• Journal of Microbiology and Biotechnology
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• v.31 no.8
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• pp.1163-1174
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• 2021

Casein-derived antioxidant peptides by using microbial proteases have gained increasing attention. Combination of two microbial proteases, Protin SD-NY10 and Protease A "Amano" 2SD, was employed to hydrolyze casein to obtain potential antioxidant peptides that were identified by LC-MS/MS, chemically synthesized and characterized in a oxidatively damaged HepG2 cell model. Four peptides, YQLD, FSDIPNPIGSEN, FSDIPNPIGSE, YFYP were found to possess high 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ability. Evaluation with HepG2 cells showed that the 4 peptides at low concentrations (< 1.0 mg/ml) protected the cells against oxidative damage. The 4 peptides exhibited different levels of antioxidant activity by stimulating mRNA and protein expression of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as nuclear factor erythroid-2-related factor 2 (Nrf2), but decreasing the mRNA expression of Kelch-like ECH-associated protein 1 (Keap1). Furthermore, these peptides decreased production of reactive oxygen species (ROS) and malondialdehyde (MDA), but increased glutathione (GSH) production in HepG2 cells. Therefore, the 4 casein-derived peptides obtained by using microbial proteases exhibited different antioxidant activity by activating the Keap1-Nrf2 signaling pathway, and they could serve as potential antioxidant agents in functional foods or pharmaceutic preparation.

• International Journal of Quality Innovation
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• v.6 no.3
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• pp.19-37
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• 2005

It is generally accepted that leadership is the foundation for creation of a company's business results. However, empirical evidence is lacking. This paper examines the relationship between leadership and key performance results based on a Return on Leadership Model. The model links Denison's four leadership traits to people results, customer results, and ultimately key performance results. Further specified, the model is a structural equation model with nine latent variables, each measured by a set of indicators, observed by survey questions. To validate the model, an empirical study was conducted, and 379 managers from medium-sized and large companies in Denmark participated. The estimation of the model shows that the model structure explains return on leadership very well, and the findings support the developed model. We are able to quantify the relationships from leadership to people results, customer results and key performance results and, in this way, the data presented here provide evidence that leadership is linked to key performance results. Several results and applications of the model are shown. The findings provide new knowledge about how leadership can be linked to performance, and how excellent leadership creates key performance results.

• Information Systems Review
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• v.19 no.4
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• pp.135-156
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• 2017

An intelligent personal assistant (IPA) is a software agent that assists people to perform basic tasks or services for an individual by commonly providing information via natural language. In spite of the versatile capabilities of the IPA to answer a user's simple information-based queries, such as the weather and driving directions, the actual usage rates for IPA services are limited to date. In this research, to evaluate the factors affecting the intention to use IPA, we develop an empirical model based on technology acceptance model, innovation diffusion theory, and IS success model. Afterward, we collect 203 questionnaires from actual users of IPAs. Finally, the structural equation model validates the causal relationship between the constructs of the model. Consequently, the innovation characteristics of IPA drawn from innovation diffusion theory, namely, relative advantage, compatibility, observability, all exerted a positive influence on perceived usefulness. Furthermore, information quality, a quality characteristic of IPA obtained from DeLone and McLean's IS success model, presented a positive effect on perceived usefulness and perceived ease of use. Finally, the perceived intelligence of IPA displayed a positive influence on perceived usefulness and ease of use. This characteristic was also a major factor that can increase the intention to use the IPA. Given these research findings, this study is significant for identifying factors that may influence the intention to use the IPA by providing strategic guidelines to relevant business operators and establishing an integrated model.

