• Journal of Acupuncture Research
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• 제23권2호
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• pp.191-195
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• 2006

This article presents a case report of complex regional pain syndrome (CRPS) involving the ankle and foot; the bee-venom herbal acupuncture (BVH) was performed as part of a pain management program. An 46-year-old man presented with CRPS in the left lower extremity that was inadequately controlled with typical oral medication. Sympathetic block the extremity did not provide significant pain relief. However, BVH resulted in significant pain relief and improvement in patient's attitude. This case report showed that BVH may be efficacious in treating patients with CRPS. Further study is needed to determine the effects of BVH on symptoms related to CRPS.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.232-239
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• 2001

Objective & Method : To identify current state of bee venom therapy(BVT) research as a treatment of autoimmune diseases, we reviewed the PubMed electronic database. 9 articles with clinical implications were discussed. Results : BVT is reported as effective in the treatment of such autoimmune related diseases as rheumatoid arthritis and insulin dependent diabetes mellitus in animal experiment, The lack of evidence on BVT as a treatment of multiple sclerosis deters us from reaching any determination. There also lacks firm evidences of immune response regulative or anti inflammatory mechanism of BVT. No clinicla trial was found. Conculsion : This review raises the urgent need of study to provide scientific and clinical evidences.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.197-204
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• 2008

Objectives : This is a clinical report about the 47-year-old female patient with Trigeminal Neuralgia(TN) treated by oriental medicine treatment including Bee Venom Pharmacopuncture therapy(BVP), without any western medical treatment. Methods : The patient was treated by acupuncture, herb medication, and BVP. The improvement of the patient was judged by Visual Analog Scale(VAS). Results : The pain was gradually reduced and VAS became 0 after 8 days of treatment. Since then the pain didn't reappeared for 6 months. Conclusions : Oriental medicine treatment including BVP was very effective to improve the TN patient's symptoms. It is necessary to have more observation and many cases of patients with TN.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.117-117
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• 2003

Bee Venom (BV) has been treated in inflammatory diseases such as rheumatoid arthritis (RA). Bee venom contains several biologically active non-peptide substances as well as two major known peptides; the hemolytic peptide melittin (50%) and the neurotoxic peptide apamin, and a number of minor peptides.(omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.93.1-93.1
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• 2003

Bee Venom (BV) has been treated in inflammatory diseases such as rheumatoid arthritis (RA). Bee venom contains several biologically active non-peptide substances as well as two major known peptides; the hemolytic peptide melittin (50%) and the neurotoxic peptide apamin, and a number of minor peptides. Previous our study showed that BV blocked LPS and SNP-induced production of NO and PG through inactivation of NF-kB which regulates expression of COX-2 and iNOS. (omitted)

• Journal of Acupuncture Research
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• 제23권4호
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• pp.69-80
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• 2006

Objectives : The occurrence of shoulder pain after attack of stroke varies from 15% to about 80% in patients. Hemiplegic shoulder pain has been shown to affect stroke outcome in a negative way that it interferes with recovery after a stroke. These following processes have been all postulated as causes of a shoulder pain: glenohumeral subluxation, spasticity, impingement, soft tissue trauma, glenohumeral capsulitis, shoulder hand syndrome. And stroke patients may suffer from pain caused by stroke itself(central post-stroke pain). The aim of this study is to investigate the effectiveness of Bee venom therapy for shoulder pain in stroke patients. Methods : To evaluate the effectiveness of Bee Venom Acupuncture Therapy, 40 patients were allocated into control and treatment group. They were monitored for 3 weeks and followed up with VAS score(with the interval of Initial(YAS1)), 1 week later(VAS2), 2 weeks later(VAS3), 3 weeks later(VAS4), Motor Grade and Passive ROM. Results : VAS score decrease in treatment group compared to control group. Bee Venom Acupuncture Therapy seems to decrease hemiplegic shoulder pain and this effect was statistically significant after 3 weeks. Therefore this therapy could be recommended for the treatment of patients with shoulder pain after stroke and further extensive clinical studies are expected. Conclusion : We suggest that GDS oral administration and electro-acupuncture at $BL_{52}$ & $GB_{39}$ are available for prevention and curing about the postmenopausal osteoporosis.

