• East Asian Journal of Business Economics (EAJBE)
• /
• v.8 no.2
• /
• pp.29-41
• /
• 2020

Purpose - This study incorporated the success factors of bio cluster and provided the ways to utilize them for managing the performance of bio cluster. The aim of this study was to present an integrated framework for the success factors of the bio cluster by combining the literature and case studies, and to measure and manage the performance of the bio cluster. Research design, data, and methodology - This study combined the literature review with the case study. We reviewed the literature on the success factors of the bio cluster presented by existing studies. We studied some cases of how these factors are actually applied in the bio cluster also. We integrated the success factors of bio cluster based on both the literature review and the case study. Results - The success factors of the bio cluster presented in this study as an integrated framework were defined as six factors: knowledge base and expertise, industrial infrastructure, funding and investment, government support, start-up activities and innovation activities. These success factors can be measured and managed by some performance indicators of each factor. Conclusions - Through this study, we can identify the integrated success factors of the bio cluster and understand how these factors work in bio cluster. In addition, this integrated framework of success factors will be effectively utilized to measure and manage the performance of the bio cluster.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.2
• /
• pp.370-379
• /
• 2018

The Korean government announced plans for the International Science Business Belt as a spatial area for promoting the linkage between scientific knowledge and commercialization in 2009. R&D and entrepreneurial activities are essential for the success of the International Science Business Belt. In particular, prioritizing the types of businesses is critical at the cluster establishment stage in that this largely affects the features and development of clusters comprising the International Science Business Belt. This research aims to predict the entry and growth of firms that specialize in four industrial clusters, including Big Science Cluster, Frontier Cluster, ICT Cluster, and Bio-Healthcare Cluster. For this purpose, we employ the Swann & Prevezer's industrial clustering model to identify sectors that affect the establishment and growth of industrial clusters in the International Science Business Belt, focusing on ICT, Bio-Healthcare and Frontier clusters. Data was collected from the 2014 Korean Innovation Survey (KIS) and University Alimi for the ICT cluster, 2014 National Bio Industry Survey and University Alimi for the Bio-Healthcare Cluster, and the 2015 National Nano Convergent Industry Survey and Annual Report of Nano Technology for the Frontier cluster. Empirical results show that the ICT service sector, bio process/equipment sector, and Nano electronic sector promote clustering in other sectors. Based on the analysis results, we discuss several policy implications and strategies that can attract relevant firms for the development of industrial clusters.

• Journal of the Economic Geographical Society of Korea
• /
• v.8 no.1
• /
• pp.1-16
• /
• 2005

Literature on cluster theory and cluster policy has been focused on the differences between mature industrial areas and innovative regions. Mature industrial areas are described as possessing little competence for innovation and lacking entrepreneurship to be transferred an innovative region, say, an innovative cluster. Old industrial regions are, however, rich in social capital, local networking, and regional institutionalization. This paper compares Buchon's mature industries with Daejon's bio-sector new start-ups in terms of innovative potential, socio-economic and cultural-economic mechanisms. Policy implications such as networking and business support systems on the differential types of industrial regions are offered.

• Journal of the Economic Geographical Society of Korea
• /
• v.26 no.4
• /
• pp.375-390
• /
• 2023

This study examined the genesis process and competitiveness determinants of overseas bio-industrial clusters. The bio industry is a promising new industry that major countries around the world are paying attention to because it can be applied to various industries and can create high added value by combining artificial intelligence and information and communication technology. In addition, the importance of clusters is emphasized in that it requires connection and cooperation with various stakeholders. However, compared to this importance and interest, related research in Korea is somewhat insufficient. In particular, overseas case studies are also overly biased toward a few leading clusters, and tend to produce policies and development plans that do not correspond to domestic local conditions. To alleviate this problem, this study looked at the birth and growth process of the BioHealth Capital Region in the United States, Cambridge Cluster in the United Kingdom, and Medicon Valley in Denmark and Sweden. Through this, we aim to enrich related case studies that were lacking, identify the determinants of competitiveness of each cluster, and present implications for the creation and development of domestic bio industry clusters.

• Natural Product Sciences
• /
• v.25 no.2
• /
• pp.150-156
• /
• 2019

Conventional extraction of oil and azadirachtin, a botanical insecticide, from Azadirachta indica involves defatting the seeds and leaves using hexane followed by azadirachtin extraction with a polar solvent. In order to simplify the process while maintaining the yield we explored a binary extraction approach using Soxhlet extraction device and hexane and ethanol as non-polar and polar solvents at various ratios and extraction times. The highest oil and azadirachtin yields were obtained at 6 h extraction time using a 50:50 solvent mixture for both neem leaves (44.7 wt%, $720mg_{Aza}/kg_{leaves}$) and seeds (53.5 wt%, $1045mg_{Aza}/kg_{leaves}$), respectively.