• Information Systems Review
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• v.18 no.4
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• pp.43-67
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• 2016

Although many studies have stressed the importance of technology in service innovation, the roles of technology in service innovation are at the center of debates in the service innovation literature. One major research stream regards technology as a trigger for other innovation based on resource advantage theory. Conversely, another major stream considers it as an enabler of other innovations based on complementary theory. The contradictory situation induces the necessity to better understand the role of technology in service innovation. Therefore, this study aims to identify the role of technology in service innovation. This study investigates the role of technology in service innovation based on a service innovation orientation framework. Four service innovation orientations (i.e., service creation, service delivery, customer interaction, and technology) are identified on the basis of Den Hertog's 4D model. This study proposes a research model that examines the indirect effect of technology orientation on innovation performance through the service creation and service delivery orientations, and the effect of technology orientation on firm performance as a moderator between customer interaction orientation and firm performance. Based on empirical data from 193 knowledge-intensive business service firms in Korea, we explain the role of technology in service innovation. The results indicate that technology orientation influences both service creation and service delivery orientations as an antecedent but customer interaction orientation as an enabler. The three service innovation orientations, which are directly and indirectly influenced by technology orientation, positively affect firm performance. The findings also show that the role of technology is different depending on the type of service innovation orientation in this study.

• The Journal of Industrial Distribution & Business
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• v.4 no.2
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• pp.21-30
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• 2013

Purpose - The objectives of this study are to find the strengths, weaknesses, opportunities, and threats related to the national innovation system of Iran (using a SWOT analysis) and to extract some strategic recommendations to modify the innovation policies of Iran. Research design, data, and methodology - This study used a literature review and field study. In the first phase, the author studied library resources and articles, and browsed through Internet information about the subject. The second phase was a field research investigation through designed questionnaires and interviews with more than 100 policymakers, officials, executives, and others related to the national innovation system in 2011. Results - In this research study, strategic recommendations were extracted through a SWOT model for improvements to the innovation policies of Iran. Conclusions - The findings of this study show the role of strengths, weaknesses, opportunities, and threats in the national innovation system of Iran and suggest strategic recommendations for its modification.

• Journal of Korean Society for Quality Management
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• v.52 no.1
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• pp.173-183
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• 2024

Purpose: This study highlights the importance of emphasizing entrepreneurship and sustainability among managers to address the challenges of Industry 6.0, especially in situations of increasing environmental uncertainty. The research model reveals the important structural relationship between entrepreneurship, sustainability, and innovation performance, and through empirical analysis, we sought to confirm that entrepreneurship in the 6th industry is related to technological innovation. Methods: A survey was conducted targeting 6th industry entrepreneurs, and the relationship was analyzed using SPSS and AMOS. Results: Despite a non-significant direct relationship between entrepreneurship and innovation performance, a notable effect of sustainability on innovation performance was identified. This highlights the fact that entrepreneurship contributes to firm performance through innovation activities, especially in the form of technological innovation. Conclusion: This study highlights the essential characteristics of entrepreneurship and sustainability, highlights their interconnectedness and suggests that their inclusion in the same management activities improves performance.

• The Journal of Society for e-Business Studies
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• v.16 no.4
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• pp.335-357
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• 2011

In this paper, we report the empirical study results theorizing IPTV user's loyalty formation process. Considering the convergent characteristics ofinnovative media and telecommunication, we employed innovation adoption and diffusion as our theoretical framework for research model development. As the purpose of this research includes verification of detail attributes of IPTV service, we formulated structural model which treats relative advantage as the second order factor, of which incorporates the seven detail attributes as the first order factors. Then, using the data collected from 250 Korean IPTV subscribers, the model is validated and relevant attributes are identified through PLS analysis. The results provide insights for future research on the adoption and diffusion of new digital convergent high-tech services.

• STI Policy Review
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• v.3 no.2
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• pp.130-151
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• 2012

