• 동아시아경상학회지
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• 제8권2호
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• pp.29-41
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• 2020

Purpose - This study incorporated the success factors of bio cluster and provided the ways to utilize them for managing the performance of bio cluster. The aim of this study was to present an integrated framework for the success factors of the bio cluster by combining the literature and case studies, and to measure and manage the performance of the bio cluster. Research design, data, and methodology - This study combined the literature review with the case study. We reviewed the literature on the success factors of the bio cluster presented by existing studies. We studied some cases of how these factors are actually applied in the bio cluster also. We integrated the success factors of bio cluster based on both the literature review and the case study. Results - The success factors of the bio cluster presented in this study as an integrated framework were defined as six factors: knowledge base and expertise, industrial infrastructure, funding and investment, government support, start-up activities and innovation activities. These success factors can be measured and managed by some performance indicators of each factor. Conclusions - Through this study, we can identify the integrated success factors of the bio cluster and understand how these factors work in bio cluster. In addition, this integrated framework of success factors will be effectively utilized to measure and manage the performance of the bio cluster.

• 한국산학기술학회논문지
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• 제19권2호
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• pp.370-379
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• 2018

우리나라는 중이온 가속기 건설을 중심으로 과학지식이 사업화로 연결될 수 있도록 하는 지리적 공간으로서의 국제과학비즈니스벨트에 관한 계획을 2009년에 확정하였다. 과학기반 클러스터의 형성 단계에서 국제과학비즈니스벨트의 각 클러스터의 우선 유치업종의 선택은 클러스터의 성격과 발전에 많은 영향을 미칠 수 있다는 점에서 매우 중요하다. 본 연구는 정부에서 제시한 국제과학비즈니스벨트의 과학기반 혁신클러스터의 조성을 위해 유치해야 할 핵심 업종들을 제시하고자 한다. 산업별로 클러스터 형성과정이 상이할 뿐만 아니라, 산업 내 특정 업종이 클러스터의 성장과정에 미치는 영향력이 다르기 때문에 혁신생태계 조성을 위한 앵커 섹터를 파악하는 것이 매우 중요하다. 국제과학비즈니스벨트 내 4개 클러스터의 형성 및 성장을 위한 기업을 분석하기 위해 본 연구는 Swann & Prevezer의 산업 클러스터링(industrial clustering) 모델을 활용하여 분석하였다. 본 연구에서는 기업 관련 자료의 경우 2014년의 제조업 및 서비스업 대상 한국기업혁신조사(ICT 클러스터), 2014년 국내 바이오산업 실태조사(바이오헬스케어 클러스터), 2015 국내 나노융합산업 실태조사(첨단산업 클러스터)에 관한 최신자료를 이용하였다. ICT, 바이오헬스케어, 나노 등 3개 산업군에 대한 클러스터링 분석을 수행한 결과 각 산업군에는 다른 여러 섹터에 속하는 기업들의 지역 내 진입을 유발하는 중심적 역할을 하는 섹터들이 있는 것으로 나타났는데, ICT 산업의 경우 정보통신서비스 섹터, 바이오헬스케어 산업의 경우 바이오공정/기기 섹터, 나노 산업군의 경우 나노전자 섹터가 각각 중심적 역할을 하는 것으로 분석되었다. 분석 결과를 바탕으로 본 연구는 국제과학비즈니스벨트 클러스터를 육성하기 위한 기업 유치 전략과 정책에 대한 시사점을 제시하였다.

• 한국경제지리학회지
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• 제8권1호
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• pp.1-16
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• 2005

클러스터에 대한 기존 논의는 성숙산업지역과 첨단산업지역의 차이를 크게 부각시켰으며 성숙산업지역은 혁신과 기업가정신이 미약하고 경쟁력이 약하여 혁신지역으로 변모하기 어렵다는 평가를 한다. 하지만 지역의 사회적 자본, 국지적 네트워크형성, 신뢰의 형성 등의 클러스터형성의 주요 요소는 산업형성의 기간이 오래된 성숙지역에 풍부하다고 할 수 있다. 성숙산업지역인 부천의 조립금속산업과 전형적인 혁신지구인 대전의 생물벤처산업의 혁신여건과 혁신출동의 여건분석을 통해, 두 지역의 혁신환경을 비교하고 클러스터의 특성에 따라 차별적인 지역내, 지역간 연계방안, 기업지원체제에 대한 시사점을 도출하였다.

• 한국경제지리학회지
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• 제26권4호
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• pp.375-390
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• 2023

본 연구는 국외 바이오산업 클러스터의 태동 과정과 경쟁력 결정요인을 살펴보았다. 바이오산업은 다양한 산업에 접목할 수 있으며, 인공지능과 정보통신기술 등과 결합한 고부가가치 창출이 가능한 까닭에 세계 주요국에서 주목하는 유망 신산업이다. 또한, 기업, 대학, 병원, 연구기관, 정부 등 여러 이해관계자와 연계·협력이 필요하다는 점에서 클러스터의 중요성이 강조된다. 그러나 이 같은 중요성과 관심에 비해 국내의 관련 연구는 다소 미흡한 편이다. 특히, 국외 사례 연구도 소수의 선도 클러스터에 지나치게 치우쳐 있어, 국내 지역 실정에 부합하지 않는 정책과 발전 방안을 내놓는 경향이 있다. 이 같은 문제를 완화하고자, 본 연구는 미국의 바이오 헬스 캐피털 리전, 영국의 케임브리지 클러스터, 덴마크와 스웨덴의 메디콘밸리 세 곳의 태동 및 성장 과정을 살펴보았다. 이를 통해, 부족했던 관련 사례 연구를 풍부하게 하고, 각 클러스터의 경쟁력 결정요인을 파악하여 국내 바이오산업 클러스터의 조성과 육성에 대한 시사점을 제시하고자 한다.

