• Animal cells and systems
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• v.13 no.2
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• pp.97-103
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• 2009

Recently, great advance is achieved in the field of genome-wide functional screening using cell-based assay. Here, we briefly introduce well-established and typical cell-based assays of GPCR and some parameters which should be considered for genome-wide functional screening. Because of characters and importance of GPCR as drug targets, several ways of assay systems were devised. Among them, high-content screening (HCS) that is based on the analysis of image by confocal microscope is becoming favorite choice. The advances in this technology have been driven exclusively by industry for their convenience. Now, it is turn for academy to define more detail signaling networks via HCS using cDNA or siRNA libraries at genome-wide level. By isolating novel signaling mediators using cDNA or siRNA library, and postulating them as new candidates for therapeutic target, more understanding about life science and more increased chances to develop therapeutics against human disease will be achieved.

• Journal of Information Science Theory and Practice
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• v.6 no.3
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• pp.16-24
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• 2018

The purpose of this paper is to investigate the domain authority, number of webpages, links, and calculate the web impact factor of six public libraries of India which are fully funded by Ministry of Culture with the supervision of administration. The data for the study were collected from websites of concerned libraries with the help of a suitable search engine, Open Site Explorer. The study found that the highest domain and page authority was recorded by Khuda Baksh Oriental Public Library and National Library, respectively. It also further revealed that excepting the two libraries, i.e., Khuda Baksh Oriental Public Library and Delhi Public Library, the internal equity-passing links and total internal links of rest of the libraries is zero. National Library leads with maximum total links and total equity-passing links, also with the highest followed linking root domains, total linking root domains, and linking C blocks, and concludes with the web impact factor of Central Secretariat Library recording the maximum, followed by National Library and Khuda Baksh Oriental Public Library.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.4
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• pp.807-819
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• 2019

Greybox fuzzing is known as an effective method to discover unknown security flaws reside in software and has been actively researched today. However, most of greybox fuzzing tools require an executable file. Because of this, a library, which cannot be executed by itself requires an additional executable file for greybox fuzzing. Generating such an executable file is challengeable because it requires both understanding of the library and fuzzing. In this research, we suggest the approach to generate an executable file automatically for a library and implement this approach as a tool based on the LLVM framework. This tool shows that executable files and seed files can be generated automatically by static/dynamic analysis of a unit test in the target project. A generated executable file is compatible with various greybox fuzzers like AFL because it has a common interface for greybox fuzzers. We show the performance of this tool as code coverage and discovered unknown security bugs using generated executable files and seed files from open source projects through this tool.

• Journal of Information Management
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• v.39 no.1
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• pp.109-129
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• 2008

This study was prepared for the purpose of suggesting the reasonable method of library management by reflecting it to the library acquisition and collection development through the user survey and analysis of an academic library. The 97,164 circulation records of C-academic library which were occurred between March 2006 and February 2007 were used, and sixteen subjects by five user groups ((1)undergraduate, (2)graduate students, (3)faculties(professors), (4)staffs, and (5)the other users) were surveyed for the study. The subject and the number of publication lapse year were categorized in this study. The non-parametric method and correlation coefficient were used for the analysis of subject part after the use factor and the number of publication lapse year were crossed by their status. Also, the same methods by use factor were used for the analysis of the number of year part.

• Korean Journal of Microbiology
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• v.42 no.4
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• pp.246-251
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• 2006

A lot of mutants which cannot initiate sexual development were screened and several loci including nsdA, nsdB, nsdC, and nsdD were identified in homothallic ascomycetes Aspergillus nidulans. The NSD206, which has nsdC6 allele, showed typical phenotype of NSD (Never in sexual development) mutants. The nsdC gene was cloned by transforming NSDP697 ($nsdC^-$, $pryG^-$) with AMA1-NotI genomic library. The transforming library DNA recovered from several transformants showing wild phenotype carried about 10 kb genomic DNA insert. The DNA sequence of nsdC was analysed using GPS (Genome priming system). The nsdC gene has an open reading frame (ORF) of 1,929 bp encoding a putative polypeptide of 643 amino acids. The NsdC carries $C_2H_2C_2H_2C_2HC$ type zinc finger DNA binding domains in the middle of the polypeptide. A coiled-coil domain at its C terminus were also found. In nsdC6 allele, a single T insertion was occurred between 407-408 bp leading to the frameshift mutation and early termination of translation producing the truncated protein which has only 139 amino acids.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37C no.9
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• pp.851-858
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• 2012