Fraunhofer was founded in 1949 and grew into Europe's largest application-oriented research organization. Fraunhofer currently employs over 20,000 members in Germany, is internationally networked, and manages an R&D budget of over 1,8 Billion Euros per year. An important step for Fraunhofer to become an integral component of the German innovation system was the introduction of the Fraunhofer Model of financing based on a performance-related system of financial management. The underlying model of the allocation and distribution of public funding to Fraunhofer that is subsequently allotted to specific research groups is one of the success factors of Fraunhofer. Fraunhofer is proud of its decentralized organizational model. Fraunhofer is comprised of 60 Institutes in Germany working in different fields, under one legal framework, and with a strong brand value. Every Fraunhofer Institute is affiliated with a German University and every institute director simultaneously holds a chair at the affiliated university. It is a challenge for the headquarter organization to balance the intended competition of individual Fraunhofer Institutes with complementarity cooperation in science among Fraunhofer-Institutes, especially when coming from different knowledge domains; however, this goal results in a significant advantage. The unique strengths of Fraunhofer offer system solutions in a world with increasingly complex R&D challenges. While growing to become the largest organization on Europe to focus on applied research it is the challenge to remain an agile organization that is flexible in organizational structure. Fraunhofer has reached a well-recognized position in the European innovation landscape. It is often referred to by science and governments as a role model for innovation policy and a key element of the latest successes in the German economy that has recovered quicker from the latest economic crisis than most other western economies. The paper explains Fraunhofer as an organizational paradigm and its underlying management model to elaborate on the challenges of managing a research organization. We wish to show how it is possible to transfer the management model and philosophy of Fraunhofer to innovation systems with different framework conditions and challenges. A universal conclusion may be drawn based on the description of Fraunhofer; however, changes in existing structures and innovation systems cannot be implemented over night.

• The Journal of Industrial Distribution & Business
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• v.13 no.8
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• pp.29-50
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• 2022

Purpose - This study aims to investigate factors affecting Chatbot service acceptance attitude. For wide use of Chatbot service, firms need to find barriers or obstacles for customers, if any, not to use Chatbot service. Research design, data, and methodology - We apply value-based accept model to investigate the quality of Chatbot, to verify the meaning of service value of Chatbot and to find the relationship among variables. To test hypotheses, we conducted survey. We collected 300 questionnaires. SPSS version 2.0 is used. Regression analysis, moderating effect test is conducted. Results - 4 Qualities of Chatbot, Ease of use, Usefulness, Enjoyment, Interaction are affecting acceptance attitude, and 5 service values, only interaction does not affect emotion. Trust, Specialty, Necessity, Social, Emotion moderating Chatbot service to accepting attitude. Regarding moderating effects by personal characteristics and personal tendency, innovation resistance, innovativeness, and social effects are turned to have influence while regulatory focus, construal level does not have moderating force. Also, the auxiliary service like Chatbot service affects customers' evaluation on the main service quality. Conclusions - Service firms adopt Chatbot service for various purposes. The results imply that customers are generally recognize the merits of Chatbot, but there are some barriers such as innovation resistance characteristic especially uncomfortable.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.17 no.5
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• pp.1-16
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• 2022

Although start-up is a key national strategy to increase national competitiveness and create employment, the survival rate of start-ups has not improved significantly. This is an important reason for the inability to provide timely and appropriate support to startups, which are in the early stages of start-up, due to the unique limitations of existing start-up support institutions and investors. The relatively recent accelerator is attracting attention as a subject of solving the above problems through professional incubation and investment. However, there are only a few empirical studies on investment determinants that affect the survival and success of accelerators, and there is a lack of theoretical evidence. Accordingly, in previous studies, 12 investment determinants were derived from a static, strategic, and dynamic perspective as accelerator investment determinants based on a business model innovation framework. This study subdivided the accelerator investment determinants derived through previous studies into 21 and analyzed the importance and priority of each factor using AHP (Analytic Hierarchy Process) analysis technique for domestic accelerator investment experts. As a result of the analysis, the top factors of importance of accelerator investment determinants were in the order of 'human resources', 'customer and market', 'intellectual resources', and 'entrepreneur's ability to realize opportunities'. It can be seen that the accelerator considers the core competencies of startups to implement solutions as the most important factor when making startup investment decisions. It was also confirmed that accelerators are strategic to create a clear value proposition and differentiated market position based on the core competitiveness of startups, and that the core value delivery method prefers a market-oriented business model and recognizes entrepreneurs's innovation capability is an important factor to realize a business model with limited resources in a rapidly changing market. This study is of academic significance in that it analyzes the importance and priority of accelerator investment determinants through demonstration as a follow-up study on accelerator investment determinants derived based on business model innovation theory that reflects the nature, goals, and major activities of accelerator investment. In addition, it is of practical value as it contributes to revitalizing the domestic startup investment ecosystem by providing accelerators with theoretical grounds for investment decisions and specific information on detailed investment determinants.