• Psychiatry investigation
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• 제15권12호
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• pp.1115-1120
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• 2018

Objective The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) is a scale used to clinically evaluate disturbances in biological rhythm. In this study, we aimed to examine the reliability and validity of the Korean version of the BRIAN (K-BRIAN) in a Korean population. Methods A total of 181 participants, including 141 outpatients with bipolar disorder (BD; type I, 62; type II, 79) and 40 controls, were recruited. Construct validity was tested by comparing the mean K-BRIAN scores of the BD patients and control subjects. Concurrent validity was tested by evaluating the association between the K-BRIAN and the Morningness-Eveningness Questionnaire (MEQ). Results The mean K-BRIAN scores of the control subjects and patients with BD differed significantly (p<0.001). Particularly, the mean K-BRIAN score was considerably lower among control subjects (mean${\pm}$standard deviation=$35.00{\pm}8.88$) than among patients with BD type I ($41.19{\pm}12.10$) and type II ($50.18{\pm}13.73$). The Cronbach's alpha for the K-BRIAN was 0.914. The K-BRIAN was found to correlate with the MEQ (r=-0.45, p<0.001). Conclusion The findings affirm that the K-BRIAN has good construct validity and internal consistency. This suggests that the K-BRIAN can be used to assess biological rhythms in the Korean population, especially for patients with mood disorder.

• 한국축산식품학회지
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• 제42권1호
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• pp.46-60
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• 2022

In this study, angiotensin-I-converting enzyme inhibitory (ACEI) activity was evaluated in fermented goat milk fermented by lactic acid bacteria (LAB) from fermented foods and breast milk. Furthermore, the potential for ACEI peptides was identified in fermented goat milk with the highest ACEI activity. The proteolytic specificity of LAB was also evaluated. The 2% isolate was inoculated into reconstituted goat milk (11%, w/v), then incubated at 37℃ until pH 4.6 was reached. The supernatant produced by centrifugation was analyzed for ACEI activity and total peptide. Viable cell counts of LAB and titratable acidity were also evaluated after fermentation. Peptide identification was carried out using nano liquid chromatography mass spectrometry (LC-MS/MS), and potential as an ACEI peptide was carried out based on a literature review. The result revealed that ACEI activity was produced in all samples (20.44%-60.33%). Fermented goat milk of Lc. lactis ssp. lactis BD17 produced the highest ACEI activity (60.33%; IC₅₀ 0.297±0.10 mg/mL) after 48 h incubation, viable cell counts >8 Log CFU/mL, and peptide content of 4.037±0.27/mL. A total of 261 peptides were released, predominantly derived from casein (93%). The proteolytic specificity of Lc. lactis ssp. lactis BD17 through cleavage on the amino acid tyrosine, leucine, glutamic acid, and proline. A total of 21 peptides were identified as ACEI peptides. This study showed that one of the isolates from fermented food, namely Lc. lactis ssp. lactis BD17, has the potential as a starter culture for the production of fermented goat milk which has functional properties as a source of antihypertensive peptides.

• 한국전자파학회논문지
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• 제14권2호
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• pp.192-201
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• 2003

본 논문은 일반적인 평면형 마이크로스트립 패치 안테나의 크기를 줄이고자 1.575 GHz 대역에서 패치면을 입체적 구조인 단방향 선형 주름형, 사각 주름형 및 격자 요철형으로 제안, 설계하였다. 설계 결과, 단방향 선형 주름형은 평면형 구조에 비해 패치의 공진길이가 21.4 % 단축되었으며, -10 dB 반사손실 대역폭은 62 MHz로서 평면형의 39 MHz(2.5 %)에 비해 23 MHz(1.5 %) 증가하였다. 이득은 평면형의 6.7 dBd에 비해 0.9 dB 저하된 5.8 dBd를 나타내었다. 3 dB 빔폭은 공진길이 단축으로 인해 E-면에서만 18$^{\circ}$ 증가하였다. 사각 주름형의 경우, 패치의 가시적 크기는 평면형에 비해 21.6 %의 면적 축소효과를 얻었다. 격자 요철형의 경우, 먼저 선형편파에 대해 패치 면적은 평면형에 비해 43.3 %의 면적 축소효과를 얻었다. -10 dB 대역폭은 70 MHz (4.4 %)로 평면형에 비해 31 MHz(2%)증가하였다. 이득은 2.2 dBd로서 평면형에 비해 4.5 dB 저하되었고, -3 dB 빔폭은 E-면에서 22$^{\circ}$, H-면에서 13$^{\circ}$ 각각 증가하였다. 원형편파의 경우, 패치의 크기는 평면형에 비해 41 %가 축소되었고, 축비는 0.8 dB의 양호한 원편파 특성을 얻었으며, 2 dB 이내 축비 대역폭은 20 MHz(1.27 %)로 평면형의 10 MHz(0.63 %)에 비해 증가되었다. 이로써 본 논문에 제안된 안테나 구조가 소형화면에서 크게 효과가 있고, 대역폭 증가로 인해 다양한 서비스가 부가된 시스템에서의 활용 가능성이 확인되었다.