Java crypto library such as SUN JCA/JCE or BC JCE is generally used to implement secure applications for smart devices using Android platform. Programming functions written by Java language are launched and executed inside Java Virtual Machine (JVM), thereby difficult to use system hardware specific functionalities and degrading performance as well. In case of crypto primitive, few secure applications can use crypto primitive executing in JVM because both amount of computing and complexity of such primitives are very high. From the aspect of performance, in particular, time sensitive real time applications such as streaming services or secure application frequently applying public key based crypto algorithm cannot use Java crypto library. To solve the problem, we design and implement crypto library which employ JNI and NDK methods to directly access functions that implemented by native language such as C or C++. The proposed Java Crypto provider supports faster execution. Also developer can use our provider in the same way by writing traditional Java crypto library.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.377-381
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• 2012

The aim of this study was to screen for polypeptides binding specifically to LoVo human colorectal cancer cells using a phage-displayed peptide library as a targeting vector for colorectal cancer therapy. Human normal colorectal mucous epithelial cells were applied as absorber cells for subtraction biopanning with a c7c phage display peptide library. Positive phage clones were identified by enzyme-linked immunosorbent assay and immunofluorescence detection; amino acid sequences were deduced by DNA sequencing. After 3 rounds of screening, 5 of 20 phage clones screened positive, showing specific binding to LoVo cells and a conserved RPM motif. Specific peptides against colorectal cancer cells could be obtained from a phage display peptide library and may be used as potential vectors for targeting therapy for colorectal cancer.

• Journal of the Korean Society for Library and Information Science
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• v.42 no.4
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• pp.533-549
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• 2008

A job analysis of subject specialist librarians is an important source providing information about definition of a job, development of a curriculum, administration of human resources, criteria of employee training, and deciding institutional and individual objectives. This study analyzes a job of subject specialist librarians in Korea, and divides their jobs into 7 duties and 58 tasks. the 7 duties are as follows; A. a development of subject information resources, B. a management of information resources classified by subjects, C. a research support service classified by subjects, D. Liasion activity of library users, E. an education of subject classification for library users, F. library management, G. personal development of classified subject areas.

• Journal of Information Science Theory and Practice
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• v.3 no.2
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• pp.58-72
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• 2015

This paper focuses generally on the ‘fourteen principles of management’ by Henri Fayol. However, it specifically analyses their application to and implications for libraries and information centres. An extensive review of published works on management generally, and library management in particular, was conducted. This yielded vital insights on the original meaning and later modifications of these principles, as well as their application in the management of various organisations. Consequently, the strengths and weaknesses of these principles were examined to determine their suitability in libraries and information centres. Inferences, illustrations, and examples were drawn from both developed and developing countries which gives the paper a global perspective. Based on available literature, it was concluded that Fayol’s principles of management are as relevant to libraries as they are in other organisations. The paper, therefore, recommends that in addition to modifying some aspects to make these principles more responsive to the peculiar needs of libraries, further research should be undertaken to expand the breadth of these principles and ascertain their impacts on the management of information organisations.

• Korean Journal of Plant Tissue Culture
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• v.26 no.2
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• pp.121-126
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• 1999

Calli were induced from the petiole explants of Pimpinella brachycarpa on MS medium supplemented with 0.5 mg/L 2,4-D and 0.1 mg/L BA after four weeks of culture. Compact clusters of small and dense cells among these calli were selected and suspension-cultured as the source of embryogenic calli. When transferred to MS medium with 0.1 mg/L NAA, the suspension-cultured cells grew to embryogenic callus. Somatic embryos derived from these embryogenic calli developed into plantlets. The cDNA library was constructed in the embryogenic callus and in order to screen the cDNA library, these cDNAs were plated at a density 1.5 $\times$ 10^5 plaques per 15 cm petridish. Among 19 clones showing preferential hybridization with petiole HD-Zip gene, five clones were obtained after second screening. Four clones among them, were highly homologous to P. brachycarpa shoot-tip Phz4 gene, but one clone, Phc5 was about 1.5 kb which has an extra 163 bp to 5' upstream of Phz4. The Phc5 was 1,531 bp containing poly A tails of 18 bases. ATG start codon for Phc5, was located at position 284 with an open reading frame of 906 by which encodes a polypeptide of 302 amino acids. The Phc5 protein revealed that the polypeptides between 135 and 195 contain a homeodomain as the `leucine zipper' motif.