• Journal of Acupuncture Research
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• v.28 no.4
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• pp.137-141
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• 2011

Objectives : To report the patient in pregnancy with external epicondylitis, who improved by acupuncture and bee venom pharmacopuncture therapy. Methods : The patient was treated by acupuncture and bee venom pharmacopuncture therapy on external epicondylitis. The improvement of the symptom was evaluated by visual analog scale(VAS) and grip strength. Results and Conclusions : After treatment, VAS and grip strength were significantly improved. In this case, we found that the acupuncture and bee venom pharmacopuncture therapy is effective for external epicondylitis.

• Journal of Acupuncture Research
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• v.22 no.4
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• pp.179-188
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• 2005

Objectives : This study is designed to observe anaphylatic reaction In two patients, who visited Dong-Eui University Oriental Medicine Center for Bee-Venom Acupuncture. Methods : Anaphylaxis is a clinical syndrome cheracterized by the acute system reaction of multiple organ systems to an IgE-mediated immunologic mediator release in previously sensitized individuals. Anaphylatic reaction of two patients treated by Bee-Venom Acupuncture were observed in order to analysis the clinical form. Results & Conclusion : STZ One case of Anaphylatic reaction was expressed clinically hypotension drowsy mentality, dizziness muscle contraction and so on. The other case was expressed ulticaria, itching sensation, nausea and erythema. Especially ulticaria erythema are end points of increased vascular permeability and vasodilatation at the extreme of the clinical spectrum.

• Journal of Pharmacopuncture
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• v.8 no.3
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• pp.129-135
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• 2005

Objective : This study was designed to investigate the effect of bee venom and Scolopendrae Corpus herbal acupuncture on the feeling of cold on legs. Methods : The patient was managed by bee venom and Scolopendrae Corpus herbal acupuncture, body acupuncture and herbal medicine. The following points were selected : BL40, BL57, BL60; SP6. After bee venom and Scolopendrae Corpus herbal acupuncture treatment, body acupuncture was performed at the same points. We evaluated the patient through Visual Analogue Scale(VAS) and Digital Infrared Thermal Imaging(D.I.T.I). Results : After 12 times of treatment, the patient showed that clinical symptoms was decreased, VAS changed from 10 to 3 and there was also improvement change on D.I.T.I.. Conclusions : According to the results, bee venom and Scolopendrae Corpus herbal acupuncture may have the effects on the feeling of cold on legs. But further studies and required to prove the effects of this methods.

• Journal of Pharmacopuncture
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• v.6 no.2
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• pp.77-90
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• 2003

The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide(LPS), sodium nitroprusside(SNP), hydrogen peroxide($H_2O_2$)-induced expressions of cyclooxygenase-2(COX-2), p38, jun N-terminal Kinase(JNK) and extra-signal response kinase(ERK) in RAW 264.7 cells, a murine macrophage cell line. Method : The expressions of COX-2, p38, JNK and ERK were determined by western blotting with corresponding antibodies. Results : 1. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly LPS and SNP-induced expression of COX-2 compared with control, respectively. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited insignificantly $H_2O_2$-induced expression of COX-2 compared with control, respectively. 2. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly LPS, SNP and $H_2O_2$-induced expression of p38 compared with control, respectively. 3. The 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly SNP-induced expression of JNK compared with control, respectively. All of bee venom inhibited insignificantly LPS and $H_2O_2$-induced expression of JNK compared with control, respectively. 4. The $5\;{\mu}g/ml$ of bee venom inhibited significantly SNP-induced expression of ERK, the $0.5\;{\mu}g/ml$ of bee venom increased significantly $H_2O_2$-induced expression of ERK compared with control. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited insignificantly LPS-induced expression of ERK compared with control, respectively.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.37-47
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• 2011

Objective : The purpose of this study is to evaluate the effect of sweet bee venom pharmacopuncture on the post-stroke hemiplegic shoulder pain. Methods : 40 patients with post-stroke hemiplegic shoulder pain were randomly divided into 2 groups : study group(sweet bee venom pharmacopuncture treatment group, n=21) and Control group(normal saline treatment group, n=19). They were monitored for 4 weeks, followed up with visual analog scale(VAS), pain rating score(PRS), painless passive shoulder range of movement(PROM) and Fugl-Meyer Motor assessment(FMMA) at before treatment(T0), after 2 weeks(T2) and after 4 weeks(T4). Results : 1. Study group and control group showed pain decrease, but study group showed more significant effectiveness in VAS and PRS than control group. 2. Although there is no significant difference in PROM between study group and control group, both groups showed increase of PROM, and study group had some effectiveness on abduction and flexion as the treatment progresses. 3. There is no significant difference in FMMA between study group and control group. Conclusions : This study suggests that sweet bee venom pharmacopuncture has significant analgesic effect on the post-stroke hemiplegic shoulder pain. And it seems that sweet bee venom pharmacopuncture can be applicable to improve PROM in hemiplegia patients with stroke. Further studies based on larger population and long term follow-up are needed to confirm this suggestion.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.7 no.2
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• pp.75-81
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• 2012

