• KSBB Journal
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• 제25권4호
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• pp.319-329
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• 2010

Bifidobacteria comprises up to 25% of the cultivable fecal bacteria in adults and 80% in infants. Many in vivo and clinical research results supporting its efficacy in the prevention and improvement of gastrointestinal health have been accumulated. As a consequence, expert committee WHO/FAO expert committee recommended Bifidobacterium as representative probiotics together with Lactobacillus acidophilus. In this review, research trends in bifidobacteria concerning the classification and identification of the genus Bifidobacterium, modulation of intestinal microflora, improvement of constipation, prevention of diarrhea, alleviation of atopy and allergy, barrier function through antimicrobial activity andimmune enhancement of the host will be introduced. Several gene expression systems based on bifidobacterial plasmids have been developed and successfully used to express several heterologous genes including anticancer proteins in Bifidogacterium. In animal test, bifidobacteria was proven to be a promising candidate for safe gene delivery system which can specifically colonize in the solid tumor.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권2호
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• pp.71-79
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• 2013

The human-associated microbiota is diverse, varies between individuals and body sites, and is important in human health. Microbes in human body play an essential role in immunity, health, and disease. The human microbiome has been studies using the advances of next-generation sequencing and its metagenomic applications. This has allowed investigation of the microbial composition in the human body, and identification of the functional genes expressed by this microbial community. The gut microbes have been found to be the most diverse and constitute the densest cell number in the human microbiota; thus, it has been studied more than other sites. Early results have indicated that the imbalances in gut microbiota are related to numerous disorders, such as inflammatory bowel disease, colorectal cancer, diabetes, and atopy. Clinical therapy involving modulating of the microbiota, such as fecal transplantation, has been applied, and its effects investigated in some diseases. Human microbiome studies form part of human genome projects, and understanding gleaned from studies increase the possibility of various applications including personalized medicine.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2010년도 한국컴퓨터종합학술대회논문집 Vol.37 No.1(C)
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• pp.512-515
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• 2010

환경오염으로 인해 아토피 등의 피부질환이 증가하고 있으며 이에 국내에서는 인터넷을 통한 아토피 진단 서비스는 많다. 하지만 단순한 설문조사 형식으로 진단에 대한 객관성을 유지하기 어려워 신뢰도가 낮다. 이에 본 논문은 컴퓨터 비전 인식 기술을 활용하여, 컴퓨터에서 처리가능한 아토피 환자의 환부 영상을 수집 및 진단하는 시스템을 개발한다. 아토피 진단 시스템은 환부 영상을 사용자로부터 입력받아 색상값에 대한 히스토그램을 만들어 정규화한다. 다음으로 정규화된 히스토그램의 확률적 분포를 이용해 역투영한 결과 영상을 만들어 내게 되며 이 역투영 영상을 바탕으로 피부색을 제외한 부분을 아토피 침범 영역이라 판단하게 된다. 최종적으로는 입력 영상으로부터 얻어진 침범 영역, 문진을 이용한 점수를 이용하여 SCORAD 지수 스코어링 하게 된다.

• 대한수의사회지
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• 제38권6호
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• pp.549-558
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• 2002

3.5살짜리 래브라도 리트리버(Labrador Retriever)는 매일 처방되는 피질스테로이드제에 무반응으로 비계절적, 심한 소양증을 2년간 앓고 있는 병력을 갖고 있었다. 공기유래 알레르겐(알러젠; Allergens)들에 대한 시험관내 RAST1(Radioallergosorbent testing; 방사선 알레르기 흡착 시험법)에 양성으로 나타난 것을 기초로 한 면역요법(Immunotherapy)을 18개월 동안 시행했으나 성공적이지 않았다. 부신피질호르몬(Adrenocorticotropic Hormone, ACTH)자극 시험법은 이것이 본래 임상수의사에 의해 발생(Iatrogenic)된 것임을 예시하여준다. 피부 찰과물(Skin scrapings)을 검사한 결과 개 천공개선충(Sarcoptic mange)이라는 진단이 내려졌다. 이버맥틴(Ivermectin)치료효과와 피질스테로이드(Corticosteroid)의 투약중지에 대한 반응이 극적으로 나타났다. 10개월 추적기간(10-month follow-up period)동안에 이 질병은 재발되지 않았다. 이것은 비록 계절적인 알레르겐을 배제하기 위해 긴 기간동안 추적이 필요하였으나 개 천공개선충이 오히려 피질스테로이드요법에 대한 2차적인 것보다는 1차적인 질병이라는 것을 말해준다. 아토피의 진단을 위해 혈청학적 시험법의 이용이 논의되었다.