• Natural Product Sciences
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• 제25권2호
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• pp.150-156
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• 2019

Conventional extraction of oil and azadirachtin, a botanical insecticide, from Azadirachta indica involves defatting the seeds and leaves using hexane followed by azadirachtin extraction with a polar solvent. In order to simplify the process while maintaining the yield we explored a binary extraction approach using Soxhlet extraction device and hexane and ethanol as non-polar and polar solvents at various ratios and extraction times. The highest oil and azadirachtin yields were obtained at 6 h extraction time using a 50:50 solvent mixture for both neem leaves (44.7 wt%, $720mg_{Aza}/kg_{leaves}$) and seeds (53.5 wt%, $1045mg_{Aza}/kg_{leaves}$), respectively.

• 한국약용작물학회지
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• 제15권5호
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• pp.357-361
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• 2007

This study was conducted to evaluate the vegetation structure of the Peucedanum japonicum community by the phytosociological method of floristic composition table and cluster analysis on the southern coast of Korea. The vegetation of the Peucedanum japonicum community was classified mainly into 2 communities such as the Miscanthus sinensis community and the Lysimachia mauritiana-Rosa wichuraiana community. The Carex boottiana and Sedum oryzifolium community were classified as the lower rank of Miscanthus sinensis community. On level 1 of the cluster analysis of plant species, they were classified into Lysimachia mauritiana and Rosa wichuraiana group, also Miscanthus sinensis, Carex boottiana and Sedum oryzifolium in Peucedanum japonicum community, which is similar to the community classification shown in the synoptic table. On level 1 of the cluster analysis of relev, inland coast with Jejudo was Lysimachia mauritiana and Rosa wichuraiana of group such as level 1 of the cluster analysis of plant species, and island coast with Geomundo was Miscanthus sinensis Carex boottiana and Sedum oryzifolium of group such as cluster analysis of plant species.

• 산업경영시스템학회지
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• 제27권3호
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• pp.83-89
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• 2004

The object of this study is to survey present conditions, to analyze the development of bio-industry in northern area of Kyonggi province by the decision making method of the SWOT model, to suggest a plan for the prospect of continued development field and the location of industry, and to extract fundamental data for establishment of annual action and investment plan which can develop bio-industry. For the purpose of making a policy decision in national operation policy, business administration policy, and new product design, the research for extracting more objective and standard approach method should be continuously conducted.

• 환경영향평가
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• 제17권6호
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• pp.335-348
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• 2008

The purpose of this study is to classify the cities on sustainability assessment score studied in advance using cluster analysis, to present efficient management and policy direction based on analysis of sustainability index in 45 cities of all over Gyeongsangnam and Gyeongsangbuk-do. According to the results of cluster analysis, 45 cities were classed into 4 clusters by "livable-welfare city", "environmental -ecological city", "scientific-technological city", and "industrial-economic city". The livable-welfare cities must keep superior environmental sustainability, promote small and medium sized business on regional characteristic. The environmental-ecological cities have to change agriculture into future environmental industry such as ecotourism, bio-industry and landscape agriculture. The scientific-technological cities are going to need support of government scale such as income enlargement of citizen and stable job security. Finally, the industrial-economic cities must increase environmental management plants and improve quality of life through securing green spaces, maintaining public peace and applying UIS because of low quality of environment and life.

• Journal of Microbiology and Biotechnology
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• 제24권10호
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• pp.1397-1404
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• 2014

A few starters have been developed and used for doenjang fermentation but often without safety evaluation. Filamentous fungi were isolated from industrial doenjang koji, and their potential for mycotoxin production was evaluated. Two fungi were isolated; one was more dominantly present (90%). Both greenish (SNU-G) and whitish (SNU-W) fungi showed 97% and 95% internal transcribed spacer sequence identities to Aspergillus oryzae/flavus, respectively. However, the SmaI digestion pattern of their genomic DNA suggested that both belong to A. oryzae. Moreover, both fungi had morphological characteristics similar to that of A. oryzae. SNU-G and SNU-W did not form sclerotia, which is a typical characteristic of A. oryzae. Therefore, both fungi were identified to be A. oryzae. In aflatoxin gene cluster analysis, both fungi had norB-cypA genes similar to that of A. oryzae. Consistent with this, aflatoxins were not detected in SNU-G and SNU-W using ammonia vapor, TLC, and HPLC analyses. Both fungi seemed to have a whole cyclopiazonic acid (CPA) gene cluster based on PCR of the maoA, dmaT, and pks-nrps genes, which are key genes for CPA biosynthesis. However, CPA was not detected in TLC and HPLC analyses. Therefore, both fungi seem to be safe to use as doenjang koji starters and may be suitable fungal candidates for further development of starters for traditional doenjang fermentation.

• Journal of Microbiology and Biotechnology
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• 제29권5호
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• pp.667-686
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• 2019

Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.