• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.74-83
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• 2020

Objectives Psychological resilience plays a significant role in many aspects of mental health. The aim of this study was to find an association between childhood attention deficit hyperactivity disorder (ADHD) features and adulthood psychological resilience in patients with mood disorders. Methods A total of 213 patients with mood disorders including major depressive disorder or bipolar I, II disorder and 909 healthy controls were included. We assessed childhood ADHD features using the Wender Utah Rating Scale (WURS), adulthood psychological resilience using the Connor-Davidson Resilience Scale (CD-RISC), and current depressive mood using the Beck Depression Inventory (BDI). Pearson's correlation, multiple linear regression and a mediation analyses were performed to examine the relationships between three WURS factor (impulsivity, inattention, and mood instability) scores, the BDI score, and the CD-RISC score. Results The CD-RISC score was negatively correlated with the WURS childhood inattention factor score and current BDI score in patients with mood disorders. BDI score mediated the influence of the inattention factor score on CD-RISC score among patients with mood disorders. The CD-RISC score was significantly lower in patients with mood disorders than in controls even after controlling for age, WURS scores, and the BDI score. Conclusions An evaluation of psychological resilience is important for enhancing recovery and quality of life in patients with mood disorders. When assessing psychological resilience, current depression and ADHD features in childhood, particularly inattention, should be considered.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.4
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• pp.113-121
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• 2022

Objectives: This study aimed to compare the quality of life (QoL) of children with attention-deficit/hyperactivity disorder (ADHD) before and during coronavirus disease-2019 (COVID-19) and to examine how their QoL is affected by emotional and environmental factors during COVID-19. Methods: Participants in the pre-COVID-19 (n=43) and COVID-19 (n=36) groups were recruited from the same university hospital. The Pediatric Quality of Life Inventory (PedsQL) 4.0 Child Self-report, the Children's Depression Inventory (CDI), the Revised Children's Manifest Anxiety Scale (RCMAS), the PedsQL 4.0 Parent Proxy Report, and the Conners' Parent Rating Scale (CPRS) were employed. Independent t-tests, Pearson's correlation analysis, and multiple regression analysis were conducted. Results: Caregivers assessed the children's QoL more negatively than the children themselves in both groups. Children with ADHD evaluated their physical function more negatively and anxiety was significantly higher in the COVID-19 group. In the COVID-19 group, the PedsQL child self-report was significantly predicted by the CPRS, the CDI, and environmental factors (i.e., relation to child and monthly household income). Conclusion: Children with ADHD in the COVID-19 group had a numerically lower QoL and significantly higher anxiety. To improve QoL, it is important to deal with not only depression but also ADHD symptoms and environmental factors.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.4
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• pp.129-136
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• 2021

Objectives: To investigate the relationship between brain structure and empathy in early adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: Nineteen early adolescents with ADHD and 20 healthy controls underwent 3T MRI. All the participants were assessed for different aspects of empathy using measures including the Interpersonal Reactivity Index and Empathy Quotient. Cortical thickness and subcortical structural volume based on T1-weighted scans were analyzed using FreeSurfer. Results: Cognitive empathy (t=-2.52, p=0.016) and perspective taking (t=-2.10, p=0.043) were impaired in the ADHD group compared with the control group. The cluster encompassing the left posterior insular, supramarginal, and transverse temporal cortices [cluster-wise p-value (CWP)=0.001], which are associated with emotional empathy, was significantly smaller in the ADHD group, and the volume of the left nucleus accumbens was greater than that of the control group (F=10.12, p=0.003, effect size=0.22). In the control group, the left superior temporal (CWP=0.002) and lingual cortical (CWP=0.035) thicknesses were positively associated with cognitive empathy, while the right amygdala volume was positively associated with empathic concern (Coef=14.26, t=3.92, p=0.001). However, there was no significant correlation between empathy and brain structure in the ADHD group. Conclusion: The ADHD group had a smaller volume of the cortical area associated with emotional empathy than the control group, and there was no brain region showing significant correlation with empathy, unlike in the control group.

• Clinical and Experimental Pediatrics
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• v.65 no.2
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• pp.85-89
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• 2022

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using I² statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (I²=0.0%, P=0.588) and RR (I²=0.0%, P=0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

• Biomolecules & Therapeutics
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• v.16 no.4
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• pp.312-319
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• 2008

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsiveness. Current estimates suggest that 4-12% of school age children are affected by ADHD, which hampers proper social relationship and achievements in school. Even though the exact etiology of the disorder is still in the middle of active investigation, the availability of pharmacological treatments for the disorder suggest that at least the symptoms of ADHD are manageable. To develop drugs with higher efficacy and fewer side effects, it is essential to have appropriate animal models for in vivo drug screening processes. Good animal models can also provide the chances to improve our understanding of the disease processes as well as the underlying etiology of the disorder. In this review, we summarized current animal models used for ADHD research and discussed the point of concerns about using specific animal models.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.192-198
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• 2005

