Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Longitudinal Alterations of Microarchitecture and Mineralization Distribution on Trabecular Bone Due to Metastatic Bone Tumor

전이성 골암에 의한 해면골의 미세구조와 골화 분포 변화

  • Park, Sun-Wook (Department of Biomedical Engineering, Yonsei University) ;
  • Jeon, Ok-Hee (Department of Biomedical Engineering, Yonsei University) ;
  • Ko, Chang-Yong (Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Chi-Hyun (Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Han-Sung (Department of Biomedical Engineering, Yonsei University) ;
  • Chun, Keyoung-Jin (Gerontechnology Center, Korea Institute of Industry Technology) ;
  • Lim, Do-Hyung (Gerontechnology Center, Korea Institute of Industry Technology)
  • 박선욱 (연세대학교 의공학과) ;
  • 전옥희 (연세대학교 의공학과) ;
  • 고창용 (연세대학교 의공학과) ;
  • 김지현 (연세대학교 의공학과) ;
  • 김한성 (연세대학교 의공학과) ;
  • 전경진 (한국생산기술연구원 실버기술개발단) ;
  • 임도형 (한국생산기술연구원 실버기술개발단)
  • Published : 2009.10.31
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Abstract

Purpose: The aim of present study is to detect longitudinal alterations of mechanical characteristic determined by bone quality (microarchitecture and degree of mineralization) on femur trabecular bone due to metastatic bone tumor Materials and Methods: Each 6 female SD rats (12 weeks old, approximate 250g) were allocated in SHAM and TUMOR Group. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was injected into the right femur (intraosseous injection) in TUMOR Group, whereas 0.9% NaCl (saline solution) was injected in SHAM Group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters, bone mineral density, X-ray attenuation and bone mineralization distribution at 0 week and 4 weeks after surgery. Results: BMD, BV/TV and Tb.N of trabecular bone in TUMOR group were markedly decreased (26%, 11% and 23%) while those in SHAM group were significantly increased (34%, 48% and 11%) (p<0.05). BS/BV, Tb.Sp and SMI in TUMOR group were significantly increased (-16%, 38% and 2%) compared with those in SHAM group (-33%, 12% and -16%) (p<0.05). Additionally, bone mineralization in TUMOR group significantly decreased while those in SHAM group was significantly increased (p<0.05). Conclusion: It is identified that how much bone microarchitecture and mineralization are diminished due to the metastatic bone tumor. The results may be helpful to prediction of fracture risk by metastatic bone tumor.

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References

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