• Title/Summary/Keyword: C&D

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The Usability Analysis of 3D-CRT, IMRT, Tomotherpy Radiation Therapy on Nasopharyngeal Cancer (NPC의 방사선치료시 3D-CRT, IMRT, Tomotherapy의 유용성 분석)

  • Song, Jong-Nam;Kim, Young-Jae;Hong, Seung-Il
    • Journal of the Korean Society of Radiology
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    • v.6 no.5
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    • pp.365-371
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    • 2012
  • The radiation therapy treatment technique is developed from 3D-CRT, IMRT to Tomotherapy. and these three technique was most widely using methods. We find out a comparison normal tissue doses and tumor dose of 3D-CRT, IMRT(Linac Based), and Tomotherapy on Head and Neck Cancer. We achieved radiological image used the Human model phantom (Anthropomorphic Phantom) and it was taken CT simulation (Slice Thickness : 3mm) and GTV was nasopharngeal region and PTV(including set-up margin) was GTV plus 2mm area. and transfer those images to the radiation planning system (3D-CRT - ADAC-Pinnacle3, Tomotherapy - Tomotherapy Hi-Art System). The prescription dose was 7020 cGy and measuring PTV's dose and nomal tissue (parotid gland, oral cavity, spinal cord). The PTV's doses was Tomotherapy, Linac Based - IMRT, 3D-CRT was 6923 cGy, 6901 cGy and 6718 cGy its dose value was meet TCP because its value was up to the 95% based on 7020 cGy, Nomal tissue (parotid gland, oral cavity, spinal cord) was 1966 cGy(Tomotherapy), 2405 cGy(IMRT), 2468 cGy(3D-CRT)[parotid gland], 2991 cGy(Tomotherapy), 3062 cGy(IMRT), 3684 cGy (3D-CRT)[oral cavity], 1768 cGy(Tomotherapy), 2151 cGy(IMRT), 4031 cGy(3D-CRT)[spinal cord] its value did not exceeded NTCP. All the treatment techniques are equated with tumor and nomal tissue doses. The 3D-CRT was worse than other techniques on dose distribution, but it is reasonable in terms of TCP and NTCP baseline Tomotherapy, IMRT -dose distribution was relatively superior- was hard to therapy to claustrophobic patients and patients with respiratory failure. Particularly, in case on Tomotherapy, it take MVCT before treatment so dose measurement will be unnecessary radiation exposure to patients. Conclusion, Tomotherapy was the best treatment technique and 2nd was IMRT, and 3rd 3D-CRT. But applicable differently depending on the the patient's condition even though dose not matter.

Immune Effect of Newcastle Disease Virus DNA Vaccine with C3d as a Molecular Adjuvant

  • Zhao, Kai;Duan, Xutong;Hao, Lianwei;Wang, Xiaohua;Wang, Yunfeng
    • Journal of Microbiology and Biotechnology
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    • v.27 no.11
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    • pp.2060-2069
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    • 2017
  • Newcastle disease is a serious infectious disease in the poultry industry. The commercial vaccines can only offer limited protection and some of them are expensive and need adjuvants. At present, DNA vaccines are widely used. However, the immune responses induced by DNA vaccines are too slow and low. Here, we constructed the transfer vectors with a different number of C3d as molecular adjuvants (n = 1, 2, 4, or 6), and the vectors were cloned into the optimal eukaryotic expression plasmid (pVAXI-optiF) that expressed the F gene of Newcastle disease virus (NDV), and named pVAXI-F(o)-C3d1, pVAXI -F(o)-C3d2, pVAXI-F(o)-C3d4, and pVAXI-F(o)-C3d6, respectively. Cell transfection test indicated that pVAXI-F(o)-C3d6 showed the highest expression. In vivo immunization showed that the chickens immunized with pVAXI-F(o)-C3d6 intramuscularly induced better immune responses than the chickens immunized with the other plasmids. The protective efficacy of pVAXI-F(o)-C3d6 was 80% after challenge with the highly virulent NDV strain F48E9. The results in this study showed that C3d6 could be used as a molecular adjuvant to quickly induce an effective immune response to control NDV.

Study on the Selection of Suitable Resident for C.B.D. Living by Using the Logit Model -The Case of Taegu City- (로짓 模型을 利用한 都心居住의 適住者 選定에 관한 硏究 - 大邱市를 中心으로 -)

  • 임준홍;김한수
    • Journal of the Korean housing association
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    • v.10 no.1
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    • pp.11-19
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    • 1999
  • This study is for the development of C.B.D. residential land that is available in the changeable housing market and urban planning paradigm. The results are as follows. First, we developed a Logit model to analyzed the suitable resident for living downtown and we used several variables in the model such as their living place, the location of their works, in come according to sex and age, and whether they have a car or not. Second, in analysis for the suitable residents using the Logit model, the main demanders who live in C.B.D. or have a job there and the young and old were chosen, Third, it shows that the suitable residents prefer semi-C.B.D. because it has convenient accessibility to C.B.D. rater quickly (in ten minutes). They prefer apartment and Mixed-Use building. Fourth, there are much residential land in semi-C.B.D. (63.7%) so as to support enough land in ease of redevelopment. The land price is tremendously low compared to that of land for business or for C.B.D.

