• Food Science of Animal Resources
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• v.18 no.3
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• pp.203-208
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• 1998

The study was carried out to screen mutagenicity of smoking materials for the determination of optimum smoking temperature for meat products. Wood materials employed for smoking were oak and apple trees. Temperatures of the generator for manufacturing of smoke flavoring were set to 250$^{\circ}C$, 400$^{\circ}C$ and 500$^{\circ}C$, respectively. Mutagenic activities of smoke flavoring were assayed according to Ames test using Salmonella typhimurium TA98 and TA 100. In oak wood smoke flavoring, Salmonella typhimurium TA98 without S-9 mix showed strong mutagenic activities at the concentration of 6$\mu\textrm{g}$/plate(250$^{\circ}C$), 4$\mu\textrm{g}$/plate(400$^{circ}C$) and 6$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA100 with S-9 mix showed strong mutagenic activities at the concentration of 10$\mu\textrm{g}$/plate(250$^{\circ}C$), 20$\mu\textrm{g}$/plate(400$^{\circ}C$) and 10$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA98 with S-9 mix showed strong mutagenic activities at the concentration of 30$\mu\textrm{g}$/plate(250$^{\circ}C$), 40$\mu\textrm{g}$/plate(400$^{\circ}C$) and 20$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA100 with S-9 mix showed strong mutagenic activities at the concentration of 30$\mu\textrm{g}$/plate(250$^{\circ}C$), 50$\mu\textrm{g}$/plate(400$^{\circ}C$) and 20$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA100 without S-9 mix showed strong mutagenic activities at the concentration of 10$\mu\textrm{g}$/plate(250$^{\circ}C$), 20$\mu\textrm{g}$/plate(400$^{\circ}C$) and 20$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA98 with S-9 mix showed strong mutagenic activities at the concentration of 30$\mu\textrm{g}$/plate(250$^{\circ}C$), 40$\mu\textrm{g}$/plate(400$^{\circ}C$) and30$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA100 with S-9 mix showed strong mutagenic activities at the concentrations 30$\mu\textrm{g}$/plate(500$^{\circ}C$). Salmonella typhimurium TA100 with S-9 mix showed strong mutagenic activities at the concentration of 30$\mu\textrm{g}$/plate(250$^{\circ}C$), 20$\mu\textrm{g}$/plate(400$^{\circ}C$) and 30$\mu\textrm{g}$/plate(500$^{\circ}C$). From these results, it could be concluded that optimum smoking temperature for meat products should be set below 400$^{\circ}C$, that the compounds like benzo[a]pyrene etc. contain a variety of mutagenic potentials, which could be generated at the higher smoking temperature.

• Korean journal of applied entomology
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• v.31 no.4
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• pp.492-495
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• 1992

Life cycle of the mirid predator, Cyrtorhinus lividipennis, was observed on the constant temper¬ature. Egg periods were 14.43, 9.33 and 6.94 days at $20^{\circ}C$, $25^{\circ}C$ and $30^{\circ}C$, respectively. Nymph periods were 24.3, 14.42, and 11.90 days at $20^{\circ}C$, $25^{\circ}C$ and $30^{\circ}C$, respectively and fe¬male longevity was 11.20, 11.93 and 11.87 days at above temperatures. Relationships between constant temperature and the developmental velocity of egg, nymph and egg-nymph were lin¬ear over temperatures tested. The calculated threshold temperatures of development were $10.7^{\circ}C$ in egg, $9.8^{\circ}C$ in nymph and $10.2^{\circ}C$ in egg-nymph. Total effective day-degrees were 133.9 in egg, 235.8 in nymph and 368.0 in egg-nymph. Number of eggs laid was 26.0 and 22.4 at $24^{\circ}C$ and $30^{\circ}C$, respectively.

