• Journal of Electrical Engineering and Technology
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• 제10권3호
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• pp.1138-1143
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• 2015

Effects of fabrication process variations on impedance of microelectrodes integrated on a neural probe were examined through equivalent circuit modeling and SPICE simulation. Process variation and the corresponding range were estimated based on experimental data. The modeling results illustrate that the process variation induced by metal etching process was the dominant factor in impedance variation. We also demonstrate that the effect of process variation is frequency dependent. Another process variation that was examined in this work was the thickness variation induced by deposition process. The modeling results indicate that the effect of thickness variation on impedance is negligible. This work provides a means to predict the variations in impedance values of microelectrodes on neural probe due to different process variations.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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• pp.405-407
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• 2008

광학적 방식에 의한 비침습적으로 신체 전체의 비만도를 측정하기 위해서는 단일 특정 부위에서 측정하는 것은 오차가 너무 크기 때문에 여러 부위에서 측정하고 이를 통계적 방법에 의해서 정확도를 높일 수 있다. 이를 위해서 백색광 LED광원을 이용하고 전기적 방식인 BIA(Bio-electrical Impedance)방식으로 동시에 측정하여 광전기적 지방측정에 관한 상관식을 유도하였다.

• 동력기계공학회지
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• 제13권1호
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• pp.65-71
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• 2009

To address the need for new intelligent sensing, this paper introduces nano sensors made of carbon nanotube (CNT) composites and presents their preliminary experiments. Having smart material properties such as piezoresistivity, chemical and bio selectivity, the nano composite can be used as smart electrodes of the nano sensors. The nano composite sensor can detect structural deterioration, chemical contamination and bio signal by means of its impedance measurement (resistance and capacitance). For a structural application, the change of impedance shows specific patterns depending on the structural deterioration and this characteristic is available for an in-situ multi-functional sensor, which can simultaneously detect multi symptoms of the structure. This study is anticipated to develop a new nano sensor detecting multiple symptoms in structural, chemical and bio applications with simple electric circuits.

• 대한의용생체공학회:의공학회지
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• 제32권3호
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• pp.207-217
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• 2011

Electrode impedances are measured to quantitatively characterize the electrode-electrolyte or cell-electrode interfaces. In the case of high-density microelectrode arrays(MEAs) that have been developed for brainmachine interface applications, the characterization process becomes a repeating and time-consuming task; a system that can perform the measurement and analysis in an automated fashion with accuracy and speed is required. However, due to the large number of channels, parasitic capacitance and off-capacitance components of the switching system become the major factors that decreased the accuracy for the measurement of high impedance microelectrodes. Here we investigated the implementation of automatic impedance measurement system with analyzing the causes of possible measurement-related problems in multichannel switching configuration. Based on our multi-channel measurement circuit model, we suggest solutions to the problems and introduce a novel impedance measurement scheme using electro-mechanical relays. The implemented measurement system could measure |Z| < 700 $k{\Omega}$ of impedance in - 10% errors, which can be widely applicable to high density neural recording MEAs.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1977-1978
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• 2008

In this paper, we compare performance of common-mode rejection between a differential and a non-differential amplifier system with two electrodes. A differential amplifier system is constant for common-mode rejection ratio(CMRR) on the frequency domain. But a non-differential amplifier's CMRR is determined by $Z_{FB}/Z_e$ ($Z_{FB}$ ; feedback impedance, $Z_e$; electrode impedance). There is trade-off between a non-differential amplifier's CMRR and its differential input impedance. And a non-differential amplifier system has some advantages for a bio-potential measurement with two electrodes because a designer can control the impedance between the body and system's common.

• 한국산업정보학회논문지
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• 제18권6호
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• pp.9-16
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• 2013

생체임피던스 측정 시스템은 비침습적이고, 환자의 수분함량을 쉽게 측정할 수 있게 한다. 생체임피던스 측정에서 정확하고 재현성 있는 결과를 얻기 위해서는 측정조건과 하드웨어 사양의 선택 및 구성이 매우 중요하다. 본 연구에서는 1kHz에서 100kHz 주파수 범위에서 락인엠프, 랩뷰 제어시스템을 이용하여 사지와 흉부에 대해 생체임피던스 측정을 각각 수행하였으며, 측정 및 모의실험 결과를 통해 제안한 모델의 파라메터와 인가 전원의 주파수에 따른 저항 및 리액턴스 변화가 인체실험 결과와 유사한 결과로 나타남을 확인하였다. 제안한 실시간 생체임피던스 측정 시스템은 높은 신뢰성을 가지며, 인체에 대한 임피던스의 임상적인 특성 연구에도 적용될 수 있을 것이다.