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The Treeing Deterioration with Prestressed D.C Voltage in Low Density Polyethylen Mixed with Organic Compounds (유기물이 첨가된 저밀도 폴리에칠렌에서 예비과전에 따른 트리잉 열화)

  • 채홍인;양계준;임기조
    • Journal of the Korean Society of Safety
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    • v.6 no.2
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    • pp.15-20
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    • 1991
  • In this paper, we have investigated the effect of organic additives and prestressed D C. voltage on the impulse tree initiation in low density polyethylene. The five klnds of organic compounds was selected for the purpose of inhibiting tree initiation and 10 wt % of each additive was mixed in low density polyethylene. The positive or negative impulse voltage was applied after prestressed D.C. voltage was applied in order to investigate the effect of the space charge influenced on tree initiation. The lengths of tree initiation in case of belng same polarity between prestressed D.C. voltage and impulse voltage were longer than those in case of being different polarity between prestressed D.C. voltage and impulse voltage. When the polarity prestressed D.C. voltage was the different plarity of impulse voltage, the length of tree initiation increased with increasing the prestressed D.C. voltage and decreasing the rest time Among the organic additives used in this paper, the m-cresol can be shown to be the most effective inhibiter to tree initiation.

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LOCI OF RATIONAL CURVES OF SMALL DEGREE ON THE MODULI SPACE OF VECTOR BUNDLES

  • Choe, In-Song
    • Bulletin of the Korean Mathematical Society
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    • v.48 no.2
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    • pp.377-386
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    • 2011
  • For a smooth algebraic curve C of genus g $\geq$ 4, let $SU_C$(r, d) be the moduli space of semistable bundles of rank r $\geq$ 2 over C with fixed determinant of degree d. When (r,d) = 1, it is known that $SU_C$(r, d) is a smooth Fano variety of Picard number 1, whose rational curves passing through a general point have degree $\geq$ r with respect to the ampl generator of Pic($SU_C$(r, d)). In this paper, we study the locus swept out by the rational curves on $SU_C$(r, d) of degree < r. As a by-product, we present another proof of Torelli theorem on $SU_C$(r, d).

The characteristics of D.C. switching threshold voltage for amorphous $As_{10}Ge_{15}Te_{75}$ thin film (비정질 $As_{10}Ge_{15}Te_{75}$박막의 D.C. 스위칭 임계전압 특성)

  • 이병석;이현용;이영종;정홍배
    • Electrical & Electronic Materials
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    • v.9 no.8
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    • pp.813-818
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    • 1996
  • Amorphous As$_{10}$Ge$_{15}$ Te$_{75}$ device shows the memory switching characteristics under d.c. bias. In bulk material, a-As$_{10}$Ge$_{15}$ Te$_{75}$ switching threshold voltage (V$_{th}$) is very high (above 100 volts), but in the case of thin film, V$_{th}$ decreases to a few or ten a few volts. The characteristics of V$_{th}$ depends on the physical dimensions such as the thickness of thin film and the separation between d.c. electrodes, and the annealing conditions. The switching threshold voltage decreases exponentially with increasing annealing temperature and annealing time, but increases linearly with the thickness of thin film and exponentially with increasing the separation between d.c. electrodes. The desirable low switching threshold voltage, therefore, can be obtained by the stabilization through annealing and changing physical dimensions.imensions.sions.

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Modeling of Fitts' Movement Time Including Effect of Control-Display Gain (C-D gain의 변화를 고려한 Fitts 이동시간 추정 모델에 관한 연구)

  • Park, Kyung-soo;Koh, Bong-kee;Kim, Un-hoi
    • Journal of the Ergonomics Society of Korea
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    • v.19 no.3
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    • pp.39-49
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    • 2000
  • During human-computer interaction(HCI), people typically send inputs to computers through electromechanical pointing devices. Many applied studies have therefore evaluated cursor-positioning movements made with various pointing devices. Though there were so many studies about performance of various pointing devices, it was nearly impossible to compare device performance each other until the Fitts' law was applied. It does appear that Fitts' law may predict performance reasonably well for the one C-D gain level. But in varying C-D gain levels, Fitts' law could not predict movement time. This study investigated the effects of C-D gain in mouse movement time and suggested a revised Fitts' model including C-D gain as an independent variable. The revised Fitts' model may use to measure the performance of various devices in varying C-D gain levels.

