• Bulletin of the Korean Chemical Society
• /
• 제35권8호
• /
• pp.2537-2540
• /
• 2014

• Journal of Microbiology and Biotechnology
• /
• 제19권6호
• /
• pp.556-559
• /
• 2009

Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-${\kappa}B$). In its active state, NF-${\kappa}B$ turns on the expression of genes related to cell proliferation or death. NF-${\kappa}B$ activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-${\kappa}B$ had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-${\kappa}B$.

• Journal of Microbiology and Biotechnology
• /
• 제22권1호
• /
• pp.100-106
• /
• 2012

In this study, the metabolite profiles of three Aspergillus strains during rice koji fermentation were compared. In the partial least squares discriminant analysis-based gas chromatography-mass spectrometry data sets, the metabolite patterns of A. oryzae (KCCM 60345) were clearly distinguished from A. kawachii (KCCM 60552) and only marginal differences were observed for A. oryzae (KCCM 60551) fermentation. In the 2 days fermentation samples, the overall metabolite levels of A. oryzae (KCCM 60345) were similar to the A. oryzae (KCCM 60551) levels and lower than the A. kawachii (KCCM 60552) levels. In addition, we identified discriminators that were mainly contributing tyrosinase inhibition (kojic acid) and antioxidant activities (pyranonigrin A) in A. oryzae (KCCM 60345) and A. kawachii (KCCM 60552) inoculated rice koji, respectively. In this study, we demonstrated that the optimal inoculant Aspergillus strains and fermentation time for functional rice koji could be determined through a metabolomics approach with bioactivity correlations.

• 대한족부족관절학회지
• /
• 제24권2호
• /
• pp.61-68
• /
• 2020

Bone marrow aspirate concentrate and matrix-induced chondrogenesis (BMIC) is an interesting treatment option for osteochondral lesions of the talus with promising short- to mid-term results. The various terminologies used to describe this surgical method need to be addressed. These include bone marrow-derived cell transplantation, matrix-induced bone marrow aspirate concentrate, and matrix-associated stem cell transplantation. BMIC is a one-stage, minimally invasive surgery performed arthroscopically or using a mini-open arthrotomy approach without a malleolar osteotomy in most cases. The lesion is replaced with hyaline-like cartilage, and treatmentrelated complications are rare. BMIC is a safe and effective treatment option and should be considered in large lesions or lesions with a prior treatment history.

• 대한지역사회영양학회:학술대회논문집
• /
• 대한지역사회영양학회 2005년도 춘계학술대회
• /
• pp.145-146
• /
• 2005

• Bulletin of the Korean Chemical Society
• /
• 제35권8호
• /
• pp.2585-2588
• /
• 2014

• Bulletin of the Korean Chemical Society
• /
• 제35권8호
• /
• pp.2487-2493
• /
• 2014

Dimeric ${\beta}$-cyclodextrin linked by a thioether bridge was synthesized from a reaction of mono-6-iodo-6-deoxy-${\beta}$-cyclodextrin with sodium sulfide, and the structure was analyzed using nuclear magnetic resonance spectroscopy and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The effects of thioether-bridged dimeric ${\beta}$-CD on the aqueous solubility of flavonols (myricetin, quercetin, and kaempferol) were investigated by ultraviolet-visible spectroscopy. The aqueous solubility of myricetin, quercetin, and kaempferol were enhanced 33.6-, 12.4-, and 10.5-fold following the addition of 9 mM of thioether-bridged dimeric ${\beta}$-CD. In comparison, the aqueous solubility of myricetin, quercetin, and kaempferol were enhanced 5.4-, 3.3-, and 2.7-fold using the same concentration of monomeric ${\beta}$-cyclodextrin. Furthermore, the formation of flavonol/thioether-bridged dimeric ${\beta}$-CD inclusion complexes was confirmed with nuclear magnetic resonance, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. The results showed that the nature of the complexes significantly differed from that of free flavonols. Herein, we suggest that the thioether-bridged dimeric ${\beta}$-CD can act as an effective complexing agent for flavonols.

• 전기전자학회논문지
• /
• 제18권2호
• /
• pp.263-271
• /
• 2014

본 논문에서는 모바일 기기의 배터리 전력관리 IC(Battery Management IC)에서 전압 및 온도를 측정하여 디지털 신호로 바꾸어 주는데 필요한 시그마-델타 모듈레이터를 설계하였다. 제안하는 이산-시간 시그마-델타 모듈레이터는 2차의 단일 비트 구조이고 0.13um CMOS 공정으로 제작되었다. 모듈레이터의 소모전류를 줄이기 위하여 switched-opamp 방식을 적용하여 설계하였다. 제안하는 모듈레이터는 오버 샘플링 비율이 256 일 때 256kHz의 클락 주파수에서 83-dB의 dynamic range와 81.7dB의 peak signal-to-(noise + distortion) ratio(SNDR)를 가진다. 3.3 V의 전원전압에서 0.66 mW의 전력을 소모하며 모듈레이터 코어의 면적은 $0.425mm^2$ 이다.

• 경영과학
• /
• 제32권1호
• /
• pp.133-145
• /
• 2015

Motion picture industry in Korea has been growing constantly and aroused various kinds of research attention. Particularly, the introduction of official box-office database service brought quantitative studies. However, approaches based on diffusion models have been rarely found with domestic film markets. In addition to the fundamental statistical review on Korea and US film markets, we applied a diffusion model to daily box-office revenue. Unlike conventional preference of Gamma distribution on the film markets, estimation results proved that BMIC can also explain the trend of daily revenue successfully. The comparison with BMIC showed that there is a distinctive difference in diffusion patterns of Korea and US film markets. Generally, word-of-mouth effect appeared more significant in Korea.

• 공업화학
• /
• 제26권3호
• /
• pp.366-371
• /
• 2015

루이스 산도가 다른 두 종류의 클로로알루미네이트계 이온성 액체(IL) 촉매를 사용하여 tetrahydrotricyclopentadiene (THTCPD) 이성화 반응 거동에 관하여 연구하였다. 루이스 산도가 낮은 1-butyl-3-methylimidazolun chloride $(BMIC)/AlCl_3$와 높은 pyridine hydrochloride $(PHC)/AlCl_3$계 IL 촉매를 이용하고 온도와 시간을 반응 인자로 하여 THTCPD의 이성화 반응 경로를 고찰하였다. IL 촉매의 루이스 산도 증가에 따라 THTCPD 이성화 전환율을 증가시킬 수 있었다. 반응온도 및 IL 촉매의 산도에 따라 THTCPD 이성화 반응경로가 바뀌었다. 산도가 낮은 $BMIC/AlCl_3$ IL 촉매의 경우에는 기존에 사용되어오던 $AlCl_3$ 촉매와 유사한 반응 경로를 보이지만, 반응온도가 높아짐에 따라 endo, exo, endo-(norbornene; NB) ${\rightarrow}$ exo, exo, endo-NB ${\rightarrow}$ diamondoid로의 골격 재배열화 반응이 일어났다. 하지만, 산도가 높은 $PHC/AlCl_3$ IL 촉매의 경우에는 $TEAC/AlCl_3$ IL 촉매와는 다른 새로운 두 가지 경로(endo, exo, endo-NB ${\rightarrow}$ exo, exo, endo- NB ${\rightarrow}$ exo, exo, exo-NB 및 endo, exo, endo-NB ${\rightarrow}$ exo, exo, endo-NB ${\rightarrow}$ exo, exo, exo-(cyclopentadiene; CP))가 추가로 관찰되었다.