• Title/Summary/Keyword: Basic Scientific Research

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Analysis of Biological Experiment on Socheongryong-tang (Xiaoqinglong-tang) (소청룡탕 효능에 관한 기초 실험 연구 문헌 분석)

  • Kim, Jung-Hoon;Shin, Hyeun-Kyoo
    • The Journal of Korean Medicine
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    • v.33 no.3
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    • pp.54-73
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    • 2012
  • Objectives: To investigate the scientific evidence of Korean Medicine (KM), papers on Socheongryong-tang (Xiaoqinglong-tang), which is frequently used in medical clinics or hospitals of Korean medicine, were collected and analyzed. Methods: Papers were classified by the registration of domestic or international journals, the year of publication, experimental models and the subjects of biological activities. The mechanisms of biological activity in accordance with therapeutic effects of Socheongryong-tang (Xiaoqinglong-tang) were noted. Results: Among 98 papers included, 21 were published in domestic journals whereas 35 were in Chinese journals and 43 in Japanese journals. Most reported biological activities were amelioration of asthma. Socheongryong-tang (Xiaoqinglong-tang) regulated interleukin and interferon and immunoglobulin, inhibited the production of nerve growth factor, endotheliln-1, nitric oxide, toll-like receptor-4, p-Akt and increased extracellular signal regulated kinase and cyclin D1, which led to decreased bronchi inflammation and bronchoconstriction, and inhibited the proliferation of airway smooth muscle cells, mucus secretion and airway hyperresponsiveness. In addition, Socheongryong-tang (Xiaoqinglong-tang) also restored tissues injured by asthma so that respiratory function recovered. Conclusions: Amelioration of asthma by Socheongryong-tang (Xiaoqinglong-tang) is supported by objective and scientific evidence.

Analysis of Biological Experiment on Immunoactivity of Sipjeondabo-tang (십전대보탕의 면역활성에 관한 기초 실험 연구 문헌 분석)

  • Kim, Jung Hoon;Shin, Hyeun Kyoo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.26 no.5
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    • pp.641-649
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    • 2012
  • To investigate scientific evidence for the use of a Korean Medicine (KM), the papers regarding Sipjeondabo-tang (Shiquandabu-tang) frequently used in Korean medical clinics and hospitals were collected and analyzed. The papers were classified as being from domestic or international journals and by the year of publication. The mechanisms of immuno-activity Sipjeondabo-tang (Shiquandabu-tang) were researched. Among 41 papers, 4 were published as Korean papers whereas 7 were as Chinese papers and 40 were as Japanese papers. Sipjeondabo-tang (Shiquandabu-tang) regulated the productions of Th1 cytokines such as interleukin-2 (IL-2) and interferon-${\gamma}$ (IFN-${\gamma}$), and Th2 cytokines such as IL-4, IL-5, IL-6, IL-12 improving the function of immune organ including bone marrow, spleen, liver, thymus and peyer's patch. It also modulated the releases of immunoglobulin-G (IgG) and IgM. Thus, Sipjeondabo-tang (Shiquandabu-tang) balanced the Th1/Th2 immune responses as well as T/B cell. The regulation of immunoactivity could be speculated as an objective and scientific evidence of Sipjeondabo-tang (Shiquandabu-tang).

Wheat Research and Technology in Australia (오스트레일리아에 있어서 소맥(小麥)의 연구(硏究)와 가공기술(加工技術))

  • Marston, P.E.
    • Korean Journal of Food Science and Technology
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    • v.9 no.1
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    • pp.84-88
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    • 1977
  • Cereal production and utilization in Australia are described briefly. Emphasis is on wheat which is the principal cereal crop for both 'home' use and for export. Some of the main fields of research on wheat quality and process technology are outlined. Reference is made to basic scientific studies in plant physiology, biochemistry and dough rheology, and a more detailed account is given of work at the Bread Research Institute on milling and baking technology.

