• Title/Summary/Keyword: Backbone model

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$^{15}N$ NMR Relaxation Studies of Backbone Motion of the catalytic Residues in Free and Steroid-bound ${\Delta}^5$-3-Ketosteroid Isomerase

  • Lee, Hee-Cheon;Sunggoo Yun
    • Journal of the Korean Magnetic Resonance Society
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    • v.5 no.2
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    • pp.130-137
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    • 2001
  • Backbone dynamics of the catalytic residues in free and steroid-bound $\Delta$$^{5}$ -3- ketosteroid isomerase from Pseudomonas testosteroni has been examined by $^{15}$ N relaxation measurements. The relaxation data were analyzed using the model-free formalism to extract the model-free parameters (S$^2$, $\tau$$_{e}$, and R$_{ex}$). Tyr-34 and Asp-99 exhibit enhanced high-frequency (pico- to nanosecond) internal motions in the free enzyme, which are restricted upon ligand binding, while Asp-38 experiences severe restriction of the internal motions in the fee enzyme, suggesting that Tyr-14 and Asp-99 are more actively involved in the ligand binding than Asp-38. The results also indicate that the H-bond network in the catalytic cavity might be slightly strengthened upon ligand binding, which may have some implications on the enzyme mechanism.he enzyme mechanism.m.

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Studies of Graft Polymers (I). Graft Site Distribution of Anionic Polymer (고분자 결합에 관한 연구 (제1보). Anionic Polymer의 Graft Site 분포)

  • Chul Yung Cha
    • Journal of the Korean Chemical Society
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    • v.20 no.4
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    • pp.251-259
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    • 1976
  • Graft site distribution of graft polymer was derived from a statistical model. Theoretical model was experimentally confirmed by preparing well defined graft polymer and using gel permeation chromatography(GPC). The results indicate that metalation of substrate polymer is statistically random process and anionic graft reaction products consist of ungrafted free side chain homopolymer; graft polymer with different number of graft chains and free backbone molecules when the averaged in the graft sites are small.

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Robust architecture search using network adaptation

  • Rana, Amrita;Kim, Kyung Ki
    • Journal of Sensor Science and Technology
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    • v.30 no.5
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    • pp.290-294
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    • 2021
  • Experts have designed popular and successful model architectures, which, however, were not the optimal option for different scenarios. Despite the remarkable performances achieved by deep neural networks, manually designed networks for classification tasks are the backbone of object detection. One major challenge is the ImageNet pre-training of the search space representation; moreover, the searched network incurs huge computational cost. Therefore, to overcome the obstacle of the pre-training process, we introduce a network adaptation technique using a pre-trained backbone model tested on ImageNet. The adaptation method can efficiently adapt the manually designed network on ImageNet to the new object-detection task. Neural architecture search (NAS) is adopted to adapt the architecture of the network. The adaptation is conducted on the MobileNetV2 network. The proposed NAS is tested using SSDLite detector. The results demonstrate increased performance compared to existing network architecture in terms of search cost, total number of adder arithmetics (Madds), and mean Average Precision(mAP). The total computational cost of the proposed NAS is much less than that of the State Of The Art (SOTA) NAS method.

THE DESIGN OF NETWORK MODEL FOR THE IMPLEMENTATION OF e-VLBI (e-VLBI 구현을 위한 네트워크 모델 설계)

  • Song, Min-Gyu;Byun, Do-Young;Kim, Hyun-Goo;Oh, Se-Jin;Han, Seog-Tae;Roh, Duk-Gyoo;Lee, Bo-Ahn
    • Publications of The Korean Astronomical Society
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    • v.20 no.1 s.24
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    • pp.63-71
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    • 2005
  • e-VLBI was invented to enhance the efficiency of VLBI (Very-Long-Baseline Interferometry) system by transmitting the data via high speed network. Korean VLBI Network (KVN) has a plan to construct e-VLBI system named e-KVN. High speed backbone network and efficient network model are essential to implement successful e-VLBI system. This paper introduces a network model based on PC cluster technology. The present status of high speed backbone network in Korea is overviewed. We suggest that the network link via Korea Advanced Research Network (KOREN) is one of feasible way for e-KVN. We also describe the principles of e-VLBI and protocol for network transmission such as VSI-E (VLBI Standard Interface - Electronic), RTP (Real-Time Transport Protocol) and RTCP (Real-Time Transport Control protocol).

Fault/Attack Management Framework for Network Survivability in Next Generation Optical Internet Backbone (차세대 광 인터넷 백본망에서 망생존성을 위한 Fault/Attack Management 프레임워크)

  • 김성운;이준원
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.40 no.10
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    • pp.67-78
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    • 2003
  • As optical network technology advances and high bandwidth Internet is demanded for the exponential growth of internet traffic volumes, the Dense-Wavelength Division Multiplexing (DWDM) networks have been widely accepted as a promising approach to the Next Generation Optical Internet (NGOI) backbone networks for nation wide or global coverage. Important issues in the NGOI based on DWDM networks are the Routing and Wavelength Assignment(RWA) problem and survivability. Especially, fault/attack detection, localization and recovery schemes in All Optical Transport Network(AOTN) is one of the most important issues because a short service disruption in DWDM networks carrying extremely high data rates causes loss of vast traffic volumes. In this paper, we suggest a fault/attack management model for NGOI through analyzing fault/attack vulnerability of various optical backbone network devices and propose fault/attack recovery procedure considering Extended-LMP(Link Management Protocol) and RSVP-TE+(Resource Reservation Protocol-Traffic Engineering) as control protocols in IP/GMPLS over DWDM.