Objectives : This review examines the extent of harmonization between the Diagnostic and Statistical Manual (fourth edition) (DSM-IV) attention deficit hyperactivity disorder (ADHD) and International Classification of Diseases (tenth edition) (ICD-10) hyperkinetic disorder (HKD). Methods : PubMed review of the clinical literatures from 1980 to March 2005 was undertaken using the search term of ADHD, HKD, DSM, ICD, diagnostic criteria, algorithm, and validity. Results : There continues to be a substantial difference in the prevalence of ADHD and HKD. Based on the limited studies that directly compare the most recent two algorithms of ADHD and HKD, several implications for clinical practice and research are discussed. Conclusion : To understand further if the criteria for DSM-IV and ICD-10 for ADHD and HKD are converged or not, more researches on the validity of ADHD and HKD subtypes should be undertaken.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.1
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• pp.14-24
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• 2018

Objective : The purpose of this study was to identify the effect of Interactive Metronome (IM) training on postural control and hand writing performance of children with Attention Deficit Hyperactivity Disorder (ADHD). Methods : Participant was a third grade elementary school student diagnosed with ADHD. ABA design was used and a total of 30 sessions were held for 3 sessions every week for a total of 10 weeks. In the intervention period, IM training was conducted for 40~50 minutes before intervention for writing, and the writing task was carried out. We evaluated the handwriting legibility and speed. Before baseline A and within a month after A' phase, Clinical Observation of Motor and Postural Skills (COMPS) was evaluated to examine the changes in postural control of the student. Results : After the IM intervention, the postural control of the student improved in the score of slow movement, finger-nose touching, and asymmetrical tonic neck reflex. The handwriting legibility and speed has also tended to increase during the intervention period, but it has not significantly changed. Conclusion : This study could be used as an evidence that the IM training aimed at postural control and handwriting ability could enhance the ability to improve postural control and thereby provide fundamental knowledge for future studies.

• The Journal of Korean Academy of Sensory Integration
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• v.12 no.1
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• pp.39-50
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• 2014

Objective : The purpose of this study was to provide for the intervention and outcome measurement tools of children with Attention Deficit Hyperactivity Disorder (ADHD) through ICF model. Methods : The systematic review methods were used. Papers published in the journal between January, 2000 and July, 2014 were searched through MEDLINE/PubMed, Sciencedirect, Ovid. The main terms searched were 'ADHD, Children, intervention, outcome measure', and 8 papers were analyzed. Results : 1. The subjects of ADHD were pure ADHD (75.8%), ADHD with dyslexia (9.1%), ADHD with conduct disorder (5.8%), ADHD with tic disorder (3.8%), ADHD with DCD (3.0%), ADHD with emotional disorder (2.5%). 2. The nonpharmacologic intervention of ADHD were functioning and disability (80%) and contextual factors (20%). Most frequently used intervention were body function and structure (60%). 3. The outcome measurement tools of ADHD were functioning and disability (80.5%) and contextual factors (19.5%). Most frequently used outcome measurement tools were body function and structure (70.8%). Conclusion : This study can provide information on the intervention and outcome measurement tools of ADHD.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.2
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• pp.15-25
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• 2018

Objective : The purpose of this study was to examine the differences between motor functions and executive functions according to the timing of children with attention deficit hyperactivity disorder (ADHD). Methods : The subjects were 32 children with ADHD aged between 6 and 12 living Busan. To assess the timing, Long Form Assessment (LFA) of Interactive Metronome (IM) was used. Bruininks-Oseretsky of Motor Proficiency, Second Edition (BOT-2) were also used to assess motor functions. STROOP Color and Word Test and Children's Color Trails Test were used to evaluate executive functions. Mann-Whitney U tests were used to determine the differences between the executive functions and the motor functions according to the timing. Results : Comparing the inter-group motor functions according to the timing, there was a statistically significant difference in the Fine manual control and Fine motor precision in BOT-2 (p<.05). Comparing the inter-group executive functions according to the timing, there was not statistically significant difference (p>.05). Conclusion : Among the deficits in ADHD children, we could see the differences between motor function and executive function according to timing function. This study would be meaningful in that the results could be a basic data for study on the timing of children of ADHD in the future.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.3
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• pp.1-13
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• 2020

Objective : The purpose of this study was to evaluate the differences in sensory processing and visual perception between school-age children with Attention Deficit Hyperactivity Disorder (ADHD) and typical children. Methods : The participants in this research were children in the first and second grade in elementary school in Kyoung-Nam Region; 25 children diagnosed with ADHD comprised the experimental group, and 51 typical children comprised the control group. To evaluate the sensory processing of the children, the Sensory Profile (SP) was used, and the Korean Developmental Test of Visual Perception-2 (K-DTVP-2) was used to assess visual perception skills. The data were analyzed using SPSS 20.0, and the Independent t-test was used to compare the sensory processing and visual perception skills of the two groups. Results : The study found differences in the Sensory Profile summary scores and factor summary scores between the two groups (p<.05). We also found differences in the visual perception index and subtest standard scores between the two groups (p<.05). Conclusion : The results of this study show that the experimental and the control groups had significant differences in sensory processing and visual perception skills. The result will contribute to the assessment and education of children with ADHD.