• Molecular & Cellular Toxicology
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• v.2 no.4
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• pp.262-265
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• 2006

We report a case of phenytoin toxicity due to impaired drug metabolism in a patient homozygous for $CYP2C9^{\ast}3$. A 46-year-old woman was taking phenytoin to prevent postoperative seizures. She attained high serum phenytoin levels at the standard doses (300 mg/day) and developed symptoms of phenytoin toxicity including blurred vision, nausea and headache. The patient was treated with reduced doses of phenytoin and then phenytoin therapy was finally discontinued. Genotyping for CYP2C9 revealed that this patient had a homozygous genotype, $CYP2C9^{\ast}3/^{\ast}3$. This is the first Korean case of phenytoin toxicity with homozygous $CYP2C9^{\ast}3$. This case suggests the clinical usefulness of pharmacogenetic testing for individualized dosage adjustments of phenytoin.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.11a
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• pp.325-328
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• 2007

In this study, intended to high flight condition test, air flow test and environmental condition test of Small-sized Gas Turbine (including auxiliary power utility - APU) improve preexisting large size test stand C-9N(SCIAM) in Russia. In the process of developing C-9N test stand, this study includes conceptual design approach. This test stand consists of environmental condition, thermostat, cooling/drying, thrust measuring system and SAR (system of automatic regulation).

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.5
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• pp.832-836
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• 1994

This study was carried out to investigate several kinds of characteristics of pork sausage prepared by different cooking temperature and time (60, 90, 120, 150, 180 minutes in $58^{\circ}C$ and 25, 40, 55, 70, 85 minutes in $65^{\circ}C$). In case of color, L(bright), a (red) and b(yellow) value were 64.60-65.26, 9.14-9.94 and 8.68-9.34 in $58^{\circ}C$, and 65.16-66.68, 8.78-9.62 and 7.66-8.36 in $63^{\circ}C$, respectively. Gel strength showed high when cooking time was 120, 250 and 180 minute in $58^{\circ}C$ and 40 minute in $65^{\circ}C$. Residual nitrite concentration showed higher $58^{\circ}C$ than $65^{\circ}C$ and decreased gradually as cooking time elevated in all cooking temperature. Total plate count in 58$^{\circ}C$ was higher than $65^{\circ}C$, was wholly $8.7{\times}10^2~3.5{\times}10^3$.In case of free amino acid content, Asp, Glu and Lys were high and Cys, Met and Tyr low and was not different with $58^{\circ}C$ and $65^{\circ}C$. The result of sensory evaluation was not different (p<0.05) with $58^{\circ}C\;and\;65^{\circ}C$.

• Korean journal of applied entomology
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• v.41 no.2
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• pp.91-97
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• 2002

This study was conducted to determine the effects of temperature and food onthe nymphal development and adult longevity of the green virid bug, Cyrtorhinus lividipennis Router. Nymphal period was 13.2 to 13.7 days at 24$^{\circ}C$, 10.4 to 10.9 days at 28$^{\circ}C$, and 9.0 to 9.3 days at 32$^{\circ}C$. Number of eggs predated by nymph was 10.6-14.3 at 24$^{\circ}C$, 7.5-9.2 at 28$^{\circ}C$, and 5.8-7.5 at 32$^{\circ}C$. Amount of predation was highest on BPH, followed by SBPH, WBPH, and GLH. Number of nympal moulting was mostly four times (55-75%) followed by three times (25-45%), regardless of temperature and food. Percent emergence rate was 52-70%, 48-66% and 22-38% at 24$^{\circ}C$, 28$^{\circ}C$ and 32$^{\circ}C$, respectively, showing a tendency to decrease with increasing temperature, and was affected by foods. Adult longevity, when supplied with one food, was 19.8 to 22.5 days at 24$^{\circ}C$, 15.6 to 17.0 days at 28$^{\circ}C$, and 10.3 to 11.7 days at 32$^{\circ}C$. There was no significant difference among foods in terms of adult longevity, but it tended to be slightly longer when provided with four foods than with one food. Number of eggs predated by an adult, when supplied with one food, was 35.7-54.2, 31.6-44.6 and 18.1-28.2 at 24$^{\circ}C$, 28$^{\circ}C$ and 32$^{\circ}C$, respectively. It was highest on BPH, followed by SBPH, WBPH and GLH regardless of temperature. Number of egg Predated by an adult, when supplied with four foods, was 4.0-28.9, 2.9-29.0 and 17-13.6 at 24$^{\circ}C$, 28$^{\circ}C$ and 32$^{\circ}C$, respectively, and was significantly different among foods supplied. The results suggest that the significantly different predation amount by adult was due to food preference amoung the different foods.

