• IMMUNE NETWORK
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• 제16권5호
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• pp.281-285
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• 2016

CD4⁺ regulatory T cells (Tregs) are essential for normal immune surveillance, and their dysfunction can lead to the development of autoimmune diseases, such as type-1 diabetes (T1D). T1D is a T cell-mediated autoimmune disease characterized by islet b cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Tregs play a critical role in the development of T1D and participate in peripheral tolerance. Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy Tregs to treat T1D as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) remain undefined, especially molecular mechanisms that direct differentiation of such Tregs. Auto Ag-specific PSC-Tregs can be programmed to be tissue-associated and infiltrate to local inflamed tissue (e.g., islets) to suppress autoimmune responses after adoptive transfer, thereby avoiding potential overall immunosuppression from non-specific Tregs. Developing auto Ag-specific PSC-Tregs can reduce overall immunosuppression after adoptive transfer by accumulating inflamed islets, which drives forward the use of therapeutic PSC-Tregs for cell-based therapies in T1D.

• 복식문화연구
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• 제10권6호
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• pp.709-717
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• 2002

In the apparel industry, the technology has been advanced rapidly. The use of 3D scanning systems fur the capture and measurement of human body is becoming common place. Three dimensional digital image can be used for design, inspection, reproduction of physical objects. The purpose of this study is to develop a method that drafts men's basic bodice pattern from scanned 3D body surface shape data. In order to pursue this purpose the researchers developed pattern drafting algorithm. The 3D scanner used in this study was Cyberware Whole Body Scanner WB-4. The bodice pattern drafting algorithm from 3D body surface shape data developed in this study is as follows. First, convert geometric 3D body surface data to 3D polygonal mesh data. Second, develop algorithm to lay out 3D polygonal patches onto a plane using Auto Lisp program. The polygon meshes are coplanar, and the individual mesh is continuously in contact with next one The bodice front surface shape data in polygonal patches form was lined up in bust and waist levels. The back bodice was drafted by lining up the polygonal mesh in scapula, chest, and waist levels. in the drafts, gaps between polygons were formed into the darts.

• 자동차안전학회지
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• 제10권2호
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• pp.6-12
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• 2018

Optimized section shape of aluminum bumper backbeam for enhancing the front high speed crashworthiness was investigated. Front body analysis model of a convertible vehicle was built up and parameter studies were carried out with changing the inner rib shape and the section thickness distribution. First an inner rib shape displaying most efficient structural performance was selected. Next, for the selected section the effect of section thickness combination was examined. Also, a light weighed backbeam section displaying crash performance over the current design was suggested. Finally RCAR front low speed impact analyses were carried out for the optimized models.

• 자동차안전학회지
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• 제3권2호
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• pp.34-41
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• 2011

Side collisions (or side crash) account for 51.6% of all car to car accidents occurred in 2010. It is necessary to analyze those vehicles' structure deformation and passengers' injuries in the side collisions. A moving barrier (950kg) is currently used in the KNCAP side impact test. However, in order to enhance a passengers' safety in the side collisions, we introduce an AE-MDB (1500kg) which provides more severe conditions for this test. In this study, the test results using both barriers are compared and analyzed.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.698-701
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• 2005

Nowadays, because of the frequent market change and variable customer's requirements, product's life-circle is becoming shorter. So, automobile companies are forced to rapidly develop new products and efficiently reduce both manufacturing lead time and cost, with the world level quality. Among them, Press Die is not only just a bottle neck but also an important resource exerting certain effect in quality of car body appearance. Since 2000, due to efforts to reduce the time of design phase, many companies have used 3D design methods. Actually the method didn't reduce the period of design because the company didn't develop the best practice. This paper wish to solve this problem by modular based hybrid dies template.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2003년도 학술대회지
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• pp.235-240
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• 2003

Auto transmission system is composed by torque converter. clutch, brake, planetary goat and valve body controlling oil pressure. In the automatic transmission, the most largest influence elements are torque converter and clutch for oil performance. In this piper I studied failure of tribology causing sealing poor of the acting parts, leakage of the oil pressure and poor of the lubrication.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 추계학술대회 논문집
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• pp.75-78
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• 2005

The static implicit finite element method is applied effectively to analyze back inner panel stamping processes, which include the forming stage Analysis results examining possibility and validity of the formulation and the factor of study are presented. Further, the simulated results for f/apron panel stamping processes are shown and discussed. Its application is being increased especially in the automotive industrial area for the cost reduction, weight saving, and improvement of strength.

• 자동차안전학회지
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• 제12권1호
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• pp.6-14
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• 2020

Personal mobility, which was used exclusively for leisure activities, has recently been used as a means of transportation, and it is expected to increase its role as the next generation transportation. Sales of personal mobility are increasing rapidly, but the problem is that traffic accidents are also increasing. In this study, human body injury caused by various collisions between electric wheel users and road users that occur on bicycle or pedestrian roads mainly used by personal mobility is analyzed through collision analysis and collision risk analysis. In the case of the collision accident for electric wheel, it is analyzed that the road users are more likely to be injured on the pedestrian road than the bicycle road. In addition, the head hit each other or fall and hit the floor caused severe head injury.

• 자동차안전학회지
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• 제11권1호
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• pp.40-47
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• 2019

First, three point bending analysis for the inclined press door impact beam was carried out to investigate inclination angle effect on the maximum strength with varying support distance. Next, for the system model with spring elements representing body stiffness at door mounting area, the bending structural behavior of impact beam mounted on vehicle was estimated. The mounting distance and inclination angle were changed and the beam bending buckling strength was presumed at the head displacement below which spring stiffness change has little effect on the load. Finally strength ratio to predict the bending buckling strength of impact beam mounted on vehicle from three point bending maximum strength of fixed support distance was suggested.

• 자동차안전학회지
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• 제13권4호
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• pp.73-80
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• 2021

Recently, Korea has established a plan for the supply of hydrogen vehicles and is promoting the expansion of the supply. Risk factors for hydrogen vehicles are hydrogen leakage, jet fire, and explosion. Therefore Safety measures are necessary for this hazard. In addition, risks in semi-closed spaces such as tunnels, underground roads, and underground parking lots should be analyzed. In this study, an explosion experiment was conducted on a hydrogen tank used in a hydrogen vehicle to analyze the risk of a hydrogen vehicle explosion accident that may occur in a semi-closed space. As results, the effect on the structure and the human body was analyzed using the overpressure and impulse values for each distance generated during the explosion.