Dynamic p-y Backbone Curves for a Pile in Saturated Sand (포화 사질토 지반에서의 동적 p-y 중추곡선)

  • Yang, Eui-Kyu;Yoo, Min-Taek;Kim, Hyun-Uk;Kim, Myoung-Mo
    • Journal of the Korean Geotechnical Society
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    • v.25 no.11
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    • pp.27-38
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    • 2009
  • In this study, a series of 1 g shaking table model pile tests were carried out in saturated dense and loose sand to evaluate dynamic p-y curves for various conditions of flexural stiffness of a pile shaft, acceleration frequency and acceleration amplitude for input loads. Dynamic p-y backbone curve which can be applied to pseudo static analysis for saturated dense sand was proposed as a hyperbolic function by connecting the peak points of the experimental p-y curves, which corresponded to maximum soil resistances. In order to represent the backbone curve numerically, empirical equations were developed for the initial stiffness ($k_{ini}$) and the ultimate capacity ($p_u$) of soils as a function of a friction angle and a confining stress. The applicability of a p-y backbone curve was evaluated based on the centrifuge test results of other researchers cited in literature, and this suggested backbone curve was also compared with the currently available p-y curves. And also, the scaling factor ($S_F$) to account for the degradation of soil resistance according to the excess pore pressure was developed from the results of saturated loose sand.

Shape Finding of Bio-Tensegrity Structural System (바이오텐세그리티 구조 시스템의 형상 결정)

  • Yang, Dae-Hyeon;Kim, Mi-Hee;Kang, Joo-Won;Kim, Jae-Yeol
    • Journal of Korean Association for Spatial Structures
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    • v.18 no.2
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    • pp.25-34
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    • 2018
  • This study investigated a bio-tensegrity structural system that combines the characteristics of a general tensegrity structural system with a biological system. The final research objective is to accomplish a changeability for the structural system as like the movement of the natural bio-system. In the study, we present a shape finding procedure for the two stage bio-tensegrity system model inspired by the movement pattern of animal backbone. The proposed system is allowing a dynamic movement by introducing the concept of "saddle" for the variable bio-tensegrity structure. Several shape finding analysis example and results are presented and shows a efficient validation and suitability.

Backbone assignment and structural analysis of anti-CRISPR AcrIF7 from Pseudomonas aeruginosa prophages

  • Kim, Iktae;Suh, Jeong-Yong
    • Journal of the Korean Magnetic Resonance Society
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    • v.25 no.3
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    • pp.39-44
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    • 2021
  • The CRISPR-Cas system provides adaptive immunity for bacteria and archaea against invading phages and foreign plasmids. In the Class 1 CRISPR-Cas system, multi-subunit Cas proteins assemble with crRNA to bind to DNA targets. To disarm the bacterial defense system, bacteriophages evolved anti-CRISPR (Acr) proteins that actively inhibit the host CRISPR-Cas function. Here we report the backbone resonance assignments of AcrIF7 protein that inhibits the type I-F CRISPR-Cas system of Pseudomonas aeruginosa using triple-resonance nuclear magnetic resonance spectroscopy. We employed various computational methods to predict the structure and binding interface of AcrIF7, and assessed the model with experimental data. AcrIF7 binds to Cas8f protein via flexible loop regions to inhibit target DNA binding, suggesting that conformational heterogeneity is important for the Cas-Acr interaction.

Algorithm Development for Movable Tensegrity Structure by Iot (Iot에 기반한 동적 텐세그리티 구조를 위한 알고리즘 개발)

  • Jeon, Sang-Hyeon;Ha, Chang-Woo;Kim, Hee-Kyun;Kim, Jae-Yeol
    • Journal of Korean Association for Spatial Structures
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    • v.20 no.4
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    • pp.35-44
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    • 2020
  • In the study, a shape finding procedure for the tensegrity system model inspired by the movement pattern of animal backbone was presented. The proposed system is allowing a dynamic movement by introducing the concept of "saddle" for the variable tensegrity structure. Mathematical process and an algorithm for movable tensegrity to specified points were established. Several examples have applied with in established shape finding analysis procedure. The final tensegrity structures were determined well to a object shape.

Comparative Study of Deep Learning Algorithm for Detection of Welding Defects in Radiographic Images (방사선 투과 이미지에서의 용접 결함 검출을 위한 딥러닝 알고리즘 비교 연구)

  • Oh, Sang-jin;Yun, Gwang-ho;Lim, Chaeog;Shin, Sung-chul
    • Journal of the Korean Society of Industry Convergence
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    • v.25 no.4_2
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    • pp.687-697
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    • 2022
  • An automated system is needed for the effectiveness of non-destructive testing. In order to utilize the radiographic testing data accumulated in the film, the types of welding defects were classified into 9 and the shape of defects were analyzed. Data was preprocessed to use deep learning with high performance in image classification, and a combination of one-stage/two-stage method and convolutional neural networks/Transformer backbone was compared to confirm a model suitable for welding defect detection. The combination of two-stage, which can learn step-by-step, and deep-layered CNN backbone, showed the best performance with mean average precision 0.868.