• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3349-3355
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• 2012

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. This work aimed to detect common chromosomal translocations and associated fusion oncogenes in adult ALL patients and study their relationship with clinical features and treatment outcome. Methods: We studied fusion oncogenes in 104 adult ALL patients using RT-PCR and interphase-FISH at diagnosis and their association with clinical characteristics and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL (t 9; 22), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (Del 1p32) were found in 82/104 (79%) patients. TCF3-PBX1 fusion gene was associated with lymphadenopathy, SIL-TAL1 positive patients had frequent organomegaly and usually presented with a platelets count of less than $50{\times}10^9/l$. Survival of patients with fusion gene ETV6-RUNX1 was better when compared to patients harboring other genes. MLL-AF4 and BCR-ABL positivity characterized a subset of adult ALL patients with aggressive clinical behaviour and a poor outcome. Conclusions: This is the first study from Pakistan which investigated the frequency of5 fusion oncogenes in adult ALL patients, and their association with clinical features, treatment response and outcome. Frequencies of some of the oncogenes were different from those reported elsewhere and they appear to be associated with distinct clinical characteristics and treatment outcome. This information will help in the prognostic stratification and risk adapted management of adult ALL patients.

• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.420-426
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• 2019

Selenoproteins,in Korean blood serum, GPx, SelP, and SeAlb were separated and determined with the use of HPLC-ICP/MS. Deuterium was used as a collision gas and affinity column with ammonium formate was used as an eluting solvent for the accurate quantitation of selenoproteins in human blood serum. Certified reference material BCR 639 (133±12 ng g^-1) was tested for the accuracy and the result was satisfactory 130±6 ng g^-1. Blood serum for the rectal cancer and controlled groups were collected and analyzed to give 84±27 ng g^-1, and 119±28 ng g^-1, respectively. The difference was statistically obvious when t-test was performed (t_cal 4.93 > t_95% 2.04). The decrease for cancer group was more obvious for female and aged group. The distributions of three selenoproteins were similar with each other, which means rectal cancer group did not show any specificity for any selenoproteins. As cancer developed, GPx showed a slight decrease but not obvious while the total concentration was increasing particularly at the second stage of cancer.

• Analytical Science and Technology
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• v.25 no.6
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• pp.350-363
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• 2012

To determine ionic species in snowpit samples using ion chromatography system, we described the performance of ion chromatography(IC) system, cleaning method of bottle, and interference by filtering procedure. The limit of detection, reproducibilities, and accuracies determined with BCR$^{(R)}$-408 were 0.01-0.26 ${\mu}g$/L, 0.4-17.4%, 4.5-12.0% for cations and 0.02-0.26 ${\mu}g/L$, 0.1-27.6%, 1.3-5.6% for anions, respectively. Lab blank test for sample bottle indicated that $CH_3CO_2{^-}$, $HCO_2{^-}$, and $NH_4{^+}$ can be easily contaminated in the lab environment. The positive interferences of $NO_3{^-}$ were partly attributed to the cleaning method of bottle. The filtering of melted snow sample should be carefully applied because it can positively affect the concentration levels of some ionic species. Finally, this method was applied to measure ionic species in snowpit samples from the upward area near NEEM camp and the uncertainties of measurement data of $F^-$ were also estimated.

• Journal of Korean Society of Environmental Engineers
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• v.32 no.7
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• pp.665-675
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• 2010

