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Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet (오적산가미방(五積散加味方)이 고지방식이 유도 비만쥐의 지질대사, 항산화계 및 전염증성 cytokine 생산에 미치는 영향)

  • Kong, In-Pyo;Park, Won-Hyung;Cha, Yun-Yeop
    • Journal of Korean Medicine Rehabilitation
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    • v.21 no.4
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    • pp.23-40
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    • 2011
  • Objectives: This study was designed to examine the effects of extracts of Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) on the lipid lowering, anti-oxidation and concentration of proinflammatory cytokines and was investigated on hyperlipidemic rats. Methods: Male rats weighing $182.39{\pm}4.71g$ were fed high fat diet for 8 weeks and 36 rats(above 400 g) were divided into 4 groups. Each of 9 rats was divided a control group and experimental groups. We fed a control group of rats a basal diet and administered normal saline(100 mg/kg, 1 time/1 day) for 4 weeks. And we fed each experimental group of rats basal diet and administered an extract of Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) extracts(100 mg/kg, 200mg/kg, 300 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. We measured lipid of plasma and liver, concentration of proinflmmatory cytokines, anti-oxidative activity and $TNF-{\alpha}$, Apo-B, Apo-E and leptin gene expression. Results: 1. Concentration of plasma free fatty(FFA) showed no significant difference in all the treatment groups. Concentration of plasma triglyceride(TG) showed a significant decrement in the 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups than that of control group. 2. Concentration of plasma total cholesterol showed a significant decrement in the 200 and 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups than that of control group. Concentration of plasma low density lipoprotein(LDL)-cholesterol showed a Significant decrement in the 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups than that of control group. Concentration of plasma high density lipoprotein(HDL)-cholesterol showed a significant increment in the 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) group. 3. Concentration of liver total cholesterol showed a tendence to decrease in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups. Concentration of liver TG showed a significant decrement in all Ojeoksangamibang groups than that of control group. 4. Concentration of plasma and liver thiobarbituric acid reactive substance(TBARS) showed a tendence to decrease in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups. 5. The values of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) activity showed a significant increment in all Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups than that of control group. 6. The values of plasma aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity showed no significant different in all treatment group. 7. Concentration of plasma $interleukin(IL)-1{beta}$ showed no significant difference in all the treatment groups. Concentration of plasma IL-6 showed a significant decrement in the 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) group than that of control group. Concentration of plasma tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ a siginifant decrement in the 200 and 300 mg/kg in Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) group than that of control group. However the concentration of plasma IL-10 in the 300 mg/kg Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups showed a significant increment than that of control group. 9. In the analysis of reverse transcription-polymerase chain reaction(RT-PCR), gene expression of $TNF-{\alpha}$, Apo-B and Apo-E in the Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups showed a lower expression than that of control group. However the gene expression of leptin showed no difference in the treatment groups. 10. The ratio of $TNF-{\alpha}$, Apo-B, and Apo-E per ${\beta}-actin$ expression in the Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) groups showed a significant decrement than that of control group. However The ratio of leptin expression per ${\beta}-actin$ expression showed no significant difference among all the treatment groups. Conclusions: According to above results, in lowering lipid effect, anti-oxidation and control of pro-inflammatory cytokines production, Ojeoksangamibang($W{\check{u}}j\bar{i}s\check{a}nji\bar{a}w\grave{e}if\bar{a}ng$) gives effect.

Structural Analysis on Clamp Guide Bar of Drawing Process System for SUS Hexagonal Bar (SUS 육각봉 인발성형 시스템의 클램프 가이드 바에 관한 구조해석)

  • Lee, Young-Sik;Yang, Young-Joon
    • Journal of the Korean Society of Mechanical Technology
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    • v.20 no.6
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    • pp.796-802
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    • 2018
  • In order to remove rust and impurities from surface of raw SUS circular bar, peeling machine is used to make lustrous and clean surface of SUS circular bar. Drawing process system is used to manufacture SUS hexagonal bar. SUS hexagonal bar have been widely used to make hexagonal bolt/nut, adapter and fittings and so on. The purpose of this study is to investigate the stabilities for guide bar of clamp in drawing process system. As the results, the guide bar showed structural stability in cases of below load of 50 Ton and over hook radius of 3.0mm. Further as the thickness of guide bar hooking with jaw was increased, minimum safety factor was decreased.

