• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.5
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• pp.383-390
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• 2013

The reduction of the maximum acceleration which causes shock for a missile is very important to prevent abnormal operation of a missile and decrease size and cost of missile components. Because the maximum acceleration created by operation of an ejection gas generator occurs in the initial ejection stage, the design parameters which affect initial ejection stage were examined. The igniter and the nozzle closure were selected as design parameters of a gas generator. The maximum acceleration created by the gas generator was examined experimentally by changing of the design parameters. Finally the reduction effect of the maximum acceleration was compared quantitatively by static fire test of a gas generator. The maximum acceleration of the best model which was applied to each optimal design parameter was about 68% reduced than that of the reference model.

• Asian Journal of Atmospheric Environment
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• v.5 no.1
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• pp.21-28
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• 2011

Occupational nanomaterial exposure is an important issue in the manufacture of such products. People are also exposed to various nanoparticles in their living environments. In this study, we investigated nanoparticle formation during the reaction of ozone and volatile organic compounds (VOCs) emitted from a commercial air freshener, one of many widely used consumer products, in a $1-m^3$ reaction chamber. The air freshener contained various VOCs, particularly terpenes. A petri dish containing 0.5 mL of the air freshener specimen was placed in the bottom of the chamber, and ozone was continuously injected into the center of the chamber at a flow rate of 4 L/min with an ozone concentration of either 50, 100 or 200 ppb. Each test was conducted over a period of about 4 h. The higher ozone concentrations produced larger secondary nanoparticles at a faster rate. The amount of ozone reacted was highly correlated with the amount of aerosol formation. Ratios of reacted ozone concentration and of formed particle mass concentration for the three injected ozone concentrations of 50, 100 and 200 ppb were similar to one other; 4.6 : 1.9 : 1.0 and 4.7 : 2.2 : 1.0 for ozone and aerosol mass, respectively.

• Macromolecular Research
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• v.16 no.8
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• pp.717-724
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• 2008

In this study, we prepared all-trans retinoic acid (ATRA)-encapsulated, surfactant-free, PLGA nanoparticles. The nanoparticles were formed by nanoprecipitation process, after which the solvent was removed by solvent evaporation or dialysis method. When a nanoparticle was prepared by the nanoprecipitation - solvent evaporation method, the nanoparticles were bigger than the nanoparticles of the nanoprecipitation - dialysis method, despite the higher although loading efficiency. Nanoparticles from the nanoprecipitation - dialysis method were smaller than 200 nm in diameter, while the loading efficiency was not significantly changed. Especially, nanoparticles prepared from DMAc, 1,4-dioxane, and DMF had a diameter of less than 100 nm. In the transmission electron microscopy (TEM) observations, all of the nanoparticles showed spherical shapes. The loading efficiency of ATRA was higher than 90% (w/w) at all formulations with exception of THF. The drug content was increased with increasing drug-feeding amount while the loading efficiency was decreased. In the drug release study, an initial burst was observed for $2{\sim}6$ days according to the variations of the formulation, after which the drug was continuously released over one month. Nanoparticles from the nanoprecipitation - dialysis method showed faster drug release than those from the nanoprecipitation - solvent evaporation method. The decreased drug release kinetics was observed at lower drug contents. In the tumor cell cytotoxicity test, ATRA-encapsulated, surfactant-free, PLGA nanoparticles exhibited similar cytotoxicity with that of ATRA itself.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.7
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• pp.623-629
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• 2013

This paper presents the implementation result of the EEG(electroencephalogram) signal transmission protocol and its test platform. EEG measured by a dry-type electrode is directly converted into digital signal by ADC(analog-to-digital converter). Thereafter it is transferred DSP(digital signal processor) platform by $I^2C$(inter-integrated circuit) protocol. DSP conducts the pre-processing of EEG and extracts feature vectors of EEG. In this work, we implement the $I^2C$ protocol with 16 channels by using 10 or 12-bit ADC. In the implementation results, the overhead ratio for the 4 bytes data burst transmission measures 2.16 and the total data rates are 345.6 kbps and 414.72 kbps with 10-bit and 12-bit 1 ksps ADC, respectively. Therefore, in order to support a high speed mode of $I^2C$ for 400 kbps, it is required to use 16:1 and $(8:1){\times}2$ ratios for slave:master in 10-bit ADC and 12-bit ADC, respectively.

• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.387-392
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• 2008

Alfuzosin, an Alphal-adrenoceptor antagonist is used for the treatment of patients with voiding and in a lesser extent storage lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH). The objective of this study was to formulate sustained release alfuzosin HCl granules and assess their formulation variables. The $Eudragit^{(R)}$ as a polymer, sustained release membrane, and dibutyl sebacate (DBS) as a plasticizer were used. Multi-coated alfuzosin HCl delivery systems composed of sugar sphere, various excipients, $Eudragit^{(R)}$ and HPMC (hydroxy propyl methyl cellulose), Cellulose Acetate were prepared by fluid-bed coater. Membrane layer were used $Eudragit^{(R)}$ RS PO and NE 30D. And the alfuzosin HCl coated beads were coated immediate release drug layer for initial burst. Its dissolution test was carried out compared to conventional products ($XATRAL^{(R)}$ XL). The release rate of drug from coated beads was higher than that from $XATRAL^{(R)}$ XL in pH 6.8.

• Journal of the Korean Institute of Gas
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• v.16 no.4
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• pp.1-7
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• 2012

Systematic safety research by Korea Government has been made to enhance the safety of CNG (compressed natural gas) vehicles since the burst of compressed cylinder of an urban bus in August 9, 2010. This article summarizes some major activities to ensure the safety of CNG vehicles, which covers review of regulation, safety management system including standard of inspection and certification, and training program of inspectors and car mechanics. Specifically, the followings were reviewed; type of CNG cylinder, location of CNG cylinder, material and type of fuel line and vent line, modification of pipeline connection, installation of gas detector, installation of emergency shutdown valve, installation of protecting cover for cylinder, obligations for CNG vehicle filling station. improving periodical inspection, routine test on gas vehicles, training program for engaged in gas vehicles, and designation of safety manager for CNG bus company. This paper suggests how to improve safety of CNG vehicles as a result of review of above mentioned check items.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.7
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• pp.977-987
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• 2019

Objective: The use of tannin extract and other phytochemicals as dietary additives in ruminants is becoming more popular due to their wide biological actions such as in methane mitigation, bypass of dietary protein, intestinal nematode control, among other uses. Unfortunately, some have strong astringency, low stability and bioavailability, and negatively affecting dry matter intake and digestibility. To circumvent these drawbacks, an effective delivery system may offer a promising approach to administer these extracts to the site where they are required. The objectives of this study were to encapsulate acacia tannin extract (ATE) with native starch and maltodextrin-gum arabic and to test the effect of encapsulation parameters on encapsulation efficiency, yield and morphology of the microparticles obtained as well as the effect on rumen in vitro gas production. Methods: The ATE was encapsulated with the wall materials, and the morphological features of freeze-dried microparticles were evaluated by scanning electron microscopy. The in vitro release pattern of microparticles in acetate buffer, simulating the rumen, and its effect on in vitro gas production was evaluated. Results: The morphological features revealed that maltodextrin/gum-arabic microparticles were irregular shaped, glossy and smaller, compared with those encapsulated with native starch, which were bigger, and more homogenous. Maltodextrin-gum arabic could be used up to 30% loading concentration compared with starch, which could not hold the core material beyond 15% loading capacity. Encapsulation efficiency ranged from $27.7%{\pm}6.4%$ to $48.8%{\pm}5.5%$ in starch and $56.1%{\pm}4.9%$ to $64.8%{\pm}2.8%$ in maltodextrin-gum arabic microparticles. Only a slight reduction in methane emission was recorded in encapsulated microparticles when compared with the samples containing only wall materials. Conclusion: Both encapsulated products exhibited the burst release pattern under the pH conditions and methane reduction associated with tannin was marginal. This is attributable to small loading percentages and therefore, other wall materials or encapsulation methods should be investigated.

• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.351-357
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• 2019

This research was performed to propose domestic standard for design and management of flexible hose by analyzing chlorine leak caused by breakage of the hose in Ulsan, 2018. The leak had multiple causes but this paper focuses on analyzing the cause of breakage of flexible hose, the direct cause. According to the analysis, flexible hose that the company of the accident used for chlorine transfer was inappropriate in several aspects including material and wall thickness. And even pressure test had been conducted below operating pressure. Upon investigation on five companies that handle chlorine in Ulsan, four companies were using inappropriate flexible hose for chlorine transfer. Since there is no domestic standard for the design of flexible hose for chlorine transfer at present, it is hard to examine its design adequacy. Design standard of flexible hose used in chlorine transfer that is applicable domestically is proposed based on this research. It will contribute to the reduction in risk of breakage of the hose if the proposed standard could be applied in design and examination of flexible hose.

• Journal of Industrial and Engineering Chemistry
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• v.67
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• pp.365-372
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• 2018

Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF and GCH-EGF/FGF) and evaluated their efficacies on the improvement of wound healing in vivo. In vitro release test showed that the growth factors were released in a sustained manner along with initial burst for 24 h. In vitro cell proliferation assay of L-929 mouse fibroblast cell line resulted in the superior ability of GCH-EGF/FGF on the rate. In vivo results demonstrated that the growth factor loaded GCHs further enhanced wound healing compared with GCH. In particular, GCH-EGF/EFG showed the most remarkable wound healing effect among the samples.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.521-521
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• 2023

지방상수도의 관 파손사고 감지 및 누수관리 방법에는 블록시스템 구축을 통한 소블록별 야간최소유량 감시방법이 가장 대표적이다. 야간최소유량은 새벽 2시와 4시 사이의 인구 활동 비율이 가장 낮은 새벽 시간대에 소블록에 공급된 유량을 의미하며, 대부분 유량 성분은 누수량일 것이라는 가정에서 출발한다. 그러나 아파트 중심의 주거 형태를 보이는 도심지의 경우, 새벽 시간대에도 다량의 물수요가 비정기적으로 발생하고 있어 관망의 이상 여부를 감시하기 위한 관리기준으로서 야간최소유량을 이용하기에는 높은 일간 변동성에 따른 한계가 있다고 할 수 있다. 즉, 야간최소유량은 관 파손사고 발생의 감시보다는 관로 연결 또는 급수전 분기 부위에서 발생하는 미량의 누수가 수개월에 걸쳐 누적되는 장기추세를 분석하여 누수탐사반의 투입 시점을 결정하기 위한 근거를 제시하기 위한 목적으로 사용되며, 아직까지 관 파손사고의 발생은 자체적인 감지보다는 민원에 의해 인지되는 경우가 많다. 최근, 스마트관망 구축사업(SWM) 등을 통해 관 파손 및 누수 감지를 위한 청음식 누수감지센서가 소블록 내 도입되고 있으나, 초기 시설투자에 큰 비용이 수반되며 주변 소음과 배터리 전원방식의 한계로 인하여 새벽 시간대에만 분석이 제한적으로 적용되는 경우가 많아 이 역시도 상시적인 관 파손사고의 감시기술이라 보기는 어렵다. 본 연구에서는 소블록 유입점에서의 유량·압력과 소블록 내에 설치된 대수용가 스마트미터, 그리고 사고감지를 위한 수압계 사이의 평상시 수리적 균형을 학습한 DNN(Deep Neural Network) 모델을 이용하여 관 파손사고를 실시간 감지하는 모델 개발연구를 수행하였다. 모델은 관 파손사고 감지를 위한 수압계의 최적 위치와 대수를 결정하기 위한 모듈과 관 파손사고 감지모듈로 구성되며, 1개 소블록 Test-Bed를 구축하여 모델을 생성하고 PDD 관망해석 모델을 통해 생성된 가상의 사고에 대한 감지 여부로서 개발 모델의 감지성능을 평가하였다.