The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling |
Lee, Sung Ryul
(Department of Integrated Biomedical Science, Cardiovascular and Metabolic disease Center, College of Medicine, Inje University)
Noh, Su Jin (Department of Physiology, Graduate School of Inje University, Cardiovascular and Metabolic Disease Center, Inje University) Pronto, Julius Ryan (Department of Physiology, Graduate School of Inje University, Cardiovascular and Metabolic Disease Center, Inje University) Jeong, Yu Jeong (Department of Physiology, Graduate School of Inje University, Cardiovascular and Metabolic Disease Center, Inje University) Kim, Hyoung Kyu (Department of Integrated Biomedical Science, Cardiovascular and Metabolic disease Center, College of Medicine, Inje University) Song, In Sung (College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) Xu, Zhelong (Department of Physiology and Pathophysiology, Tianjin Medical University) Kwon, Hyog Young (Soonchunhyang Institute of Medio-bio Science (SIMS), Soonchunhyang University) Kang, Se Chan (Department of Life Science, Gachon University) Sohn, Eun-Hwa (Department of Herbal Medicine Resource, Kangwon National University) Ko, Kyung Soo (College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) Rhee, Byoung Doo (College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) Kim, Nari (College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) Han, Jin (College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) |
1 | Khan MU, Cheema Y, Shahbaz AU, Ahokas RA, Sun Y, Gerling IC, Bhattacharya SK, Weber KT. Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states. Pflugers Arch. 2012;464:123-131. DOI |
2 | Taylor KM, Morgan HE, Johnson A, Nicholson RI. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. FEBS Lett. 2005;579:427-432. DOI |
3 | Masters BA, Quaife CJ, Erickson JC, Kelly EJ, Froelick GJ, Zambrowicz BP, Brinster RL, Palmiter RD. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J Neurosci. 1994;14:5844-5857. DOI |
4 |
Tuncay E, Okatan EN, Toy A, Turan B. Enhancement of cellular antioxidant-defence preserves diastolic dysfunction via regulation of both diastolic |
5 |
Tuncay E, Okatan EN, Vassort G, Turan B. |
6 | Dineley KE, Votyakova TV, Reynolds IJ. Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. J Neurochem. 2003;85:563-570. DOI |
7 | Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A. Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol. 2009;5:183-190. DOI |
8 | Feng P, Li T, Guan Z, Franklin RB, Costello LC. The involvement of Bax in zinc-induced mitochondrial apoptogenesis in malignant prostate cells. Mol Cancer. 2008;7:25. DOI |
9 | Wroblewski N, Schill WB, Henkel R. Metal chelators change the human sperm motility pattern. Fertil Steril. 2003;79 Suppl 3:1584-1589. DOI |
10 |
Devinney MJ, Malaiyandi LM, Vergun O, DeFranco DB, Hastings TG, Dineley KE. A comparison of |
11 | Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J Am Coll Cardiol. 2001;37:1765-1774. DOI |
12 | Costello LC, Franklin RB. Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity. Expert Rev Anticancer Ther. 2012;12:121-128. DOI |
13 | Coyle P, Philcox JC, Carey LC, Rofe AM. Metallothionein: the multipurpose protein. Cell Mol Life Sci. 2002;59:627-647. DOI |
14 | Little PJ, Bhattacharya R, Moreyra AE, Korichneva IL. Zinc and cardiovascular disease. Nutrition. 2010;26:1050-1057. DOI |
15 | Liuzzi JP, Cousins RJ. Mammalian zinc transporters. Annu Rev Nutr. 2004;24:151-172. DOI |
16 | Carpene E, Andreani G, Isani G. Metallothionein functions and structural characteristics. J Trace Elem Med Biol. 2007;21 Suppl 1:35-39. DOI |
