Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Biologically Active Chalcones and their Anti-inflammatory Effects

  • Jeon, Jae-Ho (Institute of Natural Medicine, Hallym University) ;
  • Kim, Si-Jun (Department of Chemistry and Institute of Applied Chemistry, Hallym University) ;
  • Kim, Cheol-Gi (Department of Chemistry and Institute of Applied Chemistry, Hallym University) ;
  • Kim, Jin-Kyung (Department of Biomedical Science, College of Natural Science, Catholic University of Daegu) ;
  • Jun, Jong-Gab (Institute of Natural Medicine, Hallym University)
  • Received : 2011.12.06
  • Accepted : 2012.01.07
  • Published : 2012.03.20
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Abstract

Chalcones have been reported to have various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Due to the limited natural resources, we had to prepare sizable quantities of biologically active chalcones for bio-tests. Therefore, Claisen-Schmidt condensation between substituted acetophenones and corresponding aldehydes enabled us to prepare chalcones for inflammatory studies. Chalcones thus prepared showed significant suppression of nitric oxide (NO) production at $10{\mu}M$.

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References

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