• Korean Journal of Medicinal Crop Science
• /
• v.26 no.5
• /
• pp.417-429
• /
• 2018

Background: The objective of this study was to make colloidal dispersions of the active compounds of radix of Angelica gigas Nakai that could be charaterized as nano-composites using hot melt extrusion (HME). Food grade hydrophilic polymer matrices were used to disperse these compound in aqueous media. Methods and Results: Extrudate solid formulations (ESFs) mediated by various HPMCs (hydroxypropyl methylcelluloses) and Na-Alg polymers made from ultrafine powder of the radix of Angelica gigas Nakai were developed through a physical crosslink method (HME) using an ionization agent (treatment with acetic acid) and different food grade polymers [HPMCs, such as HP55, CN40H, AN6 and sodium alignate (Na-Alg)]. X-ray powder diffraction (XRD) analysis confirmed the amorphization of crystal compounds in the HP55-mediated extrudate solid formulation (HP55-ESF). Differential scanning calorimetry (DSC) analysis indicated a lower enthalpy (${\Delta}H=10.62J/g$) of glass transition temperature (Tg) in the HP55-ESF than in the other formulations. Infrared fourier transform spectroscopy (FT-IR) revealed that new functional groups were produced in the HP55-ESF. The content of phenolic compounds, flavonoid (including decursin and decursinol angelate) content, and antioxidant activity increased by 5, 10, and 2 times in the HP55-ESF, respectively. The production of water soluble (61.5%) nano-sized (323 nm) particles was achieved in the HP55-ESF. Conclusions: Nano-composites were developed herein utilizing melt-extruded solid dispersion technology, including food grade polymer enhanced nano dispersion (< 500 nm) of active compounds from the radix of Angelica gigas Nakai with enhanced solubility and bioavailability. These nano-composites of the radix of Angelica gigas Nakai can be developed and marketed as products with high therapeutic performance.

• Microbiology and Biotechnology Letters
• /
• v.26 no.4
• /
• pp.358-364
• /
• 1998

New microbial-control agents were prepared with B. thuringiensis strain NT0423 having unique properties which are different with other B. thuringiensis strains belonging to serotype 7[Kor. J. Appl. Entomol. 32: 426-432.]. Three B. thuringiensis formulations designated as BioBact 10%, 20% and 40%, were made with various combinations of adjuvants. These formulations showed good physical properties in wettability, suspensibility, particle size and adherence. In addition the result of SDS-PAGE analysis indicated that $\delta$-endotoxins remain stably in all formulations. Among the tested formulations, two wettable powder formulations, BioBact 20% and 40%, comprising 20% and 40% of B. thuringiensis technical powder showed the effective control against diamondback moth larvae (Plutella xylostella) in laboratory and field tests. Especially, when compared with commercial B. thuringiensis formulations (A and B commercial formulations) in field evaluation, BioBact 20% and 40% formulations showed equal activity up to 80% lethality and a good persistence effect which remain on leaves at least 7 days.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.25 no.2
• /
• pp.210-217
• /
• 2022

Chemical warfare agents(CWA) such as nerve agents and vesicating agents show lethality by skin contamination. Skin protection, therefore, is one of the top priorities to deal with the growing threat from CWA. In an attempt to develop the most effective topical skin protectant(TSP), candidate substances including PFPE(perfluorinated polyether), PTFE(polytetrafluoroethylene), glycerin, and polysaccharides were evaluated in forms of various formulations against nerve agent simulant DMMP(dimethylmethyl phosphonate) penetration. The protective efficacy of the formulation against DMMP penetration was estimated as the onset time of color change of the KM9 chemical agent detection paper. Based on this study, it was found that several PFPE- and glycerin-based formulations exhibit remarkably superior efficacy as a protective cream. This protective cream is expected to be used as TSP for military application after further research.

