• Journal of Pharmaceutical Investigation
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• 제39권5호
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• pp.345-351
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• 2009

Organic cation transporters (OCTs) are important for absorption, elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is located in a cluster on chromosome 6 and OCTs are in major organs such as intestine, liver, kidney, brain and placenta. Therefore, expression levels and function of OCTs directly affect plasma levels and intracellular concentrations of drugs and thereby determine therapeutic response. The aim of this study was to investigate the frequency of the SNPs on OCT1 (C181T and C1022T) and OCT2 (G808T) to analyze haplotype frequency in healthy Korean population. Human subjects have been genotyped for OCT1 (C181T for 195 subjects and C1022T for 825 subjects), using polymerase chain reaction-based diagnostic tests (RFLP). And for OCT2 (G808T), a total of 861 subjects have been genotyped, using pyrosequencing method. Haplotype was statistically inferred using an algorithm based on the expectation-maximization (EM). OCT1 C181T genotyping showed 100% homozygous wild-type (C/C). OCT1 C1022T genotyping showed wild-type (C/C), heterozygous (C/T) and homozygous mutant-type (T/T) and each accounted for 72.1, 24.5 and 3.4%, respectively. OCT2 G808T genotyping results also showed homozygous wild-type (G/G), heterozygous (G/T) and homozygous mutant-type (T/T) and each took 81.8, 17.9 and 0.3%, respectively. Based on these genotype data, haplotype analysis between OCT1 C181T and OCT1 C1022T has proceeded. The result has revealed that linkage disequilibrium between alleles is not obvious (P=0.0122).

• 인터넷정보학회논문지
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• 제16권2호
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• pp.1-6
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• 2015

본 논문에서는 고품질 멀티미디어 데이터를 IEEE 802.1 Audio Video Bridging 기반의 네트워크를 통해 스마트 자동차와 스마트 홈 및 스마트 공연장에서 실시간으로 송수신할 수 있는 임베디드 플랫폼을 설계를 통해 정밀한 시간 동기화 표준인 IEEE 802.1AS와 QoS 보장을 위한 자원할당 표준인 IEEE 802.1Qat 프로토콜 분석을 통해 성능을 검증한다. 이를 위해 MRP(Multiple Registration Protocol), MMAP(Multicast Address Acquisition Protocol), IEEE 1722, 1722.1 등 AVB의 핵심 Layer-2 프로토콜을 리눅스 운영체제를 기반으로 구현한다. 아울러 상용 AVB 엔드포인트와 연동 실험을 통해 상호 호환성 및 멀티미디어 스트림의 실시간 송수신이 가능함을 보인다.

• Biomolecules & Therapeutics
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• 제16권2호
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• pp.77-81
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• 2008

The major aim of the Korean Pharmacogenomic Database (KPD) is to offer to users a "bridging" function, making the search for useful information easier. This database has also been established to collect unique Korean genotype data from other databases and to directly link these data to other major databases that offer more informative data. In this way, searches for information about new drug developments and easier and faster evaluation of the more complex and larger databases are possible. The KPD is located at the National Institute of Toxicological Research homepage (http://www.nitr.go.kr/nitr/contents/m134700/view.do), and offers Korean single-nucleotide polymorphism (SNP) information for 154 genes and haplotype information. It also compares the Korean SNP and haplotype frequencies with those of the other ethnic groups registered in the International HapMap. Through the Pharmacogenomic Information and Education facility, we also provide evaluators and the public with information about the concept of pharmacogenomic information, research trends, and the drug regulations of other countries. Because the drug responses of Koreans are not necessarily the same as those of Chinese or Japanese people, it is expected that the systematic operation of the KPD will allow the definition of racial differences and various genomic biomarkers (haplotypes or SNPs) for use in bridging studies and in the approval of new drugs.

• 한국도서관정보학회지
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• 제45권1호
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• pp.249-270
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• 2014

본 연구의 목적은 고령층의 모바일기반의 정보행위를 정보활동이 가장 왕성한 계층중의 하나인 대학생과 비교분석을 통하여 파악하고 동시에 이들의 정보격차해소를 위한 기초적인 방안을 모색하는 것이다. 연구의 목적을 위하여 자체 개발한 설문지를 사용하여 대구 경북지역에 거주하는 60세 이상 고령층과 이 지역에 거주하는 대학생을 대상으로 설문을 실시하였다. 회수된 설문지중 불성실하게 응답한 경우를 제외한 고령층 375명과 대학생 323명의 데이터를 카이제곱검정과 독립표본 t-검정으로 분석하였다. 분석결과 두 집단 모두 경제 상태에 따른 모바일기기 보유여부에는 차이가 없었으며, 이들 두 집단이 모바일기반의 정보행위를 하는 첫 번째 이유는 여가를 위한 것으로 나타났다. 한편 고령층은 모바일기기의 활용교육 확대를 통하여, 대학생층은 무상 혹은 저가 모바일기기의 보급을 통하여 정보활용 애로사항을 해소할 수 있다고 밝혔다. 더불어 다양한 연구결과를 표와 그림과 함께 제시하였다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 학회창립 10주년 기념 1999년도 가을 학술발표회 논문집
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• pp.183-186
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• 1999

Up to date, it is difficult to estimate the consistence of properties on the epoxy liner in service time because an estimation of the long term environment-deterioration with aging has not been processed. In the study, the estimation on epoxy liner is carried by the physical test 7 rounds. There are the elongation the and the crack bridging test in the part of physical tests. An elongation test is carried out with epoxy membrane and a crack bridging test is carried out with specimen painted epoxy on concrete. The subjects of test and estimation are a containment quality system and a fibre-glass reinforced system. The materials of these systems are a Robber added Epoxy, a Silica added Epoxy, and a Fiber reinforced Epoxy. Ensuring the test data, properties of epoxy liner was estimated and the change of properties was predicted on epoxy liners.

