• Title/Summary/Keyword: Brain- based Research

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Patients Setup Verification Tool for RT (PSVTS) : DRR, Simulation, Portal and Digital images (방사선치료 시 환자자세 검증을 위한 분석용 도구 개발)

  • Lee Suk;Seong Jinsil;Kwon Soo I1;Chu Sung Sil;Lee Chang Geol;Suh Chang Ok
    • Radiation Oncology Journal
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    • v.21 no.1
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    • pp.100-106
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    • 2003
  • Purpose : To develop a patients' setup verification tool (PSVT) to verify the alignment of the machine and the target isocenters, and the reproduclbility of patients' setup for three dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT). The utilization of this system is evaluated through phantom and patient case studies. Materials and methods : We developed and clinically tested a new method for patients' setup verification, using digitally reconstructed radiography (DRR), simulation, porial and digital images. The PSVT system was networked to a Pentium PC for the transmission of the acquired images to the PC for analysis. To verify the alignment of the machine and target isocenters, orthogonal pairs of simulation images were used as verification images. Errors in the isocenter alignment were measured by comparing the verification images with DRR of CT Images. Orthogonal films were taken of all the patients once a week. These verification films were compared with the DRR were used for the treatment setup. By performing this procedure every treatment, using humanoid phantom and patient cases, the errors of localization can be analyzed, with adjustments made from the translation. The reproducibility of the patients' setup was verified using portal and digital images. Results : The PSVT system was developed to verify the alignment of the machine and the target isocenters, and the reproducibility of the patients' setup for 3DCRT and IMRT. The results show that the localization errors are 0.8$\pm$0.2 mm (AP) and 1.0$\pm$0.3 mm (Lateral) in the cases relating to the brain and 1.1$\pm$0.5 mm (AP) and 1.0$\pm$0.6 mm (Lateral) in the cases relating to the pelvis. The reproducibility of the patients' setup was verified by visualization, using real-time image acquisition, leading to the practical utilization of our software Conclusions : A PSVT system was developed for the verification of the alignment between machine and the target isocenters, and the reproduclbility of the patients' setup in 3DCRT and IMRT. With adjustment of the completed GUI-based algorithm, and a good quality DRR image, our software may be used for clinical applications.

The Effects of Virtual Competitors on AR (Augmented Reality) Home Training System: Focusing on Immersion, Perceived Competition, and Learning Motivation (증강현실을 활용한 홈 트레이닝에서 가상 참여자의 영향: 몰입, 인지된 경쟁, 그리고 정보 습득의 욕구를 중심으로)

  • Choi, Sungho;Lee, Wonouk;Kim, Hyunju;Won, Jongseo;Lee, Jeehang;Lee, Yeonjoo;Kim, Jinwoo
    • Science of Emotion and Sensibility
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    • v.20 no.3
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    • pp.119-130
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    • 2017
  • The purpose of the study is discovering the effects of virtual competitors on user in AR (Augment Reality) home training system. Specifically, the current research examined their effects on immersion, perceived competition, and leaning motivation. The paper tested three unexplored relationship. First, introducing virtual competitors in home training system will enhance user's immersion. Second, presenting virtual competitors in home training system will increase user's perceived competition. Third, virtual competitors in home training system will raise user's learning motivation. For empirical analysis, we developed home training system, which could check and give feedback automatically, based on user's posture. Using this AR home training system, the study empirically shows how and why virtual competitors affect users. The results give implications not only on service design; but also on the idea that virtual other could affect user's behavior.

Effects of Sleep on Balance Control and Reaction Time to Visual Stimuli (수면이 균형조절과 시각적 자극 반응시간에 미치는 영향)

  • Park, Sookyoung;Park, Jung-A;Park, Kanghui;Kim, Joo-Heon;Hong, Yonggeun
    • Sleep Medicine and Psychophysiology
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    • v.23 no.2
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    • pp.68-76
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    • 2016
  • Objectives: To find evidence that sleep is necessary for normal brain function, thus indicating that declines in both sleep quality and quantity are related to worse performance of many daily tasks and deteriorated physical functions. The present study investigates the relationships of balance control and reaction time with sleep quality. Methods: 58 healthy (male 20, female 38) volunteers with informed consent participated in this study. The Self-reported Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality and relevant factors, and the subjects were divided into groups A (PSQI < 5) and B ($PSQI{\geq}5$) based on this index. Static balance control and reaction time to visual stimuli were conducted to assess their relationship with sleep quality. Results: Group B exhibited excessive daytime sleepiness significantly more often compared to group A. Static balance control did not markedly change relative to sleep quality, but reaction time and error to visual stimuli were significantly increased in group B compared to group A. Conclusion: These findings indicate that a decline in sleep quality can result in delayed reactions, as well as decreased accuracy of these reactions. They also suggest that low sleep quality may be associated with changes in physical functions, including balance control through reduced selective attention.