The effects of chemical binders (ladle slag, ordinary portland cement (OPC), hydroxyapatite and calcium hydroxide) on the solidification/stabilization of heavy metals (Cd, Cu, Ni, Pb, Zn) in sewage sludge were evaluated by chemical leaching tests such as EDTA extraction, TCLP and sequential extraction. The results of EDTA extraction showed that heavy metal concentrations in sewage sludge were highly reduced after solidification/stabilization with slag, cement or calcium hydroxide. However, EDTA interrupted solidification/stabilization of heavy metals by hydroxyapatite. The TCLP-extracted heavy metal concentrations in sewage sludge after solidification/stabilization with chemical amendments were highly reduced. However, Cu concentration in the sewage sludge solidified/stabilized with slag, cement or calcium hydroxide increased because the pH of TCLP solution was higher than 7. Mixtures of sludge 1 : slag 0.2 : calcium hydroxide 0.1 (wt ratio) showed the least leachability in batch TCLP and EDTA extraction. The results of sequential extraction (SM&T, formaly BCR) indicated that the distribution of heavy metals changed from exchangable and carbonate fractions to strongly bound organic fraction. It was found that maximum leachate concentrations of Ba, Cd, Cr and Pb from sewage sludge amended with slag and calcium hydroxide were far below US EPA TCLP regulations.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.4
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• pp.129-142
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• 2016

This study performs an evaluation, using the economic feasibility analysis method, of the LTE based railway wireless networks (LTE-R) service that is planned to be used for the future railway networks in Korea. Its objectives are using the evaluation results and working to reflect the factors that lead to a maximization of benefits in designing an integrated railway wireless network. This study analyzes the impact of implementing an LTE-R on the railway networks, in contrast to the existing wireless network methods, e.g. VHR and TRS to new rail lines on an economic view. This results found that the benefit cost ratio is greater than 1.0 with a 10% contribution to benefits of the wireless network service in the case study on the Wonju-Gangneung rail line that will start operations in 2018; as a result, an ICT design is desired. For the introduction of an LTE-R service for the Wonju-Gangneung rail line, design specifications need to increase to benefits for each service, which will verify actual contributions and therefore result in an overall economic effect.

• Analytical Science and Technology
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• v.23 no.6
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• pp.524-530
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• 2010

Chloramphenicol is one of the most effective antibiotics for treatment of food-producing animals for typhoid fever. However, it has been reported that it caused severe side effects such as aplastic anemia in human, therefore the use of chloramphenicol for food-producing animal is prohibited by European Union and other countries. In this study, the analytical method using isotope dilution liquid chromatography-mass spectrometry (ID-LC/MS) was established for accurate determination of chloramphenicol in meat. Chloramphenicol was extracted with ethylacetate from porcine and solid phase extraction cartridge was used for enhancing the recovery. The residue of chloramphenicol in porcine was analyzed using the liquid chromatography mass spectrometer (LC/MS) interfaced with electrospray ionization source. Analysis was performed in negative mode with selected reaction mornitoring mode at m/z 321${\rightarrow}$257 of $[M-H]^-$ ${\rightarrow}$ $[M-H-(HCOCl)]^-$ and m/z 326 ${\rightarrow}$ 262 channels for its isotope. The established method was tested using fortified samples at the level of 0.2 1, 10, $25\;{\mu}g$/kg and analytical results agreed with the gravimetrically fortified values within their uncertainties. This method was validated by analyzing a certified reference material, BCR 445, from IRMM (Institute for Reference Materials and Measurement). Our measurement values agreed with the certified value within their uncertainties. The uncertainty of our measured value was much lower than that the certified value from IRMM.

• Journal of Internet Computing and Services
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• v.16 no.1
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• pp.91-100
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• 2015

Recently many companies began to feel the pressures of cost savings due to the global recession, so they have been interested in the Cloud Computing. Cloud Computing is one of using method of IT resources through the network. Users can borrow softwares or hardwares instead of buying them. Many people expect remarkable growth in Cloud Computing industry because of it's effectiveness. But Cloud Computing industry is still at an early stage. Especially, people who in the public sector hesitate to adopt Cloud Computing Services due to security issues and their conservative views. Also, they just have limited understanding, so we need to investigate what they really know and understand. Researches about the Cloud Computing generally focus on technical issues, so we can hardly find researches reference for decision making in considering the services. The study aims to investigate diverse factors for agencies' adoption decisions, such as benefits, costs, and risk in developing the most ideal type of cloud computing service for them, and performs priority analyses by applying ANP (Analytic Network Process). The results identify that features pertaining to the risk properties were considered the most significant factors. According to this research, the usage of private cloud computing services may prove to be appropriate for public environment in Korea. The study will hopefully provide the guideline to many governmental agencies and service providers, and assist the related authorities with cloud computing policy in coming up with the relevant regulations.

