• Clinics in Shoulder and Elbow
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• 제25권1호
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• pp.15-21
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• 2022

Background: This study was performed to identify the incidence of screw in-type lateral anchor pull-out in patients older than 60 years who underwent rotator cuff repair for large to massive rotator cuff tear (RCT). Methods: We reviewed 25 patients over 60 who were diagnosed with large to massive RCT and underwent arthroscopic rotator cuff repair in our hospital from March 2017 to February 2021. Preoperative tear size (anterior to posterior, medial to lateral) was measured via preoperative magnetic resonance imaging (MRI). All 25 patients underwent MRI scanning on postoperative day 1 and at 3 months after surgery. The change of anchor position was measured in axial views on MRI images postoperative day 1 and 3 months after surgery. And it was statistically compared according to bone mineral density (BMD), sex, and number of lateral anchors. Results: Two MRIs (postoperative day 1 and 3 months) in 25 patients were compared. Anchor pull-out occurred in six patients during 3 months (6.7%), and the mean pull-out length difference was 1.56 mm (range, 0.16-2.58 mm). There was no significant difference in the number of pull-out anchors, degree of pull-out difference by comparing BMD (A, BMD≤-2.5; B, BMD>-2.5), sex, or number of anchors used in each surgery (C, two anchors; D, three anchors) (p>0.05). Conclusions: Pull-out of screw in-type anchors was rarely observed and the mean pull-out length difference was negligibly small in our study. The screw in-type lateral anchor seems to be a decent option without concern of anchor pull-out even in elderly patients.

• 치위생과학회지
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• 제10권3호
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• pp.147-153
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• 2010

본 연구에서는 대학생들을 대상으로 영양상태평가를 위해 먼저 식품섭취빈도조사지를 이용하여 이들의 식이섭취행태를 영양소 단위에서 분석하고, 두 번째로 체성분 및 골밀도를 측정하였으며, 마지막으로 구강검진을 시행하여 여대생들의 전반적인 식이섭취행태, 체성분 및 골밀도와 치아우식증과의 관련성에 대해 분석하였다. 본 연구대상자는 지역적 편차와 지리적 접근이 용이한 부산광역시 소재 D대학 치위생과 재학생 150명을 연구모 집단으로 선정하여 2009년 10월 10일 1차 조사를 시행하여 자발적으로 연구참여에 동의한 150명중 자료처리에 부적합한 18명을 제외한 132명을 최종 연구대상자로 선정하였다. 본 연구결과는 다음과 같다. 1. 본 연구대상자의 일반적 특성에서 총 섭취에너지는 평균 $1921.230{\pm}236.865kcal$였고, 나트륨 섭취는 $4433.026{\pm}1970.72mg$으로 상당히 높게 나타났고, 체형은 $2.98{\pm}0.99$점으로 표준체형(3점)이었으며, T-score는 평균 $-1.110{\pm}1.647$로 대부분의 학생이 약간의 골감소증(T-Score -1 ~ -2.5이내)이 있는 것으로 나타났고 우식경험영구치지수는 평균 $6.03{\pm}1.95$개로 나타났다. 2. 분석결과 대상자의 1일 평균 영양소 섭취량과 우식경험영구치지수와의 상관관계 검정에서 1일 평균 섭취에너지, 영양소 모두에서 우식경험영구치지수와는 유의하지 않은 것으로 나타났다. 3. 분석결과 대상자의 체성분과 우식경험영구치지수와의 상관관계 검정에서도 유의하지 않은 것으로 나타났다. 4. 분석결과 대상자의 골밀도와 우식경험영구치지수와의 상관관계 검정에서 SOS, BQI에서 우식경험영구치와 유의한 상관관계가 ${\pm}0.2$미만으로 아주 미약하게 나타났다(p<0.05). 5. 독립변수들의 유의성 검증결과 T-score(p<0.05)가 ${\alpha}=0.05$수준에서 통계적으로 유의한 것으로 나타나 우식경험영구치지수에 영향을 주는 요인으로 나타났다. 이상의 결과를 종합해 볼 때 여대생들의 영양상태 및 체성분은 치아우식증과 유의한 관련성은 없는 것으로 나타났으나 골밀도척도인 SOS, BQI에서는 미약한 상관관계를 나타내고, T-score는 우식경험영구치지수에 영향을 주는 요인으로 나타났다. 추후 연구조사에서 연구대상자의 수를 확대시키고 구강관리행태와 사회경제적 요인을 보정하여 연령별 영양상태, 체성분 및 골밀도과 치아우식증간의 관련성을 구명할 수 있는 자료를 더 많이 확보하여야 할 것으로 생각된다.