• Korean Journal of Medicinal Crop Science
• /
• v.15 no.5
• /
• pp.357-361
• /
• 2007

This study was conducted to evaluate the vegetation structure of the Peucedanum japonicum community by the phytosociological method of floristic composition table and cluster analysis on the southern coast of Korea. The vegetation of the Peucedanum japonicum community was classified mainly into 2 communities such as the Miscanthus sinensis community and the Lysimachia mauritiana-Rosa wichuraiana community. The Carex boottiana and Sedum oryzifolium community were classified as the lower rank of Miscanthus sinensis community. On level 1 of the cluster analysis of plant species, they were classified into Lysimachia mauritiana and Rosa wichuraiana group, also Miscanthus sinensis, Carex boottiana and Sedum oryzifolium in Peucedanum japonicum community, which is similar to the community classification shown in the synoptic table. On level 1 of the cluster analysis of relev, inland coast with Jejudo was Lysimachia mauritiana and Rosa wichuraiana of group such as level 1 of the cluster analysis of plant species, and island coast with Geomundo was Miscanthus sinensis Carex boottiana and Sedum oryzifolium of group such as cluster analysis of plant species.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.27 no.3
• /
• pp.83-89
• /
• 2004

The object of this study is to survey present conditions, to analyze the development of bio-industry in northern area of Kyonggi province by the decision making method of the SWOT model, to suggest a plan for the prospect of continued development field and the location of industry, and to extract fundamental data for establishment of annual action and investment plan which can develop bio-industry. For the purpose of making a policy decision in national operation policy, business administration policy, and new product design, the research for extracting more objective and standard approach method should be continuously conducted.

• Journal of Environmental Impact Assessment
• /
• v.17 no.6
• /
• pp.335-348
• /
• 2008

The purpose of this study is to classify the cities on sustainability assessment score studied in advance using cluster analysis, to present efficient management and policy direction based on analysis of sustainability index in 45 cities of all over Gyeongsangnam and Gyeongsangbuk-do. According to the results of cluster analysis, 45 cities were classed into 4 clusters by "livable-welfare city", "environmental -ecological city", "scientific-technological city", and "industrial-economic city". The livable-welfare cities must keep superior environmental sustainability, promote small and medium sized business on regional characteristic. The environmental-ecological cities have to change agriculture into future environmental industry such as ecotourism, bio-industry and landscape agriculture. The scientific-technological cities are going to need support of government scale such as income enlargement of citizen and stable job security. Finally, the industrial-economic cities must increase environmental management plants and improve quality of life through securing green spaces, maintaining public peace and applying UIS because of low quality of environment and life.

• Journal of Microbiology and Biotechnology
• /
• v.24 no.10
• /
• pp.1397-1404
• /
• 2014

A few starters have been developed and used for doenjang fermentation but often without safety evaluation. Filamentous fungi were isolated from industrial doenjang koji, and their potential for mycotoxin production was evaluated. Two fungi were isolated; one was more dominantly present (90%). Both greenish (SNU-G) and whitish (SNU-W) fungi showed 97% and 95% internal transcribed spacer sequence identities to Aspergillus oryzae/flavus, respectively. However, the SmaI digestion pattern of their genomic DNA suggested that both belong to A. oryzae. Moreover, both fungi had morphological characteristics similar to that of A. oryzae. SNU-G and SNU-W did not form sclerotia, which is a typical characteristic of A. oryzae. Therefore, both fungi were identified to be A. oryzae. In aflatoxin gene cluster analysis, both fungi had norB-cypA genes similar to that of A. oryzae. Consistent with this, aflatoxins were not detected in SNU-G and SNU-W using ammonia vapor, TLC, and HPLC analyses. Both fungi seemed to have a whole cyclopiazonic acid (CPA) gene cluster based on PCR of the maoA, dmaT, and pks-nrps genes, which are key genes for CPA biosynthesis. However, CPA was not detected in TLC and HPLC analyses. Therefore, both fungi seem to be safe to use as doenjang koji starters and may be suitable fungal candidates for further development of starters for traditional doenjang fermentation.

• Journal of Microbiology and Biotechnology
• /
• v.29 no.5
• /
• pp.667-686
• /
• 2019

Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.