Evaluation of Tension Behavior in FRP Hybrid Bar Affected by UV Exposure and Freezing/Thawing Tests (UV 폭로 및 동결융해 시험을 거친 FRP Hybrid Bar의 인장거동 평가)

  • Yoon, Yong-Sik;Park, Jae-Sung;Park, Ki-Tae;Kwon, Seung-Jun
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.5 no.2
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    • pp.130-136
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    • 2017
  • The present work is for an evaluation of tension behavior and surface deterioration of FRP Hybrid Bar due to UV exposure and freezing/thawing(F/T) actions. For the work, FRP Hybrid Bar is subjected to UV exposure test, then F/T test is performed successively to 180 cycles. In FRP Hybrid Bar, no significant surface deterioration is evaluated after UV exposure. Tension hardening performance, a unique engineering advantage of FRP Hybrid Bar, is still maintained after F/T test. The performance in FRP Hybrid Bar exposed to UV is still effective. FRP Hybrid Bar exposed to UV have almost similar tension behavior of FRP Hybrid Bar without UV exposure. Although F/T cycles increase to 180, steel rebar, FRP Hybrid Bar, and FRP Hybrid Bar exposed to UV show no significant changes in tension behavior. In the work, UV exposure and F/T actions are evaluated to have little negative effect on surface deterioration and tensile performance in FRP Hybrid Bar, however spalling of silica coating due to impact should be considered since it affects bonding strength to outer concrete.

Study on $Ch{\acute{e}}n$ $Xiuyu\acute{a}n$ by analysing $Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$ (의학삼자경(醫學三字經)에 나타난 진수원(陳修園) 의학 사상에 대한 문헌적 연구 I)

  • Kim, Jai-Eun;Choi, Dall-Yeong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.4
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    • pp.709-717
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    • 2008
  • $Ch\acute{e}n\;Xiuyu\acute{a}n$(陳修園) was a famous doctor and educator of the late Tang Dynasty. He was well known both for his books for beginners, and for his unique medical theories based on his profound research of <$Sh\bar{a}ngh\acute{a}nl\grave{u}n$(傷寒論)> and <$J\bar{i}nku\grave{i}y\grave{a}ol\ddot{u}e$>. He wrote <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$(醫學三字經)> to establish the basic textbook for the beginners to set up right principles in pursuing their medical career. <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> was written in rhyme form, so that it can be easily memorized and used in future practices. There are quite many medical books in rhyme form, but this book is very unique as $Ch\acute{e}n\;Xiuyu\acute{a}n$ annotated his own notes, which is rare in this form of books. This feature makes <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> very outstanding, also with the fact that $Ch\acute{e}n\;Xiuyu\acute{a}n$ was the one with profound understanding and original theories based on medical bibles such as <$N\grave{e}ij\bar{i}ng$(內經)> and <$Sh\bar{a}ngh\acute{a}nl\grave{u}n$(傷寒論)>. We have translated this precious educational material into korean, hoping that this work could be of any help to students of korean medicine. And while doing this work, we have found followings: <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> covers the entire fields of medicine from theoretical discussions to practical clinical information. Nevertheless, as this is written in rhyme form, there are few phrases that are not easily understood for the sake of rhyme. Beginners probably may have difficulties in reading this book. To make this difficulty alleviated, and to develop our own educational material, we need to study further on the notes that $Ch\acute{e}n\;Xiuyu\acute{a}n$ annotated himself.