• 한국노년학
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• 제31권2호
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• pp.355-369
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• 2011

본 연구는 장기간의 복합운동이 골다공증 노인의 신체부위별 골밀도와 심혈관질환 위험요인에 어떠한 영향을 미치는가를 규명함으로써 골다공증 노인의 골밀도 개선과 심혈관질환을 예방하기 위한 운동 지침을 제공하고자 실시하였다. 연구의 대상자는 서울 S·K타워 실버타운에 입주하여 거주하는 골다공증 노인 여성 31명으로 규칙적인 복합운동군(n=16)과 통제군(n=15)으로 무선배정 하였다. 복합운동프로그램으로 동적 및 정적 스트레칭으로 이루어진 준비운동과 정리운동을 각각 10분씩 실시하고, 본 운동에서 유산소운동으로 자전거와 트레드밀을 이용하여 30~45분(예비 심박수; HRR 40%~60%) 동안 실시하였으며, 무산소운동으로는 대근육 단련을 위한 7가지 웨이트트레이닝(1RM * 50-70%; 8-10회 * 2세트 ~ 10-15회 * 1세트)을 주당 5일 1년간 시행하였다. 통제군은 실험이 진행되는 기간 동안 S·K타워에서 규칙적인 운동 및 신체활동에 참여하지 않고 TV 시청이나 회원과의 담소를 나누는 정도의 좌업생활을 하였다. 또한 이들은 실험 전, 중, 후에 신체 부위별 골밀도(상지, 하지, 골반, 척추, 체간 및 T-score)와 심혈관질환 위험요인(혈압, 혈중지질)을 측정하였다. 그 결과 첫째, 신체 부위별 골밀도에서는 골반, 척추, 체간 및 T-score에서 유의한 차이를 나타내었다. 둘째, 심혈관질환 위험요인 중 혈압(SBP, DBP)에서도 유의한 차이를 나타내었으며, 혈중지질의 변인 중 TC, TG, LDL-C 및 HDL-C에서도 유의한 차이를 나타내었다. 결론적으로 장기간 실시하는 복합운동은 골다공증 노인에게 있어 골반, 척추, 체간의 골밀도 및 T-score 개선과 함께 심혈관 질환 위험요인을 감소시킴에 따라 심혈관 질환으로 인한 사망률과 골절의 위험성을 감소시키고, 삶의 질을 향상 시킬 수 있을 것으로 생각된다. 이에 향후 연구에서는 골다공증과 만성질환의 다각적인 연구를 통하여 만성질환으로 인한 조기 사망률 감소와 삶의 질 향상을 위한 프로그램 개발이 논의 되어야 할 것이다.

• 대한의용생체공학회:의공학회지
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• 제30권5호
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• pp.444-451
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• 2009

Purpose: The aim of present study is to detect longitudinal alterations of mechanical characteristic determined by bone quality (microarchitecture and degree of mineralization) on femur trabecular bone due to metastatic bone tumor Materials and Methods: Each 6 female SD rats (12 weeks old, approximate 250g) were allocated in SHAM and TUMOR Group. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was injected into the right femur (intraosseous injection) in TUMOR Group, whereas 0.9% NaCl (saline solution) was injected in SHAM Group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters, bone mineral density, X-ray attenuation and bone mineralization distribution at 0 week and 4 weeks after surgery. Results: BMD, BV/TV and Tb.N of trabecular bone in TUMOR group were markedly decreased (26%, 11% and 23%) while those in SHAM group were significantly increased (34%, 48% and 11%) (p<0.05). BS/BV, Tb.Sp and SMI in TUMOR group were significantly increased (-16%, 38% and 2%) compared with those in SHAM group (-33%, 12% and -16%) (p<0.05). Additionally, bone mineralization in TUMOR group significantly decreased while those in SHAM group was significantly increased (p<0.05). Conclusion: It is identified that how much bone microarchitecture and mineralization are diminished due to the metastatic bone tumor. The results may be helpful to prediction of fracture risk by metastatic bone tumor.