• Journal of Acupuncture Research
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• 제34권1호
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• pp.31-38
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• 2017

Objectives : The purpose of this study was to analyze the components of the clinically used bee venom (BV) pharmacopuncture. Methods : Two kinds of bee venom pharmacopuncture (BV-I and II), three kinds of separate purification BV (SPBV) pharmacopuncture (SPBV-I, II, and III), and apitoxin were investigated in this study. We performed a component analysis of melittin, apamin, and phospholipase $A_2$ using high-performance liquid chromatography (HPLC). Results :1. BV-I contained approximately 40% more melittin than BV-II did. 2. In the three separate purification BV pharmacopuncture, SPBV-I, SPBV-II, and SPBV-III, phospholipase $A_2$ content decreased remarkably. 3. The melittin content in SPBV-I increased by 5% compared to that in BV-I. 4. The amount of melittin in apitoxin was similar to that in SPBV-I. Conclusion : The compositions of the BV pharmacopuncture and separate purification BV pharmacopuncture changed depending on the collection method and concentration. Therefore, it is necessary to choose the most suitable BV for each specific medical treatment target. Furthermore, research into the composition of BV may be needed for its safe and effective use.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.80-88
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• 2003

Objective : This study was performed in order to evaluate the effect of bee venom therapy on rheumatoid arthritis by randomized controlled double blind method. Methods : RA patients were recruited and divided into an experiment group and a control group by random selection. As a double blind test, the experiment group was treated with bee venom injection on acupoints, and the control group was treated with normal saline injection on acupoints twice a week for 8 weeks. Tender joint count, swollen joint count, morning stiffness, pain, health assessment questionnaire, ESR, and CRP were estimated and analyzed at baseline, and at 1 month and 2 months after bee venom therapy. Results : Compared to the control group, the experiment group showed significant decrease in tender joint count, swollen joint count, morning stiffness, and health assessment questionnaire after 2 months. Pain, ESR and CRP showed significant decrease in the experiment group after 1 & 2 months. Conclusions : These results suggests that bee venom therapy could be an effective method in the treatment of patients with rheumatoid arthritis.

• Journal of Acupuncture Research
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• 제28권4호
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• pp.85-92
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• 2011

Objectives : This study was designed to compare the effect between method of regulating ascending kidney water and descending heart fire and sweet bee venom pharmacopuncture on peripheral facial paralysis. Methods : We investigated 30 cases of patient with peripheral facial paralysis who visited at Dept. of Acupuncture & Moxibustion, of Oriental Medicine Dong-eui University from November 29, 2010 to May 15, 2011. Subjects were divided randomly into two groups, group A and group B. We applied method of regulating ascending kidney water and descending heart fire twice or three times a week for group A and sweet bee venom pharmacopuncture with same cycle for group B. We measured the effect of treatment to each group five times by using Yanagihara's unweighed grading system. at first examination, after 1 week, 2 weeks, 3 weeks, and 4 weeks. Results : Both groups showed significant improvement in Yanagihara's scores. And group A was improved better than group B for two weeks from the first examination significantly. But after one week from then, the Yanagihara's scores of group B were higher than those of group A significantly. There were no significant differences during other period. Conclusions : Method of regulating ascending kidney water and descending heart fire is more effective than sweet bee venom pharmacopuncture on peripheral facial paralysis during acute period. And after acute period, sweet bee venom pharmacopuncture is more effective than method of regulating ascending kidney water and descending heart fire.

• Journal of Acupuncture Research
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• 제21권5호
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• pp.13-25
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• 2004

Objective : Herniation of Nucleus Pulpous(HNP) of Lumbar is the most important reason that causes low back pain. The aim of this study is to investigate the effectiveness of Bee-venom acua-acupuncture therapy for protrusion disc patients. Methods : To evaluate the effectiveness of Bee-Venom Acupuncture Therapy, 20 patients were treated by bee-venom acua-acupuncture therapy. To estimate the efficacy of treatment, we used Quardruple Visual Analog Scale(QVAS). Results : 1. As a objectivity treatment record, they test treatment record good 60%, fair 25%, excellent 15%. 2. After bee-venom therapy, pain rate changed from 8.25 to 2.15. 3. By the results which puts out the statistics in sex, a pain rate of male changed from 8.75 to 2.50, a pain rate of female 7.92 to 1.92. Intentional difference is none as a therapy. By the results which puts out the statistics in age, after forties changed from 7.78 to 2.22 and before forties changed from 7.90 to 1.92. By the results which puts out the statistics in disc herniation, pain rate of central type changed from 8.29 to 2.29, pain rate of left type changed from 8.20 to 1.40, pain rate of Right type changed from 8.00 to 4.00.