The biblographical study on $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine -(Comparative study between Oriental and Western Medicine)- (두풍(頭風)과 편두통(Migraine)에 대(對)한 동서의학적(東西醫學的) 문헌고찰(文獻考察))

  • Oh, So-Jeo;Jeong, Ji-Cheon;Lee, Won-Chul
    • The Journal of Internal Korean Medicine
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    • v.14 no.1
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    • pp.129-138
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    • 1993
  • This report on the $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine comes to conclude, through the study of the Oriental- Western medical references, as follow; 1. First, $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine had some concurrencies that both the two symptoms have appeared severe and recurrent headache and more often to the female. 2 Many of them e.g. Sensory disturbance, Vertigo, Nausea, Vomiting, Tinnitus etc. in the prodrome and main symptom of $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine were identical, especially the symptom of the $f{\bar{e}}ng\;t{\acute{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$ was similar to the prodrome of the Migraine. We could find out the semilarity of the symptoms through that Migraine is proximately set in unilateral, and $Pi{\bar{a}}nT{\acute{o}}u\;f{\bar{e}}ng$ is so called alias $B{\grave{a}}n\;bi{\bar{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$. 3. The pathogeny of $T{\acute{o}}u\;f{\bar{e}}ng$ include the case of ‘$f{\bar{e}}ng\;xi{\acute{e}}\;r{\grave{u}}\;n{\bar{a}}o$’, the patient feeling weak condition, $T{\acute{a}}n,\;T{\acute{a}}nshi,\;T{\acute{a}}nhu{\breve{o}},\;Y{\grave{u}}q{\grave{i}}$, etc. and, ‘$t{\acute{a}}n\;zhu{\grave{o}}\;sh{\grave{a}}ng\;y{\acute{a}}o$’, ‘$G{\bar{a}}n\;y{\acute{a}}ng\;hu{\grave{a}}\;f{\bar{e}}ng$’. There were variable that $F{\bar{e}}ng,\;Xu{\grave{e}},\;F{\bar{e}}ngr{\grave{a}},\;F{\bar{e}}ngx{\bar{u}},\;Xu{\grave{e}}x{\bar{u}},\;Hu{\check{o}}$ in the left, and $t{\acute{a}}n,\;R{\grave{e}},\;t{\acute{a}}nr{\grave{e}},\;Qir{\acute{a}}$ in the right partial pathogeny. It was referred $Sh{\grave{a}}o\;y{\acute{a}}ng\;j{\bar{i}}ng$, $Ju{\acute{e}}\;y{\bar{i}}n\;j{\bar{i}}ng$, $Y{\acute{a}}ng\;m{\acute{i}}ng\;j{\bar{i}}ng$, $T{\grave{a}}i\;y{\acute{a}}ng\;j{\bar{i}}ng$ in connection with the Meridian system. And otherwise the primary cause of Migraine is still unknown to us. Heredity is probably important, but the mode of transmission is uncertain. Recently, the important assumption is the vasomotor change caused by vasoconstrictors like that norepinephrine, epinephrine, and serotonin etc.

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Truth of Mahāyāna Thought -The Controversy Between The Madhyamaka and The Yogācāra on Sunya and The two truth theories of Nāgārjuna (대승불교의 진리관 -용수(龍樹)의 공(空)과 이체설(二諦說)에 대한 중관학파(中觀學派)와 유지학파(唯識學派)의 논쟁을 중심으로)