• Journal of the Korean Geotechnical Society
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• v.20 no.3
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• pp.107-117
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• 2004

This paper is to investigate the reinforcing effects of newly devised Tire-cell mat made of waste tires in sand. Parametric study on number of connection bolts between Tirecells, relative density of sand, embedded depth, number of reinforced layers and width of Tirecell mat was made by using plate loading tests. It is found that the number of connection bolt was enough to maintain the given pressure. The bearing capacity ratio(BCR), which is defined as the rate of ultimate bearing capacity of reinforced soil to that of unreinforced soil, is the highest at the lowest density. And the reinforcing effect can be obtained in case of embedded depth within 1.0B, where B is loading width. Also settlement reduction is the highest at the lowest density of sand. The effect of number of Tirecell reinforced layers with 0.4B to 0.5B interval is limited to 2 layers and further reinforcing effects can not be obtained beyond 3 layers. Especially, the bearing capacity increased remarkably at 1 layer of reinforcement and the degree of increase was small from 1 layer to 2 layers of reinforcement. The effect of mat width of Tirecell was not significant because of high stiffness of Tirecell although the maximum bearing capacity was shown at the 2.0B mat width and the reinforcing effects of Tirecell, in general, was prominent compared with those of commercial Geoweb.

• Journal of Navigation and Port Research
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• v.35 no.5
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• pp.415-421
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• 2011

The purposes of this study were to identify the economic impacts of hosting a marine leisure event and thus provide fundamental information that helps maximize the economic value of the event. In order to accomplish such purposes, this study employed both an economic impact analysis(EIA) using regional input output model and a benefit and cost ratio analysis(BCR). In specific, this study utilized a survey method with a total of 300 event visitors and 70 foreign players and thus collected expenditure data from 110 valid out of town visitors and 58 foreign players. In addition, investment expenditure data were collected from the host city official. Accordingly, EIA and BCR indicated following findings. First, the total direct impact from both visitors and players was 387 million Won and this direct impact resulted in output multiplier effect(OME) of 591 million Won, value added multiplier effect(VAME) of 306 million Won and income multiplier effect(IME) of 252 million Won. Second, the host city's investment expenditure created OME, VAME and IME of 825, 432 and 366 million Won, respectively. In conclusion, these findings suggest that in order to effectively boost potential economic benefits, more marketing efforts development policies should be implemented for increasing the number of out of town visitors and the amount of spendings from them.

• Journal of the Korean Society for Library and Information Science
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• v.56 no.3
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• pp.265-290
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• 2022

An economic evaluation was conducted using cost-benefit analysis for an integrated service platform of open access research articles. The data needed for benefit measurement were collected by conducting a series of surveys to service beneficiaries, including 1,313 academic researchers, 49 bio-industry researchers, and 102 researchers in various industries. Cost-benefit analysis and sensitivity analysis were conducted after estimating the total costs for system construction and operations, anticipated direct and indirect benefits. With respect to the cost-benefit analysis limited to direct benefits, the estimated benefit was KRW 82 billion, which is about 14 times of the total costs for eight years of the entire business period. With respect to the cost-benefit analysis for both direct and indirect benefits, BCR was estimated to be about 98.9 and NPV to be KRW 538.8 billion, indicating that economic feasibility of the project was sufficiently secured. The results of this analysis may help securing the investment to the integrated service platform for OA research products, and the benefit estimation model developed in this study would be utilized as an assessment tool during the rest of this project.