• 전기학회논문지
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• 제63권12호
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• pp.1671-1674
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• 2014

This paper presents a frequency-dependent cell impedance analysis chip for use in cancer and normal cell discrimination. The previous cell impedance analysis chips for flowing cells cannot allow enough time for cell-to-electrode contact to monitor frequency-dependent impedance response. Another type of the previous cell impedance analysis chips for the cells clamped by membranes need complex sample control for making stable cell-to-electrode contact. We present a new impedance analysis chip using the microchamber array, on which a PDMS cover is placed to make stable cell-to-electrode contact for the individual cell trapped in each microchamber; thus achieving frequency-dependent single-cell impedance analysis without complex sample control. Compared to the normal cells, the magnitude of NHBE cells is $60.07{\sim}97.41k{\Omega}$ higher than A549 cells in the frequency range of 95.6 kHz~2MHz and the phase of NHBE is $3.96^{\circ}{\sim}20.8^{\circ}$ higher than A549 cells in the frequency range of 4.37 kHz~2MHz, respectively. It is demonstrated experimentally that the impedance analysis chip performs frequency-dependent cell impedance analysis by making stable cell-to-electrode contact with simple sample control; thereby applicable to the normal cell and cancer cell discrimination.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 V
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• pp.2887-2890
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• 2003

This paper describes the possibility of analyzing gait pattern from the variation of the lower leg electrical impedance. This impedance is measured by the four-electrode method. Two current electrodes are applied to the thigh, knee, and foot, and two potential electrodes are applied to the lateral, medial, and posterior position of lower leg. The correlation coefficients of the joint angle and the impedance change from human leg movement was obtained using electrogoniometer and 4ch impedance measurement system developed in this study. We found the optimal electrode position for ankle, knee and hipjoint movements based on high correlation coefficient, least interference, and maximum magnitude of impedance change. The correlation coefficients of the ankle, knee, and the hip movements -0.87, 0.957 and 0.80. respectively. From such features of the lower leg impedance, it has been made clear that different movement patterns exhibit different impedance patterns and impedance level. This system showed possibility that lower leg movement could be easily measured by impedance measurement system with a few skin-electrodes.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.693-696
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• 2006

본 연구에서는 생체 임피던스의 변화를 계측하여 혈류량의 변화를 추정하기 위한 시스템을 구현하였다. 구현된 시스템은 인위적인 압력을 가하여 압력의 변화에 따른 임피던스의 변화량을 측정할 수 있도록 구성하였으며, 크게 압력 측정부와 4 전극법을 이용한 임피던스 측정부로 구분할 수 있다. 압력 측정부는 반도체식 압력센서와 센서의 출력신호를 처리하기 위한 전자회로부로 구성하였고, 임피던스 측정부는 교류 정전류원 회로와 임피던스 신호의 검출을 위한 락인 증폭기로 시스템을 구성하였다. 구현된 시스템의 성능평가를 위하여 표준저항을 이용한 임피던스 측정부의 특성조사 실험을 수행 하였다. 그리고 실제 실험군을 대상으로 임피던스의 계측을 통한 혈류량 변화 추정실험을 수행하였고, 혈류량 변화와 평균 동맥압을 이용한 혈류 저항비를 추정하였다 그 결과 혈류저항비와 혈류량의 변화는 반비례관계를 명확하게 보여 주었으며, 상관분석을 수행한 결과 상관계수가 -0.96776으로 강한 음의 상관관계를 나타내었다.

• 한국전기전자재료학회논문지
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• 제21권8호
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• pp.776-781
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• 2008

In this study, ubiquitous health care system attaching in chair to monitor ECG for health care was developed at the unconsciousness state. The system conveniently and simple measured ECG at non-consciousness. We measured the contact impedance to skin-electrode of metal mesh electrodes of the system. Contact impedance enable the electrode to use for ECG measurement. The results are that the impedance of the metal mesh electrodes according to sizes is low when the size is 4$cm^2$. As the result, when the size of the metal mesh electrode is 4$cm^2$, the electrode is fit for ECG measurement. We can acquired by positing the arm on the metal mesh electrode. The ECG signal was detected using a high-input-impedance bio-amplifier, and then passed filter circuitry. The measured signal transmitted to a PC through the bluetooth wireless communication and monitored. Data of the non-constrained ECG system attaching in chair is noise-data when comparing metal mesh electrode with the Ag/Agcl electrode but the data is significant to monitor ECG for check the body state.