• 제목/요약/키워드: Bio-Sensing

검색결과 217건 처리시간 0.022초

A Possible Merge of FRET and SPR Sensing System for Highly Accurate and Selective Immunosensing

  • Lee, Jae-Beom;Chen, Hongxia;Lee, Jae-Wook;Sun, Fangfang;Kim, Cheol-Min;Chang, Chul-Hun L.;Koh, Kwang-Nak
    • Bulletin of the Korean Chemical Society
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    • 제30권12호
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    • pp.2905-2908
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    • 2009
  • Immuno-sensing for high accurate and selective sensing was performed by fluorescence spectroscopy and surface plasmon resonance (SPR), respectively. Engineered assembly of two fluorescent quantum dots (QDs) with bovine serum albumin (BSA) and anti-BSA was fabricated in PBS buffer for fluorescence analysis of fluorescence resonance energy transfer (FRET). Furthermore, the same bio-moieties were immobilized on Au plates for SPR analysis. Naturally-driven binding affinity of immuno-moieties induced FRET and plasmon resonance angle shift in the nanoscale sensing system. Interestingly, the sensing ranges were uniquely different in two systems: e.g., SPR spectroscopy was suitable for highly accurate analysis to measure in the range of 10$^{-15{\sim}-10$ng/mL while the QD fluorescent sensing system was relatively lower sensing ranges in 10$^{-10{\sim}-6$ng/mL. However, the QD sensing system was larger than the SPR sensing system in terms of sensing capacity per one specimen. It is, therefore, suggested that a mutual assistance of FRET and SPR combined sensing system would be a potentially promising candidate for high accuracy and reliable in situ sensing system of immune-related diseases.

Quorum Sensing-Based Multiple Access Networks

  • Tissera, Surani;Choe, Sangho
    • 한국통신학회논문지
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    • 제41권7호
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    • pp.750-753
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    • 2016
  • Quorum sensing (QS) is a bacterium-to-bacterium cell communication mechanism allowing bio-cell network construction but such mechanism is not well defined yet. We construct a QS-based multiple access network (MAN) and then numerically analyse its average uplink channel capacity as well as BER performance over diffusion-based 3-D molecular communication channels.

생체 신호 측정용 저 잡음 저 전력 용량성 계측 증폭기 (A Low Noise Low Power Capacitive Instrument Amplifier for Bio-Potential Detection)

  • 박창범;정준모;임신일
    • 센서학회지
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    • 제26권5호
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    • pp.342-347
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    • 2017
  • We present a precision instrument amplifier (IA) designed for bio-potential acquisition. The proposed IA employs a capacitively coupled instrument amplifier (CCIA) structure to achieve a rail-to-rail input common-mode range and low gain error. A positive feedback loop is applied to boost the input impedance. Also, DC servo loop (DSL) with pseudo resistors is adopted to suppress electrode offset for bio-potential sensing. The proposed amplifier was designed in a $0.18{\mu}m$ CMOS technology with 1.8V supply voltage. Simulation results show the integrated noise of $1.276{\mu}Vrms$ in a frequency range from 0.01 Hz to 1 KHz, 65dB SNR, 118dB CMRR, and $58M{\Omega}$ input impedance respectively. The total current of IA is $38{\mu}A$. It occupies $740{\mu}m$ by $1300{\mu}m$ including the passive on-chip low pass filter.

Cucurbitacin B Activates Bitter-Sensing Gustatory Receptor Neurons via Gustatory Receptor 33a in Drosophila melanogaster

  • Rimal, Suman;Sang, Jiun;Dhakal, Subash;Lee, Youngseok
    • Molecules and Cells
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    • 제43권6호
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    • pp.530-538
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    • 2020
  • The Gustatory system enables animals to detect toxic bitter chemicals, which is critical for insects to survive food induced toxicity. Cucurbitacin is widely present in plants such as cucumber and gourds that acts as an anti-herbivore chemical and an insecticide. Cucurbitacin has a harmful effect on insect larvae as well. Although various beneficial effects of cucurbitacin such as alleviating hyperglycemia have also been documented, it is not clear what kinds of molecular sensors are required to detect cucurbitacin in nature. Cucurbitacin B, a major bitter component of bitter melon, was applied to induce action potentials from sensilla of a mouth part of the fly, labellum. Here we identify that only Gr33a is required for activating bitter-sensing gustatory receptor neurons by cucurbitacin B among available 26 Grs, 23 Irs, 11 Trp mutants, and 26 Gr-RNAi lines. We further investigated the difference between control and Gr33a mutant by analyzing binary food choice assay. We also measured toxic effect of Cucurbitacin B over 0.01 mM range. Our findings uncover the molecular sensor of cucurbitacin B in Drosophila melanogaster. We propose that the discarded shell of Cucurbitaceae can be developed to make a new insecticide.

