital area, by comparing between high-class general hospitals and general hospitals, and by comparing between high-class general hospitals in Seoul and 5 big hospitals. As a result of analysis, the major university hospitals in capital area showed high efficiency as a whole close to "1," but indicated low efficiency relatively in CCR field. Thus, the expansion in scale within capital area was indicated to reach the limit. Second, in a model of analyzing the standard for number of patients, the medical institutions, which are being operated efficiently, were indicated to be 10 DMUs. In the standard for medical profit, 12 DMUs were analyzed to be operated efficiently. Third, the efficiency in general hospital was higher than high-class general hospital. Thus, the efficiency of operation was indicated to be more important than scale. Also, large high-class hospitals(big 5) where are located in downtown Seoul showed the higher efficiency than other general high-class general hospitals, but were indicating very low efficiency in some DMUs. Fourth, as a result of generalizing and evaluating the number of patients and the medical profit, the efficient DMU was indicated to be more when analyzing on the basis of medical profit than the standard for number of patients. Thus, major university hospitals in capital area were indicated to make more effort for section in medical profit. Based on the analytical results of efficiency, a strategy for reinforcing efficiency in inefficient DMU was indicated to be needed a strategy of creating customers for promoting number of patients and a strategy for making operation efficient for increasing profitability.

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Operational Efficiency Analysis of ODCYs as Logistic Facilities in the Hinterland of Busan North Port : Based on DEA Modeling (DEA모형을 이용한 부산항 배후물류시설 ODCY의 운영효율성 분석)

  • Seo, Dong-Gyun
    • Journal of Korea Port Economic Association
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    • v.27 no.4
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    • pp.51-71
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    • 2011
  • The purpose of this study is to use DEA modeling to make an analysis on 12 ODCYs in the hinterland of Busan North Port, so that it may propose possible ways to efficiently operate them. For analysis, this study adopted 3 input factors such as CY area, number of employees and number of cargo work equipments and also adopted 1 output factor, i.e. container throughput. According to the analysis DEA-CCR model, it was found that Chunil(YongDang CY) was the most efficient one among companies engaged in the operation of ODCY. And it was found that KCTC(YongDang CY), Kukbo(U-Am CY), KORAIL(BusanJin CY) and Hanjin (JaeSong CY) would need to boost the container throughput 5 or more times higher than current throughput with a view to improving cargo handling efficiency, while Sebang(U-Am CY), KCTC(U-Am CY), KCTC(YongDang CY), Hyopsung(YongDang CY) and Kukbo(U-Am CY) need to work on personnel restructuring targeted to current employees. Based on the analysis DEA-BCC model, it was found that Chunil(YongDang CY), Dongbu(ShinYoung GamMan CY), Intergis(GamMan CY) and Sebang(U-Am CY) were efficient companies, but KCTC(YongDang CY), Kukbo(U-Am CY), KORAIL(BusanJin CY) and Hanjin(JaeSong CY) were inefficient companies. Particularly, it was found that both KCTC(U-Am CY) and Kukbo(U-Am CY) would need to try harder to carry out personnel reshuffle than other comparable companies.

A Study on the Efficiency Analysis for the Automotive Parts Manufacturer Using Data Envelopment Analysis (DEA를 활용한 자동차부품 기업의 효율성 평가에 관한 연구)

  • Cho, Hyung-Kook;Lee, Cheol-Gyu;Yoo, Wang-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.2
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    • pp.609-615
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    • 2014
  • Due to the recent global recession, the car industry demand levels have plummeted which led to a crisis in the automotive parts industry for the first time in history. Since the fourth quarter of 2008, the automotive parts manufacturers in America have faced a record loss and those in Japan and Europe who also had a strong track record are facing a weak economy. In addition, the domestic automotive parts industry is also affected by the global economic crisis. This research is that the relative efficiency analysis utilizing the DEA has done on the object of 25 small and medium-sized automotive parts manufacturers publicly listed, As the efficiency analysis result 6 of 25 manufacturers are efficient in CCR model and 12 manufactures have shown efficiency in BCC model, the efficiency analysis in consideration of the manufacturer size. The manufacturers with efficiency 1 in 25 manufacturers are DMU 1, 5, 7, 10, 18, 24 and the relatively benchmarking objects in other manufactures are DMU 1, 10, 24, Based on the results of this research, a direction to the domestic automotive parts manufacturers as well as a significant information will be provided in managing the companies in the future by the improvement of management efficiency through the practical efficiency analysis.