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The initial mass loss rates and the changes in carbon/nitrogen ratio of dead woods for the three dominant tree species in tropical rainforests of Brunei Darussalam (브루나이 열대우림 내 주요 3개 수종 고사목의 초기 질량 감소율과 탄질율 변화)

  • Roh, Yujin;Jang, Minju;Son, Yowhan
    • Korean Journal of Environmental Biology
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    • v.39 no.2
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    • pp.218-224
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    • 2021
  • This study was conducted to determine the mass-loss rates and the changes in carbon/nitrogen (C/N) ratio of dead woods, which were of following species: Dryobalanops aromatic, D. rappa, and Cratoxylum arborescens. These were dominant tree species in mixed Dipterocarp forests (MDF) and peat swamp forests (PSF) in Brunei Darussalam. In May, 2019, 48 dead wood samples (15 cm×4.8 cm×5 cm) were placed in MDF and PSF sites, and all the samples were collected after 16 months. The effects of species on mass loss were statistically significant (p<0.05); however, no difference was observed in the mass loss obtained from the two forest types (p>0.05). The initial density (g·cm-3) of the dead woods D. aromatic, D. rappa, and C. arborescens, was 0.64±0.02, 0.60±0.00, and 0.44±0.01, respectively. Also the annual mass loss rate (%) was estimated to be 6.37, 8.17, and 18.53 for D. aromatic, D. rappa, and C. arborescens, respectively. The proportion of dead woods in decay class III was only 25% of C. arborescens samples, which were attacked by wood-feeding invertebrates, such as termites. The C/N ratio decreased significantly in D. aromatic and D. rappa, but the decreasing trend of C/N ratio was not statistically significant in C. arborescens. The results indicate that physical traits of dead woods, such as density, could be one of the main factors causing the decomposition of dead woods initially, as invertebrates such as termites are one of the key decomposers of dead wood in tropical rainforests. In the samples of C. arborescens, which was attacked by invertebrates, nitrogen immobilization occurred to lesser extent as compared to that observed in D. aromatic and D. rappa.

Cloning and Expression of D-amino Acid Oxidise from Trigonopsis variabilis for Cephalosporin C Biotransformation (Cephalosporin C의 생변환을 위한 Trigonopsis variabilis의 D-amino Acid Oxidase 유전자의 클로닝 및 발현)

  • 이진형;정태완
    • KSBB Journal
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    • v.10 no.3
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    • pp.264-270
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    • 1995
  • Trigonopsis variabilis is a strong producer of D-amino acid oxidase that can transform cephalosporin C(ceph C) to ${\alpha}$-keto-adipyl-7-aminocephalosporanic acid(AKA-7ACA). Polymerase chain reaction (PCR) was applied to isolate the D-AAO gene from T. variabilis. To clone the PCR fragment, four different methods were examined using enzymatic reactions of Taq DNA polymerase, Klenow, T4 DNA polymerase I, Alkaline phosphatase Calf Intestinal, and T4 kinase. Ligation of phosphorylated blunt-end PCR fragment and dephosphorylated blunt-end of pUC18 plasmid yielded the best cloning efficiency One of recombinant E. coli transformants showed D-AAO activity against ceph C in both cell extracts and permeabilized cells.

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Binding Mode of [Ruthenium(II)$(1,10-Phenanthroline)_2L]^{2+}\;to\;Poly(dG){\cdot}poly( dC){\cdot}poly(dC)^+$ Triplex DNA

  • Jo, Chang Beom;Jo, Tae Seop;Kim, Bok Jo;Han, Seong Uk;Jeong, Maeng Jun
    • Bulletin of the Korean Chemical Society
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    • v.21 no.10
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    • pp.1052-1054
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    • 2000
  • Binding geometries of $[Ru(II)(110-phenanthroline)_2L]^2+$, complexes (where L = dipyrido [3,2-a:2',3'-c]phena-zine (DPPZ) or benzodipyrido[3,2-a:2',3'-c] phenazine (BDPPZ)) to poly(dG)${\cdot}$poly(dC)${\cdot}$poly(dC) + triplex DNA (CGC + triplex) has been investigated by linear dichroism and normal absorption spectroscopy. Analysis of the linear dichroism for the CGC+ triplex and $[Ru(II)(phen)_2BDPPZ]^2+$ complex indicates that the extended ligand of the metal complex lie perpendicular to the polynucleotide helix axis. Together with strong hypochromism and red shift in the interligand absorption region, we concluded that the extended BDPPZ or DPPZ ligand in-tercalated between the bases of polynucleotide. The spectral properties of the metal complexes bound to CGC+ triplex are similar to those bound to $poly(dA)[poly(dT)]^2$ triplex (Choi et al., Biochemistry 1997, 36, 214), sug-gesting that the metal complex is located in the minor groove of the CGC+ triplex.