• Korean Journal of Clinical Laboratory Science
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• v.39 no.3
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• pp.217-222
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• 2007

In the last 5 years the Epidermal Growth Factor Receptor (EGFR) has emerged as one of the most important targets for drug development in oncology. Monoclonal antibodies targeting the external domain of EGFR have been shown to have clinical benefits in colorectal and head and neck cancer when combined with chemotherapy and/or radiation. Also the targeting of the epithelial growth factor receptor (EGFR) kinase domain using the closely related inhibitors gefitinib and erlotinib has generally been ineffective against solid tumors, many of which over express the receptor. We found that there were some differential expressions according to primary antibodies of the EGFR protein which being used as one of the histological tumor markers for non-small cell lung cancer (NSCLC). We also found that there are some differential expressions according to antibodies, the pH of the antigen retrieval (AR) buffer solutions and kinds of enzymes. There were some differential expressions according to the secondary antibodies and the detection systems. We analyzed the correlations between the immunohistochemical expressions of the EGFR protein and the gene mutations of the EGFR. The differences between automatic stainers and manual staining methods were also evaluated.

• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.2179-2188
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• 2015

Recently, many researches have been done to solve the challenging problem of Blind Source Separation (BSS) problems in the underdetermined cases, and the “Two-step” method is widely used, which estimates the mixing matrix first and then extracts the sources. To estimate the mixing matrix, conventional algorithms such as Single-Source-Points (SSPs) detection only exploits the sparsity of original signals. This paper proposes a new underdetermined mixing matrix estimation method for time-delayed mixtures based on the receiver prior exploitation. The prior information is extracted from the specific structure of the complex-valued mixing matrix, which is used to derive a special criterion to determine the SSPs. Moreover, after selecting the SSPs, Agglomerative Hierarchical Clustering (AHC) is used to automaticly cluster, suppress, and estimate all the elements of mixing matrix. Finally, a convex-model based subspace method is applied for signal separation. Simulation results show that the proposed algorithm can estimate the mixing matrix and extract the original source signals with higher accuracy especially in low SNR environments, and does not need the number of sources before hand, which is more reliable in the real non-cooperative environment.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.2
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• pp.50-59
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• 2006

In this paper, We are going to propose the fire protection system using CAN(Controller Area Network). The larger, higher and deeper buildings an, the more dangerous people are when fire happens. We should be aware of the problems of prior fire protection system. Therefore, we construct the embedded system based on CAN communication that is capable of N to N communication, and build independent fire protection system. If the fire is occurred on the building, the problem is that how fast we can detect the fire and put it on by using available system, this is major factor that reduces damage of our wealth. Therefore in this studies, We would like to design more stable system than current system. This system is based on CAN communication which is available N to N communication constructs and designed to compensate for each fault, so that our aim is to reduce the wires of system, cost of installation and to suppose future type fire protection system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.29 no.2
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• pp.113-121
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• 2011

In this paper, we proposed the method automatically to match areal feature based on similarity using spatial information. For this, we extracted candidate matching pairs intersected between two different spatial datasets, and then measured a shape similarity, which is calculated by an weight sum method of each matching criterion automatically derived from CRITIC method. In this time, matching pairs were selected when similarity is more than a threshold determined by outliers detection of adjusted boxplot from training data. After applying this method to two distinct spatial datasets: a digital topographic map and street-name address base map, we conformed that buildings were matched, that shape is similar and a large area is overlaid in visual evaluation, and F-Measure is highly 0.932 in statistical evaluation.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9927-9931
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• 2014

The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.

• Journal of Satellite, Information and Communications
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• v.12 no.1
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• pp.101-106
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• 2017

In this paper, we present Emergency exit signs are installed to provide escape routes or ways in buildings like shopping malls, hospitals, industry, and government complex, etc. and various other places for safety purpose to aid people to escape easily during emergency situations. In case of an emergency situation like smoke, fire, bad lightings and crowded stamped condition at emergency situations, it's difficult for people to recognize the emergency exit signs and emergency doors to exit from the emergency building areas. This paper propose an automatic emergency exit sing recognition to find exit direction using a smart device. The proposed approach aims to develop an computer vision based smart phone application to detect emergency exit signs using the smart device camera and guide the direction to escape in the visible and audible output format. In this research, a CAMShift object tracking approach is used to detect the emergency exit sign and the direction information extracted using template matching method. The direction information of the exit sign is stored in a text format and then using text-to-speech the text synthesized to audible acoustic signal. The synthesized acoustic signal render on smart device speaker as an escape guide information to the user. This research result is analyzed and concluded from the views of visual elements selecting, EXIT appearance design and EXIT's placement in the building, which is very valuable and can be commonly referred in wayfinder system.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.06a
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• pp.347-350
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• 2007