Competition and Coexistence of Visual Representations: Controversies about the Mechanism of Face Recognition in Neuroscience (시각화를 통한 재현의 경쟁과 공존: 신경과학의 얼굴 인식 메커니즘에 관한 논쟁을 중심으로)

  • Chang, Ha-Won
    • Journal of Science and Technology Studies
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    • v.10 no.2
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    • pp.107-141
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    • 2010
  • Visualization techniques are transformed into reliable representations through socio-technological processes which include the agreement on the instrument and the embodiment of practices in relevant scientific communities. Visual representations thus produced are justified by realistic and epistemic virtues in science. This paper analyzes different visual images presented in the scientific papers of two research groups who argue different theories about the mechanism of face perception. These two scientific groups use the same fMRI technology; yet, different experimental paradigms and visual stimuli change their hypotheses into distinct testable theories, which in turn lead to different evidences to support their own theories. Visual evidences are intermediate representations which lie between fMRI brain images and scientific theories, and theoretical models obtain the scientific value based on the consistency in the chain of visual representations. This study shows that representations in science tend to be good representations within the context of scientific communities. It will provide a chance to think of the value and limit of the scientific knowledge

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Analyzing association between low-density lipoprotein reduction by statin and adherence to medication using national health insurance service-national sample cohort (NHIS-NSC) (표본코호트기반 고지혈증 약제의 저밀도 콜레스테롤 감소량 및 투약순응도 분석)

  • Kim, Kyu-Jin;Jun, Chi-Hyuck;Lee, Hyeseon;Kim, Hun-Sung
    • Journal of the Korean Data and Information Science Society
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    • v.28 no.5
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    • pp.1027-1041
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    • 2017
  • Hyperlipidemia, the status of blood with high level of low-density lipoprotein cholesterol (LDL-C), is known as a main cause of coronary artery diseases such as myocardiac infarction or brain infarct. Statin is the representative prescription to hyperlipidemia and the effects of it depend on the patient's individual conditions such as health-caring habits or adherence to medication. The main effect of statin is reducing LDL-C, which should reach the target range based on National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) guideline. In this research, the reduction of LDL-C and attainment to patient's target range are considered effects of statin. The association between factors - individual conditions and adherence to medication of patients - and the effects of statin is analyzed with National Health Insurance Service-National Sample Cohort (NHIS-NSC).

The Association of the 2nd to 4th Digit Ratio with the Age of Onset and Metabolic Factors in Korean Patients with Schizophrenia (한국 조현병 환자에서 검지-약지 길이비와 발병 연령 및 대사 장애와의 연관성)

  • Kim, Hong Rae;Lee, Jung Sun;Joo, Yeon Ho;Won, Seunghee;Ryu, Seunghyong;Hong, Kyung Sue;Kwon, Jun Soo;Lee, Seung Yeoun;Oh, Hong Seok;Choi, Joon Ho;Lee, Yu Sang
    • Korean Journal of Biological Psychiatry
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    • v.24 no.3
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    • pp.142-148
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    • 2017
  • Objectives The ratio of second to fourth digit length (2D : 4D) could be a potential epigenetic marker of sexual dimorphism reflecting prenatal testosterone exposure. Testosterone is known to affect the development of the brain through an epigenetic mechanism. The purpose of this study was to investigate the effects of exposure to fetal testosterone on the metabolic syndrome based on 2D : 4D of schizophrenia patients and the relationship with the age of onset of schizophrenia. Methods A total of 214 schizophrenia patients participated in this study. The participant's physical and blood tests were performed according to the American National Cholesterol Education Program's Third Amendment of the Metabolic Syndrome Diagnostic Criteria, and the 2D : 4D was measured by the method designed by McFadden. Data were statistically analyzed by t-test, Pearson's correlation analysis and multiple regression model analysis. Results 2D : 4D was significantly higher in female than male in both hands, and there was a statistically significant negative correlation between 2D : 4D and the age of onset of schizophrenia in male. However, 2D : 4D did not show statistically significant correlation with metabolic factors. Conclusions Fetal testosterone suggests the possibility of affecting the age of onset of schizophrenia through the epigenetic mechanism, but there is no clear relationship with metabolic factors.

A survey on the topic introductory materials of the 7th grade mathematics textbooks and its usages - Centered on the 6th and 7th curriculum based textbooks - (수학과 7-가 교과서 단원도입 활동의 내용소재 변화 및 활용실태 조사 연구 -제 6차와 7차 교과서를 중심으로-)