Objectives : According to previous reports, heating-conduction acupuncture treatment is very effective for sprain and strain of ligament. But there was no report about pain aggravation by heating-conduction acupuncture and relief from bee venom injection. In this article, we report two cases of pain aggravation by heating-conduction acupuncture treatment and relief from bee venom injection. Methods : We used heating-conduction acupuncture treatment on possible sprain of sacroiliac ligament diagnosed by physical examination. Outcomes were measured by Visual Analogue Scale(VAS), Range of Motion(ROM) and Belt test, Goldthwait test. Results : The patient has shown an aggravation on pain and ROM. And after we use subcutaneous bee venom injection, pain has relieved and ROM improved. Belt test, Goldthwait test also changed from positive to negative. Conclusions : In this report, we assured the effect of Bee venom injection. Further well-designed, controlled studies and more cases are needed to differentiate the indication of heating-conduction acupuncture and bee venom injection.

• Journal of Acupuncture Research
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• v.21 no.4
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• pp.251-262
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• 2004

Objective: Ths research was to investigate the efficacy of bee venom theraphy on peripheral facial paralysis. Methods: Thirty patients were deyided into two groups with fifteen patients each. Group A and B were both treated with basic oriental medicine treatment, and also group A was treated with bee venom aqua-acupunture additionaly. The groups were evaluated by Yanagihara's unweighted grading system before treatment, and at every one week till four weeks after treatment. Results: The Yanagihara's scores of group B were higher than those of group A before treatment, after one week and two weeks, but not statistically significant. After three and four weeks, the Yanagihara's scores of group A were higher than those of group B, but not statistically significant. The improvement indexes of group A were higher than those of group B from the first week and statistically significant after three and four weeks. Conclusion: Combinding bee venom aqua-acupunture theraphy on peripheral facial paralysis was more efficacious than the only use of basic oriental medicine treatment.

• Journal of Pharmacopuncture
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• v.6 no.2
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• pp.119-125
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• 2003

Objective : The purpose of this study is to show that there was a significant result in prescribing Herb remedy and Korean-Bee-Venom acupuncture and acupuncture & moxibustion therapy to Urinary incontinence patients due to Neurologic Bladder caused by Cauda equina syndrome after having an vertebrae lumbale operation. Method : The methods used in this study was observe the patient's subjective improvement, valuation of the bladder function and the change of the sensibility drop when Herb remedy and Korean-Bee-Venom acupuncture and acupuncture was applied. Results : When acupuncture and Korean-Bee-Venom acupuncture was both applied the function of Bladder changed from score 10 to 0 and the Grade of Urinary Incontinence changed from Grade III to 0 also with the sensibility drop. Conclusion : The results show that when using Umnungchon(SP9), Yangnungchon (GB34), Taedon(LR1), Kokkol(CV2) there was an effect to some degree to the Urinary incontinence patients but when Korean-Bee-Venom was acupunctured to Kwanwon(CV4) and Kihae(CV6) the effect increased. Further studies and examples for evidence are required.

• Journal of Acupuncture Research
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• v.30 no.3
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• pp.117-124
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• 2013

Objectives : This study was designed to compare the effect of bee venom pharmacopuncture treatment and Hwangryun pharmacopuncture treatment in patients with cervical disc herniation Methods : This study was done on 48 cases of patients with cervical disc herniation diagnosed by MRI, symptoms and physical test who admitted in Bu-cheon Jaseng Hospital of Oriental Medicine from January 1st, 2012 to August 31th, 2012. We divided patients into two groups. Bee venom group was treated by bee venom pharmacopuncture treatment and Hwangryun group was treated by Hwangryun pharmacopuncture treatment. We measured the efficacy of treatment with numerical rating scale(NRS) and neck disability index(NDI). The evaluations performed at admission day and 14th day after admission. Results : In both bee venom group and Hwangryun group, NRS and NDI decreased significantly in statistics as treatment was performed. Though bee venom group showed a decreasing NRS and NDI score compared to Hwangryun group, there is no statistical significant difference between the result of both groups. Conclusions : The result of this study suggest that both bee venom pharmacopuncture treatment and Hwangryun pharmacopuncture treatment is effective in reducing pain for patients with cervical disc herniation. Further clinical research is needed to verify these results and findings.

• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.47-55
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• 2007

Objectives : To verify pain relief effects and allergy inhibitory action for the osteoarthritis of the knee joint in Sweet Bee Venom in which allergy causing enzyme is removed. Methods : We randomly allocated 36 participants to treatment group Sweet Bee Venom and Bee Venom. Outcomes on pain reduction were measured by 100mm VAS(Visual Analog Scale). And we recorded into details allergic responses during Pharmacopuncture treatment. Results : Whole body condition and pain rate through VAS measurement were improved significantly in 2 weeks. We could get difference in pain score of two Pharmacopuncture groups significantly in 2 weeks. BV group showed superior reduction in pain compared to the Sweet BV group. But we could not get difference in whole score of two pharmacopuncture groups significantly. On the other hand other allergic responses such as edema, itchiness, pain were significantly lower in the Sweet BV group.