[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2004.25.7.991

Synthesis of Certain 6-(Arylthio)uracils and Related Derivatives as Potential Antiviral Agents

El-Emam, Ali A. (Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University)
Massoud, Mohamed A.M. (Departments of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura)
El-Bendary, Eman R. (Departments of Meducinal Chemistry, Faculty of Pharmacy, University of Mansoura)
El-Sayed, Magda A. (Departments of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura)

Publication Information

Bulletin of the Korean Chemical Society / v.25, no.7, 2004 , pp. 991-996 More about this Journal

Abstract

New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.

Keywords

Substituted uracils; Benzothiopyrano[2,3-d]pyrimidine; Pyrimido[5,4-f]benzo[1,4]thiazepines; Antiviral activity; Cytotoxicity;

Citations & Related Records

Times Cited By Web Of Science : 5 (Related Records In Web of Science)
Times Cited By SCOPUS : 5

Reference
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