  • 이영하;김미연
    • School Mathematics
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    • v.4 no.3
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    • pp.375-399
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    • 2002
  • When a curriculum change is being an issue, the editorships and the promotive directions reflect to supplement the social requests. However it is often criticized that such changes in the textbook itself are not satisfactory enough as to coherent to the editoships. And we set the following research questions; (1) One of the most important changes in the new 7th curriculum is to encourage the students' activities. We checked if it is well suited in the new textbooks. (2) Often textbook itself is not important In class, while instructor or students want something else other than the one suggested in the textbook. We asked 187 teachers how they use the textbooks in class. To answer (1), we checked up the introductory - activity - contents with 7 categories, which are ${\circled1}$ of real life sources ${\circled2}$ in use of concrete manipulative ${\circled3}$ in use of computers or calculators ${\circled4}$ in use of historical resources ${\circled5}$ stimulating to recall a relevant previous knowledges ${\circled6}$ of coherence between the activity and the exploratory contexts. ${\circled2}$ were increased, rewarding to the decrease of ${\circled5}$, in the new textbooks, while changes in ${\circled3}$ and ${\circled4}$ were not enough to talk about increments. Especially slight decrease in ${\circled6}$ were detected and it seemed to attribute to the unmatchable use of ${\circled1}$ and ${\circled2}$ with the explanation of mathematical subjects, which also implies how difficult to match ${\circled1}$ and ${\circled2}$ with ${\circled6}$. Analyzing the reponses of (2), about 70% of the teachers used the introductory activities in the textbook, which led better attention of sudents, while 30% of teachers do not use it because they felt that its inroductory activities had not been adequate for their purposes. Teachers counted inadequacy reasons for not being helpful in class, lack of time or lack of support of students, etc. Those teachers use introductory activities invented of their own for classes. As some results of the study, we suggest firstly that authors of textbooks have to get more informations to provide ways to entcourage students' interest in mathematics classes. The ways must be practical and brain storming as well as More use of computers and calculators and mathematical history are expected. Secondly, we are emphasizing the feedbacks between the textbook authors and the users(teachers and students) through internet. Which, we anticipate, will get better communications between them and be a good foundations of continuous modifications of textbooks.

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Screening of Chicken Genes Related to Germ Cell Development (닭에서 생식세포 발달에 관여하는 유전자 검색)

  • Lee, Jee-Young;Kim, Hee-Bal;Kim, Duk-Kyung;Song, Ki-Duk;Lim, Jeong-Mook;Han, Jae-Yong
    • Journal of Animal Science and Technology
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    • v.49 no.2
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    • pp.183-194
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    • 2007
  • We examined the expression patterns of the chicken TCs(tentative consensus sequences) originated from GermOnline genes in various chicken tissues, applying information from GermOnline to chicken organisms. 42 TCs among 84 chicken homologous TCs from the pool of 84 genes related to germ cell lineage in mouse(10), rat(71) and human(3) had high homology based on a BLAST search. Of these, Hmgcs2 and Sycp3 was shown to be expressed in a testis- specific manner and a reproductive organ(testis and ovary)-specific manner, respectively, by RT- PCR analysis. Crmp4, Cyct, Ldhc, Epha7, Pcsk4 and Dnmt3a are expressed in brain, testis, and ovary. The characterization of chicken genes originated from GermOnline in this research may give an enormously useful source of information related to germ cell development.

A review on Cognitive Information Processing and Emotional Changes of Athletes by Overtraining: P300, EEG Cerebral Hemispheric Asymmetry (과훈련에 따른 선수의 인지정보처리와 정서변화에 대한 문헌 고찰: P300, EEG 대뇌반구비대칭 연구를 중심으로)

  • Ha, Tae-Ho;Kim, Jin-Gu;Kim, Sung-Woon
    • Journal of Digital Convergence
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    • v.15 no.8
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    • pp.501-509
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    • 2017
  • The purpose of this study was to review the effects of the physical fatigue induced by overtraining on cognitive information processing and emotional change of athletes by neurophysiologic study. And to provide basic data for the athletes and coaches in the sports field to improve understanding of the overtraining symptoms from the brain physiological point of view. We reviewed the domestic and international academic materials and research reports published in the last 20 years using electronic databases and examined the literature that is consistent with the purpose of this study among the retrieved documents. Based on the reviewed literature, we examined the cognitive information processing and emotional change of the athlete according to the training, and overtraining can accumulate the fatigue of the body, which can cause severe side effects in terms of cognitive ability and emotional ability of athletes as well as deterioration of performance. The study using P300 and EEG cerebral hemispheric asymmetry difference indices also confirmed the possibility of a new approach to understand psychological and physiological effects of overtraining on information processing and emotional changes.

The Effects of Cognitive Reserve on Adult's Cognitive Function -Focusing on the Multiple Mediation Effect- (성인의 인지예비능이 인지기능에 미치는 영향 -우울, 주관적 기억감퇴 및 삶의 질의 다중매개효과를 중심으로-)

  • Kim, Ji-Hyun;Chung, Min-Jung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.9
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    • pp.358-372
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    • 2020
  • This study examined the effect of cognitive reserve on the cognitive function in adults. In addition, this study investigated the direct and indirect effects of factors, such as subjective memory decline, depression, and quality of life on the cognitive function. The participants consisted of 253 adults who were 40 to 80 years of age. The assessment tools included the cognitive function scale, depression scale, quality of life scale, subjective memory decline, and cognitive reserve scale. The data results were analyzed using SPSS 25.0, and PROCESS macro for SPSS Version 3.3 and bootstrapping were used. The results of multiple mediating of the cognitive reserve and cognitive function in adults did not have a mediating effect in depression and subjective memory decline, and the quality of life showed a complete mediating effect in the relationship between the cognitive reserve and subjective cognitive function. Based on the results of this study, adults must accumulate cognitive reserve continuously through various activities and continuous training so that the cognitive function can lead to a positive direction. Nevertheless, more studies on cognitive reserve and cognitive function in healthy adults are needed.