• Journal of Ginseng Research
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• v.42 no.4
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• pp.436-446
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• 2018

Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated. Methods: We used an acute experimental autoimmune encephalomyelitis animal model of multiple sclerosis and determined the effects and mechanism of KRGE on spinal myelination. Results: Pretreatment with KRGE (100 mg/kg, orally) for 10 days before immunization with myelin basic protein $(MBP)_{68-82}$ peptide exerted a protective effect against demyelination in the spinal cord, with inhibited recruitment and activation of immune cells including microglia, decreased mRNA expression of detrimental inflammatory mediators (interleukin-6, interferon-${\gamma}$, and cyclooxygenase-2), but increased mRNA expression of protective inflammatory mediators (insulin-like growth factor ${\beta}1$, transforming growth factor ${\beta}$, and vascular endothelial growth factor-1). These results were associated with significant downregulation of p38 mitogen-activated protein kinase and nuclear factor-${\kappa}B$ signaling pathways in microglia/macrophages, T cells, and astrocytes. Conclusion: Our findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-${\kappa}B$ signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed.

• Journal of Adhesion and Interface
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• v.9 no.4
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• pp.1-11
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• 2008

In the present study, kenaf fibers were treated with sodium hydroxide using soaking and ultrasonic methods prior to biocomposite processing, respectively. The effect of alkali treatment on the kenaf-PLA interfacial adhesion and mechanical and thermal characteristics of kenaf/poly(lactic acid) biocomposites was investigated in terms of their interfacial shear strength, flexural properties, dynamic mechanical properties and thermal stability and also microscopic observations of kenaf fibers and the composite fracture surfaces. As a result, use of both soaking and ultrasonic methods for treating kenaf fiber surfaces played a role in increasing the fiber-matrix adhesion and the mechanical properties of the biocomposites. Their characteristics depended not only on the fiber surface treatment method but also on the treatment condition like alkali concentration and treatment time.

• Journal of the Korean Chemical Society
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• v.47 no.2
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• pp.127-132
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• 2003

We have developed a direct polymerase chain reaction (PCR) and electrophoresis method for the diagnosis of bovine theileriosis from whole blood DNA analysis without DNA extraction. The technique empolyed a FoLT (formamide, low temp.) technique and was utilized in the diagnosis of bovine theileriosis. Formamide solubilize the blood cells, and the lowered incubation temperatures reduced protein coagulation. 100-200 nL of whole blood and PCR reagents were introduced directly into a PCR tube. After the amplification, the PCR product (816-bp DNA) was introduced into the electrophoresis system. The results of this analysis were consist with those obtained using purified DNA.

• Journal of Environmental Science International
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• v.24 no.6
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• pp.755-762
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• 2015

The present study was conducted to develop seed treatment for the production of healthy and clean peanut sprout. Dry heat treatment of peanut seeds reduced the incidence of the rot. The seed treatment condition at $52^{\circ}C$ for 10 h. was the most efficient without inhibiting seed viability significantly. Seeds were dark cultured at $27^{\circ}C$ for up to 9 days. The treatment of Indole-B and gibberellic acid influenced germination, T50, fresh, dry weight, hypocotyl length, hypocotyl length diameter, root length, number of lateral root and epicotyl of peanut sprout. There were no differences in the germinability of peanut seeds between gibberellic acid treatment methods but higher fresh weight was observed in the GA3 solution spray after 2 hour water soaking. The general growth and lateral root development of peanut sprouts were suppressed by Indole-B which is used for inhibiting root formation and promoting hypocotyls. The treatment of gibberellic acid promoted hypocotyl elongation, but it did not influence on the growth of hypocotyls and root system.

• International Journal of Oral Biology
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• v.36 no.2
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• pp.103-108
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• 2011

Measurement of estrogen concentration in bio-samples are very important for differential diagnosis of various disease or evaluation of health status. However, it is difficult to collect immediate data of estrogen concentration because they are measured by radioimmunoassay or chromatography which need time- and cost-consuming sample pre-treatment. This study was performed for development of new estrogen biosensor employing taste principles, and for evaluation of cross reactivity between various steroid hormones. Gene sequence of ligand binding domain of ${\alpha}$-human estrogen receptor (amino acid 302-553; hER-LBD) was cloned from human breast cancer cell line. The proteins of hER-LBD were produced by T7-E.coli expression system, and isolated by chromatography. hER-LBD were coated on the gold plated quartz crystal (AT-cut 9MHz), and resonance frequencies were measured by universal frequency counter. Estradiol, progesterone, testosterone, and aldosterone were used for cross reactivity of the hER-LBD. We also monitored influences of pH change in resonance frequency. The resonance frequencies of hER-LBD coated quartz crystal were decreased during increase of estrogen concentration from $15 \;{\mu}g/mL$ to $50\;{\mu}g/mL$. However, similar steroid hormones, progesterone and aldosterone, did not elicit the change in resonance frequency. Testosterone evoke weak change in resonance frequency. The new estrogen biosensor was more sensitive in pH 7.2 than in pH 7.6. These results suggest that hER-LBD coated quartz crystal biosensor is a probable estrogen biosensor.