17 | Langmade SJ, Ravindra R, Daniels PJ, Andrews GK. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem. 2000;275:34803-34809. DOI |
18 |
Colvin RA, Bush AI, Volitakis I, Fontaine CP, Thomas D, Kikuchi K, Holmes WR. Insights into |
19 | Hogstrand C, Kille P, Nicholson RI, Taylor KM. Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends Mol Med. 2009;15:101-111. DOI |
20 | Kiedrowski L. Proton-dependent zinc release from intracellular ligands. J Neurochem. 2014;130:87-96. DOI |
21 | Shuttleworth CW, Weiss JH. Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci. 2011;32:480-486. DOI |
22 |
Nowakowski A, Petering D. Sensor specific imaging of proteomic |
23 |
Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. Modulation of mitochondrial function by endogenous |
24 | Kamalov G, Deshmukh PA, Baburyan NY, Gandhi MS, Johnson PL, Ahokas RA, Bhattacharya SK, Sun Y, Gerling IC, Weber KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol. 2009;53:414-423. DOI |
25 |
Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, Sekler I. Identification of the |
26 | Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002;109:817-826. DOI |
27 | Maret W. The function of zinc metallothionein: a link between cellular zinc and redox state. J Nutr. 2000;130(5S Suppl):1455S-1458S. DOI |
28 | Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC. Zinc inhibition of cAMP signaling. J Biol Chem. 2002;277:11859-11865. DOI |
29 |
Alvarez-Collazo J, Diaz-Garcia CM, Lopez-Medina AI, Vassort G, Alvarez JL. Zinc modulation of basal and |
30 | Puceat M, Bony C, Jaconi M, Vassort G. Specific activation of adenylyl cyclase V by a purinergic agonist. FEBS Lett. 1998;431:189-194. DOI |
31 |
Gomez AM, Kerfant BG, Vassort G. Microtubule disruption modulates |
32 | Volpe SL, Lowe NM, Woodhouse LR, King JC. Effect of maximal exercise on the short-term kinetics of zinc metabolism in sedentary men. Br J Sports Med. 2007;41:156-161. DOI |
33 | Aslund F, Beckwith J. Bridge over troubled waters: sensing stress by disulfide bond formation. Cell. 1999;96:751-753. DOI |
34 | Bellomo E, Massarotti A, Hogstrand C, Maret W. Zinc ions modulate protein tyrosine phosphatase 1B activity. Metallomics. 2014;6:1229-1239. DOI |
35 |
Pandey NR, Vardatsikos G, Mehdi MZ, Srivastava AK. Cell-type-specific roles of IGF-1R and EGFR in mediating |
36 | Haase H, Maret W. Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants. Biometals. 2005;18:333-338. DOI |
37 |
Turan B, Fliss H, Desilets M. Oxidants increase intracellular free |
38 | Tuncay E, Bilginoglu A, Sozmen NN, Zeydanli EN, Ugur M, Vassort G, Turan B. Intracellular free zinc during cardiac excitation-contraction cycle: calcium and redox dependencies. Cardiovasc Res. 2011;89:634-642. DOI |
39 | Korichneva I, Hoyos B, Chua R, Levi E, Hammerling U. Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen. J Biol Chem. 2002;277:44327-44331. DOI |
40 |
Wang G, Strang C, Pfaffinger PJ, Covarrubias M. |
41 | Zhang S, Kehl SJ, Fedida D. Modulation of Kv1.5 potassium channel gating by extracellular zinc. Biophys J. 2001;81:125-136. DOI |
42 | Mahaut-Smith MP. The effect of zinc on calcium and hydrogen ion currents in intact snail neurones. J Exp Biol. 1989;145:455-464. |
43 | Atar D, Backx PH, Appel MM, Gao WD, Marban E. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels. J Biol Chem. 1995;270:2473-2477. DOI |
44 | Stanfield PR. The effect of zinc ions on the gating of the delayed potassium conductance of frog sartorius muscle. J Physiol. 1975;251:711-735. DOI |
