Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effect of Administration of Sodium Carboxymethylcellulose and Dextran on Prevention of Adhesion Formation on Uterus and Embryo Collection in Rabbits

Sodium Carboxymethylcellulose 및 Dextran의 투여가 토끼 자궁의 유착방지와 수정란에 미치는 영향

  • 이효종 (경상대학교 수의과대학, 동물의학연구소) ;
  • 강태영 (경상대학교 수의과대학, 동물의학연구소) ;
  • 윤희준 (경상대학교 수의과대학, 동물의학연구소) ;
  • 최민철 (경상대학교 수의과대학, 동물의학연구소)
  • Published : 1996.06.01
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Abstract

The effectiveness of sodium carboxymethylcellulose (SCMC) and deztran in the prevention of adhesion formation on the uterus and embryo collection in rabbits was elucidated. Following induction of adhesion on uterus and uterine horns by abrasion and retrograde flushing of embryos in gonadotropins primed rabbits, the solutions of saline (for control), 1% SCMC, 10% dextran and a synthetic solution of 1% SCNC and 10% dextran in saline were infused in the abdominal cavity at the dose of 5 ml/kg of body weight. The average percentage of adhesion was 11.1, 28.6, 41.7 and 73.3% in the rabbits infused with the synthetic, 1% SCMC, 10% dextran and saline solutions, respectively. The synthetic solution was more effective than other solutions in the rabbits. The average number and recovery rate of embryos were significantly (P<0.01) higher in the synthetic solution group than 1% SCMC, 10% dextran or saline solution groups. Among the collected embryos in the groups, the distribution of the normal embryos was higher in the synthetic solution group (99%) and the 10% dextran solution group (95.7%) than the 1% SCMC solution group (78.4%) and saline (66.2%). Theretore, a synthetic solution which is combined with 1% SCMC and 10% deztran in saline can be effectively used for the prevention of adhesion formation after uterine surgery and embryo collection.

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References

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