• 방송공학회논문지
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• 제15권2호
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• pp.280-289
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• 2010

H.264/AVC 표준은 영상간의 시간적 중복성(Temporal Redundancy)을 줄여 부호화 효율을 높이는 인터예측 방법을 사용한다. 하지만, 영상에서 발생할 수 있는 지역적인 밝기 변화를 효율적으로 부호화 할 수 없기 때문에, 화질의 열화가 발생하여 부호화 효율이 떨어지는 문제점을 지니고 있다. 본 논문은 지역적인 밝기 변화를 인접화소 및 움직임벡터 재조정을 이용하여 효율적으로 부호화 할 수 있는 방법을 제안한다. 제안하는 방법은, H.264/AVC와 비교하여 0.01 ~ 0.21dB의 BD-PSNR (Bj$\o$ntegaard Delta Peak Signal-to-noise) 이득을 얻을 수 있었다.

• 한국산업융합학회 논문집
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• 제21권6호
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• pp.429-437
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• 2018

The process gas piping of the offshore plant can cause a massive explosion if the gas leakage occurs during operation. For the purpose of precaution of gas leakage accident, an air pressure test is performed on the process equipment tests using a test pump as much as the power to the piping inner side, mix 99% nitrogen gas and 1% helium gas. The purpose of the air pressure test is to check the work conformity process by handling and regulation for initial piping process, assembly, installation of module, welding, center alignment of the pipes assembling flange gasket in an unrestrained free state. In this paper, the regulation of the problematic air pressure test was analyzed and the solution criteria were established. And leakage tests of existing equipment were performed applying these solution methods. As a result, it was confirmed that there was no problem.

• 약학회지
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• 제56권3호
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• pp.191-197
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• 2012

We previously reported that the novel isoflavone-free peptide mixture (black soybean peptide, BSP) had several beneficial effects like antiobesity and hypotriglyceridemic effect. However, there are no reports for BSP on anti-hypertensive activity. BSP induced heme oxygenase-1 (HO-1) in HUVECs, thus investigated the HO-1-induced activity in HUVECs and the anti-hypertensive effects in SHR animal model. BSP significantly induced HO-1 expression both at transcriptional and protein levels in a time- and dose-dependent manner as measured by RT-PCR and Western blot analysis, respectively. These inductions were abolished by pretreatment of N-acetyl-cystein (NAC, 1~10 mM), but not by employing Tempol, a superoxide dismutase (SOD) mimetic (1~5 mM). As expected, enzymatic activity (~2 fold) determined by bilirubin formation assay and cGMP concentration (~6 fold) were significantly increased in BSP-treated cells. Based on the numerous evidences on the beneficial effects of HO-1 and our results, we investigated in vivo effects of BSP on the antihypertensive activity. The administration of BSP (1% in drinking water) significantly decreased mean blood pressure (BP) (from $218.6{\pm}6.99$ to $190.0{\pm}3.42$ mm Hg, p<0.01). This result indicates that BSP is strong inducer of HO-1 expression, which may be triggered by oxidative stress, and has anti-hypertensive activity.

• 마이크로전자및패키징학회지
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• 제21권3호
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• pp.31-35
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• 2014

본 연구에서는 $TiO_2$ 나노입자를 LED패키지의 봉지재인 실리콘에 분산시키고, 이에 따른 굴절률, 투과율 및 광효율 변화를 평가하였다. $TiO_2$ 나노입자는 LED 봉지재의 굴절율을 증가시켜 LED 패키지의 광추출 효율을 향상시키기 위해 봉지재에 적용되었다. $TiO_2$는 수열합성법을 통해 합성되었고, 합성된 $TiO_2$ 입자에 긴 체인구조의 vinyl silane을 코팅하여 분산시켰다. 분산 처리를 실시한 후에는 대부분의 $TiO_2$ 나노입자가 10~40 nm 이하로 분산되었으나, 100 nm 이상의 긴 입자도 관찰되었다. 실리콘 봉지재에 $TiO_2$ 나노입자 양이 증가할수록 굴절율은 증가하였으나, 투과율은 감소하였다. $TiO_2$ 나노입자가 포함된 실리콘 봉지재로 LED 패키지를 제조하였고, $TiO_2$ 나노입자가 분산된 LED가 $TiO_2$ 나노입자가 없는 LED패키지에 비해 약 13% 이상 광효율이 향상되었다.

