Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.93.1-93.1
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- 2003
Anti-inflammatory mechanism of melittin, a component of bee venom in Raw 264.7 cells and Synoviocyte
- Park, Hye-Ji (College of Pharmacy, Chungbuk National University) ;
- Kim, Kee-Hyun (College of Oriental Medicine, Kyungwon University) ;
- Lee, Chung-Ou (KRIB) ;
- Lee, Sun-Young (KRIB) ;
- Lee, Seung-Ho (KRIB) ;
- Son, Dong-Ju (KRIB) ;
- Yun, Yeo-Pyo (KRIB) ;
- Oh, Ki-Wan (KRIB) ;
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Oh, Goo-Taeg
(KRIBB)
- Published : 2003.10.01
Abstract
Bee Venom (BV) has been treated in inflammatory diseases such as rheumatoid arthritis (RA). Bee venom contains several biologically active non-peptide substances as well as two major known peptides; the hemolytic peptide melittin (50%) and the neurotoxic peptide apamin, and a number of minor peptides. Previous our study showed that BV blocked LPS and SNP-induced production of NO and PG through inactivation of NF-kB which regulates expression of COX-2 and iNOS. (omitted)
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