• 대한방사성의약품학회지
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• 제3권2호
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• pp.80-84
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• 2017

Re-188 is an excellent and practical radioisotope produced by W-188/Re-188-generator for therapy. We prepared Re-188-tin colloid for therapy of various diseases and tried to treat peritoneal effusion in animal model. Sarcoma-180 cells were injected into ICR mice to induce peritoneal effusion and the mice were grown for 3 d. Re-188-tin colloids (0.25, 0.5, and 1 mCi/mL per 30 g body weight) were injected into the mice and the mice were grown for 90 d. Planar gamma scintigraphy showed even distribution of Re-188-tin colloid radioactivity. Bax expression was found to be dose dependent to Re-188-tin colloid. Normal saline treated group showed the shortest survival time. Among the treated groups, 0.5 mCi dose group showed the longest survival time. In conclusion, Re-188-tin colloid was prepared successfully and showed the feasibility to use as a peritoneal effusion treatment in mice.

• Applied Microscopy
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• 제18권2호
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• pp.187-204
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• 1988

The present experiment was performed to investigate the acute and subacute effect of lead acetate on ultrastructural and biochemical changes in mouse diencephalon. In acute case, mouse were peritoneally injected with lead acetate at a dose of 0.26 mmole/kg body weight, and after treatment, mouse were sacrificed at time intervals of 12, 24, 48, and 96 hours. In subacute case, mouse were injected at doses of 0.07 mmoie/kg B. W. and 0.13 mmole/kg B.W. once at two days, and after treatment, mouse wee sacrificed at 1 week, 2 weeks, and 3 weeks. It was observed that after acute treatment, changes composed of increased monoamine oxidase activity, $Na^{+}-K^{+}$ ATPase activity, decreased $Mg^{2+}$-APTase activity, wrinkled myelin, swollen Golgi apparatus and more dense synaptic vesicle in nerve terminal. After subacute treatment, decreased monoamine oxidase activity, increased $Mg^{2+}$-ATPase, $Na^{+}-K^{+}$ ATPase, lose of myelin, uneven mitochondrial distribution, synaptic vesicular density and edema, but at a higher dose the effect was more severe. Therefore, lead acetate caused abnormal change of diencephalon, and at a subacute, it appears metal accumulative toxicity.

• 한국임상수의학회지
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• 제13권2호
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• pp.144-148
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• 1996

The effectiveness of sodium carboxymethylcellulose (SCMC) and deztran in the prevention of adhesion formation on the uterus and embryo collection in rabbits was elucidated. Following induction of adhesion on uterus and uterine horns by abrasion and retrograde flushing of embryos in gonadotropins primed rabbits, the solutions of saline (for control), 1% SCMC, 10% dextran and a synthetic solution of 1% SCNC and 10% dextran in saline were infused in the abdominal cavity at the dose of 5 ml/kg of body weight. The average percentage of adhesion was 11.1, 28.6, 41.7 and 73.3% in the rabbits infused with the synthetic, 1% SCMC, 10% dextran and saline solutions, respectively. The synthetic solution was more effective than other solutions in the rabbits. The average number and recovery rate of embryos were significantly (P<0.01) higher in the synthetic solution group than 1% SCMC, 10% dextran or saline solution groups. Among the collected embryos in the groups, the distribution of the normal embryos was higher in the synthetic solution group (99%) and the 10% dextran solution group (95.7%) than the 1% SCMC solution group (78.4%) and saline (66.2%). Theretore, a synthetic solution which is combined with 1% SCMC and 10% deztran in saline can be effectively used for the prevention of adhesion formation after uterine surgery and embryo collection.

• 대한가정학회지
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• 제33권6호
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• pp.199-211
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• 1995

The purpose of this study was to provide a brassiere size chart for making the well-fitted brassiere. The subjects are 2811 women whose range of age is 12 to 59. These woman were classified into 5 age groups by seniority ; age group 1(12~19), age group 2(20~29), age group 3(30~39), age group 4(40~49), age group 5(50~59). statistical differences of measurements were analyzed among 5 age groups through ANOVA. Correlation between measurements were analyzed by correlation analysis. In addition, new brassiere size chart and production rate tables were proposed in this study. The results of the study were as follows. 1) Most of the body measurements were significantly different among 5 age groups. The height was decreasing by getting older while weight was increasing significantly. The 3 girth measurements(top bust, bust, under bust girth) in breast, bust width, bust depth were apt to increase definitely. The 3 girth measurements had high Correlation coefficients among 3 girth mesurements. Therefore, it is valid to pick out cup size and under bust girth for representative items of size chart. 2) Under bust girth and cup size were chosen as 2 axes of brassiere size chart. From the dual distribution table whose intervals had been determined by KS size chart, 17 sizes, which had more than 2% of appearance, were suggested for brassiere size chart. Through these new size charts, the suggested brassiere sizes covered 82.5% of all subjects. The suggested brassiere size chart would be more helpful than KS size chart in making the well-fitted brassiere.

