• Journal of Information Technology Applications and Management
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• 제16권1호
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• pp.137-148
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• 2009

Knowledge management becomes the key point for organizations to survive and maintain competitive advantages in the knowledge economy era. E-learning plays a vital role for the organizational learning. How to share the experience of knowledge and the success of the knowledge management has great connection with the organizational culture. This study focuses on the factors of effective E-learning as well as its relation to the organizational culture. A successful e-learning system should not only aim at different statistical variables but emphasize on : course contents, variety of teaching methods and establishes a stable network environment. A stable E-learning platform and speedy bandwidth is a must to achieve the non-barrier communication and built an interactive learning environment. To achieve success in E-learning, it is not necessary to divide the organizational culture to strengthen the course content multiplication and plans the E-learning supervisory work by the sole responsibility unit. It should establish an ample teaching frequency width and platform and also must establish the appropriate study network frequency width and hardware equipment to achieve the best E-learning effect. The interaction in different organizational culture in adapting E-learning, those Ad-hoc and Marketing Culture, are mostly influence by the external environment and have more interactive content. Those in Clan and Hierarchy Culture are affected by traditional conception and lack of interaction. Meanwhile, under the cost consideration, Clan and Ad-hoc Culture on the dynamic side prefer to spend more cost on E-Learning while the stable side, Hierarchy and Marketing culture are willing to pay more expenses on E-Learning.

• 한국군사과학기술학회지
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• 제12권1호
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• pp.123-132
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• 2009

Civil petitions and law suits against the military rifle shooting noise have been increased because many military shooting ranges are located near civilian residential area. In order to solve the noise problems, military have devised various methods. In this study, propagation properties of rifle shot through atmosphere were investigated. The military rifle shooting noise level at 5m from muzzle was between $l14{\sim}120dB$ in all directions. The noise level loom both backward and sideward away from system firing range consisting lines of 8 shooting locations were 90dB, when shots were all fired within 10 seconds. At present some of military bases established sound barriers, muzzle enclosures, silencers, and indoor shooting ranges to reduce noises and these prevention methods can reduce noise by $5{\sim}20dB,\;5{\sim}9dB,\;5{\sim}13dB,\;40{\sim}50dB$, respectively. Even though indoor shooting range has the best performance, it requires very expensive construction cost and has short length between target and shooter. In comparison, muzzle enclosure is cheap, but because it is installed in fixed position it can only be used in one shooting position. Therefore a commander should select appropriate methods to reduce military rifle shooting noise considering distance from residential area to the range, mission of military training, budget, etc.

• Archives of Pharmacal Research
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• 제28권4호
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• pp.443-450
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• 2005

In the present study, we have characterized the choline transport system and examined the influence of various amine drugs on the choline transporter using a conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) in vitro. The cell-to-medium (C/M) ratio of $[^3{H}]choline$ in TR-BBB cells increased time-dependently. The initial uptake rate of $[^3{H}]choline$ was concentration-dependent with a Michaelis-Menten value, $K_{m}$, of $26.2\pm2.7{\mu}M$. The $[^3{H}]choline$ uptake into TR-BBB was $Na^{+}-independent$, but was membrane potential-dependent. The $[^3{H}]choline$ uptake was susceptible to inhibition by hemicholinium-3, and tetraethy-lammonium (TEA), which are organic cation transporter substrates. Also, the uptake of $[^3{H}]choline$ was competitively inhibited with $K_{i}$ values of $274 {\mu}M, 251 {\mu}M and 180 {\mu}M$ in the presence of donepezil hydrochloride, tacrine and $\alpha-phenyl-n-tert-butyl nitrone$ (PBN), respectively. These characteristics of choline transport are consistent with those of the organic cation transporter (OCT). OCT2 mRNA was expressed in TR-BBB cells, while the expression of OCT3 or choline transporter (CHT) was not detected. Accordingly, these results suggest that OCT2 is a candidate for choline transport at the BBB and may influence the BBB permeability of amine drugs.

