• Toxicological Research
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• v.18 no.4
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• pp.369-374
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• 2002

The present study was performed to validate an automated image analysis system (Loats Automated Micronucleus Scoring System) for the mouse bone marrow micronucleus assay, comparing with conventional microscopic scoring. Two studies were conducted to provide slides for a comparison of micro-nucleated polychromatic erythrocytes (MNPCEs) values collected manually to those collected by the auto-mated system. Test article A was used as an example of a compound negative for the induction of micronuclei and test article B was wed as a micronucleus-inducing agent to elicit a positive response. Cyclophosphamide was included to provide an positive control in two studies. Bone marrow samples were collected 24 h after administration of test article A and B in male ICR mice. The cells were fixed with absolute methanol and stained with May-Grunwald and Giemsa. The number of MNPCEs was determined by the analysis of 1000 total PCEs per bone marrow sample. In addition to micronucleus scoring, an index of bone marrow toxicity based on PCE ratio (% of PCEs to total erythrocytes) was determined for each sample. The automated and manual scoring was similar when the MNPCEs incidence induced by each test article was less than 10. However manual scoring was able to effectively enumerate micronucleated PCEs in mouse bone marrow when MNPCEs incidence was more than 10, such as cyclophosphamide treatment. Conversely, PCE ratio was superior in computer-assisted image analysis. Taken together, it is suggested that improvement of the automated image analysis may be necessary to render the automatic scoring as sensitive as manual scoring for routine counting of micronuclei, especially because it is superior in objectivity and high throughput scoring.

• Structural Engineering and Mechanics
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• v.65 no.2
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• pp.129-139
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• 2018

Post-tensioning (PT) tendons are commonly used for the assembly of modularized concrete members, and tension is applied to the tendons during construction to facilitate the integrated behavior of the members. However, the tension in a PT tendon decreases over time due to steel corrosion and concrete creep, and consequently, the stress on the anchor head that secures the PT tendon also diminishes. This study proposes an automatic detection system to identify tension reduction in a PT tendon using pulsed-eddy-current (PEC) measurement. An eddy-current sensor is installed on the surface of the steel anchor head. The sensor creates a pulsed excitation to the driving coil and measures the resulting PEC response using the pick-up coil. The basic premise is that the tension reduction of a PT tendon results in stress reduction on the anchor head surface and a change in the PEC intensity measured by the pick-up coil. Thus, PEC measurement is used to detect the reduction of the anchor head stress and consequently the reduction of the PT tendon force below a certain threshold value. The advantages of the proposed PEC-based tension-reduction-detection (PTRD) system are (1) a low-cost (< $ 30), low-power (< 2 Watts) sensor, (2) a short inspection time (< 10 seconds), (3) high reliability and (4) the potential for embedded sensing. A 3.3 m long full-scale monostrand PT tendon was used to evaluate the performance of the proposed PTRD system. The PT tendon was tensioned to 180 kN using a custom universal tensile machine, and the tension was decreased to 0 kN at 20 kN intervals. At each tension, the PEC responses were measured, and tension reduction was successfully detected.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.12
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• pp.61-68
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• 2010

In this paper, we investigate the performance of ARQ-aided Time Switched Transmit Diversity (ARQ-TSTD) applying the multi-level control signaling in the WCDMA LCR-TDD system. Proposed ARQ-TSTD system applies the multi-level control signaling scheme in which the receiver sends the response signal (ACK or NACK signal) to the transmitter and defines NACK2 signal for multi-level control. Transmitter utilize the NACK2 control signal to the postponement of transmission and multi-user scheduling scheme proposed by this paper. Simulation results demonstrate that the proposed postponement of transmission and multi-user scheduling scheme yield about 1.3dB, 1.4dB performance gain respectively, compared with the conventional ARQ-TSTD with antenna switching scheme in tenn of the frame error rate (FER) for mobile speed of 3km/h and FER value of 10%. In addition, 14% and 11.5% of throughput gain respectively is shown when Eb/N0=-3dB.

• The KIPS Transactions:PartB
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• v.16B no.6
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• pp.451-462
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• 2009

The spread of satellite image increases various services using it. Especially, 3D visualization services of the whole earth such as $Google\;Earth^{TM}$ and $Virtual\;Earth^{TM}$ or 3D GIS services for several cities provide realistic geometry information of buildings and terrain of wide areas. These service can be used in the various fields such as urban planning, improvement of roads, entertainment, military simulation and emergency response. The research about extracting the building and terrain information effectively from the high-resolution satellite image is required. In this paper, presents a system for effective extraction of the building model from a single high-resolution satellite image, after examine requirements for building model extraction. The proposed system utilizes geometric features of satellite image and the geometric relationship among the building, the shadow of the building, the positions of the sun and the satellite to minimize user interaction. Finally, after extracting the 3D building, the fact that effective extraction of the model from single high-resolution satellite will be show.