• 대한족부족관절학회지
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• 제10권2호
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• pp.207-212
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• 2006

Purpose: To evaluate the results of ankle lateral malleolar fractures classified as Danis-Weber type B accompanying osteoporosis that were treated with lag screw. Materials and Methods: 15 cases of Danis-Weber type B ankle lateral malleolar fractures that had T score of less than -2.5 in BMD(bone mineral density) test were selected from June 2003 to December 2005. 10 cases were males and 5 cases were females with mean age of 59 years. The main injury mechanism was supination and external rotation. Mean follow-up period was 16 months. Clinical and radiologic evaluation was done according to Meyer and Kumler's criteria. Results: All cases showed satisfying result and mean radiologic bone union period was 3 months. Anatomic reduction and bone union was acquired in all cases without complications including wound infection, skin necrosis, delayed union and nonunion Conclusions: Lag screw fixation seem to be excellent treatment of Danis-Weber type B lateral malleolar fractures with osteoporosis as it can minimize soft tissue injury and enable anatomic reduction with firm fixation.

• 대한의생명과학회지
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• 제9권1호
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• pp.9-13
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• 2003

Currently bone biochemical markers are considered to be the best indicators of present and the future state of bone turnover. A recent study has reported that chlorella increases the bone mineral density (BMD) on postmenopausal women, but presently there are no studies on bone biochemical markers treated with chlorella dietary supplementation. The purpose of the present study was to assess the bone biochemical markers for the short term and long term treatment groups, and non-treatment group as a control. Twenty two postmenopausal woman were treated for four months and eighteen for one year with 4 gm of chlorella dietary supplementation per day, and then assessed bone biochemical markers from serum and urine samples. Bone turnover rates calculated with Osteocalcin (OC), bone specific alkaline phosphatase (BAP) as a bone formation markers and deoxypyridinoline (DP), cross-linked N-telopeptides of type I collagen (NTx) as a bone resorption markers, showed 1131$\pm$87% for control group, 61$\pm$11% for short term treated group and 190$\pm$101% for long term treated group. We conclude that chlorella dietary supplementation enhances the bone formation, and NTx as a single markers, OC/Dp as a single markers of bone turnover rate were very useful tools for determine the effectiveness of chlorella dietary supplementation (or the postmenopausal women.

• 대한방사선기술학회지:방사선기술과학
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• 제39권4호
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• pp.527-534
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• 2016

DEXA는 골다공증 진단에 가장 많이 사용되는 표준 측정법이다. 현재 국내에서 운영되고 있는 DEXA 장치는 5,671대이다. 본 연구에서는 국내에서 설치 운영되고 있는 DEXA장비의 품질관리 실태를 조사하였다. 3,000개 기관을 대상으로 한 설문 조사에서 12.6%의 응답을 받아 그 결과를 분석하였다. 결과에서 77.5%가 일일 품질관리를 시행하고 있으나 Shewhart chart는 68.5%, CUSUM chart는 86.0%가 모르거나 사용하지 않는다고 답하여 정확한 품질관리가 되지 않는 것으로 조사되었다. 정확한 골밀도 검사는 환자의 골절의 위험도를 산정하기 위한 자료로 활용된다. 하지만 부적절한 검사는 오진을 유발할 가능성을 높여준다. 따라서 정확한 골밀도 검사를 위해서는 적절한 보조기구를 사용하고 장치의 품질관리를 반드시 시행하여 장치와 자세에 대한 오차를 줄이고 검사 의료진의 교육을 통해 오류 요인을 줄이는 것이 필수적이다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.518-521
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• 2005

We performed the mechanical test for obtaining properties of femoral head. Tested sample was male and 35 years old. We measured bone mineral density by dual X-ray absorption method(DEXA). Results of DEXA, he has normal condition of bone density. His BMD $1.159g/cm^2$ and T-Score is 1.6. Tested femurs were harvested by surgical method from donated cadaver. We made 9 specimens in femoral head, 8 specimens in neck used by diamond core drill. Then we performed compressive test in saline solution at $38^{\circ}C$. We obtained results that elastic modulus of femoral head was 0.439GPa, neck was 0.459GPa. Compressive strength of femoral head was 7.441 MPa, neck was 7.095MPa. There was no significant difference of mechanical properties between left and right femoral head & neck. Invested local properties of femoral head have more strength superior and anterior side, femoral neck has more strength in superior and inferior side but other side except for superior has more weakness along the lateral side.