• 대한지역사회영양학회지
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• 제8권3호
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• pp.302-310
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• 2003

This study was undertaken to assess nutritional status of the low income elderly residing in Gwangju. Anthropometric data showed that mean height of the subjects was lower than that of Korean Standard Growth data but weight was similar to that standard value. As the subjects became older, their heights and weights were decreased. Body mass index (BMI) in males and females were 22.9 and 24.4 respectively. However, BMI distribution showed that 56% of the elderly females under 75 were underweight. Advancing age conoibutes significant difference in triceps skinfold thickness in females (p < 0.001). Total cholesterol level was higher in the elderly females than the males. It was found that a considerable number of subjects had anemia determined by hemoglobin and hematocrit level, which indicated un iron deficiency. Twenty-four hour dietary recall revealed that, except for phosphorus and vitamin C, all the nutrient intakes of the subjects were below 75％ of Korean RDA. Surprisingly, vitamin A and riboflavin intakes of the elderly were below 50％ of Korean RDA. Energy intakes of the elderly males and females were 58.7% and 59.6% of Korean RDA respectively. Unbalanced energy ratios of carbohydrate, protein and fat were noted in both genders. Nutrient intakes of females' were lower than those of males'. Thus, there was a significant gender difference in nutrient intakes. It might be further suggested that an appropriate nutritional program should be developed and implemented to improve the Poor nutritional status of the low income elderly living in cities.

• Journal of Microbiology and Biotechnology
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• 제19권12호
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• pp.1569-1572
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• 2009

The pharmacokinetics of decursin and decursinol angelate (D/DA) were investigated in male SD rats following oral and intravenous administration. D/DA and metabolites obtained from in vitro samples were evaluated by LC/MS. The levels of D/DA and metabolized decursinol in the blood following oral and intravenous administrations declined according to first-order kinetics, with $T_{1/2}$ values of 56.67, 58.01, and 57.22 h, respectively, being observed after administration of a dose of 2 mg/kg body weight. The large intestine was the major site of disposition following oral administration. These data indicate that D/DA is rapidly absorbed from the gastrointestinal tract. In in vitro experiment utilizing liver microsomal protein, the major metabolic reaction of D/DA occurred to change decursinol. The cumulative biliary, urinary, and fecal excretions of D/DA in bile duct-cannulated rats was $36.10{\pm}2.9%$, $25.35{\pm}3.8%$, and $34.20{\pm}3.2%$, respectively, at 72 h after administration. These results indicate that the absorption of D/DA is almost complete, and that its metabolites are primarily excreted into feces through the bile. These results indicate that D/DA is subject to enterohepatic circulation.

• 동의생리병리학회지
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• 제17권3호
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• pp.810-814
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• 2003

Backgroud and Purpose ; I intented to be helpful to treat adult disease through a clinical study of effect of vegetable ferment. Methods ; I studied 40 women of adipositas during 3 months from August. 2002 to July. November 2002, and then I analyzed level of examination after administration of vegetable ferment. Results and Conclusion ; vegetable ferment was administered to 40 women of adipositas for 3 months. The results level of cholesterol significantly decreased after administration of vegetable ferment, but triglyceride and HDL-C increased. And the results level of fat mass, fat ratio significantly decreased after administration of vegetable ferment but obesity, fat distribution of abdomen and body weight didn't decreased.

• 한국정밀공학회지
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• 제32권9호
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• pp.825-831
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• 2015

In this paper, capture motion and visual information from a virtual reality luge simulator to analyze muscular activity in the lower limbs. The Luge Simulator consists of a motion platform with a pneumatic module for weight distribution. We recruited luge athletes and healthy subjects and made real-time surface EMG measurements to estimate the muscular activity in the lower limbs according to the motion protocol of a simulator, and a test was conducted for each subject. The results indicated that the rectus femoris had the highest muscular activity according to the level of the slope and velocity of the luge. The soleus muscle showed a high level of activity during a turn in the luge according to the direction. We found that the development of a virtual reality sports simulator based on physical reaction results could bring positive effects to optimize reality and human cenesthesia.

• 대한수의학회지
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• 제44권1호
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• pp.7-13
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• 2004

Severe hypertension (>180 mmHg) develops in spontaneously hypertensive rats (SHR) after 12 wk-old; however, it is not clear whether what kinds of molecular mechanism leads to altered cardiac performance following developmental stages in SHR. Also, although the effect of calcineurin (Cn) to promote cardiomyocyte hypertrophy in vivo and in vitro is established, its overall necessity as a hypertrophic mediator is currently an area of ongoing debate. Thus, we have examined i) body weight and blood pressure, ii) differences of expression and distribution of signaling molecules such as Cn, protein kinase B/Akt (PKB/Akt), and extracellular signal-regulated kinase (ERK) between SHR and their age-matched control Wistar-Kyoto (WKY) rats following developmental stages. In 16 wk-old SHR compared with WKY, 2-dimentional echocardiography showed cardiac enlargement and hypertrophy of left ventricle, significantly. Taken together, we suggest that Cn is associated with hereditary cardiac hypertrophy, the process being related to the molecular signaling mechanisms involving PKB/Akt and ERK.

• 대한수의학회지
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• 제55권1호
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• pp.57-60
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• 2015

To investigate kinetics of free $^{177}Lu$ and $^{177}Lu$-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of $5{\mu}Ci$/mouse or 15 mg/kg body weight, respectively. Free $^{177}Lu$ radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. $^{177}Lu$-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.