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http://dx.doi.org/10.4333/KPS.2008.38.6.387

Formulation and Preparation of Sustained Release Pellet for Alfuzosin HCI Using Fluid-bed coater  

Na, Jin-Sang (Kyunghee University Graduate School of East-West Medical Science & College of Oriental Medicine)
Yoon, Yang-No (College of Pharmacy, Sungkyunkwan University)
Seo, Hui (College of Pharmacy, Chungnam National University)
Jeong, Sang-Young (College of Pharmacy, Chungnam National University)
Park, Eun-Seok (College of Pharmacy, Sungkyunkwan University)
Hwan, Sung-Joo (College of Pharmacy, Chungnam National University)
Shin, Byung-Cheol (Korea Research Institute of Chemical Technology Drug Discovery Division)
Kim, Sung-Hoon (Kyunghee University Graduate School of East-West Medical Science & College of Oriental Medicine)
Cho, Sun-Hang (Korea Research Institute of Chemical Technology Drug Discovery Division)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.6, 2008 , pp. 387-392 More about this Journal
Abstract
Alfuzosin, an Alphal-adrenoceptor antagonist is used for the treatment of patients with voiding and in a lesser extent storage lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH). The objective of this study was to formulate sustained release alfuzosin HCl granules and assess their formulation variables. The $Eudragit^{(R)}$ as a polymer, sustained release membrane, and dibutyl sebacate (DBS) as a plasticizer were used. Multi-coated alfuzosin HCl delivery systems composed of sugar sphere, various excipients, $Eudragit^{(R)}$ and HPMC (hydroxy propyl methyl cellulose), Cellulose Acetate were prepared by fluid-bed coater. Membrane layer were used $Eudragit^{(R)}$ RS PO and NE 30D. And the alfuzosin HCl coated beads were coated immediate release drug layer for initial burst. Its dissolution test was carried out compared to conventional products ($XATRAL^{(R)}$ XL). The release rate of drug from coated beads was higher than that from $XATRAL^{(R)}$ XL in pH 6.8.
Keywords
Alfuzosin HCl; Fluid-bed coater; $Eudragit^{(R)}$ RS PO; $Eudragit^{(R)}$ NE 30D; Sustained-release pellet;
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Times Cited By KSCI : 4  (Citation Analysis)
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