Application of Integrated Modelling Framework Consisted of Delft3D and HABITAT for Habitat Suitability Assessment (생물서식지 적합성 평가를 위한 Delft3D와 HABITAT 모델의 연계 적용)

  • Lim, Hyejung;Na, Eun Hye;Jeon, Hyeong Cheol;Song, Hojin;Yoo, Hojun;Hwang, Soon Hong;Ryu, Hui-Seong
    • Journal of Korean Society on Water Environment
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    • v.37 no.3
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    • pp.217-228
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    • 2021
  • This paper discusses a methodology where an integrated modelling framework is used to quantify the risk derived from anthropic activities on habitats and species. To achieve this purpose, a tool comprising the Delft3D and HABITAT model, was applied in the Yeongsan river. Delft3D effectively simulated the operational condition and flow of weirs in river. In accuracy evaluation of the Delft3D-FLOW, the Bias, Pbias, Mean Absolute Error (MAE), Nash-Sutcliffe Efficiency (NSE), and Index of Agreement (IOA) were used, and the result was evaluated as grade above 'Satisfactory'. The HABITAT calculated Habitat Suitability Value (HSV) for the following eight species: mammal, fish, aquatic plant, and benthic macroinvertebrate. An Area was defined as a suitable habitat if the HSV was larger than 0.5. HABITAT was judged accurately by measuring the Correct Classification rate (CCR) and the area under the ROC curve (AUC). For benthic macroinvertebrate, the CCR and AUC were 77% and 0.834, respectively, at thresholds of 0.017 and 4 inds/m2 for HSV and individuals per unit area. This meant that the HABITAT model accurately predicted the appearance of the benthic macroinvertebrates by approximately 77% and that the probability of false alarms was also very low. As a result of evaluating the suitability of habitats, in the Yeongsan river, if the annual "lowest level" (Seungchon weir: 2.5 EL.m/ Juksan weir: -1.35 EL.m) was maintained, the average habitat improvement effect of 6.5%P compared to the 'reference' scenario was predicted. Consequently, it was demonstrated that the integrated modelling framework for habitat suitability assessment is able to support the remedy aquatic ecological management.

Efficiency evaluation of nursing homes in China's eastern areas Based on DEA-Malmquist Model (DEA-Malmquist를 활용한 중국 동부지역 요양원의 효율성 평가에 관한 연구)

  • Chu, Ting;Sim, Jae-yeon
    • Journal of the Korea Convergence Society
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    • v.12 no.7
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    • pp.273-282
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    • 2021
  • Nursing home plays a role in providing elderly care in the context of China's rapid population aging, but little understanding of the efficiency of the nursing homes. In this paper, we investigated the efficiency in nursing homes using Data Envelopment Analysis (DEA) and Malmquist index (MPI) for the modeling of the number of nursing home beds, fixed assets, and medical personnel as input variables, and the number of elderly people of self-care, the number of elderly people of partial self-care, the number of bed-ridden elderly people and the income of nursing homes as output variables. Stratification analysis showed that the top two provinces in the DEA-CCR yield were Beijing and Shanghai in the five-year survey period. Four provinces (Beijing, Jiangsu, Shandong, and Shanghai) scored 1.00 in terms of DEA-BCC yield. The MPI analysis showed that Hainan ranked the highest five-year average in the included provinces. In terms of resource utilization, internal management, operation scale, and other aspects, the nursing homes in the provinces with high-efficiency evaluation results show high efficiency and technological progress, whereas the areas with low-efficiency evaluation showed a feature of the improving technical efficiency.

CD7-Specific Single Chain Antibody Mediated Delivery of siRNA to T Cells Inhibits HIV Replication in a Humanized Mouse Model

  • Ban, Hong-Seok;Kumar, Priti;Kim, Na-Hyun;Choi, Chang-Son;Shankar, Premlata;Lee, Sang-Kyung
    • Proceedings of the Microbiological Society of Korea Conference
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    • 2008.05a
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    • pp.62-64
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    • 2008
  • A major hurdle to the development of RNA interference as therapy for HIV infection is the delivery of siRNA to T lymphocytes which are difficult cells to transfect even in vitro. We have employed a single chain antibody to the pan T cell surface antigen CD7 was conjugated to an oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in NOD/SCIDIL2${\gamma}$-/- mice reconstituted with human peripheral blood lymphocytes (Hu-PBL). Using a novel delivery, we first show that scFvCD7-9R efficiently delivered CD4 siRNA into human T cells in vitro. In vivo administration to Hu-PBL mice resulted in reduced levels of surface CD4 expression on T cells. Mice infected with HIV-1 and treated on a weekly basis with scFvCD7-9R-siRNA complexes targeting a combination of viral genes and the host coreceptor molecule CCR5 successfully maintained CD4/CD3 T cell ratios up to 4 weeks after infection in contrast to control mice that displayed a marked reduction in CD4 T cell numbers. p24 antigen levels were undetectable in 3 of the 4 protected mice. scFvCD7-9R/antiviral siRNA treatment also helped maintain CD4 T cell numbers with reduced plasma viral loads in Hu-PBL mice reconstituted with PBMC from donors seropositive for HIV, indicating that this method can contain viral replication even in established HIV infections. Our results show that scFvCD7-9R could be further developed as a potential therapeutic for HIV-1 infection.

