• Journal of the Microelectronics and Packaging Society
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• v.23 no.4
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• pp.57-61
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• 2016

Thick film sealing glass paste is required for cell packaging of NaS based battery for energy storage system, to join the beta-alumina electrolyte tube and the alpha-alumina battery cell cap components. This paper presents the effect of the particle sizes of seal glass powder and the sealing temperatures on the microstructure of the glass sealants was investigated. It was found that the larger in the particle size of seal glass powder, the smaller the pore volume and the number of pores in a unit area. Also, the number of pores decreased with increasing the sealing temperatures while the pore size was increased. This result enables the control of porosity, pore distribution and number of pores in a microstructure of glass sealing component by proper selection of glass powders particle size and sealing temperature.

• Journal of Convergence for Information Technology
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• v.10 no.8
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• pp.179-186
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• 2020

The purpose of this study was to investigate the effects on the bio signal of brain waves and pulse waves using acupressure thermal bed combined with acupressure and thermal therapy. Forty healthy adults were divided into 20 experimental groups using combinatorial stimulation beds and 20 non-irritating controls. As a result of the experiment, the EEG was significantly increased in the delta wave and theta wave in the experimental group, and the alpha wave and beta wave decreased significantly. The pulse wave increased the parasympathetic activity index in the experimental group and the heart rate decreased. There was no difference in the control group. This change in EEG can be seen as a combination stimulation bed having a sleep-inducing effect, and a change in pulse wave can seen as having a relaxing effect. This study is expected to be used as basic data for the development of various combination stimulators and functional bed products.

• The Korean Journal of Food And Nutrition
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• v.32 no.5
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• pp.408-416
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• 2019

This study investigated the anti-inflammatory effects of processed (Beopje) curly dock (Rumex crispus L.) in LPS (lipopolysaccharide)-stimulated murine RAW 264.7 cells. The experimental group was classified into five groups : LPS no treatment, CD (curly dock), CD-B (CD processed through Beopje), LPS, LPS+CD-B (LPS+CD processed through Beopje) and LPS+CD (LPS+CD). Treatment of the Raw 264.7 cell lines using LPS led to a significant increase in NO production, pro-inflammatory cytokines ($TNF-{\alpha}$, IL-6 and $IL-1{\beta}$), and inflammation related genes (COX-2 and iNOS). Investigation of the inhibitory effects of CD and processed CD on NO production and expression of iNOS and COX-2 was done in LPS-induced RAW 264.7 cells. There was significant inhibition of NO production by LPS+CD and LPS+CD-B in a dose-dependent manner (p<0.05). Particularly, LPS+CD-B exhibited reduced mRNA expression of iNOS and COX-2 and NO production as compared to LPS+CD in Raw 264.7 cell lines (p<0.05). These results may explain some known biological activities of curly dock including the anti-inflammatory effects. CD-B in particular exhibited the highest anti-inflammatory effects of inhibiting production of NO, through the regulation of inflammatory related genes and pro-inflammatory cytokines. These results of Beopje processing might help decrease the anti-biological effects and increase several active substances of curly dock.

• Journal of Convergence for Information Technology
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• v.9 no.10
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• pp.39-47
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• 2019

The purpose of this study is to provide basic data on the development of disaster nursing training program by analyzing disaster nursing knowledge, preparedness, core competencies of disaster nursing in hospital nurses. This study was conducted in 177 nurses in an university hospital in C area. The results of the study showed that the significant positive correlation(r=.787, p<.001) between core competencies of disaster nursing and disaster preparedness, and disaster preparedness(${\beta}=.791$) was the factor affecting the core competencies of disaster nursing, and explanatory power was 62.3%. In this way, it is necessary to develop and education program of disaster nursing education in the form of simulation training in order to improve the core competencies of disaster nursing in hospital nurses.