• 마이크로전자및패키징학회지
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• 제21권3호
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• pp.25-29
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• 2014

본 연구에서는 친환경적이고, 보관수명이 1년 이상이며, 부식특성이 좋은 플라즈마 유기막 표면처리에 대한 솔더링 특성을 기존 표면처리법인 OSP와 비교하였다. 플라즈마 표면처리는 할로겐계 전구체를 사용하여 CVD 방법으로 증착하였고, 증착두께는 20 nm이었다. 본 연구에서 사용된 솔더 조성은 Sn-3.0 wt%Ag-0.5 wt%Cu이었다. 염수분무시험에서 플라즈마 표면처리 유기막은 OSP보다 우수한 부식 저항성을 나타내었다. 멀티리플로우 조건에서 플라즈마 표면처리는 OSP보다 우수한 솔더 퍼짐성을 나타내었다. 솔더링 후 단면 미세조직을 분석한 결과, 플라즈마 표면처리와 OSP시편 모두 유사한 금속간화합물층 두께 및 형상을 갖고 있었다. 플라즈마 표면처리와 OSP 모두 유사한 접합강도를 가지고 있었다.

• 공업화학
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• 제21권5호
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• pp.542-547
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• 2010

디젤연료 및 바이오 디젤을 포함하는 디젤연료는 성분 내에 n-파라핀과 포화 지방산 메틸에스테르가 저온에서 결정화가 이루어져 연료의 저온 특성을 감소시키는 현상이 발생한다. 이러한 문제를 방지하기 위하여 많은 방법들이 알려져 있으며, 그 중에서 알킬 메타크릴레이트계 중합체가 저온유동특성을 향상시키는 첨가제로 많이 사용되고 있다. 본 연구에서는 LMA (lauryl methacrylate), SMA (stearyl methacrylate)를 각각 측쇄 구조가 다른 알킬 메타크릴레이트를 사용하여 70 : 30의 몰 비율로 라디칼 공중합체를 합성하였다. 합성된 공중합체의 구조는 $^1H$-NMR 및 FT-IR 스펙트럼으로 분석하였으며, GPC로 분자량을 측정하였다. 이 공중합체를 디젤연료에 500~1000 ppm, 바이오디젤을 5%, 20% 함유한 디젤연료(BD5 및 BD20)에 1000~10000 ppm을 각각 첨가하여 유동점, 구름점 및 저온필터막힘점 등의 저온유동특성을 조사하였다. 저온유동특성을 측정한 결과 BD5에서 SMA를 포함한 공중합체 $PSMAmR_2n$에서 첨가 전 대비 유동점 $15^{\circ}C$, 구름점 $6^{\circ}C$, 저온필터막힘점 $10^{\circ}C$ 강하되어 가장 우수한 결과를 나타냈다.

• Nutrition Research and Practice
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• 제16권3호
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• pp.314-329
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• 2022

BACKGROUND/OBJECTIVES: Oocyte lipid droplets play a crucial role in meiosis and embryo development. Biotin is associated with fatty acid synthesis and is the coenzyme for acetyl-CoA carboxylase (ACC). The effects of a biotin deficiency on the oocyte lipid metabolism remain unknown. This study examined the effects of a biotin deficiency and its replenishment on murine 1) oocyte lipid droplet levels, 2) ovary lipid metabolism, and 3) oocyte meiosis. MATERIALS/METHODS: Mice were divided into 3 groups: control, biotin deficient (BD), and recovery groups. The control and BD groups were fed a control diet or BD diet (0.004 or 0 g biotin/kg), respectively. The recovery group mice were fed a BD diet until day 21, and were then fed the control diet from days 22 to 64. This study then quantified the oocyte lipid droplet levels, assessed the oocyte mitochondrial function, and examined the ability of oocytes to undergo meiosis. Ovarian phosphorylated ACC (p-ACC), lipogenesis, β-oxidation, and ATP production-related genes were evaluated. RESULTS: The BD group showed a decrease in lipid droplets and mitochondrial membrane potential and increased p-ACC levels. In the recovery group, the hepatic biotin concentration, ovarian p-ACC levels, and mitochondrial membrane potential were restored to the control group levels. On the other hand, the quantity of lipid droplets in the recovery group was not restored to the control levels. Furthermore, the percentage of oocytes with meiotic abnormalities was higher in the recovery group than in the control group. CONCLUSIONS: A biotin deficiency reduced the oocyte lipid droplet levels by downregulating lipogenesis. The decreased lipid droplets and increased oocyte meiosis failure were not fully restored, even though the biotin nutrition status and gene expression of lipid metabolism was resumed. These results suggest that a biotin deficiency remains robust and can be long-lasting. Biotin might play a crucial role in maintaining the oocyte quality.