Feasibility Study for an Optical Sensing System for Hardy Kiwi (Actinidia arguta) Sugar Content Estimation

  • Lee, Sangyoon;Sarkar, Shagor;Park, Youngki;Yang, Jaekyeong;Kweon, Giyoung
    • 농업생명과학연구
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    • 제53권3호
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    • pp.147-157
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    • 2019
  • In this study, we tried to find out the most appropriate pre-processing method and to verify the feasibility of developing a low-price sensing system for predicting the hardy kiwis sugar content based on VNIRS and subsequent spectral analysis. A total of 495 hardy kiwi samples were collected from three farms in Muju, Jeollabukdo, South Korea. The samples were scanned with a spectrophotometer in the range of 730-2300 nm with 1 nm spectral sampling interval. The measured data were arbitrarily separated into calibration and validation data for sugar content prediction. Partial least squares (PLS) regression was performed using various combinations of pre-processing methods. When the latent variable (LV) was 8 with the pre-processing combination of standard normal variate (SNV) and orthogonal signal correction (OSC), the highest R2 values of calibration and validation were 0.78 and 0.84, respectively. The possibility of predicting the sugar content of hardy kiwi was also examined at spectral sampling intervals of 6 and 10 nm in the narrower spectral range from 730 nm to 1200 nm for a low-price optical sensing system. The prediction performance had promising results with R2 values of 0.84 and 0.80 for 6 and 10 nm, respectively. Future studies will aim to develop a low-price optical sensing system with a combination of optical components such as photodiodes, light-emitting diodes (LEDs) and/or lamps, and to locate a more reliable prediction model by including meteorological data, soil data, and different varieties of hardy kiwi plants.

Bio-optical properties of the Yellow Sea

  • Yoo, Sin-Jae;Park, Ji-Soo
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 1998년도 Proceedings of International Symposium on Remote Sensing
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    • pp.393-398
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    • 1998
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에너지 효용 증대를 위한 바이오 센서 개발에 관한 연구 (A Study on Development of Ubiquitous Bio-Sensors for Increasing Energy Efficiency)

  • 한승훈
    • 한국태양에너지학회 논문집
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    • 제28권6호
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    • pp.58-63
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    • 2008
  • It is essential to investigate the structure and the main characteristic of Home USN (Ubiquitous Sensor Network) technologies in built ubiquitous environment while designing bio-sensors. For this study, Thermistor elements and Thermopile black body have been selected to implement ubiquitous technologies for bio-sensors and wireless network such as WiBro has been used to transfer sensing data to the BSN (Bio-Sensor Network) gateway. It is certain that efficiency of ubiquitous space design is improved if main components of each specific sensor network are analyzed precisely in digital way and corresponding communication modules are prepared accordingly. Ubiquitous technology, in conclusion, has to be applied not only with systematical mechanism or electronic setting but in human-centered atmosphere as well, keeping with deep consideration for bio-housing service factors in eco-friendly surrounding.

BioPebble: 개인화된 해석을 지원하는 돌 타입 휴대용 생체신호 측정센서 (BioPebble: Stone-type physiological sensing device Supporting personalized physiological signal analysis)

  • 최아영;박고은;우운택
    • 한국HCI학회:학술대회논문집
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    • 한국HCI학회 2008년도 학술대회 1부
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    • pp.13-18
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    • 2008
  • 최근 건강 관리에 대한 관심이 증가하면서 착용형 생체 신호 센서, 재택형 무구속계측 센서에 관한 연구가 활발하게 진행되고 있다. 그러나, 측정 기술의 발전과 달리 측정결과를 제공하는 단계에서는 심장 박동수, 체온 등의 값을 단일된 임계치 기반으로 판단하며, 분석된 결과가 사용자에게 어떤 의미를 주는지에 대한 해석은 제공하지 않고 있다. 따라서 본 논문에서는 사용하기 편한 돌 형태의 휴대형 생체신호 측정센서를 기반으로 사용자 별로 적합한 생체신호 해석 방법을 제안한다. 개인화된 생체 신호 해석을 위해 1 주일간 사용자의 시간대별 데이터를 획득하고 사용자 별 특성에 따라 모델링을 한 후, 모델에 기반하여 사용자에게 맞는 생체 신호 범위를 정하고 이를 판단하는 근거로 활용한다, 센서는 기존의 착용형 생체 신호 센서 및 이를 이용한 응용에 폭넓게 사용될 수 있다.

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Triboelectrification based Multifunctional Tactile Sensors

  • Park, Hyosik;Kim, Jeongeun;Lee, Ju-Hyuck
    • 센서학회지
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    • 제31권3호
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    • pp.139-144
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    • 2022
  • Advanced tactile sensors are receiving significant attention in various industries such as extended reality, electronic skin, organic user interfaces, and robotics. The capabilities of advanced tactile sensors require a variety of functions, including position sensing, pressure sensing, and material recognition. Moreover, they should comsume less power and be bio-friendly with human contact. Recently, a tactile sensor based on the triboelectrification effect was developed. Triboelectric tactile sensors have the advantages of wide material availability, simple structure, and low manufacturing cost. Because they generate electricity by contact, they have low power consumption compared to conventional tactile sensors such as capacitive and piezoresistive. Furthermore, they have the ability to recognize the contact material as well as execute position and pressure sensing functions using the triboelectrification effect. The aim of this study is to introduce the progress of research on triboelectrification-based tactile sensors with various functions such as position sensing, pressure sensing and contact material recognition.