45 | Vogt K, Mellor J, Tong G, Nicoll R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron. 2000;26:187-196. DOI |
46 |
Kerchner GA, Canzoniero LM, Yu SP, Ling C, Choi DW. |
47 |
Andersson DA, Gentry C, Moss S, Bevan S. Clioquinol and pyrithione activate TRPA1 by increasing intracellular |
48 | Ye B, Maret W, Vallee BL. Zinc metallothionein imported into liver mitochondria modulates respiration. Proc Natl Acad Sci U S A. 2001;98:2317-2322. DOI |
49 |
Kleiner D. The effect of |
50 | Maret W, Jacob C, Vallee BL, Fischer EH. Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proc Natl Acad Sci U S A. 1999;96:1936-1940. DOI |
51 | Meeusen JW, Nowakowski A, Petering DH. Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine. Inorg Chem. 2012;51:3625-3632. DOI |
52 | Vallee BL. Metallothionein: historical review and perspectives. Experientia Suppl. 1979;34:19-39. DOI |
53 |
Brown AM, Kristal BS, Effron MS, Shestopalov AI, Ullucci PA, Sheu KF, Blass JP, Cooper AJ. |
54 | Maret W, Heffron G, Hill HA, Djuricic D, Jiang LJ, Vallee BL. The ATP/metallothionein interaction: NMR and STM. Biochemistry. 2002;41:1689-1694. DOI |
55 | Skulachev VP, Evtodienko IuV, Iasaitis AA, Gmirnova EG, Chistiakov VV. Reversible suppression of electron transfer between cytochromes B and C. Vopr Med Khim. 1966;12:438-440. |
56 |
Berry EA, Zhang Z, Bellamy HD, Huang L. Crystallographic location of two |
57 | Gazaryan IG, Krasnikov BF, Ashby GA, Thorneley RN, Kristal BS, Brown AM. Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. J Biol Chem. 2002;277:10064-10072. DOI |
58 | Feng W, Cai J, Pierce WM, Franklin RB, Maret W, Benz FW, Kang YJ. Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts. Biochem Biophys Res Commun. 2005;332:853-858. DOI |
59 | Kelleher SL, McCormick NH, Velasquez V, Lopez V. Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr. 2011;2:101-111. DOI |
60 | Costello LC, Franklin RB, Feng P. Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer. Mitochondrion. 2005;5:143-153. DOI |
61 | Wudarczyk J, Debska G, Lenartowicz E. Zinc as an inducer of the membrane permeability transition in rat liver mitochondria. Arch Biochem Biophys. 1999;363:1-8. DOI |
62 | Haase H, Rink L. Multiple impacts of zinc on immune function. Metallomics. 2014;6:1175-1180. DOI |
63 | Feng P, Li TL, Guan ZX, Franklin RB, Costello LC. Direct effect of zinc on mitochondrial apoptogenesis in prostate cells. Prostate. 2002;52:311-318. DOI |
64 | Calderone A, Jover T, Mashiko T, Noh KM, Tanaka H, Bennett MV, Zukin RS. Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death. J Neurosci. 2004;24:9903-9913. DOI |
65 | McCord MC, Aizenman E. The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Front Aging Neurosci. 2014;6:77. |
66 | Maret W. Zinc and human disease. Met Ions Life Sci. 2013;13:389-414. DOI |
67 | Frederickson C, Frederickson CJ, Maret W, Sandstead H, Giblin L, Thompson R. Meeting report: zinc signals 2007-expanding roles of the free zinc ion in biology. Sci STKE. 2007;2007:pe61. |
68 | Foster M, Samman S. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients. 2012;4:676-694. DOI |
69 | Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology. 2007;148:13-20. DOI |
70 | Mlyniec K, Budziszewska B, Holst B, Ostachowicz B, Nowak G. GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus. Int J Neuropsychopharmacol. 2014;18. doi: 10.1093/ijnp/pyu002. |
71 |
Popovics P, Stewart AJ. GPR39: a |
72 |
Weiss JH, Sensi SL, Koh JY. |
73 | Halas ES, Hunt CD, Eberhardt MJ. Learning and memory disabilities in young adult rats from mildly zinc deficient dams. Physiol Behav. 1986;37:451-458. DOI |
