• Biomolecules & Therapeutics
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• 제20권5호
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• pp.487-491
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• 2012

The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide ($H_2O_2$) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by $500{\mu}M$ $H_2O_2$, as assessed by 4',6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by $H_2O_2$, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.

• The Journal of Korean Physical Therapy
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• 제32권2호
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• pp.80-87
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• 2020

Purpose: Some patients who have undergone surgery due to lumbar disc herniation still complain of leg pain and other abnormal sensations. Therefore, the study examined the effects of the neurodynamics on pain and other abnormal nerve sensations in post-operated patients with lumbar disc herniation. Methods: The participants of this study comprised 20 adults (10 males and 10 females) who were diagnosed with lumbar disc herniation. The subjects were classified into two groups of 10 patients each in the lower extremity neurodynamics (LEN) and lumbar stabilization exercise (LSE) groups. Each intervention was applied twice a day for one week and was composed of two different exercise patterns; one was applied by a therapist, and the other was performed by the patients themselves. The data were analyzed using assessment methods of Digital Infrared Thermal Imaging (DITI), Toronto clinical neuropathy scoring system (TCNSS), Sympathetic Skin Response (SSR) test, and Oswestry Disability Index (ODI) scale. Results: Significant differences in TCNSS, DITI, ODI scale were observed between the LEN and LSE group (p<0.01). On the other hand, there was no significant difference in the SSR test between pre and post-treatment (p>0.05). Conclusion: The results indicated that neurodynamics treatment is effective in pain reduction and abnormal sensations, such as leg muscle cramps, in post-operated patients with lumbar disc herniation.

• 자원환경지질
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• 제33권4호
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• pp.261-271
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• 2000

In order to evaluate the environmental impact of U anormaly in the drainage system around the Shinbo talc mine area, U contents, their distribution patterns, bioaccumulation and a-radioactivity in stream water, stream sediments and aquatic organisms were investigated. The U contents of stream water attenuated with increasing distance from the mine area. The same attenuation pattern is shown in stream sediments from mine to 0.75 km downstream, although these contain highly enriched U contents (24~83 mg/kg) comparing with the international average concentration of surface soils (0.79~11 mg/kg). However, U content increases abruptly in sediment at 1.5 km downstream, probably due to detrital migration and rediposition of U enriched sediments. Futhermore, enriched U in downstream sediments occur in high proportions of carbonate and Fe-Mn oxide bounded forms, which show high potential of a secondary pollution source. For aquatic organisms, bio accumulation degree of U are in the order: aquatic larvae>black snail>mountain frog>crawfish. Cultured trout by the U enrich groundwater (387 ${\mu}g$/l) shows U accumulation in the part of branchia (CRs 5.25) and bones (CRs 11.2) but not in flesh (CRs 0.03). Total a-radioactivity have been measured in the level as 0.47 nCi/l for groundwater, 2.94~18 nCi/kg${\cdot}$DW for organisms and 93~328 nCi/kg${\cdot}$DW for sediments.

• 한국대기환경학회지
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• 제8권4호
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• pp.269-276
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• 1992

인체에 영향을 미치는 중금속은 대개 환경중에서 음식물, 공기, 먼지 및 음료수를 통하여 축적된다. 본 연구는 중금속중 납이 인체에 미치는 유해정도를 평가하기 위하여 서울과 여주등 대기중 납농도가 차이가 나는 지역주민들의 혈액중 납농도를 측정하여 Bio kinetic Model을 이용 납에 대한 인체의 위해성 정도를 알아보았으며 그 결과는 다음과 같다. - 지역별로는 혈액중 납농도가 별다른 차이를 보이지 않았으나 나이와 성별에 따라서는 다소 차이가 나고 있다. - 또한 혈액중 납농도는 log normal 분포를 나타내고 있음. - 기하표준편차는 1.2 $\sim$ 1.3 정도의 값으로 미국 EPA에서 추정한 1.31 $\sim$ 1.41의 값보다 약간 적은 값을 나타냈다.

• 디지털콘텐츠학회 논문지
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• 제17권2호
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• pp.97-103
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• 2016

이 논문에서는 심장이상 관리와 심혈관 위험 평가를 위해 임상 관련성과 연관지어 주요한 요소와 원인을 파악하는데 필요한 심전도(ECG) 데이터의 시각화 분석을 위해 경험한 기술을 소개한다. 특히, MIT-BIH ECG 데이터베이스를 기반으로 복잡한 ECG 데이터를 시각화하여 다양한 차트, 그래프로 표현할 수 있는 접근방법을 소개한다. 이러한 경험 기술 소개를 통해 많은 연구자들은 ECG 데이터베이스를 보다 쉽게 접근할 수 있고 다양한 형태로 시각화된 ECG 데이터의 의미를 직관적으로 이해할 수 있다.