  • Yun, Jong-gab
    • Journal of Korean Philosophical Society
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    • v.116
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    • pp.225-256
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    • 2010
  • The two school $M{\bar{a}}dhyamika$ and $Yog{\bar{a}}c{\bar{a}}ra$ act as a representative of $Mah{\bar{a}}y{\bar{a}}na$ Buddhism in India. But the two school disputed with each other insisting ${\acute{s}}{\bar{u}}nyat{\bar{a}}-v{\bar{a}}da$ and $vij{\tilde{n}}aptim{\bar{a}}trav{\bar{a}}da$ separately. To introduce the disputation shortly is as follow. $N{\bar{a}}g{\bar{a}}rjuna$ explained the world and truth by two truth theories(二諦說) which carry out truth of a word and the dimension(spiritual enlightenment) which is absolute(ultimate) to it being lokasaṁvṛtisatya(世俗諦) about the truth which can be expressed verbally, and which is phenomenon-like (everyday) at paramaarthasatya(勝義諦). By the way, lokasaṁvṛtisatya and paramaarthasatya are actually distinction of the recognition which is not an ontological distinction. That is, lokasaṁvṛti(世俗) is paramaartha(勝義) as it is the time of seeing by the eyes of those who have realized. The two truth theories of $N{\bar{a}}g{\bar{a}}rjuna$ was developed logical more precisely by his successors. With an everyday language, the position of Candrakīrti(月稱) that it cannot be expressed as the position of $Bh{\bar{a}}vaviveka$(淸辨) that paramaarthasatya can be expressed logically is opposed to each other, and dissociates by $Sv{\bar{a}}tantrika$(自立論證派) and $P{\bar{a}}rsagika$(歸謬論證派). Confrontation of $Sv{\bar{a}}tantrika$ and $P{\bar{a}}rsagika$ is the dispute about the ability of s which is the highest truth to be proved logically. The $P{\bar{a}}rsaga$ of Candrakirti thinks that people exist truly, and is because it claims not existing in the world where a favorite thing is actually actual. However, $Bh{\bar{a}}vaviveka$ proved Sunyata(空性)을 positively based on the reliance to language and logic. Also the mokṣa of $M{\bar{a}}dhyamika$ is not recovery of original condition of $vij{\tilde{n}}apti$ which is pure in itself as $Yog{\bar{a}}c{\bar{a}}ra$ saying, as well as obtaining a thing which is dravya-sat as $Sarv{\bar{a}}stiv{\bar{a}}din$ saying. The mokṣa of $M{\bar{a}}dhyamika$ means a condition of liberated from karma and pains through extinction of $prapa{\tilde{n}}ca$ and discrimination by realizing the real aspect of all dharma which is said by pratītyasamutpāda, $praj{\tilde{n}}apti$, niḥsvabhāva, ${\acute{s}}{\bar{u}}nya$, $madhyam{\bar{a}}pratipad$.

New emerging surface treatment of GFRP Hybrid bar for stronger durability of concrete structures

  • Park, Cheolwoo;Park, Younghwan;Kim, Seungwon;Ju, Minkwan
    • Smart Structures and Systems
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    • v.17 no.4
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    • pp.593-610
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    • 2016
  • In this study, an innovative and smart glass fiber-reinforced polymer (GFRP) hybrid bar was developed for stronger durability of concrete structures. As comparing with the conventional GFRP bar, the smart GFRP Hybrid bar can promise to enhance the modulus of elasticity so that it makes the cracking reduced than the case when the conventional GFRP bar is used. Besides, the GFRP Hybrid bar can effectively resist the corrosion of conventional steel bar by the GFRP outer surface on the steel bar. In order to verify the bond performance of the GFRP hybrid bar for structural reinforcement, uniaxial pull-out test was conducted. The variables were the bar diameter and the number of strands and pitch of the fiber ribs. Tensile tests showed a excellent increase in the modulus of elasticity, 152.1 GPa, as compared to that of the pure GFRP bar (50 GPa). The stress-strain curve was bi-linear, so that the ductile performance could be obtained. For the bond test, the entire GFRP hybrid bar test specimens failed in concrete splitting due to higher shear strength resulting in concrete crushing as a function of bar deformation. Investigation revealed that an increase in the number of strands of fiber ribs enhanced the bond strength, and the pitch guaranteed the bond strength of 19.1 mm diameter hybrid bar with 15.9 mm diameter of core section of deformed steel the ACI 440 1R-15 equation is regarded as more suitable for predicting the bond strength of GFRP hybrid bars, whereas the CSA S806-12 prediction is considered too conservative and is largely influenced by the bar diameter. For further study, various geometrical and material properties such as concrete cover, cross-sectional ratio, and surface treatment should be considered.