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Bedside Education Will Be More Important than Now in the Age of Artificial Intelligence (인공지능 시대에 더 중요해질 침상 옆 교육)

  • Yeh, Byung-Il
    • Korean Medical Education Review
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    • v.18 no.2
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    • pp.58-64
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    • 2016
  • The birth of the scientific revolution, brought forth by Vesalius and Copernicus in 1543, marked the beginning of a new age. However, the changes such as treatment effectiveness, survival rate, prevalence of specific diseases, etc. had not yet become clear during the 16th century. In the early 17th century, Boerhaave emphasized bedside teaching and practice. His attitude influenced numerous students and educators, so many medical students visited hospital wards where he worked. From the late 18th to 19th centuries, Jenner's smallpox vaccination, Pasteur's anthrax and rabies vaccinations, and Koch's four postulates used to detect pathogens were developed using the scientific research method, which initiated big changes for medicine. Flexner, credited for reporting the new medical education system, adopted scientific medicine. He believed medical students must study basic medical science since it could be the foundation of clinical medicine and lead to a revolution in the field. He proposed a new medical curriculum composed of two-years of basic medicine and two-years of clinical medicine, which has been used more than 100 years. During the late 20th century, bedside teaching rounds decreased gradually as scientific medicine has become popular. Many medical educators in many articles have proposed bedside education as an effective method for medical learning. Despite the advent of the age of artificial intelligence and the changing of medical environments in the near future, bedside education will be more useful and important for medical students, educators, and patients as it is a traditional method and essential for patients who desire a more personal approach.

Student Research in Basic Medical Education: Why Do We Say Student Research? (의학교육기관의 학생연구: 왜 우리는 학생연구를 말하는가?)

  • Park, Won Kyun
    • Korean Medical Education Review
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    • v.17 no.2
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    • pp.57-59
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    • 2015
  • Student research has been proposed as an educational strategy to fulfill the current requirements in basic medical education (BME) and to compatible with the self-directed development of professionalism. It is commonly accepted that the goals of student research are to develop the competencies of critical, reflective, and self-directed thinking; problem-solving; and creativity; as well as to acquire the skills necessary to search for information and analyze the literature; to cultivate the talent of mastering a specialized field through deeply intensified learning; and to establish close relationships between students and supervisors. To successfully implement student research, authorities on BME should to plan the procedure for the student research projects and allocate personal and material resources adequately in order to provide the opportunity for self-evaluation and reflection through the completion of daily records, to develop the habit of consistently evaluating one's own study, and to maintain a collegial relationship between students and supervisors by offering the proper feedbacks in a timely and consistent manner. In conclusion, despite several obstacles and difficulties in the establishment of successful student research projects, student research could provide students the motivation to develop themselves into expert academic researchers, and play a role in educating students to help solve patients' problems based on scientific evidence in the future.

An Efficient ATM Traffic Generator for the Real-Time Production of a Large Class of Complex Traffic Profiles

  • Loukatos Dimitrios;Sarakis Lambros;Kontovasilis Kimon;Mitrou Nikolas
    • Journal of Communications and Networks
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    • v.7 no.1
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    • pp.54-64
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    • 2005
  • This paper presents an advanced architecture for a traffic generator capable of producing ATM traffic streams according to fully general semi-Markovian stochastic models. The architecture employs a basic traffic generator platform and enhances it by adding facilities for 'driving' the cell generation process through high-level specifications. Several kinds of optimization are employed for enhancing the software's speed to match the hardware's potential and for ensuring that traffic streams corresponding to models with a wide range of parameters can be generated efficiently and reliably. The proposed traffic generation procedure is highly modular. Thus, although this paper deals with ATM traffic, the main elements of the architecture can be used equally well for generating traffic loads on other networking technologies, IP-based networks being a notable example.

Hull Form and Layouts of 740-ton Replacement Vessel for R/V Eardo of KIOST: Ship Design and SMRs (740톤급 종합해양연구선 이어도호 대체선 선형 및 설계 특성)