74 | Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010;17:1-14. DOI |
75 | Seth R, Corniola RS, Gower-Winter SD, Morgan TJ Jr, Bishop B, Levenson CW. Zinc deficiency induces apoptosis via mitochondrial p53- and caspase-dependent pathways in human neuronal precursor cells. J Trace Elem Med Biol. 2015;30:59-65. DOI |
76 | Lee J, Kim CH, Kim DG, Ahn YS. Zinc inhibits amyloid beta production from Alzheimer's amyloid precursor protein in SH-SY5Y cells. Korean J Physiol Pharmacol. 2009;13:195-200. DOI |
77 | Tamaki M, Fujitani Y. Role of zinc in type 2 diabetes. Nihon Eiseigaku Zasshi. 2014;69:15-23. DOI |
78 | Miao X, Sun W, Fu Y, Miao L, Cai L. Zinc homeostasis in the metabolic syndrome and diabetes. Front Med. 2013;7:31-52. DOI |
79 | Yi T, Vick JS, Vecchio MJ, Begin KJ, Bell SP, Delay RJ, Palmer BM. Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013;305:H706-715. DOI |
80 | Ciofalo FR, Thomas LJ Jr. The effects of zinc on contractility, membrane potentials, and cation content of rat atria. J Gen Physiol. 1965;48:825-839. DOI |
81 | Schnieden H, Small RC. Spasmolytic effects of cadmium and zinc ions upon the guinea-pig isolated ileum preparation. Br J Pharmacol. 1971;41:488-499. DOI |
82 | Gomez E, del Diego C, Orden I, Elosegui LM, Borque L, Escanero JF. Longitudinal study of serum copper and zinc levels and their distribution in blood proteins after acute myocardial infarction. J Trace Elem Med Biol. 2000;14:65-70. DOI |
83 | Evangelou A, Kalfakakou V. Electrocardiographic alterations induced by zinc ions on isolated guinea pig heart preparations. Biol Trace Elem Res. 1993;36:203-208. DOI |
84 | Oster O, Dahm M, Oelert H. Element concentrations (selenium, copper, zinc, iron, magnesium, potassium, phosphorous) in heart tissue of patients with coronary heart disease correlated with physiological parameters of the heart. Eur Heart J. 1993;14:770-774. DOI |
85 | Shokrzadeh M, Ghaemian A, Salehifar E, Aliakbari S, Saravi SS, Ebrahimi P. Serum zinc and copper levels in ischemic cardiomyopathy. Biol Trace Elem Res. 2009;127:116-123. DOI |
86 | Foster M, Samman S. Zinc and redox signaling: perturbations associated with cardiovascular disease and diabetes mellitus. Antioxid Redox Signal. 2010;13:1549-1573. DOI |
87 | Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006;11:19-24. DOI |
88 | Meerarani P, Reiterer G, Toborek M, Hennig B. Zinc modulates PPARgamma signaling and activation of porcine endothelial cells. J Nutr. 2003;133:3058-3064. DOI |
89 | Cho YS, Lee KH, Park JW. Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1alpha. Korean J Physiol Pharmacol. 2010;14:91-97. DOI |
90 | Alcantara EH, Shin MY, Feldmann J, Nixon GF, Beattie JH, Kwun IS. Long-term zinc deprivation accelerates rat vascular smooth muscle cell proliferation involving the down-regulation of JNK1/2 expression in MAPK signaling. Atherosclerosis. 2013;228:46-52. DOI |
91 | Donnelly TE Jr. Effects of zinc chloride on the hydrolysis of cyclic GMP and cyclic AMP by the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart. Biochim Biophys Acta. 1978;522:151-160. DOI |
92 | Prost AL, Bloc A, Hussy N, Derand R, Vivaudou M. Zinc is both an intracellular and extracellular regulator of KATP channel function. J Physiol. 2004;559:157-167. DOI |
93 | Chowanadisai W, Lonnerdal B, Kelleher SL. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem. 2006;281:39699-39707. DOI |
94 | Fraker PJ, King LE. Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr. 2004;24:277-298. DOI |
95 | Haase H, Beyersmann D. Intracellular zinc distribution and transport in C6 rat glioma cells. Biochem Biophys Res Commun. 2002;296:923-928. DOI |