• Child Studies in Asia-Pacific Contexts
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• 제2권1호
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• pp.29-43
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• 2012

The purpose of the study was to generate the candidate items for the Adolescent Friendship Social Capital Scale. Both inductive and deductive approaches were used to generate the scale items. Halpern's conceptual map of social capital served as the theoretical basis of this scale, and guided the development of items. Semi-structured interviews with adolescents in Sydney, Melbourne and Beijing generated the initial pool of scale items. Twenty-six items were generated for the Adolescent Friendship Social Capital Scale. The items are organised in four theoretical constructs: Bonding Networks, Bridging Norms, Bridging Sanctions, and Linking Networks. Each item is a short statement followed by a five-point Likert scale anchored by 1= "Strongly disagree" and 5= "Strongly agree". The scale has several advantages over previous measures of adolescent friendship networks and friendship social capital. The scale has a strong and clear theoretical structure, the scale items demonstrate initial construct and content validity, and the format of the scale enables the collection of continuous data. However, in order to ensure the validity and reliability of the scale, another two stages of research need to be conducted in the future: scale development and scale evaluation.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 심포지엄 논문집 정보 및 제어부문
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• pp.86-88
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• 2004

Personal Robot System in developing, have a module architecture, each module are connected through variety network system like ethernet, WLAN (802.11), IEEE 1394 (firewire), bluetooth, CAN, or RS-232C. In developing personal robot system. We think that the key of robot performance is interoperablity among modules. Each network protocol are well connected in the view of network system for the interoperability. So we make a bridging architecture that can routing converting, and transporting packets with matching each network's properties. Furthermore, we suggest a advanced design scheme for realtime / non-realtime and control signal (short, requiring hard-realtime) / multimedia data (large, requiring soft-realtime).

• Nuclear Engineering and Technology
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• 제56권1호
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• pp.340-356
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• 2024

Bridging traditional experts' disciplinary boundaries is important for nuclear knowledge management systems. However, expert competences are often described in unstructured texts and require substantial human effort to link related competences across disciplines. The purpose of this research is to develop and evaluate a natural language processing approach, based on Latent Semantic Analysis, to enable the automatic linking of related competences across different disciplines and communities of practice. With datasets of unstructured texts as input training data, our results show that the algorithm can readily identify nuclear domain-specific semantic links between words and concepts. We discuss how our results can be utilized to generate a quantitative network of links between competences across disciplines, thus acting as an enabler for identifying and bridging communities of practice, in nuclear and beyond.

• Journal of Pharmaceutical Investigation
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• 제38권3호
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• pp.199-205
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• 2008

Famciclovir, 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine, is an oral prodrug of the antiherpesvirus nucleoside analogue, penciclovir. In human, famciclovir is orally well absorbed and then undergoes extensive first pass metabolism to penciclovir and essentially no parent compound is recovered from plasma or urine. The purpose of the present study was to evaluate the bioequivalence of two famciclovir tablets, Famvir tablet 750 mg (Novartis Korea Ltd.) and Famcivir tablet 750 mg (Hanmi Pharmaceutical. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of famciclovir from the two famciclovir formulations in vitro was tested using KP VIII Apparatus II method with water. Twenty six healthy male subjects, $23.38{\pm}1.72$ years in age and $68.59{\pm}7.84\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 750 mg as famciclovir was orally administered, blood samples were taken at predetermined time intervals and the concentrations of penciclovir in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations ere similar at water. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Famvir^{(R)}$ tablet 750 mg, were -0.53%, 1.12% and -24.82% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., $log\;0.9569{\sim}log\;1.0423$ and $log\;0.8763{\sim}log\;1.2136$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Famcivir tablet 750 mg was bioequivalent to Famvir tablet 750 mg.

• Journal of Pharmaceutical Investigation
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• 제40권1호
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• pp.51-57
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• 2010

Losartan potassium, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol mono-potassium salt, is a new class of antihypertensive agents, and is an antagonist in angiotensin receptor. The purpose of the present study was to evaluate the bioequivalence of two Losartan potassium tablets, Cozaar tablet (MSD Pharmaceutical Co., Ltd.) and Losata tablet (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of losartan from the two losartan potassium formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media. Twenty eight healthy male subjects, $23.86{\pm}1.80$ years in age and $67.27{\pm}6.60\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 50 mg as losartan potassium was orally administered, blood samples were taken at predetermined time intervals, and the concentrations of losartan in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and Equiv Test/K-BE Test 2002 was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, Cozaar, were -2.70%, 1.45% and 2.31% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.8852~log 1.0655 and log 0.8319~log 1.2342 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Losata tablet was bioequivalent to Cozaar tablet.