• Journal of Navigation and Port Research
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• v.40 no.5
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• pp.241-247
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• 2016

The tracking filter plays a key role in the accurate estimation and prediction of maneuvering a vessel's position and velocity when attempting to enhance safety by avoiding collision. Therefore, in order to achieve accurate estimation and prediction, many oceangoing vessels are equipped with the Automatic Radar Plotting Aid (ARPA) system. However, the accuracy of prediction depends on the tracking filter's ability to reduce noise and maintain a stable transient response. The purpose of this paper is to derive the optimal values of the gain parameters used in tracking a High Dynamic Warship. The algorithm employs a ${\alpha}-{\beta}-{\gamma}$ filter to provide accurate estimates and updates of the state variables, that is, positions, velocity and acceleration of the high dynamic warship based on previously observed values. In this study, the filtering coefficients ${\alpha}$, ${\beta}$ and ${\gamma}$ are determined from set values of the damping parameter, ${\xi}$. Optimization of the damping parameter, ${\xi}$, is achieved experimentally by plotting the residual error against different values of the damping parameter to determine the least value of the damping parameter that results in the optimum smoothing coefficients leading to a reduction in the noise corruption effect. Further investigation of the performance of the filter indicates that optimal smoothing coefficients depend on the initial and average velocity of the target.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.38 no.7
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• pp.716-726
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• 2010

In this research, design optimization of an aircraft wing has been performed using the fully automated Multidisciplinary Design Optimization (MDO) framework, which integrates aerodynamic and structural analysis considering nonlinear structural behavior. A computational fluid dynamics (CFD) mesh is generated automatically from parametric modeling using CATIA and Gambit, followed by an automatic flow analysis using FLUENT. A computational structure mechanics (CSM) mesh is generated automatically by the parametric method of the CATIA and visual basic script of NASTRAN-FX. The structure is analyzed by ABAQUS. Interaction between CFD and CSM is performed by a fully automated system. The Response Surface Method (RSM) is applied for optimization, helping to achieve the global optimum. The optimization design result demonstrates successful application of the fully automated MDO framework.

• Journal of Korea Multimedia Society
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• v.21 no.8
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• pp.837-848
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• 2018

Monitoring technology of machining has a long history since unmanned machining was introduced. Despite the long history, many researchers have presented new approaches continuously in this area. Sound based machine fault diagnosis is the process consisting of detecting automatically the damages that affect the machines by analyzing the sounds they produce during their operating time. The collected sound is corrupted by the surrounding work environment. Therefore, the most important part of the diagnosis is to find hidden elements inside the data that can represent the error pattern. This paper presents a feature extraction methodology that combines various digital signal processing and pattern recognition methods for the analysis of the sounds produced by tools. The magnitude spectrum of the sound is extracted using the Fourier analysis and the band-pass filter is applied to further characterize the data. Statistical functions are also used as input to the nonlinear classifier for the final response. The results prove that the proposed feature extraction method accurately captures the hidden patterns of the sound generated by the tool, unlike the conventional features. Therefore, it is shown that the proposed method can be applied to a sound based automatic diagnosis system.

• Biomedical Science Letters
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• v.15 no.3
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• pp.249-255
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• 2009

All living things have been developed efficient strategies to cope with external and internal environmental changes via a process termed 'homeostasis'. However, chronic prenatal maternal stress may significantly contributes to pregnancy complications by disturbing hypothalamic-pituitary-adrenal (HPA) axis and the automatic nervous system (ANS), and results in unfavorable development of the fetus. Dysregulation of these two major stress response systems lead to the increased secretion of the glucocorticoids (GCs) which are known to be essential for normal development and the maturation of the central nervous system. As Hox genes are master key regulators of the embryonic morphogenesis and cell differentiation, we aimed to determine the effects of dexamethasone, a potent synthetic glucocorticoid, on gene expression in mesenchymal stem cell C3H10T1/2. Analysis of 39 Hox genes based on reverse transcription PCR (RT-PCR) method revealed that the expression patterns of Hox genes were overall upregulated by long dexametasone treatment. These results indicate that maternal stress may have a deleterious effect on early developing embryo through the stress hormone, glucocorticoid.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.1
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• pp.333-342
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• 2012

This paper presents a vowel onset point (VOP) detection method based on the human auditory system. This method maps the "perceptual" frequency scale, i.e. Mel scale onto a linear acoustic frequency, and then establishes a series of Triangular Mel-weighted Filter Bank simulate the function of band pass filtering in human ear. This nonlinear critical-band filter bank helps greatly reduce the data dimensionality, and eliminate the effect of harmonic waves to make the formants more prominent in the nonlinear spaced Mel spectrum. The sum of mel spectrum peaks energy is extracted as feature for each frame, and the instinct at which the energy amplitude starts rising sharply is detected as VOP, by convolving with Gabor window. For the single-word database which contains 12 vowels articulated with different kinds of consonants, the experimental results showed a good average detection rate of 72.73%, higher than other vowel detection methods based on short-time energy and zero-crossing rate.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.6
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• pp.25-30
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• 2015

One of the hottest issues of security is information leakage of financial institution. Financial institutions including commercial banks are frequently threatened by attempts of leakage through hacking and vulnerability, and this information is centered on personal information of their clients. Through this study, I found out that security managers of financial institutions are trying to prevent the leaking of private information, but in fact most of them barely know where their personal information is. Even if they know where it is and trace the data, it is often found in unexpected places. Because there is a lot of waste in time and human resources as search is done manually, we have understood that responding to IT Compliance requires a lot of effort. This study is to improve IT Compliance response and protect information leakage through monitoring PC and servers, the main storage of personal information by automated system, periodically.