96 | Frederickson CJ, Kasarskis EJ, Ringo D, Frederickson RE. A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain. J Neurosci Methods. 1987;20:91-103. DOI |
97 | Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993;73:79-118. DOI |
98 | Raulin J. Annales des sciences naturelles. Botanique Et BIologie Vegetale. 1869;11:93-345. |
99 | Prasad AS, Halsted JA, Nadimi M. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med. 1961;31:532-546. DOI |
100 | Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006;20:3-18. DOI |
101 | Andreini C, Bertini I, Rosato A. Metalloproteomes: a bioinformatic approach. Acc Chem Res. 2009;42:1471-1479. DOI |
102 | Kochanczyk T, Drozd A, Krezel A. Relationship between the architecture of zinc coordination and zinc binding affinity in proteins--insights into zinc regulation. Metallomics. 2015;7:244-257. DOI |
103 | Costello LC, Fenselau CC, Franklin RB. Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells. J Inorg Biochem. 2011;105:589-599. DOI |
104 | Dudev T, Lim C. Principles governing Mg, Ca, and Zn binding and selectivity in proteins. Chem Rev. 2003;103:773-788. DOI |
105 | Permyakov EA, Kretsinger RH. Cell signaling, beyond cytosolic calcium in eukaryotes. J Inorg Biochem. 2009;103:77-86. DOI |
106 | Xu Z, Zhou J. Zinc and myocardial ischemia/reperfusion injury. Biometals. 2013;26:863-878. DOI |
107 | Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem. 2011;16:1123-1134. DOI |
108 | Oteiza PI. Zinc and the modulation of redox homeostasis. Free Radic Biol Med. 2012;53:1748-1759. DOI |
109 | Hughes S, Samman S. The effect of zinc supplementation in humans on plasma lipids, antioxidant status and thrombogenesis. J Am Coll Nutr. 2006;25:285-291. DOI |
110 | Taylor KM, Hiscox S, Nicholson RI, Hogstrand C, Kille P. Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Sci Signal. 2012;5:ra11. |
111 | Haase H, Rink L. Zinc signals and immune function. Biofactors. 2014;40:27-40. DOI |
112 |
Takeda A, Nakamura M, Fujii H, Tamano H. Synaptic |
113 | Barnett JP, Blindauer CA, Kassaar O, Khazaipoul S, Martin EM, Sadler PJ, Stewart AJ. Allosteric modulation of zinc speciation by fatty acids. Biochim Biophys Acta. 2013;1830:5456-5464. DOI |
114 | Maret W. Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr. 2013;4:82-91. DOI |
115 | Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev. 1985;65:238-309. DOI |
116 | Tran CD, Butler RN, Philcox JC, Rofe AM, Howarth GS, Coyle P. Regional distribution of metallothionein and zinc in the mouse gut: comparison with metallothionien-null mice. Biol Trace Elem Res. 1998;63:239-251. DOI |
117 | Scott BJ, Bradwell AR. Identification of the serum binding proteins for iron, zinc, cadmium, nickel, and calcium. Clin Chem. 1983;29:629-633. |
118 | Taylor KM, Nicholson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim Biophys Acta. 2003;1611:16-30. DOI |
119 | Sekler I, Sensi SL, Hershfinkel M, Silverman WF. Mechanism and regulation of cellular zinc transport. Mol Med. 2007;13:337-343. |
120 | Palmiter RD, Huang L. Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers. Pflugers Arch. 2004;447:744-751. DOI |
121 | Powell SR, Aiuto L, Hall D, Tortolani AJ. Zinc supplementation enhances the effectiveness of St. Thomas' Hospital No. 2 cardioplegic solution in an in vitro model of hypothermic cardiac arrest. J Thorac Cardiovasc Surg. 1995;110:1642-1648. DOI |
122 | Taylor KM, Morgan HE, Johnson A, Nicholson RI. Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Biochem J. 2004;377:131-139. DOI |
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