  • Park, Cheong Kee;Park, Dong-Won;Lee, Gun Chang;Kim, Young Jun;Min, Young Ki
    • Ocean and Polar Research
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    • v.42 no.2
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    • pp.171-178
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    • 2020
  • R/V EARDO, commissioned in 1992, has successfully carried out ocean research campaigns in Korean jurisdictional and adjacent waters, including continental margins and coastal zones within the Korean Exclusive Economic Zone (EEZ), for 29 years. However, it will soon be reaching the end of its useful service life. A replacement for R/V EARDO is urgently needed to ensure the safety of vessel itself and its crews, and efficient ship operation and maintenance, as well as to meet modern scientific mission requirements (SMRs). Basic specifications for a replacement ship have been devised and reviewed over the past nine months. A test of the proposed hull form was also performed. The total tonnage of the proposed vessel is approximately 740 tons, and the overall length and width are 62.0 and 11.6 m, respectively. The new ship will thus be 73% larger than the current R/V EARDO; in particular, the research workspace will be 4.4 times larger. The major design priorities are the propulsion system, efficiency of radiated noise and vibration control, and the dynamic positioning system. An environmentally friendly emission system, meeting International Maritime Organization (IMO) Tier III regulations, will be installed in the third exhaust pipe. Various wet and dry lab spaces as well as 32 different scientific instruments have also been considered in the ship design.

An Analysis of Distributed Lag Effects of Expenditure by Type of R&D on Scientific Production: Focusing on the National Research Development Program (연구개발단계별 연구개발투자와 논문 성과 간의 시차효과 분석: 국가연구개발사업을 중심으로)

  • Pak, Cheol-Min;Ku, Bon-Chul
    • Journal of Korea Technology Innovation Society
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    • v.19 no.4
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    • pp.687-710
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    • 2016
  • This study aims to empirically estimate distributed lag effects of expenditure by type of R&D on scientific publication in the national R&D program. To analyze the lag structure between them, we used a dataset comprised of panel data from 104 technologies categorized by 6T (IT, BT, NT, ST, ET, CT) from 2007 to 2014, and employed multiple regression analysis based on the polynomial distributed lag model. This is because it is highly likely to emerge multicollinearity, if a distributed lag model without special restrictions is applied to multiple regression analysis. The main results are as follows. In the case of basic research, its lag effects are relatively evenly distributed during four years. On the other hand, the applied research and experimental development have distributed lag effects for three years and two years respectively. Therefore, when it comes to analyzing performance of scientific publication, it is necessary to be performed with characteristics of the time lag by type of R&D.

A Study on the Optimal Establishment of the National Scientific and Technical Information Center (국가과학기술문헌센터 건립 최적화 연구)

  • Hong, Hyun-Jin;Jeong, Jun-Min;Kang, Mi-Hee;Jeong, Dae-Keun
    • Journal of the Korean Society for information Management
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    • v.20 no.2
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    • pp.285-318
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    • 2003
  • The purpose of this research is to suggest a theoretical base and guideline for the national scientific and technical information center which is assigned to take charge of the management and building knowledge and information infrastructure of the national scientific technology. And the objective of this study is to contribute to strengthen the need of the building of the national scientific and technical information center and provide operation programs and vision toward information center which will be established later. This study suggests a plan and strategy which make it possible to conduct functions as the national repository, clearinghouse, and portal gateway of the electronic resource and propose space program for the optimal building construction. Therefore, the contents of this study cover the building of the national scientific and technical information center as well as the basic plan of scale and space program, validity analysis of site location and environment.

Exploring Scientific Reasoning in Elementary Science Classroom Discourses (초등 과학 수업 담화에서 나타나는 과학적 추론 탐색)

  • Lee, Sun-Kyung;Choi, Chui Im;Lee, Gyuho;Shin, Myeong-Kyeong;Song, Hojang
    • Journal of The Korean Association For Science Education
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    • v.33 no.1
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    • pp.181-192
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    • 2013
  • This study aims to explore scientific reasoning that students and their teachers constructed in elementary science classroom discourses in terms of basic reasoning types; deduction, induction, and abduction. For this research, data were collected from 13 classes of 4th grade science activities during a period of three months and analyzed three types of scientific reasoning in elementary school science discourses. We found that deduction (one discourse segment), induction (one discourse segment), and deduction-abduction (two discourse segments) were presented in the discourses. They showed that: first, scientific reasoning proceeded explicitly or implicitly in elementary science discourses; second, the students and their teachers have potentials to increase the quality of reasoning depending on their inter-subjectivity; and last, the students' background knowledge were very important in the development of their reasoning. Implication and remarks on science education and research were presented based on this results as well.