• Nutrition Research and Practice
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• 제12권4호
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• pp.275-282
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• 2018

BACKGROUND/OBJECTIVE: There is intense interest in soy isoflavone as a hormone replacement therapy for the prevention of postmenopausal osteoporosis. A new kind of isoflavone-enriched whole soy milk powder (I-WSM) containing more isoflavones than conventional whole soy milk powder was recently developed. The aim of this study was to investigate the effects of I-WSM on bone metabolism in ovariectomized mice. MATERIALS/METHODS: Sixty female ICR mice individually underwent ovariectomy (OVX) or a sham operation, and were randomized into six groups of 10 animals each as follows: Sham, OVX, OVX with 2% I-WSM diet, OVX with 10% I-WSM diet, OVX with 20% I-WSM diet, and OVX with 20% WSM diet. After an 8-week treatment period, bone mineral density (BMD), calcium, alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP) 5b, osteocalcin (OC), procollagen 1 N-terminal propeptide (P1NP), and osteoprotegenin (OPG) were analyzed. RESULTS: BMD was significantly lower in the OVX group compared to the Sham group but was significantly higher in OVX + 10% I-WSM and OVX + 20% I-WSM groups compared to the OVX group (P < 0.05). Serum calcium concentration significantly increased in the OVX + 10% and 20% I-WSM groups. Serum ALP levels were significantly lower in the OVX + 10% and 20% I-WSM groups compared to the other experimental groups (P < 0.05). OC was significantly reduced in the OVX group compared to the Sham group (P < 0.05), but a dose-dependent increase was observed in the OVX groups supplemented with I-WSM. P1NP and OPG levels were significantly reduced, while TRAP 5b level was significantly elevated in the OVX group compared with the Sham group, which was not affected by I-WSM (P < 0.05). CONCLUSIONS: This study suggests that I-WSM supplementation in OVX mice has the effect of preventing BMD reduction and promoting bone formation. Therefore, I-WSM can be used as an effective alternative to postmenopausal osteoporosis prevention.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권4호
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• pp.293-300
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• 2011

Purpose: Substance P is a well known neurotransmitter and has been known to mediate pain. Recently, it has been unveiled that substance P is involved in the recruitment of mesenchymal stem cells to wound sites. The purpose of this study was to exam bone formation when a combination of substance P and silk fibroin was used in a bone defect model. Methods: Twenty rabbits were used and 40 calvarial defects were formed. They were divided as 4 groups (unfilled control, silk only, silk+$10{\mu}g$/ml substance P; Sub10, and silk+$100{\mu}g$/ml substance P; Sub100). All animals were humanely sacrificed 4 or 8 weeks after grafting. The specimens were analyzed by micro-computerized tomography and histological analysis. Results: When compared to the unfilled control to silk only group, there was significant difference in bone mineral density (BMD) and the attenuation coefficient (AC) at 4 weeks ($p$=0.037 and 0.038, respectively). When compared Sub10 group to Sub100 group, there was significant difference in BMD and AC at 8 weeks ($p$=0.004 for all). Residual graft amounts were $52.1{\pm}15.8$%, $15.2{\pm}9.2$% and $9.0{\pm}3.3$% for silk only, Sub10, and Sub100 groups, respectively. When comparing the residual graft amount of silk only to sub10 or sub100, the differences were statistically significant ($p$ <0.001). Conclusion: The silk fibroin scaffold showed higher BMD and AC than the unfilled control. The combination graft with substance P and silk fibroin scaffold showed a faster graft degradation than with a silk fibroin scaffold only.