• Bioinformatics and Biosystems
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• 제1권1호
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• pp.38-45
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• 2006

본 논문은 베이지안 네트워크를 기반으로 대규모 유전자 상호작용 네트워크를 추론하기 위한 클라이언트-서버 시스템 구조를 제시한다. 유전체 수준(genome-wide)의 대규모 유전자 상호작용 네트워크를 베이지안 네트워크 형태로 추론하기 위해서는 병렬 서버를 이용하더라도 통상 수십시간이 소요된다. 따라서, 일반적인 대화형(interactive) 독자(standalone) 시스템 구조보다는 배치형(batch) 분산(distributed) 시스템 구조가 적합하다. 본 논문에서는 그와 같은 상황에 적합한 느슨한 연결의 (loosely-coupled) 클라이언트-서버 시스템을 구현할 결과를 기술한다. 유전자 상호작용 네트워크 추론은 크게 두 단계로 나누어진다. 첫째로, 생물주석정보(biological annotation)과 유전자 발현정보(expression data)를 사용하여, 전체 유전자 집단을 서로 중복이 가능한 모듈들로 나누며, 둘째로, 각각의 모듈들에 대해 독립적인 베이지안 학습을 수행하여 추론결과를 얻고, 각 모듈들이 공통으로 포함하는 유전자를 사용하여 각 모듈의 추론결과들을 하나로 통합한다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.202-205
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• 2005

Cell phenotypes are determined by the concerted activity of thousands of genes and their products. This activity is coordinated by a complex network that regulates the expression of genes. Understanding this organization is crucial to elucidate cellular activities, and many researches have tried to construct gene regulatory networks from mRNA expression data which are nowadays the most available and have a lot of information for cellular processes. Several computational tools, such as Boolean network, Qualitative network, Bayesian network, and so on, have been applied to infer these networks. Among them, Bayesian networks that we chose as the inference tool have been often used in this field recently due to their well-established theoretical foundation and statistical robustness. However, the relative insufficiency of experiments with respect to the number of genes leads to many false positive inferences. To alleviate this problem, we had developed the algorithm of MONET(MOdularized NETwork learning), which is a new method for inferring modularized gene networks by utilizing two complementary sources of information: biological annotations and gene expression. Afterward, we have packaged and improved MONET by combining dispersed functional blocks, extending species which can be inputted in this system, reducing the time complexities by improving algorithms, and simplifying input/output formats and parameters so that it can be utilized in actual fields. In this paper, we present the architecture of MONET system that we have improved.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.164-169
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• 2003

In this paper, we propose the integrated Bayesian network framework to reconstruct genetic regulatory networks from genome expression data. The proposed model overcomes the dimensionality problem of multivariate analysis by building coherent sub-networks from confined gene clusters and combining these networks via intermediary points. Gene Shaving algorithm is used to cluster genes that share a common function or co-regulation. Retrieved clusters incorporate prior biological knowledge such as Gene Ontology, pathway, and protein protein interaction information for extracting other related genes. With these extended gene list, system builds genetic sub-networks using Bayesian network with MDL score and Sparse Candidate algorithm. Identifying functional modules of genes is done by not only microarray data itself but also well-proved biological knowledge. This integrated approach can improve there liability of a network in that false relations due to the lack of data can be reduced. Another advantage is the decreased computational complexity by constrained gene sets. To evaluate the proposed system, S. Cerevisiae cell cycle data [1] is applied. The result analysis presents new hypotheses about novel genetic interactions as well as typical relationships known by previous researches [2].

• 한국지능시스템학회:학술대회논문집
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• 한국지능시스템학회 2008년도 춘계학술대회 학술발표회 논문집
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• pp.151-154
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• 2008

본 논문은 Bayesian Networks를 이용해서 EEG 신호를 분석해서 사람의 감정을 분석하는 방법을 제안하였다. 현제 연구자들은 Electroencephalogram(EEG) 신호를 기반으로 사람의 두뇌와 컴퓨터의 인터페이스에 관한 연구를 하고 있다. 기존에는 간질이나 발작 등을 의학 분야와 사람의 정서에 따라 뇌파분석을 하는 심리학의 영역에서 연구가 되어져 왔다. 최근에는 사람의 두뇌와 컴퓨터 간의 인터페이스를 통한 여러 가지 공학적인 접근이 이루어지고 있다. 본 논문에서는 사람의 감정에 따라 Brain-Computer Interface (BCI)를 통해서 EEG 신호를 분석하고 잡음을 제거해서 보다 정확한 신호를 추출한 다음 각각의 주파수 영역으로 분류를 하였다. 분류된 값들은 Bayesian Networks를 이용해서 피 실험자가 어떠한 감정을 나타내는지 확률 값으로 나타낸다. 확률 값에 의해서 피 실험자가 어떠한 감정인지를 인식하게 되는 것이다.