• Molecules and Cells
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• 제43권3호
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• pp.251-263
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• 2020

Flagellin, a major structural protein of the flagellum found in all motile bacteria, activates the TLR5- or NLRC4 inflammasome-dependent signaling pathway to induce innate immune responses. Flagellin can also serve as a specific antigen for the adaptive immune system and stimulate anti-flagellin antibody responses. Failure to recognize commensal-derived flagellin in TLR5-deficient mice leads to the reduction in anti-flagellin IgA antibodies at steady state and causes microbial dysbiosis and mucosal barrier breach by flagellated bacteria to promote chronic intestinal inflammation. Despite the important role of anti-flagellin antibodies in maintaining the intestinal homeostasis, regulatory mechanisms underlying the flagellin-specific antibody responses are not well understood. In this study, we show that flagellin induces interferon-β (IFN-β) production and subsequently activates type I IFN receptor signaling in a TLR5- and MyD88-dependent manner in vitro and in vivo. Internalization of TLR5 from the plasma membrane to the acidic environment of endolysosomes was required for the production of IFN-β, but not for other pro-inflammatory cytokines. In addition, we found that anti-flagellin IgG2c and IgA responses were severely impaired in interferon-alpha receptor 1 (IFNAR1)-deficient mice, suggesting that IFN-β produced by the flagellin stimulation regulates anti-flagellin antibody class switching. Our findings shed a new light on the regulation of flagellin-mediated immune activation and may help find new strategies to promote the intestinal health and develop mucosal vaccines.

• Tuberculosis and Respiratory Diseases
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• 제69권2호
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• pp.75-80
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• 2010

The year of 2009~2010 brought a number of concepts and new ideas were evaluated with promising results. However, some studies that challenged many beliefs. In acute respiratory distress syndrome (ARDS), recent clinical studies took into consideration of pathophysiologic changes of respiratory system compliance. Meta-analysis of positive end-expiratory pressure trials showed survival benefit of high positive end-expiratory pressure in ARDS. Until now, prone positioning did not show survival benefit in patients with ARDS. Extracorporeal membrane oxygenation (ECMO) based management improved survival in patients with severe ARDS. ECMO can be a management option in severe ARDS. Sedation is a standard practice in critically ill patients needing mechanical ventilation. However, Danish group reported less sedation of critically ill patients receiving mechanical ventilation was associated with an increase in days without ventilation. Although this single center study has some limitations, the overall results are promising. Use of maximal sterile barrier precautions (mask, sterile gown, sterile gloves, and large sterile drapes) with chlorhexidine-impregnated dressing reduced central venous catheter related infection. Selective oropharyngeal decontamination (application of topical antibiotics in the oropharynx) reduced the mortality rate of an intensive care unit (ICU) population. Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) trial reported intensive glucose control increased mortality among adults in the ICU. Some of the results of above papers are promising. However, some ideas may need for more frequent individual assessment and increase the workload of ICU staffs. Before implementation of new practice in ICU, we should take into consideration of individual hospital situation including human and material resources.

• 한국전자파학회논문지
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• 제22권3호
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• pp.345-353
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• 2011

H-대역(220~325 GHz)의 주파수 범위에서 동작하는 송신기와 수신기를 구현하였으며, 1.485 Gbps 비디오 신호 전송을 국내 최초로 시연하였다. H-대역의 RF front-end는 쇼트키 배리어 다이오드 기술을 이용한 서브 하모닉 믹서, 주파수 3배기, 대각선 혼 안테나로 구성하였다. 송신 및 수신 캐리어 주파수는 H-대역 중에서 246 GHz를 사용하여 구현하였고, 서브 하모닉 믹서의 LO 주파수는 각각 120 GHz, 126 GHz이다. 변조 방식은 ASK(Amplitude Shift Keying), IF 주파수는 5.94 GHz이며, 수신기는 헤테로다인 구조와 ZBD(Zero Bias Detector) 두 방식 모두를 이용하여 envelop 신호를 검출하는 방식이다. HD-SDI 형식을 갖는 1.485 Gbps 비디오 신호를 송신기 출력 20 ${\mu}W$에서 약 5 m까지 성공적으로 HDTV로 전송하였다.

• 대한약침학회지
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• 제12권1호
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• pp.67-76
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• 2009