• Journal of the korean academy of Pediatric Dentistry
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• v.26 no.2
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• pp.339-349
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• 1999

The dental structure substituted by restorative materials may produce discomfort resulting from hot or cold stimuli. To investigate the effects of this stimuli on the human teeth, thermal analysis was carried out by calculation of general heat conduction equation in a modeled tooth using numerical method. The method has been applied to axisymmetric and two-dimensional model, analyzing the effects of constant temperature $4^{\circ}C\;and\;60^{\circ}C$. That thermal shock was provided for 2 seconds and 4 seconds, respectively and recovered to normal condition of $20^{\circ}C$ until 10 seconds. The thermal behavior of tooth covered with a crown of gold or stainless steel was compared with that of tooth without crown. At the same time, the effects of restorative materials(amalgam, gold and zinc oxide-eugenol(ZOE)) on the temperature of PDJ(pulpo-dentinal junction) has been studied. The geometry used for thermal analysis so far has been limited to two-dimensional as well as axisymmetric tooth models. But the general restorative tooth forms a cross shaped cavity which is no longer two-dimensional and axisymmetric. Therefore, in this study, the three-dimensional model was developed to investigate the effect of shape and size of cavity. This three-dimensional model might be used for further research to investigate the effects of restorative materials and cavity design on the thermal behavior of the real shaped tooth. The results were as follows; 1. When cold temperature of $4^{\circ}C$ was applied to the surface of the restored teeth with amalgam for 2 seconds and recovered to ambient temperature of $20^{\circ}C$, the PDJ temperature decreased rapidly to $29^{\circ}C$ until 3 seconds and reached to $25^{\circ}C$ after 9 seconds. This temperature decreased rather slowly with stainless steel crown, but kept similar temperature within $1^{\circ}C$ differences. Using the gold as a restorative material, the PDJ temperature decreased very fast due to the high thermal conductivity and reached near to $25^{\circ}C$ but the temperature after 9 seconds was similar to that in the teeth without crown. The effects of coldness could be attenuated with the ZOE situated under the cavity. The low thermal conductivity caused a delay in temperature decrease and keeps $4^{\circ}C$ higher than the temperature of other conditions after 9 seconds. 2. The elapse time of cold stimuli was increased also until 4 seconds and recovered to $20^{\circ}C$ after 4 seconds to 9 seconds. The temperature after 9 seconds was about $2-3^{\circ}C$ lower than the temperature of 2 seconds stimuli, but in case of gold restoration, the high thermal conductivity of gold caused the minimum temperature of $21^{\circ}C$ after 5 seconds and got warm to $23^{\circ}C$ after 9 seconds. 3. The effects of hot stimuli was also investigated with the temperature of $60^{\circ}C$. For 2 seconds stimuli, the temperature increased to $40^{\circ}C$ from the initial temperature of $35^{\circ}C$ after 3 seconds of stimuli and decreased to $30^{\circ}C$ after 9 seconds in the teeth without crown. This temperature was sensitive to surface temperature in the teeth with gold restoration. It increased rapidly to $41^{\circ}C$ from the initial temperature of $35^{\circ}C$ after 2 seconds and decreased to $28^{\circ}C$ after 9 seconds, which showed $13^{\circ}C$ temperature variations for 9 seconds upon the surface temperature. This temperature variations were only in the range of $5^{\circ}C$ by using ZOE in the bottom of cavity and showed maximum temperature of $37^{\circ}C$ after 3 seconds of stimuli.