• Journal of the Korea Convergence Society
• /
• v.11 no.5
• /
• pp.241-251
• /
• 2020

This study was performed to develop the cosmetics containing extract of U.davidiana, which has been confirmed as a functional ingredient of anti-microbial, anti-oxidant, and anti-inflammatory effects, and also to evaluate the improvement effects of dry and sensitive skin such as atopic dermatitis. Toxicity tests of the Ulmus davidiana supercritical fluid residue 60% EtOH extracts(USCFR), Ulmus davidiana supercritical fluid extracts(USCF) and preliminary formulations, DKBP-1903(gel), containing the USCFR and USCF were determined to be 'Non-toxic'. Based on this, the stability test of the lotion, cream, gel formulation was conducted and the results showed that cream and gel formulation were stable. A 48-hour moisturizing sustainability test and the improvement test on the pruritus caused by dryness were selected for the cosmetic efficacy test to evaluate the improvement of atopic dermatitis and as a result both cream and gel have been found to be relatively safe moisturizers that can help dry and sensitive skin.

• The Korean Journal of Pesticide Science
• /
• v.2 no.3
• /
• pp.36-44
• /
• 1998

To develope cost-effective new granular formulation of mixture with 7.0% chlomethoxyfen and 3.5% butachlor, this study was conducted by investigation of floatability, dispersibility or collapsability and released concentration of active ingredients in water and bio-efficacies of the granules formulated by different formulation methods compared to commercial pellet-extruded granules. They were formulated by coating on or impregnation into extruded pellets, sands and zeolites with two active ingredients, binders, friction reducer, dispersing agents and bentonite. Pellet-coated method showed similar floatability, collapsability and bio-efficacy to the commercial pellet-extruded one or better than that but unstable patterns of released concentration of chlomethoxyfen because of easy isolation of coated technical particles from the surface of granules. Sand-coated methods showed similar physical properties, released pattern of two active ingredients, and bio-efficacy to the commercial one. Liquid binders and/or dispersing agents are more important than powdered ones to control released concentration of active ingredients from the granule mixtures, to improve the floatability and dispersibility, and to show good bio-efficacy. Sand-coated one might be a suitable method if types and amount of liquid binders and dispersing agents are selected.

• Proceedings of the Korea Technology Innovation Society Conference
• /
• 2015.05a
• /
• pp.215-221
• /
• 2015

본 연구는 대표적인 지식기반산업인 생명의료산업클러스터인 첨단의료복합단지 조성정책의 형성과정을 분석하고자 한다. 첨단의료복합단지는 미래첨단산업육성정책, 국가산업진흥정책 그리고 지역균형발전정책이 첨예하게 대립했던 첨단의료산업 발전정책과 그 산물로서 2005년부터 시작한 첨단의료복합단지의 건립과정에 대한 경과를 분석하여 그 과정, 절차 그리고 결과를 분석해 보고자 한다. 첨단의료복합단지를 둘러싼 정책형성과정에 대한 분석은 단지 하나의 이벤트나 사건으로 머물지 않고 우리나라의 미래첨단산업정책, 국가신성장동력육성정책, 및 지역균형발전정책 등과 밀접히 관련되어 있다는 데 그 의의를 두고자 한다. 분석결과 첨단 의료산업분야의 정책형성 과정은 여러 정책행위자들이 간여하였다. 특히 해당 정책형성과정은 경제발전과정에서 보여준 한국 산업정책 고유특성이 반영된 합리적 행위자로서의 정부역할이 강하게 나타났다. 아울러 분석결과 다양한 정책행위자의 역동적인 역할이 정책형성의 여러 지점에 반영되었다는 점을 조명하였다.

• The Korean Journal of Mycology
• /
• v.30 no.1
• /
• pp.50-55
• /
• 2002

Biological control against mushroom fly, Lycoriella mali, was performed by using Bacillus thuringiensis subsp. israelensis Bti-D and Bti-U, isolated from dead mushroom fly in oyster mushroom houses. Control values of the bacterial strains Bti-D and Bti-U against L. mali in bottle culture of oyster mushroom were 74.4% and 64.2%, respectively, and the value in small tray culture were 75.8% and 56.8%, respectively. In the experiment to develop the mass, cheap media for Bti-D and Bti-U isolates, the Biji broth (bean curd residue, called Biji in Korean language) was selected as a culture medium for an inexpensive and mass cultivation by the measurement of optical density of the two bacteria grown in the different media tested. Insecticidal effect of the formulation contained different ingredients that were prepared by using the Bti-D strain cultured in the Biji broth was tested in tray and bottle culture of oyster mushroom. The WCS formulation that contained corn starch as bio-gel (86.4%) was more effective to control the mushroom fly than living cells (69.1%) in bottle culture of oyster mushroom. Moreover, insecticidal effect of the WCS formulation was improved when water of pH 8 was used for dilution of the formulation. Effect of the WCS formulation using water of pH 8 and chemicals, Zuron (dimillin) W.P. on the control of mushroom fly and the productivity of oyster mushroom was investigated in tray culture of oyster mushroom. The Zuron W.P. was more effective to control the mushroom fly than the WCS formulation. However, compared with no treatment, the productivity of the mushroom treated with the WCS formulation was improved than that of the mushroom with Zuron W.P.