• Child Health Nursing Research
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• 제24권2호
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• pp.166-177
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• 2018

Purpose: The purpose of this study was to explore and describe the meaning and essence of experiences of stress in mothers of preschoolers with atopic dermatitis. Methods: This study employed a qualitative research design. Seven mothers of preschoolers with atopic dermatitis were interviewed and the data were analyzed using Giorgi's phenomenological method. Results: Five main themes and 12 theme clusters emerged. The 5 main themes were 1) the mother's enduring heartache from the conflict that arise among family members, 2) the complete loss of daily happiness, 3) the steady stream of emotional fluctuations, 4) struggling to bear the heavy financial burden, and, 5) a life of hope accompanied by stress. Conclusion: The results of this study provide an in-depth understanding of stress among mothers of preschoolers with atopic dermatitis. These results can be used in the development of nursing interventions to provide psychological and emotional support for mothers and family members.

• 대한한의학방제학회지
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• 제11권1호
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• pp.197-204
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• 2003

The skin is a barrier between the living organism and its environment, and this barrier function resides in the stratum corneum. The main function of the stratum corneum is to serve as a barrier preventing the penetration of irritants and transepidermal water loss(TEWL). The rate of transepidermal water loss is a convenient parameter for expressing barrier function. Impaired barrier function was manifested by a greatly increased rate of transepidermal water loss. In atopic dermatitis the rate of transepidermal water lossis greatly increased transepidermal water loss. Medication of Gagampalmultang restored to normal the abnormally high rates of transepidermal water loss in the 104 patients with atopic dermatitis. It specifically plays an important role in regulating barrier function.

• Clinical and Experimental Pediatrics
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• 제52권3호
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• pp.283-288
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• 2009

Pneumonia remains the leading cause of mortality in children. Diagnosis depends on a combination of factors, including clinical assessment, radiological and laboratory findings. Although Streptococcus pneumoniae remains the most important cause of childhood bacterial pneumonia, the great majority of cases of community-acquired pneumonia (CAP) are of viral etiology. A new, rapid, and inexpensive test that differentiates viral from bacterial pneumonia is needed to decide empiric antibiotic treatment. Antibiotics effective against the expected bacterial pathogens should be instituted where necessary. The role of emerging pathogens and the effect of pneumococcal resistance and heptavalent conjugate pneumococcal vaccines are to be considered in practice. There are reports supporting the valid and highly efficacious use of penicillin as a first-line drug for treating CAP. This review raises the issue of the overuse of unnecessary antibiotics in viral CAPs and the use of second or third-line antibiotics for non-complicated pneumonias in most clinical settings.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 하계학술발표대회 논문집
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• pp.737-741
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• 2008

The indoor environment has an effect on heath of human in indoor room that they live largely. We will know Bio-Aerosol that causes illness, such as a flu, an asthma and an atopy etc. and see a relationship between Bio-Aerosol and temperature as an experiment in Air-Conditioned room. In the future, this data can use a basic data for an effect of Bio-Aerosol on indoor environment.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 춘계 학술논문 발표대회
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• pp.184-185
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• 2019

Korea has defined fine dust as a social disaster as the problem of fine dust and air pollution becomes serious. Fine dust is classified as class one carcinogens because it is harmful to human body. When fine dusts enter the human body, they cause bronchial and skin diseases such as respiratory allergies, irritable pneumonia, asthma and atopy. As the air pollution becomes serious, the government is demanding measures to reduce fine dust. The polluted air in the outdoor is introduced into the room, thereby increasing the pollution degree of the indoor air quality. In this study, an adsorption type matrix for the improvement of indoor air quality was produced. Magnesium oxide and magnesium chloride were used as binders and diatomaceous earth was used as a adsorption material.

• 한국병원경영학회지
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• 제16권1호
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• pp.10-26
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• 2011

This study attempted to develop the directions for developing customized health tourism programs of Gangwon province. The data was collected by telephone surveys for 500 citizens in a metropolitan and regional cities in Korea in 2009. In conclusion, the province has many advantages to develop health tourism industries because the image of Gangwon health tour was represented to be generally positive and more than 65% of respondents were interested in participating health tourism of the province. The respondents also considered that the purpose of the tour is for relaxation rather than medical treatments. However, it requires flexible seasonal employment, scientific investigations of the natural environmental treatments and connectionwithleisureactivities, also need to collaborated with health and hospital services.