Journal of the Korea Institute of Military Science and Technology (한국군사과학기술학회지)

The Korea Institute of Military Science and Technology (한국군사과학기술학회)
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Study on the formulations for Topical Skin Protectant against Liquid-Phase Chemical Warfare Agents

액체성 화학작용제의 흡수를 차단하는 피부보호제 제제 설계 연구

  • Kim, Sang Woong (Research and Development Center, Hanso Inc.) ;
  • Seo, Dong Sung (Research and Development Center, Hanso Inc.) ;
  • Son, Hong Ha (Department of Technology, MuNTech Inc.) ;
  • Yu, Chi Ho (Chem-Bio Technology Center, Agency for Defense Development) ;
  • Joe, Hae Eun (Chem-Bio Technology Center, Agency for Defense Development) ;
  • Cho, Young (Research and Development Center, Hanso Inc.)
  • 김상웅 (한소주식회사 부설연구소) ;
  • 서동성 (한소주식회사 부설연구소) ;
  • 손홍하 (뮤앤텍 기술부) ;
  • 유치호 (국방과학연구소 Chem-Bio기술센터) ;
  • 조혜은 (국방과학연구소 Chem-Bio기술센터) ;
  • 조영 (한소주식회사 부설연구소)
  • Received : 2021.10.25
  • Accepted : 2022.01.21
  • Published : 2022.04.05
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Abstract

Chemical warfare agents(CWA) such as nerve agents and vesicating agents show lethality by skin contamination. Skin protection, therefore, is one of the top priorities to deal with the growing threat from CWA. In an attempt to develop the most effective topical skin protectant(TSP), candidate substances including PFPE(perfluorinated polyether), PTFE(polytetrafluoroethylene), glycerin, and polysaccharides were evaluated in forms of various formulations against nerve agent simulant DMMP(dimethylmethyl phosphonate) penetration. The protective efficacy of the formulation against DMMP penetration was estimated as the onset time of color change of the KM9 chemical agent detection paper. Based on this study, it was found that several PFPE- and glycerin-based formulations exhibit remarkably superior efficacy as a protective cream. This protective cream is expected to be used as TSP for military application after further research.

Keywords

Acknowledgement

본 연구는 국방과학연구소의 연구비(과제명: rTSP제재 피부 보호 및 제독제 개발) 지원을 받아 수행되었으며 기술적으로 도와주신 국방과학연구소 Chem-Bio 기술센터에 감사 드립니다.

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