• The Journal of the Korea Contents Association
• /
• v.10 no.10
• /
• pp.54-67
• /
• 2010

Applying the conventional machine-learning method which has been frequently used in health-care area has several fundamental problems for modern U-health service analysis. First of all, we are still lack of application examples of the traditional method for our modern U-health environment because of its short term history of U-health study. Second, it is difficult to apply the machine-learning method to our U-health service environment which requires real-time management of disease because the method spends a lot of time in the process of learning. Third, we cannot implement a personalized U-health diagnosis system using the conventional method because there is no way to assign weights on the disease-related variables although various kinds of machine-learning schemes have been proposed. In this paper, a novel diagnosis scheme PCADP is proposed to overcome the problems mentioned above. PCADP scheme is a personalized diagnosis method and it makes the bio-data analysis just a 'process' in the U-health service system. In addition, we offer a semantics modeling of the U-health ontology framework in order to describe U-health data and service specifications as meaningful representations based on this PCADP. The PCADP scheme is a kind of statistical diagnosis method which has characteristics of flexible structure, real-time processing, continuous improvement, and easy monitoring of decision process. Upto the best of authors' knowledge, the PCADP scheme and ontology framework proposed in this paper reveals one of the best characteristics of flexible structure, real-time processing, continuous improvement, and easy monitoring among recently developed U-health schemes.

• Food Science and Preservation
• /
• v.20 no.3
• /
• pp.289-295
• /
• 2013

The capacity of a pressure fan can be designed based on the air flow resistance of containers packed with fruits and vegetables in a pressure cooling system. This study was conducted to develop an air flow resistance model that was dependent on changes in the air flow rate and the method of stacking containers. The air flow resistance of a container packed with uniformly shaped balls was 1.5 times greater than the sum of the air flow resistance of a vacant container and that of a wire net container packed with only balls. In addition, the air flow resistance increased exponentially as the width of the stacks increased; however, the air flow resistance did not increase greatly as the length and height of the stacks increased, which indicates that the air flow resistance is primarily influenced by the width of the stack in the air flow direction. The air flow resistance in two lines of stacking was up to 17% less than that of the width of the stack. It was also possible to determine the air flow resistance using a function of the air flow resistance through a single container and develop a prediction model. A prediction model of air flow resistance that is dependent on the stacking method and the air flow resistance of a single container was developed.

• Journal of Life Science
• /
• v.24 no.3
• /
• pp.290-296
• /
• 2014

The present experiment investigated putative anxiolytic-like effects of quercetin using an elevated plus-maze (EPM) and hole-board apparatus test in mice. Quercetin is a flavonoid widely distributed in nature. Quercetin (1.25, 2.5, 5, or 10 mg/kg) was orally administered to ICR mice 1 h before a behavioral evaluation in the EPM. Control mice were treated with an equal volume of vehicle, and positive control mice were treated with buspirone (2 mg/kg, i.p.). The mice administered quercetin (5 mg/kg) spent a significantly longer percentage of time in the open arms of the EPM and their percentage of entries into the open arms was significantly increased compared to the vehicle-treated controls (p<0.05). The anxiolytic-like activities of quercetin were antagonized by trans-4-aminocrotonic acid (a $GABA_{A-{\rho}}$ agonist, 20 mg/kg) but not by flumazenil (a $GABA_A$ antagonist, 10 mg/kg) or WAY-100635 (a $5-HT_{1A}$ antagonist, 0.3 mg/kg). Moreover, there were no changes in the locomotor activity or myorelaxant effects in any group compared with the vehicle-treated controls. In the hole-board apparatus test, the number of head-dips increased significantly in the single treatment with quercetin (5 mg/kg) group compared to the vehicle-treated controls (p<0.05). These findings suggest that quercetin can promote anxiolytic-like activity, mediated by the GABAergic nervous system, in mice.