Objective : Following central nervous system(CNS) injury, inhibitory influences at the site of axonal damage occur. Glial cells become reactive and form a glial scar, gliosis. Also myelin debris such as MAG inhibits axonal regeneration. Astrocyte-rich gliosis relates with up-regulation of GFAP and CD81, and eventually becomes physical and mechanical barrier to axonal regeneration. MAG is one of several endogenous axon regeneration inhibitors that limit recovery from CNS injury and disease. It was reported that molecules that block such inhibitors enhanced axon regeneration and functional recovery. Recently it was reported that treatment with anti-CD81 antibodies enhanced functional recovery in the rat with spinal cord injury. So in this current study, the author investigated the effect of the water extract of Uncariae Ramulus et Uncus on the regulation of CD81, GFAP and MAG that increase when gliosis occurs. Methods : MTT assay was performed to examine cell viability, and cell-based ELISA, western blot and PCR were used to detect the expression of CD81, GFAP and MAG. Then also immunohistochemistry was performed to confirm in vivo. Results : Water extract of Uncariae Ramulus et Uncus showed relatively high cell viability at the concentration of 0.05%, 0.1% and 0.5%. The expression of CD81, GFAP and MAG in astrocytes was decreased after the administration of Uncariae Ramulus et Uncus water extract. These results was confirmed in the brain sections following cortical stab injury by immunohistochemistry. Conclusion : The authors observed that Uncariae Ramulus et Uncus significantly down-regulates the expression of CD81, GFAP and MAG. These results suggest that Uncariae Ramulus et Uncus can be a candidate to regenerate CNS injury.

• 방사성폐기물학회지
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• 제9권2호
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• pp.99-105
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• 2011

중저준위 방사성폐기물 처분장의 안전성 평가를 위하여 지하 사일로와 그 주변의 굴착손상영 역 (EDZ) 및 단열암반을 고려한 지하수유동해석과 핵종이동해석의 통합모델을 개발하였다. 사일로를 다중방벽개념으로 고려하여 사일로를 구성하는 3개의 특성지역 (waste, buffer, concrete)으로 구분하여 해석하였고, EDZ는 사일로 주변과 건설운영 터널 주변의 손상영역을 고려하였다. 단열암반의 불균일성은 분리단열 (discrete fractures)로 부터 해석된 불균일한 지하수 유속계로 도출하였고, 그 결과를 핵종의 이동경로를 모사하는데 사용하였다. 현 모델은 핵종누출에 따른 사일로 배치의 최적화와 안전성의 정량화를 도출하는데 사용가능하다.

• 방사성폐기물학회지
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• 제16권2호
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• pp.137-164
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• 2018

심지층처분장 공학적방벽의 성능 보장은 장기처분안전성 측면에서 뿐만 아니라 심지층처분장의 효율적인 설계를 위해서도 매우 중요하다. 따라서 지하실험시설에서 수행되는 현장실험들을 통해 심지층처분장 조건 하에서의 공학적방벽 성능을 입증할 필요가 있다. 이 논문에서는 심지층처분장 공학적방벽의 성능을 실증하기 위해, 지난 수십 년 동안 전 세계에서 수행되어온 주요 현장실험의 현황과 그 결과에 대해 검토하였다. 먼저 심지층처분장의 폐쇄 후 성능을 모사하는 공학적방벽시스템의 열-수리-역학적 복합거동을 규명하기 위한 현장실험들이 분석되었다. 아울러 실제 심지층처분장의 환경에서 완충재의 성능을 조사하기 위한 현장실험들이 검토되었다. 완충재-콘크리트 상호반응, 완충재, 뒷채움재 및 플러그의 설치, 그리고 근계암반 특성과 처분용기 재질의 부식 현상을 규명하기 위한 현장실험들의 기술현황도 분석되었다.

• 한국표면공학회지
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• 제50권5호
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• pp.339-344
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• 2017

Highly corrosion resistance performance of CrAlSiN coatings were obtained by applying ultrathin $Al_2O_3$ thin films using atomic layer deposition (ALD) method. CrAlSiN coatings were prepared on Cr adhesion layer/SUS304 substrates by a hybrid coating system of arc ion plating and high power impulse magnetron sputtering (HiPIMS) method. And, ultrathin $Al_2O_3$ passivation layer was deposited on the CrAlSiN/Cr adhesion layer/SUS304 sample to protect CrAlSiN coatings by encapsulating the whole surface defects of coating using ALD. Here, the high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) and energy dispersive X-ray spectrometry (EDX) analysis revealed that the ALD $Al_2O_3$ thin films uniformly covered the inner and outer surface of CrAlSiN coatings. Also, the potentiodynamic and potentiostatic polarization test revealed that the corrosion protection properties of CrAlSiN coatings/Cr/SUS304 sample was greatly improved by ALD encapsulation with 50 nm-thick $Al_2O_3$ thin films, which implies that ALD-$Al_2O_3$ passivation layer can be used as an effect barrier layer of corrosion.