• Journal of Convergence Korean Medicine
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• v.4 no.1
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• pp.19-27
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• 2022

Objectives: TSepsis and subsequent acute lung injury (ALI) is a critical state of health caused by infection or endotoxins. This study was conducted to evaluate the effect of Water Extract of Aconiti Lateralis Preparata Radix (AR) on lipopolysaccharide (LPS)-induced sepsis in C57BL/6 mice. Methods: Male C57BL/6 mice were intraperitoneally injected with LPS to induce sepsis and ALI. AR was orally fed twice at 30 min and 180 min after LPS injection. At 24 h post injection, mice were sacrificed, bronchoalveolar lavage fluid (BALF) and blood was collected, and lung tissue was harvested. Hematoxylin and eosin staining was performed in lung tissues, wet/dry ratio of the lung tissue was measured, and the serum cytokine and chemokine levels were analyzed. Results: AR revoked the LPS-induced pathological changes in lung tissues, such as abnormal histological structures, immune cell infiltration and lung edema. Also, AR suppressed the neutrophil infiltration into the lung which was greatly increased by LPS injection based on the cell content of collected BALF. Serum cytokines and chemokines were measured, and AR reversed the LPS-induced increase of cytokines such as interleukin 1 beta, interleukin 6, tumor necrosis factor alpha and chemokines including C-X-C motif chemokine ligand 1 and 2. Conclusion: TAR showed a protective effect in the pathological progress of LPS-induced ALI. Especially, AR suppressed lung edema and infiltration of neutrophils by inhibiting cytokine and chemokine expressions. Such results demonstrate the potential of AR as a therapeutic agent for sepsis and sepsis-induced ALI.

• The Journal of the Petrological Society of Korea
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• v.26 no.1
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• pp.45-54
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• 2017

The characteristics of the rock cleavage in Jurassic Geochang granite were analysed using the distribution of microcrack lengths and spacings. The phases of distribution of the above lengths and spacings were derived from the enlarged photomicrographs(${\times}6.7$) of the thin section. First, the length and spacing-cumulative diagrams for the six directions of rock cleavages were arranged in increasing order($H2{\rightarrow}R1$) on the density(${\rho}$) of microcrack length. The various parameters were extracted through the combination of the above two types of diagrams. The discrimination factors representing the three quarrying planes and three rock cleavages were acquired through the mutual contrast between the values of parameters. The analysis results of the research are summarized as follows. The evaluation for the six directions of rock cleavages was performed using the parameters such as (1) intersection angle(${\alpha}-{\beta}$) and (2) exponent difference(${\lambda}_S-{\lambda}_L$) between two exponential straight lines related to spacing(${\alpha}$, ${\lambda}_S$) and length(${\beta}$, ${\lambda}_L$). The values of parameters(1 and 2) are in order of H(hardway, (H1 + H2)/2) < G(grain, (G1 + G2)/2) < R(rift, (R1 + R2)/2). On the contrary, the values of the above two parameters for three planes are in order of R < G < H. Meanwhile, the direction of convergence between two exponential straight lines was derived. The above direction is compliant to arrangement of the line os' centering around the line ol. The above two lines converge in the direction of the Y-axis when the line ol and line os' occupy the upper region on the left and the lower region on the right, respectively(R-type). On the contrary, the above two lines converge in the direction of the X-axis when the order of arrangement between line ol and line os' is reversed(H-type). Especially, the positive(+) or negative(-) value of intersection angle(${\alpha}-{\beta}$) is determined by the arrangement of two vertical lines. This type of correlation analysis is useful for evaluating the relative strength of rock cleavage and discriminating three quarrying planes.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.1
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• pp.57-67
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• 2019

Particulate matters with a diameter of < $10{\mu}m$ (PM10) exert oxidative stress and inflammatory events in various organs. The purpose of this study was to examine the molecular mechanism of reactive oxygen species (ROS) production induced by PM10 in the human epidermal keratinocytes (HEKs). When cultured HEKs were exposed to PM10, ROS production was induced and it was inhibited by apocynin, an antioxidant. The mRNA expression of NADPH oxidase (NOX) family was analyzed in order to examine their role in PM10-induced ROS production. PM10 increased the mRNA expression of NOX1, NOX2, dual oxidase (DUOX) 1 and DUOX2. HEKs expressed DUOX1 and DUOX2 at higher levels compared to other NOXs. The mRNA expression of dual oxidase maturation factors, DUOXA1 and DUOXA2, was also increased by PM10. We examined whether these calcium-dependent enzymes, DUOX1 and DUOX2, mediate the PM10-induced ROS production. A selective intracellular calcium chelator, BAPTA-AM, attenuated ROS production induced by PM10 or calcium ionophore A23187. The small intereference RNA (siRNA)-mediated down-regulation of DUOX2, but not DUOX1, attenuated the ROS production induced by PM10. PM10 increased the expression of inflammatory cytokines such as interleukin $(IL)-1{\beta}$, IL-6, IL-8 and interferon $(IFN)-{\gamma}$. SiRNA-mediated down-regulation of DUOX2 suppressed the PM10-induced expression of $IFN-{\gamma}$ but not other cytokines. This study suggests that DUOX2 plays a crucial role in ROS production and inflammatory response in PM10-exposed keratinocytes.