• Journal of Life Science
• /
• v.30 no.11
• /
• pp.956-964
• /
• 2020

The radical scavenging activity measurement system linked with liquid chromatography (LC) is a useful tool for identifying the radical scavenging active compound in a sample composed of numerous compounds such as plant extracts. Using this system, DPPH and ABTS radical scavenging activity were measured on extracts of Ulmus pumila cortex, which is known as an herbal medicine with antioxidant activity. Mass spectrometry (MS) was performed on the identified radical scavenging active compounds to identify the four components estimated to be procyanidin B2, procyanidin B3, catechin-7-O-β-D-apiofuranoside, and catechin-5-O-β-D-apiofuranoside, respectively. In order to compare the relative contents between extract samples, multiple reaction monitoring (MRM) mode analysis conditions were set for the four compounds in order to examine the possibility of comparing the content of radical scavenging active compounds in Ulmus pumila cortex extract using LC-MS/MS. As a result of the relative content comparison, it was found that the higher the ethanol concentration of the extraction solvent, the higher the content of radical scavenging active compounds. As with the results of measuring the radical scavenging activity of each extract, it was confirmed that the content difference of three of the compounds (all except the compound estimated as procyanidin B3) was not significantly observed in the extracts with an ethanol concentration of 50% or more.

• The Journal of the Korea Contents Association
• /
• v.10 no.12
• /
• pp.59-69
• /
• 2010

The research on protein for the diseases analysis and the new medicines development is one of the most important themes in biotechnology. Since the analysis on diseases and protein needs to handle a large scale of data, we don't use the way to approach it by the experiments anymore. In recent, we have accelerated the research on diseases and protein analysis by sharing and connecting the various experimental data by combining the biotechnology with the IT technology. However, many biotechnology researchers have difficulty in handling the protein analysis tools based on the IT knowledge. In order to solve such problems, data analysis tools through the cooperation between IT researchers and biologists have been developed. However, the existing data analysis tools still have the problems that it is very hard for biologists to extend their functions and to use them. In this paper, we design and implement an effective analysis system for diseases and protein based on components that alleviates the problems of the existing data analysis systems.

• Journal of The Korean Society of Agricultural Engineers
• /
• v.59 no.1
• /
• pp.45-55
• /
• 2017

Climate change causes changes in rainfall patterns, temperature and drought frequency. Climate change impact influences on water management and crop production. It is critical issue in agricultural industry. Rice is a staple cereal crop in South Korea and Korea uses a ponding system for its paddy fields which requires a significant amount of water. In addition, water supply has inter-relationship with crop production which indicates water productivity. Therefore, it is important to assess overall impacts of climate change on water resource and crop production. A water footprint concept is an indicator which shows relationship between water use and crop yield. In addition, it generally composed of three components depending on water resources: green, blue, grey water. This study analyzed the change trend of water footprint of paddy rice under the climate change. The downscaled climate data from HadGEM3-RA based on RCP 8.5 scenario was applied as future periods (2020s, 2050s, 2080s), and historical climate data was set to base line (1990s). Depending on agro-climatic zones, Suwon and Jeonju were selected for study area. A yield of paddy rice was simulated by using FAO-AquaCrop 5.0, which is a water-driven crop model. Model was calibrated by adjusting parameters and was validated by Mann-Whitney U test statistically. The means of water footprint were projected increase by 55 % (2020s), 51 % (2050s) and 48 % (2080s), respectively, from the baseline value of $767m^2/ton$ in Suwon. In case of Jeonju, total water footprint was projected to increase by 46 % (2020s), 45 % (2050s), 12 % (2080s), respectively, from the baseline value of $765m^2/ton$. The results are expected to be useful for paddy water management and operation of water supply system and apply in establishing long-term policies for agricultural water resources.