Evaluations of Swaging Process for Rotor Core of Induction Motors II (유도전동기 회전자 제작시 압입작업 평가 II)

  • Park, Sang-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.6
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    • pp.464-469
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    • 2017
  • This study evaluated the displacements of a Cu bar in the Y-direction and the relationship between swaging pressures and total contact forces to increase the productivity of the rotor core swaging process. Elastic-plastic numerical analyses of four different Cu bar shapes were performed with a constant swaging pressure to evaluate the displacements of the Cu bar in the Y-direction and the contact force distributions at the contact surfaces during the swaging process. Based on the numerical analysis results, the following conclusions were obtained. First, a simplified 2-dimensional cyclic symmetric analysis model was developed for the numerical analysis of the rotor core swaging process. Second, the final displacements of the Cu bar in the Y-direction were nearly the same as the change of the Cu bar size at a constant swaging pressure. Third, a linear relationship between the swaging pressures and the total contact forces, the so called resistance forces, was suggested.

Fabulous Horses out of Water in B.Sīlā as Depicted in the Kūshnāma: A Cultural Encounter between East and West Asia

  • LIU, YINGJUN
    • Acta Via Serica
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    • v.4 no.1
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    • pp.87-109
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    • 2019
  • In the Iranian epic $K{\bar{u}}shn{\bar{a}}ma$, there is a rather interesting story that recounts how the inhabitants of $B.s{\bar{i}}l\bar{a}$ cross-breed their domesticated horses with a magical horse living in the sea in order to obtain fine-bred ones. What is even more interesting is that similar accounts are also seen in many of other classical Perso-Arabic works and Chinese sources. The regions that such events took place in mainly spread over Central Asia and western China while in $K{\bar{u}}shn{\bar{a}}ma$, the story happens in $B.s{\bar{i}}l\bar{a}$, a legendary kingdom with its historical prototype being Silla. By sorting out certain records of how ancient people sought fine horses by cross-breeding domesticated horses with wild horses that inhabited mountains and waters within Chinese sources and classical Muslim works, and comparing these accounts with similar plot lines as depicted in $K{\bar{u}}shn{\bar{a}}ma$, this paper attempts to elucidate that the story in $K{\bar{u}}shn{\bar{a}}ma$ is a result of flourishing land and maritime exchanges between East Asia and West Asia during ancient and medieval times, rather than a purely literary fiction. It was not only influenced by the horse culture that thrived over the Eurasian Steppe, but the story is also coincidentally in accordance with the fact that the nomadic zone which lies within the central Eurasian continent extends as far as the Korean Peninsula in northeast Asia.

The Effect of Soil Moisture Stress on the Growth of Barley and Grain Quality (토양수분 스트레스가 보리생육 및 종실품질에 미치는 영향)

  • Park, Moo-Eon
    • Korean Journal of Soil Science and Fertilizer
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    • v.28 no.2
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    • pp.165-175
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    • 1995
  • To determine the effect of soil moisture stress on growth of barley and grain quality, a pot experiment was carried out for two barley varieties(Olbori and Chogangbori) by using large plastic pot(52cm in diameter and 55cm in depth) filled with sandy loam soil under rain-controlled open green house. By means of measuring soil water potential with micro tensiometer and gypsum block installed at 10cm in soil depth, soil moisture was controlled by sub-irrigation at several irigation points such as -0.05bar, -0.2bar, -0.5bar, -1.0bar, -5.0bar and -10.0bar in soil water potential. The lower soil water potential was controlled, the shorter length of stem and internode became, and the more narrow stem diameter was. Leaf area was significantly decreased when soil water potential was controlled lower than -0.5bar, although chlorophyll content of flag and first leaves was not changed so much. Weight of grain and ear was significantly decreased when soil water potential was lower than -5.0bar and the highest grain yield was obtaind in a plot where soil water potential was controlled at -0.2bar. However, the most efficient water use of Olbori and Chogangbori was obtained at -0.5bar and -1.0bar in water potentials, respectively. Crude protain content, maximum viscosity, consistency and ${\beta}$-glucan content of barley flour increased as soil water potential significantly decreased, especially below -5.0bar, but gelatination temperature decreased as soil water potential decreased.

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