• Communications for Statistical Applications and Methods
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• 제9권1호
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• pp.155-166
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• 2002

Neural networks have been studied as a popular tool for classification and they are very flexible. Also, they are used for many applications of pattern classification and pattern recognition. This paper focuses on Bayesian approach to feed-forward neural networks with single hidden layer of units with logistic activation. In this model, we are interested in deciding the number of nodes of neural network model with p input units, one hidden layer with m hidden nodes and one output unit in Bayesian setup for fixed m. Here, we use the latent variable into the prior of the coefficient regression, and we introduce the 'sequential step' which is based on the idea of the data augmentation by Tanner and Wong(1787). The MCMC method(Gibbs sampler and Metropolish algorithm) can be used to overcome the complicated Bayesian computation. Finally, a proposed method is applied to a simulated data.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제15권1호
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• pp.72-76
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• 2009

최근 유비쿼터스 컴퓨팅에 대한 관심이 높아지면서 유비쿼터스 환경에서의 서비스를 위한 인간과 컴퓨터의 상호 작용, 특히 인간의 행동을 인식하는 연구가 활발히 진행되고 있다. 기존의 영상기반 연구와는 달리 모바일 환경에 적합하도록 가속도 센서, 생리신호 센서 등 다양한 센서들을 활용하여 사용자의 행동을 인식하는 기법이 연구되고 있다. 본 논문에서는 멀티모달 센서들을 통합하고 동적 베이지안 네트워크를 계층적으로 구성하여 사용자의 행동을 인식하는 방법을 제안한다. 연산량이 비교적 적은 베이지안 네트워크로 전반적인 사용자 행동을 추론하고 획득된 각 행동의 확률순으로 동적 베이지안 네트워크를 구성한다. 동적 베이지안 네트워크는 OVR(One-Versus-Rest) 전략으로 학습되며, 확률순으로 행동이 검증되어 임계치를 넘는 경우 선택된 행동보다 낮은 확률의 행동에 대한 동적 베이지안 네트워크를 검증하지 않아 추론 연산량을 줄인다. 본 논문에서는 가속도 센서와 생리적 신호 센서를 기반으로 총 8가지의 행동을 인식하는 문제에 제안하는 방법을 적용하여 평균적으로 97.4%의 분류 정확률을 얻었다.

• 제어로봇시스템학회논문지
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• 제22권2호
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• pp.104-109
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• 2016

In this paper, a localization method for multiple robots based on Bayesian inference is proposed when multiple robots adopting multi-RAT (Radio Access Technology) communications exist in cognitive radio networks. Multiple robots are separately defined by primary and secondary users as in conventional mobile communications system. In addition, the heterogeneous spectrum environment is considered in this paper. To improve the performance of localization for multiple robots, a realistic multiple primary user distribution is explained by using the probabilistic graphical model, and then we introduce the Gibbs sampler strategy based on Bayesian inference. In addition, the secondary user selection minimizing the value of GDOP (Geometric Dilution of Precision) is also proposed in order to overcome the limitations of localization accuracy with Gibbs sampling. Via the simulation results, we can show that the proposed localization method based on GDOP enhances the accuracy of localization for multiple robots. Furthermore, it can also be verified from the simulation results that localization performance is significantly improved with increasing number of observation samples when the GDOP is considered.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4913-4916
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• 2016

Objective: As a source of information, medical data can feature hidden relationships. However, the high volume of datasets and complexity of decision-making in medicine introduce difficulties for analysis and interpretation and processing steps may be needed before the data can be used by clinicians in their work. This study focused on the use of Bayesian models with different numbers of nodes to aid clinicians in breast cancer risk estimation. Methods: Bayesian networks (BNs) with a retrospectively collected dataset including mammographic details, risk factor exposure, and clinical findings was assessed for prediction of the probability of breast cancer in individual patients. Area under the receiver-operating characteristic curve (AUC), accuracy, sensitivity, specificity, and positive and negative predictive values were used to evaluate discriminative performance. Result: A network incorporating selected features performed better (AUC = 0.94) than that incorporating all the features (AUC = 0.93). The results revealed no significant difference among 3 models regarding performance indices at the 5% significance level. Conclusion: BNs could effectively discriminate malignant from benign abnormalities and accurately predict the risk of breast cancer in individuals. Moreover, the overall performance of the 9-node BN was better, and due to the lower number of nodes it might be more readily be applied in clinical settings.

• International Journal of Computer Science & Network Security
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• 제23권4호
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• pp.85-94
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• 2023

Image halftoning is a technique for varying grayscale images into two-tone binary images. Unfortunately, the static representation of an image-half toning, wherever each pixel intensity is combined by its local neighbors only, causes missing subjective problem. Also, the existing noise causes an instability criterion. In this paper an image half-toning is represented as a dynamical system for recognizing the global representation. Also, noise is reduced based on a probabilistic model. Since image half-toning is considered as 2-D matrix with a full connected pass, this structure is recognized by the dynamical system of Cellular Neural Networks (CNNs) which is defined by its template. Bayesian Rough Sets is used in exploiting the ideal CNNs construction that synthesis its dynamic. Also, Bayesian rough sets contribute to enhance the quality of the halftone image by removing noise and discovering the effective parameters in the CNNs template. The novelty of this method lies in finding a probabilistic based technique to discover the term of CNNs template and define new learning rules for CNNs internal work. A numerical experiment is conducted on image half-toning corrupted by Gaussian noise.

• Journal of the Korean Statistical Society
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• 제36권3호
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• pp.435-445
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• 2007

This paper addresses for the first time the use of complete data information criteria in unsupervised learning of the Naive-Bayes model. A Monte Carlo study sets a large experimental design to assess these criteria, unusual in the Bayesian network literature. The simulation results show that complete data information criteria underperforms the Bayesian information criterion (BIC) for these Bayesian networks.