• Journal of the Korean GEO-environmental Society
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• v.18 no.7
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• pp.21-35
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• 2017

The 3S Basin is described as an important contributor in terms of many aspects in the Mekong River Basin in Southeast Asia. However, the 3S Basin has been suffering adverse consequences of changing discharge and sediment, which are derived from farming, deforestation, hydropower dam construction, climate change, and soil erosion. Consequently, a large population and ecology system that live along the 3S Basin are seriously affected. Accordingly, the calculating and simulating discharge and sediment become ever more urgent. There are many methods to simulate discharge and sediment. However, most of them are designed only during a single rainfall event and they require many kinds of data. Therefore, this study applied a Catchment-scale Soil Erosion model (C-SEM) to simulate discharge and sediment in the 3S Basin. The simulated results were judged with others references's data and the observed discharge of Strung Treng station, which is located in the mainstream and near the outlet of the 3S Basin. The results revealed that the 3S Basin distributes 31% of the Mekong River Basin's total discharge. In addition, the simulated sediment results at the 3S Basin's outlet also substantiated the importance of the 3S Basin to the Mekong River Basin. Furthermore, the results are also useful for the sustainable management practices in the 3S Basin, where the sediment data is unavailable.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.924-926
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• 2015

In this paper, we use the interface, which many countries concentrates research of Brain - Computer Interface with the device and MyndPlay based on the IoT intelligent Arduino. Finally we will make the Brain - Computer Connection environment, the purpose of Brain - Computer Interface. Recognizes the EEG of a person who wearing the equipment, analyze, classify, and we did a research to design an intelligent thing to suit user's condition. In addition, we use the XBee, and Bluetooth to communicate to other devices, such as smart phone. In conclusion, this paper check users current status via brain waves, and it allows to control the power and other objects by using the EEG(Electroencephalography).

• Korean Chemical Engineering Research
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• v.45 no.6
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• pp.611-618
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• 2007

We demonstrate the sol-gel coating technique of colloidal clusters for producing hollow micro-particles with complex morphologies. Cross-linked amidine polystyrene (PS) microspheres were synthesized by emulsifier-free emulsion copolymerization of styrene and divinylbenzene. The amidine PS particles were self-organized inside toluene-in-water emulsion droplets to produce large quantities of colloidally stable clusters. These clusters were coated with thin silica shell by sol-gel reaction of tetraethylorthosilicate (TEOS) and ammonia, and the organic polystyrene cores were removed by calcination at high temperature to generate nonspherical hollow micro-particles with complex morphologies. This process can be used to prepare hollow particles with shapes such as doublets, tetrahedra, icosahedra, and others.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.4C
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• pp.329-337
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• 2012

Capsule Endoscope(CE) is a capsule-shaped electronic device which can examine the lesions in digestive tract of human body. Recently the medical procedure using capsule endoscope is receiving great attention to both doctors and patients, since the conventional push-typed endoscope using cables brings great pain and fear to the patients. The technique was firstly available in 2000 and is based on a convergence techniques among BT(Bio Technology), IT(Information Technology), and NT(Nano Technology). The device consists of an optical parts including LEDs(Light Emitting Diodes), an image sensor, a communication module and a power module. Capsule endoscope is the embodiment of the state-of-the art technology and requires key technologies in the various engineering fields. Therefore, in this paper, we introduce the composition of the capsule endoscope system, and compare the communication method between RF(Radio Frequency) communication and HBC(Human Body Communication), which are typically used for data transmission in the capsule endoscope. Furthermore, we analyze the specification of commercialized capsule endoscopes and present the future developments and technical challenges.

• Korea Information Processing Society Review
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• v.15 no.2
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• pp.15-28
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• 2008

The Korea UK e-Science Collaboration project has been aimed at supporting research and collaboration between Korean and UK researchers. Its goal is to benefit the nation by reducing cost and time in constructing the National e-Science Research Environment' by studying and benchmarking the cases in countries that have already procured advanced technologies in the area. Two joint workshops were held in a year where researchers from the two countries had the opportunities to share their research results with each other. Also, the project has supported exchanges of researchers fostering expertise in the field. In the course of the project, the e-Science Centre in the UK and KISTI have signed MoU(Memorandum of Understanding) in 2006. Moreover, there have been active research collaboration between Korea and the UK. The University of Southampton will share the BioSimGrid data with the Korean counterpart, and the University of York has provided the AURA software. In the future, KISTI and the UK NGS(National Grid Service) will organize a working group at OGF that will work mainly on the standardization of Parameter Sweep and bring it to lead the global standard. KISTI will include its own AURORA system into OMI-UK software stack, which will enable access to NGS resources through AURORA user application. The collaboration with the UK has opened up more opportunities for collaboration with other countries as well. KISTI and HLRS in Germany have agreed to share the COVISE and will have research exchanges. As such, it is expected that Korea will play a major role in e-Science research by building strategic and systematic collaborative relations with its International partners.