• Molecules and Cells
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• v.38 no.9
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• pp.796-805
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• 2015

Gintonin is a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand. Oral administration of gintonin ameliorates learning and memory dysfunctions in Alzheimer's disease (AD) animal models. The brain cholinergic system plays a key role in cognitive functions. The brains of AD patients show a reduction in acetylcholine concentration caused by cholinergic system impairments. However, little is known about the role of LPA in the cholinergic system. In this study, we used gintonin to investigate the effect of LPA receptor activation on the cholinergic system in vitro and in vivo using wild-type and AD animal models. Gintonin induced $[Ca^{2+}]_i $ transient in cultured mouse hippocampal neural progenitor cells (NPCs). Gintonin-mediated $[Ca^{2+}]_i $ transients were linked to stimulation of acetylcholine release through LPA receptor activation. Oral administration of gintonin-enriched fraction (25, 50, or 100 mg/kg, 3 weeks) significantly attenuated scopolamine-induced memory impairment. Oral administration of gintonin (25 or 50 mg/kg, 1 2 weeks) also significantly attenuated amyloid-${\beta}$ protein ($A{\beta}$)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (ChAT) activity and immunoreactivity, and increased acetylcholine esterase (AChE) activity. In a transgenic AD mouse model, long-term oral administration of gintonin (25 or 50 mg/kg, 3 months) also attenuated AD-related cholinergic impairments. In this study, we showed that activation of G protein-coupled LPA receptors by gintonin is coupled to the regulation of cholinergic functions. Furthermore, this study showed that gintonin could be a novel agent for the restoration of cholinergic system damages due to $A{\beta}$ and could be utilized for AD prevention or therapy.

• The Journal of the Convergence on Culture Technology
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• v.4 no.2
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• pp.161-169
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• 2018

This study aimed to evaluate seaweed polysaccharide extracts as a cosmetic material. To assess anti-microbial efficacy, Staphylococcus aureus (S. aureus) was treated with seaweed polysaccharide extracts and zones of inhibition were measured. In addition, the anti-inflammatory effect was confirmed in RAW 264.7cells, and seaweed polysaccharide extracts was applied to the dorsal skin of Sprague-Dawley (SD) rats to evaluate single-dose toxicity. As a results, seaweed polysaccharide extracts did not exhibit cytotoxicity at concentrations up to $1,000{\mu}g/mL$ in skin fibroblasts. Furthermore, when S. aureus was treated with 1% seaweed polysaccharide extracts, clear zones of $1.52{\pm}0.34cm$ formed, confirming sufficient anti-microbial activity. When RAW 264.7 cells were treated with seaweed polysaccharide extracts extract, nitric oxide (NO) production decreased in a concentration-dependent manner and the production of inflammation-related cytokines, such as interleukin 1 beta ($IL1{\beta}$), tumor necrosis factor alpha ($TNF{\alpha}$), and prostaglandin E2(PGE2), decreased. When seaweed polysaccharide extracts extract was applied at various concentrations to rats, symptoms did not change for more than 14 d, and there was no change in body or organ weights. In conclusion we found that seaweed polysaccharide extracts is not cytotoxic and has anti-microbial and anti-inflammatory effects. Therefore, it is suitable for use as a cosmetic material.

• Journal of Digital Convergence
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• v.11 no.10
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• pp.557-569
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• 2013

This study was conducted to identify factors related to subjective happiness Index and by analyzing students, health behavior, smart phone addiction, suicidal Ideation, and in order to develop appropriate measure tp prevent suicide among university students. Methods: From November 19, 2012 until December 14, 2012, 300 college students from one of the iniversities located at K city were surveyed. Data were analyzed using with SPSS window 18.0. Results: The mean score for college students' subjective happiness Index was 4.58 on a scale of 7. There were significant differences on the Subjective happiness Index for the following areas: sex, parental survival & living and household monthly income. There was a negative correlation among the subjective happiness Index, smart phone addiction, suicidal Ideation. Conclusion: Results indicate that factors influencing Subjective happiness are smart phone addiction, suicidal ideation. We suggest that need to establish policies providing family support, smartphone addiction prevention program suicide prevention program to improve a level of happiness.