• Bulletin of the Korean Chemical Society
• /
• v.33 no.3
• /
• pp.953-957
• /
• 2012

Chalcones have been reported to have various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Due to the limited natural resources, we had to prepare sizable quantities of biologically active chalcones for bio-tests. Therefore, Claisen-Schmidt condensation between substituted acetophenones and corresponding aldehydes enabled us to prepare chalcones for inflammatory studies. Chalcones thus prepared showed significant suppression of nitric oxide (NO) production at $10{\mu}M$.

• Journal of the Korean Chemical Society
• /
• v.56 no.2
• /
• pp.251-256
• /
• 2012

A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.2
• /
• pp.470-472
• /
• 2010

• Bulletin of the Korean Chemical Society
• /
• v.31 no.7
• /
• pp.1827-1828
• /
• 2010

• Journal of the Korean Chemical Society
• /
• v.53 no.4
• /
• pp.471-475
• /
• 2009

• Bulletin of the Korean Chemical Society
• /
• v.35 no.9
• /
• pp.2669-2672
• /
• 2014

Double bond migration of butene-2 to butene-1 over ${\eta}$-alumina was investigated. The effects of calcination temperature on catalytic properties were analyzed by applying BET surface area, XRD, $NH_3$-TPD, and FT-IR of adsorbed pyridine techniques. The highest activity of the ${\eta}$-alumina catalyst calcined at $600^{\circ}C$ could be attributed not only to the highest amount of weak and medium strength acid sites, but also to the highest ratio of medium to weak strength Lewis acid sites.

• Bulletin of the Korean Chemical Society
• /
• v.25 no.7
• /
• pp.991-996
• /
• 2004

New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.

• Journal of the Korean Applied Science and Technology
• /
• v.26 no.1
• /
• pp.60-68
• /
• 2009

In this work, the synthetic approaches for a series of aminopyrimiclinylmethanone derivatives 1a-i, which versatile biological activities such as antibacterial and anticancer activities are expected from a structural point of view, were described. Nicotinic acid was converted to (2-methylsulfonylpyrimidin-4-yl) (pyridin-3-yl)methanone, a key intermediate, which was reacted with nucleophiles to yield the desired aminopyrimidinylmethanone derivatives 1a-i bearing various substituents.

• The Korean Journal of Ceramics
• /
• v.3 no.2
• /
• pp.129-133
• /
• 1997

Fine powder of $\alpha$-tricalcium phosphate, tetracalcium phosphate and dicalcium phosphate were mixed together to prepare self-setting cements which form hydroxyapatite, one of the well-known biocompatible materials, as the end of products of hydration. Hardening behaviour of the cements was examined at the temperature range of 37~$70^{\circ}C$ and 150~$250^{\circ}C$ under the normal and hydrothermal condition respectively. The conversion of cements into hydroxyapatite was significantly improved ast elevated temperature and the paste was strengtheed by interlocking of hydroxyapatite crystals, indicating that the strength is determined by microtexture rather the amount of conversion of cements into hydroxyapatite.

• 한국생물공학회:학술대회논문집
• /
• 2003.04a
• /
• pp.743-746
• /
• 2003

The major pathological lesion in Parkinson's disease(PD) is selective degeneration and loss of pigmented dopaminergic neurons in substantia nigra (SN). Although the initial cause and subsequent molecular signaling mechanisms leading to the dopaminergic cell death underlying the PD process is elusive, the potent neurotrophic factors (NTFs), brain derived neurotrophic factor (BDNF) and glial cell line derived neurotrophic factor (GDNF), are known to exert dopaminergic neuroprotection both in vivo and in vitro models of PD employing the neurotoxin, MPTP. BDNF and its receptor, trkB are expressed in SN dopaminergic neurons and their innervation target. Thus, neurotrophins may have autocrine, paracrine and retrograde transport effects on the SN dopaminergic neurons. This study determined the BDNF secretion from SN dopaminergic neurons by ELISA. Regulation of BDNF synthesis/release and changes in signaling pathways are monitored in the presence of free radical donor, NO donor and mitochondrial inhibitors. Also, this study shows that BDNF is able to promote survival and phenotypic differentiation of SN dopaminergic neurons in culture and protect them against MPTP-induced neurotoxicity via MAP kinase pathway.