• The Korean Journal of Physiology and Pharmacology
• /
• v.19 no.3
• /
• pp.219-228
• /
• 2015

Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. Thus, the regulation of microglial activation has been evaluated as effective therapeutic strategies. Although dieckol (DEK), one of the phlorotannins isolated from marine brown alga Ecklonia cava, has been previously reported to inhibit microglial activation, the molecular mechanism is still unclear. Therefore, we investigated here molecular mechanism of DEK via extracellular signal-regulated kinase (ERK), Akt and nicotinamide adenine dinuclelotide phosphate (NADPH) oxidase-mediated pathways. In addition, the neuroprotective mechanism of DEK was investigated in microglia-mediated neurotoxicity models such as neuron-microglia co-culture and microglial conditioned media system. Our results demonstrated that treatment of anti-oxidant DEK potently suppressed phosphorylation of ERK in lipopolysaccharide (LPS, $1{\mu}g/ml$)-stimulated BV-2 microglia. In addition, DEK markedly attenuated Akt phosphorylation and increased expression of $gp91^{phox}$, which is the catalytic component of NADPH oxidase complex responsible for microglial reactive oxygen species (ROS) generation. Finally, DEK significantly attenuated neuronal cell death that is induced by treatment of microglial conditioned media containing neurotoxic secretary molecules. These neuroprotective effects of DEK were also confirmed in a neuron-microglia co-culture system using enhanced green fluorescent protein (EGFP)-transfected B35 neuroblastoma cell line. Taken together, these results suggest that DEK suppresses excessive microglial activation and microglia-mediated neuronal cell death via downregulation of ERK, Akt and NADPH oxidase-mediated pathways.

• The Korean Journal of Physiology and Pharmacology
• /
• v.19 no.5
• /
• pp.389-399
• /
• 2015

Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc ($Zn^{2+}$) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc's critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of $Zn^{2+}$ activity has been presumed to parallel the degree of calcium's participation in cellular processes. Whole body and cellular $Zn^{2+}$ levels are largely regulated by metallothioneins (MTs), $Zn^{2+}$ importers (ZIPs), and $Zn^{2+}$ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion channels that play a pivotal role in controlling cardiac contractility are common targets of $Zn^{2+}$. However, these regulatory actions of $Zn^{2+}$ are not limited to the function of the heart, but also extend to numerous other organ systems, such as the central nervous system, immune system, cardiovascular tissue, and secretory glands, such as the pancreas, prostate, and mammary glands. In this review, the regulation of cellular $Zn^{2+}$ levels, $Zn^{2+}$-mediated signal transduction, impacts of $Zn^{2+}$ on ion channels and mitochondrial metabolism, and finally, the implications of $Zn^{2+}$ in health and disease development were outlined to help widen the current understanding of the versatile and complex roles of $Zn^{2+}$.

• Journal of Digital Convergence
• /
• v.12 no.3
• /
• pp.367-375
• /
• 2014

In this thesis we observe microvascular structure in mice by using micro-computed tomography (CT), which is high-resolution X-ray imaging equipment that can acquire Real-time dynamic image, and it aims to investigate the usefulness of micro-CT developed by Institute for Radiological Imaging Science Wonkwang University School of Medicine. After acquiring the systemic images of rats, contrast-enhanced 3D images of vascular structures could be acquired by using Maximum Intensity Projection (MIP) and Volume Rending Technique (VRT), This was divided into each vascular system of head, abdomen and heart and systemic vascular system.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.6 no.1
• /
• pp.133-158
• /
• 2011

In 2030s, as we enter in to the era of BT (Bio-Technology) market opening up, technologies in all areas such as IT, data analysis, IC and biochemistry are necessitated. New development in technology will be based on "Convergence", especially between IT and BT. In order to have synergy effects from the convergence, those related industries and universities should be physically inter-related in an appropriate location. Until 2009, 819 industrial clusters where many Korean industries and firms are concentrated have been constructed in Korea. They have had supports from various institutions and facilities. However, few systems designed to assist "intellectual property (IP) service" for technology convergence are found in Korea. Thus, by analyzing current problems and challenges of the Korean industrial clusters, this paper suggests a possible answer to maximize the synergy from technology convergence through organic cooperation among companies in industrial clusters. This paper finds that the Korean industrial clusters need to establish IP service supporting center while suggesting its function and concept on organization structure, and work flow, which help firms to develop IP strategies. In addition, the paper provides a direction for current IP system and policies implemented by the Korean government to be more effective to small-and-medium-sized companies located in the industrial clusters.