• Journal of Ginseng Research
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• v.21 no.3
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• pp.141-146
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• 1997

The role of cAMP in the differentiation process of F9 cells induced by ginsenosides was examined by performing transient transfixion assay with CRE-luciferase reporter plasmid, GR thansactivation assay with GRE-luciferase activity with or without treatment of CAMP and forskolin, an activator of adenylate cyclase, and protein klnase A assay in the presence of ginsenosides. Ginsenosides had no effect on CRE-transactivation activity, whereas retinoic acid induced the activity. When cAMP or forskolin was treated with ginsenosides, GRE-luciferase activity was further augumented by them. In addition, ginsenosides induced protein kinase A activity in the presence of cAMP. These results suggest that ginsenosides activate cAMP-dependent protein kinase A which, in turn, increase GR activity in F9 cells.

• Journal of Forest and Environmental Science
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• v.9 no.1
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• pp.67-80
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• 1993

There are a lot of serious problums associated with conventional pulping processes, such as kraft and sulfite. In order to tackle these difficulties, organic acid pulping of Populus tomentiglandulosa T. Lee and Pinus densiflora S. et Z. have been investigated as on alternative method. The acetic acid cooking of Populus tomentiglandulosa T. Lee achieved good delignification with pulp yields of 55-65% under almost all cooking conditions. In the acetic acid cooking of Pinus densiflora S. et Z., it was not cooked at a low temperature. The strength properties of the acetic acid pulps from Pinus tomentiglandulosa T. Lee showed the optimum with 95% acetic acid concentration at $185^{\circ}C$ maximum cooking temperature for 0.5hr cooking time. The strength properties of the acetic acid pulps from Pinus densiflora S. et Z. displayed excellent tear strength in comparison with those of the other softwoods. In the process of acetic acid cooking, glucose has been removed a little, but other sugars have been eliminated. The elemental compositions and $C_9$ formulas of acetosolv lignins from Populus tomentiglandulosa T. Lee were 63.88% carbon, 5.45% hydrogen and 30.67% oxygen and $C_9H_{9.15}O_{3.24}$ The elemental compositions and $C_9$ formulas of acetosolv lignins from Pinus densiflora S. et Z. were 61.85% carbon, 6.14% hydrogen and 32.01% oxygen and $C_9H_{9.15}O_{3.50}$ The Wt. av. MWT's of the acetosolv lignins from Pinus tomentiglandulosa T. Lee and Pinus densiflora S. et Z. were 731 and 725.

• Korean journal of applied entomology
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• v.42 no.3
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• pp.211-216
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• 2003

Development and reproduction of Dichromothrips smithi were investigated under different temperatures, Durations of the development from egg to pre-adult of D. smithi were measured under 11 temperature ranges and it was 44.0 days at 13$^{\circ}C$ and 8.7 days at 32$^{\circ}C$. Developmental zero point and total effective temperature for the development of egg and larva, prepupa, pupa and for the complete development (egg to emergence) were 9.4, 8.9, 10.5, 10.8 and 9.5$^{\circ}C$, and 46.1, 90.1, 23.9, 41.2 and 204.4 degree days, respectively. The adult longevity was 28.3 days at 15 C and 14.3 days at 30$^{\circ}C$. The highest average fecundity per female was 69.3 at 25 C. The highest intrinsic rate of natural increase (r$\_$m/) and the highest net reproduction rate (R$\_$o/) were 0.241 at 30$^{\circ}C$ and 56.56 at 25$^{\circ}C$. The optimum temperature range for the growth of D. smithi was between 25$^{\circ}C$ and 30$^{\circ}C$.