• Nuclear Engineering and Technology
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• 제30권4호
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• pp.342-352
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• 1998

A nuclear design feasibility of soluble boron free(SBF core for the medium-sized(600MWe) PWR was investigated. The result conformed that soluble boron free operation could be performed by using current PWR proven technologies. Westinghouse advanced reactor, AP-600 was chosen as a design prototype. Design modification was applied for the assembly design with burnable poison and control rod absorber material. In order to control excess reactivity, large amount of gadolinia integral burnable poison rods were used and B4C was used as a control rod absorber material. For control of bottom shift axial power shape due to high temperature feedback in SBF core, axial zoning of burnable poison was applied to the fuel assemblies design. The combination of enrichment and rod number zoning for burnable poison could make an excess reactivity swing flat within around 1% and these also led effective control on axial power offset and peak pin power, The safety assessment of the designed core was peformed by the calculation of MTC, FTC and shutdown margin. MTC in designed SBF core was greater around 6 times than one of Ulchin unit 3&4. Utilization of enriched BIO(up to 50w1o) in B4C shutdown control rods provided enough shutdown margin as well as subcriticality at cold refueling condition.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.137-140
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• 2000

Numerous novel marine natural products have been discovered and isolated from varied marine organisms by the diligent bio-prospectors over the past decades. An assessment of the current status of commercial development of these natural compounds indicates only minimal commercialization due to the lack of sustainable supply. To bridge the gaps between discovery and commercialization of these tantalizing bioactive compounds, marine bioprocess engineering is the key for its success. The problems, challenges and opportunities for marine bioprocess engineers are examined for the timely transformation of the discovery into commercial reality. Marine bioprocess engineers will find it the most rewarding practice of their expertise in diving into the ocean.

• 한국재료학회지
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• 제30권5호
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• pp.252-261
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• 2020

We prepare ZnO nanoparticles by environmentally friendly synthesis using Cyathea nilgiriensis leaf extract. Various phytochemical constituents are identified through the assessment of ethanolic extract of plant Cyathea nilgiriensis holttum by GC-MS analysis. The formation of ZnO nanoparticles is confirmed by FT-IR, XRD, SEM-EDX, TEM, SAED and PSA analysis. TEM observation reveals that the biosynthesized ZnO nanopowder has a hexagonal structure. The calculated average crystallite size from the high intense plane of (1 0 1) is 29.11 nm. The particle size, determined by TEM analysis, is in good agreement with that obtained by XRD analysis. We confirm the formation of biomolecules in plant extract by FT-IR analysis and propose a possible formation mechanism of ZnO nanoparticles. Disc diffusion method is used for the analyses of antimicrobial activity of ZnO nanoparticles. The synthesized ZnO nanoparticles exhibit antimicrobial effect in disc diffusion experiments. The biosynthesized ZnO nanoparticles display good antibacterial performance against B. subtilis (Gram-positive bacteria) and K. pneumonia (Gram-negative bacteria). Bio-synthesized nanoparticles using green method are found to possess good antimicrobial performance.

• Toxicological Research
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• 제30권3호
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• pp.159-168
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• 2014

Pesticides have provided significant benefits including plant disease control and increased crop yields since people developed and utilized them. However, pesticide use is associated with many adverse effects, which necessitate precise toxicological tests and risk assessment. Most of these methods are based on animal studies, but considerations of animal welfare and ethics require the development of alternative methods for the evaluation of pesticide toxicity. Although the usage of laboratory animals is inevitable in scientific evaluation and alternative approaches have limitations in the whole coverage, continuous effort is necessary to minimize animal use and to develop reliable alternative tests for pesticide evaluation. This review discusses alternative approaches for pesticide toxicity tests and hazard evaluation that have been used in peer-reviewed reports and could be applied in future studies based on the critical animal research principles of reduction, replacement, and refinement.

• Wind and Structures
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• 제17권3호
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• pp.245-262
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• 2013

The flow interaction between two identical neighboring twin square prisms in a staggered arrangement in an open terrain was investigated experimentally. The downwind prism was mounted on a rigid-aeroelastic setup in an open-terrain boundary layer flow to measure its acrosswind root-mean-square responses and aerodynamic damping ratios. By varying the relative location of the upwind prism and the Scruton number associated with the downwind prism, the acrosswind aeroelastic behavior of the downwind prism was analyzed and compared to that of an isolated one. Results showed that the acrosswind root-mean-square response of the downwind prism could be either suppressed or enhanced by the wake flow produced by the neighboring upwind prism. Besides the assessment of the wake effect of the downwind prism, finally, regressed relationships were presented to describe the variation of the aerodynamic damping ratio so as to predict its acrosswind fluctuating response numerically.