• Journal of Biomedical Engineering Research
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• v.25 no.1
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• pp.57-64
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• 2004

The non pulsation blood pump is divided into axial flow and centrifugal style according to the direction of inlet and outlet flow. An axial flow blood pump can be made smaller than a centrifugal blood pump because centrifugal pump's rpm is fewer than axial flow pump. Hemolysis is an important factor for the development of an axial flow blood pump. It is difficult to identify the areas where hemolysis occurs. Evaluation of hemolysis both in in-vitro and in-vivo test requires a long-time and more expensive. Computational fluid dynamics(CFD) analysis enables the engineer to predict hemolysis on a computer which just can get not only amount of htmolysis but also location of hemolysis. It takes shorter time and less expensive than in-vitro test. The purpose of this study is to git Computational fluid dynamics in axial flow pump and to verify the accuracy of prediction by the possibility of design comparing CFD results with in-vitro experimental results. Also, wish to figure out the correction method that can bring improvement in shape of axial flow blood pump using CFD analysis.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1655-1659
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• 2008

Using numerical models, we investigated the efficiency of toxin removal using pulsatile flow in blood purification systems that use semipermeable membranes. The model consisted of a three-compartmental mass transfer model for the inside body and a solute kinetics model for the dialyzer. The model predicted the toxin concentration inside the body during blood purification therapy, and the toxin removal efficiencies at different flow configurations were compared quantitatively. According to the simulation results, the clearances of urea and ${\beta}_2$ microglobulin (B2M) using a pulsatile pump were improved by up to 30.9% for hemofiltration, with a 2.0% higher urea clearance and 4.6% higher B2M clearance for high flux dialysis, and a 3.9% higher urea clearance and 8.2% higher B2M clearance for hemodiafiltration. These results suggest that using a pulsatile blood pump in blood purification systems with a semipermeable membrane improves the efficacy of toxin removal, especially for large molecules and hemofiltration treatment.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.4
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• pp.500-506
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• 2012

A method to model left ventricular assist device (LVAD) and detect suction occurrence for safe LVAD operation is presented. An axial flow blood pump as a LVAD has been used to assist patient with heart problems. While an axial flow blood pump, a kind of a non-pulsatile pump, has relative advantages of small size and efficiency compared to pulsatile devices, it has a difficulty in determining a safe pump operating condition. It can show different pump operating statuses such as a normal status and a suction status whether suction occurs in left ventricle or not. A fuzzy subtractive clustering method is used to determine a model of the axial flow blood pump with this pump operating characteristic and the developed pump model can provide blood flow estimates before and after suction occurrence in left ventricle. Also, a fuzzy subtractive clustering method is utilized to develop a suction detection model which can identify whether suction occurs in left ventricle or not.

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.310-315
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• 2007

The axial-flow type blood pump(XVAD) which has been developed in our group consists of mechanical parts (an impeller, a diffuser and a flow straightener) and electrical parts (a motor and a magnetic bearing). The magnetic bearing system fully levitates the impeller to remove mechanical coupling with other parts of the pump with constant gap, which needs non-contact type gap sensing. Conventional gap sensors are too large to be adopted to the implantable axial -flow type blood pump. Thus, in this paper, the compact eddy current type gap sensor system proper for the implantable axial-flow type blood pump was developed and its performance was evaluated in vitro. The developed eddy current type gap sensor system is a transformer type and has a differential probe. Sensor coil(probe) has small dimensions(6 mm diameter, 2 mm thickness) and its optimal inductance was determined as 0.068 mH for the measurement range of $0\sim3mm$. It could be manufactured with 130 turns of the 0.04 mm diameter copper coil. The characteristics of the developed eddy current type gap sensor system was evaluated by in vitro experiment. At experiment, it showed satis(actory performance to apply to the magnetic bearing system of the XVAD. It could measure the gap up to 3mm, but the linearity was decreased at the range of $1.8\sim3.0mm$. Moreover, it showed no difference in different media such as the water and the blood at the temperature range of $35\sim40^{\circ}C$.

• The KSFM Journal of Fluid Machinery
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• v.19 no.6
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• pp.55-60
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• 2016

We present an experimental setup for measuring the mechanical performance of centrifugal blood pumps. Using a 3D printer to construct supporting parts and magnetic couplings, we developed the measurement setup that can be used for various types of blood pumps. The experimental setup is equipped with sensors to measure a variety of mechanical characteristics of blood pumps including pressure, flow rate, torque, temperature, and rotating speed. Our experimental measurements for two commercial blood pumps are consistent with data provided by manufacturers, which indicates that the our setup offers the accurate measurements of blood pump performance. Utilizing the experimental setup, we tested aqueous glycerin solutions mimicking the density and viscosity of blood, which enabled us to predict the difference in operations using water and blood.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.4
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• pp.526-533
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• 2011

This research is about the pulsatile pump system utilized in the perfusion bioreactor for the in vitro human tissue culture. A pulsatile pump system which can be applied to the culture of the vascular tissues including blood vessel is developed by using the idea of human heart's blood pumping into organs as followings: culture chamber, a pressurizing device which generates laminar pulsatile flow by controlling the x-sectional area of the culture media delivering tubing, a compliance chamber which supplies the pressuring device with a constant pressure, and a peristaltic pump which circulates the culture media in a circuit ranging from the culture chamber to the compliance chamber. The developed pulsatile pump system shows that a physiology of the human heart's blood pumping including pulsatile pressure waveform of systolic-diastolic pressure is well represented. Not only time domain but also frequency domain characteristics of pulsatile pump system which are necessary for the vascular tissue culture such as pulsatile pressure waveform's shape, the frequency, and the magnitude can be easily generated and manipulated by using the proposed system.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.51 no.10
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• pp.477-482
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• 2002

One of the key technologic requirements for rotary blood pumps is the sealing of the motor shaft. A mechanical seal, a journal bearing, magnetic coupling, and magnetic suspension have been developed, but they have drawbacks such as wear, thrombus formation, and power consumption. A magnetic fluid seal is durable, simple, and non power consumptive. Long-term experiments confirmed these advantages. The seal body was composed of a Nd-Fe-B magnet and two pole pieces; the seal was formed by injecting magnetic fluid into the gap (50${\mu}m$) between the pole pieces and the motor shaft. To contain the ferro-fluid in the seal and to minimize the possibility of magnetic fluid making contact with blood, a shield with a small cavity was attached to the pole piece. While submerged in blood, the sealing pressure of the seal was measured and found to be 31kPa with magnetic fluid LS-40 (saturated magnetization, 24.3 KA/m) at a motor speed of 10,000 rpm and 53kPa under static conditions(0mmHg). The specially designed magnetic fluid seal for keeping liquids out is useful for axial flow blood pumps. The magnetic fluid seal was incorporated into an intra-cardiac axial flow blood pump.

• International Journal of Fluid Machinery and Systems
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• v.4 no.4
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• pp.375-386
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• 2011

The turbo-type blood pump studied in this paper has an impeller that is magnetically suspended in a double volute casing. The impeller rotates with minimal fluctuations caused by fluid and magnetic forces. In order to improve stability of the rotating impeller and to facilitate long-term use, a careful investigation of the pressure fluctuations and of the fluid force acting on the impeller is necessary. For this purpose, two models of the pump with different volute cross-sectional area are designed and studied with computational fluid dynamics software. The results show that the fluid force varies with the flow rate and shape of the volute, that the fluctuations of fluid force decrease with increasing flow rate and that the vibratory movement of the impeller is more efficiently suppressed in a narrow volute.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.216.2-216.2
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• 2008

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.337-341
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• 2005

Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.