An ECG analysis with activity monitoring for the home care of elderly persons or patients, using wireless sensors technology was design and implemented. The changes in heart rate occur before, during, or following behavior such as posture changes, walking and running. Therefore, it is often very important to record heart rate along with posture and behavior, for continuously monitoring a patient's cardiovascular regulatory system during their daily life activity. The ECG and accelerometer data are continuously recorded with a built-in automatic alarm detection system, for giving early alarm signals even if the patient is unconscious or unaware of cardiac arrhythmias. The hardware allows data to be transmitted wirelessly from on-body sensors to a base station attached to server PC using IEEE802.15.4. If any abnormality un at server then the alarm condition sends to the doctor' PDA (Personal Digital Assistant).

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.9A
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• pp.1372-1382
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• 1999

The major source of errors in high-speed networks such as Broadband ISDN(B-lSDN) is buffer overflow during congested conditions. These congestion errors are the dominant sources of errors in 1high-speed networks and result in cell losses. Conventional communication protocols use error detection and retransmission to deal with lost packets and transmission errors. However, these conventional ARQ(Automatic Repeat Request) methods are not suitable for the high-speed networks since the transmission delay due to retransmissions becomes significantly large. As an alternative, we have presented a method to recover consecutive cell losses using forward error correction(FEC) in ATM(Asynchronous Transfer Mode)networks to reduce the problem. The performance estimation based on the cell discard process model has showed our method can reduce the cell loss rate substantially. Also, the performance estimations in ATM networks by interleaving and IP multicast service are discussed.

• Korean Journal of Cognitive Science
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• v.25 no.1
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• pp.51-71
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• 2014

This paper presents an image enhancement method in real road traffic scenes. The images captured by the camera on the car cannot keep the color constancy as illumination or weather changes. In the real environment, these problems are more worse at back light conditions and at night that make more difficult to the applications of the vision-based intelligent vehicles. Using the existing image enhancement methods without considering the position and intensity of the light source and their geometric relations the image quality can even be deteriorated. Thus, this paper presents a fast and effective method for image enhancement resembling human cognitive system which consists of 1) image preprocessing, 2) color-contrast evaluation, 3) alpha blending of over/under estimated image and preprocessed image. An input image is first preprocessed by gamma correction, and then enhanced by an Automatic Color Enhancement(ACE) method. Finally, the preprocessed image and the ACE image are blended to improve image visibility. The proposed method shows drastically enhanced results visually, and improves the performance in traffic sign detection of the vision based intelligent vehicle applications.

• Proceedings of the KSRS Conference
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• v.1
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• pp.500-503
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• 2006

To adjust the discrepancy between Light Detection and Ranging (LIDAR) strips, previous researches generally have been conducted using conjugate features, which are called feature-based approaches. However, irrespective of the type of features used, the adjustment process relies upon the existence of suitable conjugate features within the overlapping area and the ability of employed methods to detect and extract the features. These limitations make the process complex and sometimes limit the applicability of developed methodologies because of a lack of suitable features in overlapping areas. To address these drawbacks, this paper presents a methodology using area-based algorithms. This approach is based on the scheme that discrepancies make complex the local height variations of LIDAR data whithin overlapping area. This scheme can be helpful to determine an appropriate transformation for adjustment in the way that minimizes the geographical complexity. During the process, the contour tree (CT) was used to represent the geological characteristics of LIDAR points in overlapping area and the Iterative Closest Points (ICP) algorithm was applied to automatically determine parameters of transformation. After transformation, discrepancies were measured again and the results were evaluated statistically. This research provides a robust methodology without restrictions involved in methods that employ conjugate features. Our method also makes the overall adjustment process generally applicable and automated.