Bee Venom Therapy on Autoimmune Disease Reviewed in PubMed Database

자가면역질환의 봉독요법에 대한 Pubmed 검색을 통한 고찰

  • Yi Woong-Kyung (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee Yun-Ho (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
  • Koh Hyung-Kyun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University)
  • 이웅경 (경희대학교 한의과대학 침구학교실) ;
  • 이윤호 (경희대학교 한의과대학 침구학교실) ;
  • 고형균 (경희대학교 한의과대학 침구학교실)
  • Published : 2001.12.20

Abstract

Objective & Method : To identify current state of bee venom therapy(BVT) research as a treatment of autoimmune diseases, we reviewed the PubMed electronic database. 9 articles with clinical implications were discussed. Results : BVT is reported as effective in the treatment of such autoimmune related diseases as rheumatoid arthritis and insulin dependent diabetes mellitus in animal experiment, The lack of evidence on BVT as a treatment of multiple sclerosis deters us from reaching any determination. There also lacks firm evidences of immune response regulative or anti inflammatory mechanism of BVT. No clinicla trial was found. Conculsion : This review raises the urgent need of study to provide scientific and clinical evidences.

Keywords

References

  1. Bee Product The Role of Hymenopterous Venom in Nature Zlotkin, E.;Mizrahi, A;Lensky, Y.
  2. Bee Venom Simics, M.
  3. 대한침구학회지 v.15 no.1 봉독요법에 대한 한의학 최초의 문헌기록: 마왕퇴의서의 봉독요법 2례 인창식;고형균
  4. Immunobiology Janeway, C.A.;Travers, P.;Walport, M.;Capra, J.D.
  5. 대한한의학회지 v.21 no.3 봉독요법-임상활용방법을 중심으로 이재동
  6. R.N. v.61 no.8 A therapeutic bee sting? Cerrato, P.L.
  7. Ann. Rheum. Dis. v.32 Effect of bee venom on experimental arthritis Zurier, R.B.;Mitnick, H.;Bloomgarden, D.;Weissmann, G.
  8. Agents and Actions v.9 Anti-arthritic effect of bee venom Chang, Y.H.;Bliven, M.L.
  9. 대한침구학회지 v.18 no.5 PubMed 검색을 이용한 관절염 관련 봉독 연구에 대한 고찰 김태우;고형균;박동석;이재동
  10. 대한침구학회지 v.17 no.4 암관련 봉독 연구에 대한 고찰-PubMed를 이용한 Medline 검색 윤형석;이재동;이윤호
  11. 대한약침학회지 v.3 no.1 통증관련 봉독 연구에 대한 고찰 윤형석;김용석;이재동
  12. 경희한의대논문집 v.20 no.1 MEDLINE에서 검색한 봉독과 면역에 대한고찰 이홍석;고형균;김용석;박영배;김창환;강성길
  13. NCBI
  14. J. Vet. Med. Sci. v.63 no.3 Bee venom pretreatment has both an antinociceptive and antiinflammatory effect Lee, J.H.;Kwon, Y.B.;Han, H.J.;Mar, W.C.;Lee, H.J.;Yang, I.S.;Beitz, A.J.;Kang, S.K.
  15. Pain v.90 no.3 Bee venom injection into an acupuncture point reduces arthritis associated edema Kwon, Y.B.;Lee, J.D.;Lee, H.J.;Han, H.J.;Mar, W.C.;Kang, S.K.;Beitz, A.J.;Lee, J.H.
  16. Health Technol. Assess. v.4 no.27 Treatment for fatigue in multiple sclerosis: a rapid and systemic review Branas, P.;Jordan, R.;Fry-Smith, A.;Burls, A.;Hyde, C.
  17. J. Korean Med. Sci. v.14 no.6 Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice Kim, J.Y.;Cho, Y.W.;Jang, E.C.;Park, S.Y.;Kim, E.J.;Lee, S.K.
  18. Rheum. Dis. Clin. North Am. v.25 no.4 Venoms, copper and zinc in the treatment of arthritis Caldwell, J.R.
  19. J. Am. Vet. Med. Assoc. v.214 no.7 Bee sting envenomation resulting in secondary immune-mediated hemolytic anemia in two dogs Noble, S.J.;Armstrong, P.J.
  20. Biochem. Biophys. Res. Commun. v.238 no.2 Mellitin binds to secretory phospholipase A2 and inhibits its enzymatic activity Saini, S.S.;Peterson, J.W.;Chopra, A.K.
  21. Immunology v.71 no.3 Human rheumatoid synovial cell stimulation by the membrane attack complex and other pore-forming toxins in vitro: the role of calcium in cell activation Daniels, R.H.;Williams, B.D.;Morgan, B.P.
  22. Agents Actions v.27 no.3;4 Rheumatoid arthritis synovial fluid phospholipase A2 activating protein(PLAP) stimulates human neutrophil degranulation and superoxide ion production Bomalaski, J.S.;Baker, D.;Resurreccion, N.V.;Clark, M.A.
  23. Int. Arch. Allergy Immunol. v.117 no.1 Determinants and mechanisms of human immune response to bee venom phospholipase A2 Blaser, K.;Carballido, J.;Faith, A.;Crameri, R.;Akdis, C.