• Journal of Microbiology and Biotechnology
• /
• v.18 no.12
• /
• pp.1903-1907
• /
• 2008

Prodigiosin is a natural red pigment with algicidal activity against Cochlodinium polykrikoides, a major harmful red-tide microalga. To increase the yield of prodigiosin production by Hahella chejuensis KCTC 2396, significant medium components were determined using a two-level Plackett-Burman statistical design technique. Among 12 components included in basal medium, $NaHCO_3$, ${Na}_{2}{SiO}_{3}$, ${NH_4}{NO_3}$, ${Na}_{2}{SO}_{4}$ and $CaCl_2$ were determined to be important for prodigiosin production. The medium formulation was finally optimized using a Box-Behnken design as follows: 1% sucrose; 0.4% peptone; 0.1 % yeast extract; and (g/l): NaCl, 20.0; ${Na}_{2}{SO}_{4}$, 9.0; $CaCl_2$, 1.71; KCl, 0.4; and (mg/l): ${H_3}{BO_3}$, 10.0; KBr, 50.0; NaF, 2.0; $NaHCO_3$, 45.0; ${Na}_{2}{SiO}_{3}$, 4.5; ${NH_4}{NO_3}$, 4.5. The predicted maximum yield of prodigiosin in the optimized medium was 1.198 g/l by the Box-Behnken design, whereas the practical production was 1.495 g/l, which was three times higher than the basal medium (0.492 g/l).

• Journal of the Korean Institute of Landscape Architecture
• /
• v.29 no.4
• /
• pp.53-66
• /
• 2001

Modern art has had a great impact on the concepts and the formal attributes of modern landscape design. This study aimed at examining the origins of modern landscape design languages especially in relation to the influence of find art during the modernist age. The formal reductionism of Cubistic paintings finally lead to the formulation of Geometrical Abstractionism which became the basic formal model for ˝Regular Style˝; one of the representative modern landscape style. This Regular Style is mostly based on the formal structure of ´Grids´, which was developed by many landscape designer like Eckbo, Kley and Halprin. On the other hand, the ´Bio-morphic Form´ originally used in Surrealistic Art became the formal model for ˝Organic Style˝; the other representative modern landscape style, developed mostly by the landscape designers like Church, Burle-Mark and Bye. Thus, ´Grids´ and ´Bio-morphic Form´ became the dual icons of modern art and modern landscape design. Although these modern landscape design styles were ground breaking departure from the conventional formal/informal tradition and expanded possibilities in formal experimentations, They also produced several crucial limitations originated from the scientific reductionism and autonomous aesthetics of modern art, like the physical and cultural discontinuation from surrounding environments and the formal alienation from the real life world, which gave rise to the emergence of post-modern thinking of landscape design.

• Asian Journal of Turfgrass Science
• /
• v.23 no.2
• /
• pp.209-218
• /
• 2009

Bacterial isolates collected from rhizosphere of turfgrass showed strong in vitro antagonistic activities against a number of turfgrass soilborne pathogens such as Rhizoctonia cerealis, R. solani AG-1(1B), Sclerotinia homoeocarpa and Typhula incarnata. In vivo study, four bacterial isolates selected have control values over 60% against one or more turfgrass pathogenic fungi. The antagonistic effects of the bacterial isolates varied depending on fungal species, host plant, and disease pressure, indicating that control effects of the antagonists could be variable depending on field conditions. They were classified as belonging to the genus Pseudomonas species, based on morphological and biochemical characteristics as well as 16S rRNA analysis. The four bacterial isolates are under a study for finding proper cultural conditions and determination formulation type.