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Effect of Tang-gwi-eum-za-gagambang along with External Spray Therapy on the Spontaneously Occurring Atopic Dermatitis Development in NC/Nga Mouse (당귀음자가감방(當歸飮子加減方)과 외치방(外治方) 병용이 NC/Nga 아토피 생쥐에 미치는 영향)

  • Kim, Sung-Hun;Kim, Jong-Han;Park, Su-Yeon;Choi, Jung-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.18 no.1
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    • pp.27-49
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    • 2005
  • 당귀음자가감방(當歸飮子加減方)과 외치방(外治方) 병용의 아토피 치료 기전을 규명하고자 NC/Nga 생쥐의 동물 병태 모델을 이용하여 다양한 면역 반응을 관찰하였던 바, 다음과 같은 결론을 얻었다. 1. NC/Nga 생쥐의 피부손상 정도 16주와 20부에 대조군에 비해 36.0%, 37.8% 감소하다. 2. NC/Nga 생쥐의 혈중(血中) IgE, IL-4, IL-5, IL-6, IgM, IgG1 및 IgG2a 수준은 대조군에 비하여 유의성 있게 감소하였고, IL-13 수준은 대조군에 비하여 감소하였으나 유의성을 나타내지 않았다. 반면, $IFN-{\gamma}$ 수준은 유의성 있게 증가하다. 3. NC/Nga 생쥐의 비장 무게는 대조군에 비하여 유의성있게 감소하였다. 4. NC/Nga 생쥐의 lymph node에서 B/f ratio는 증가된 대조군에 비하여 감소하였으며, $CD4^+$$CD8^+$ 세포 발현은 대조군에 비하여 증가하였고, $CD4^+$는 유의성있는 감소를, $CD8^+$는 유의성 없는 약간의 증가를 나타내었다. $CD69^+$, CD11a 세포 발현은 대조군에 비하여 유의성있게 감소하였다. 5. NC/Nga 생쥐의 피부조직배양에서 IL-4 IL-5, CCR3 유전자 발현은 대조군에 비하여 현저히 감소하였고, IL-6, IL-13, $CD69^+/CD3{\varepsilon}^+,{\;}CD19^+/CD44^+$ 발현량은 유의성있게 감소하였으며, $IFN-{\gamma}$의 유전자 발현은 대조군에 비하여 증가하였다. 6. NC/Nga 생쥐 귀, 목의 피부 조직 변화에서는 표피와 진피의 염증 정도와 침윤된 염증 면역세포 등이 대조군에 비하여 현저하게 감소되었다. 7. Lymphokine assay에서 IL-4 발현량은 대조군에 비하여 유의성 있게 감소(減少)하였고, $IFN-{\gamma}$의 발현량은 유의성 있게 증가하였다.

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The Inhibitory Effects of Lactose-${\beta}$-sitosterol on the Inflammatory Responses of HMC-1 Cells and EoL-1 Cells

  • Yang, Eun-Ju;Kim, In-Sik
    • Biomedical Science Letters
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    • v.17 no.3
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    • pp.217-223
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    • 2011
  • ${\beta}$-sitosterol glucoside exists in a variety of plants and have anti-tumor, anti-microbial, and immunomodulatory activities. Mast cells and eosinophils play important roles in a variety of inflammatory diseases, specifically asthma and atopic dermatitis. In the present study, we used lactose-${\beta}$-sitosterol (L-BS) and investigated the effect of L-BS on inflammatory responses of the human mast cell line, HMC-1 and the human eosinophilic leukemia cell line, EoL-1. In HMC-1 cells, L-BS significantly inhibited cell migration in response to stem cell factor without cytotoxicity. However, the mRNA expression of CC chemokine receptors (CCRs), including CCR1-5, were not altered after L-BS treatment in HMC-1 cells. LPS-induced IL-4 production was also suppressed by L-BS in a dose-dependent manner. In EoL-1 cells, the concentration ranging from 0.1 ${\mu}M$ to 10 ${\mu}M$ of L-BS had no cytotoxicity and had no effect on mRNA expression of major protein-mediators derived from activated eosinophils. However, 100 ${\mu}M$ of L-BS induced the apoptosis of EoL-1 cells in a time-dependent manner. This finding indicates the possibility of L-BS as a potential therapeutic molecule in inflammatory diseases and may contribute to the need to improve current therapeutic drugs.