• BMB Reports
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• v.54 no.7
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• pp.335-343
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• 2021

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss of NUMB expression leads to uncontrolled proliferation and amplification of the CSC pool, which promotes the Notch signaling pathway and reduces the expression of the p53 protein. NUMB genes are alternatively spliced to produce six functionally distinct isoforms. An interesting recent discovery is that the protein NUMB isoform produced by alternative splicing of NUMB plays an important role in promoting carcinogenesis. In this review, we summarize the known functions of NUMB and NUMB isoforms related to the proliferation and generation of CSCs.

• Korean Management Science Review
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• v.33 no.4
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• pp.65-75
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• 2016

We study limit pricing in a price-based duopoly market under asymmetric information on the demand state. An incumbent, who is a monopolist in the initial period, has complete information on the size of a market, while a potential entrant only knows it partially. After observing the sales price of the incumbent in the first period, the entrant decides whether to enter a duopoly market and the sales price if she chooses to. We present a separating perfect Bayesian equilibrium, which indicates that limit pricing can deter the entry of a potential entrant under price competition when there is information asymmetry about the demand state.

• Communications for Statistical Applications and Methods
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• v.18 no.1
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• pp.147-153
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• 2011

In this paper a new sampling procedure for estimating the population mean is introduced. The performance of the new population mean estimator is discussed, along with its properties, and it is shown that the proposed method generates an unbiased estimator. The relative efficiency of the suggested estimator is computed, in regards to the simple random sample(SRS), and comparisons are made to the ranked set sampling(RSS) and extreme ranked set sampling(ERSS) estimators used for asymmetric distributions. The results indicate that the proposed estimator is more efficient than the estimators based on the ERSS. In addition, the folded ranked set sampling(FRSS) procedure has an advantage over the RSS and ERSS in that it reduces the number of unused sampling units.

• International Journal of Air-Conditioning and Refrigeration
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• v.13 no.3
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• pp.145-151
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• 2005

A thermally asymmetric straight rectangular fin is analysed and optimized using the two-dimensional separation of variables method. The optimum heat loss is presented as a function of bottom to top Biot number ratio, fin base length and top Biot number. Decreasing rate of the optimum fin length with the increase of the fin base length is listed. The optimum fin tip length is shown as a function of bottom to top Biot number ratio, fin base length and tip to top Biot number ratio. One of the results shows that the optimum heat loss and the actual optimum fin length decrease while the optimum fin tip length increases as the fin base length increases.

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.135-142
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• 2007

Icon conveys symbolic information which they have become ubiquitous as main element of GUI. However, users often cannot intuitively understand its functional meanings. Icon has to be designed for users to easily understand functional meanings. In order to evaluate icon, the spreading activation model can be used to effectively understand the process of information retrieval. In asymmetric spreading activation model is that in the two nodes the degree of spreading activation is different according to direction. Thus, asymmetric spreading activation theory was performed evaluating the strength of association when users see visual image to associate their verbal meaning (visual image - verbal meaning pair) and users see verbal meaning to associate their visual image (verbal meaning - visual image pair). According to the direction, this study hypothesizes that the well-designed icons have symmetric relationship rather than asymmetric relationship between the two pairs. The strength of association is measured through the reaction time and the accuracy rate. In performing SAT (spreading activation test), the ten icons were selected as word processing software icons. After first SAT, newly designed icons were developed based on Korean mental model, and second SAT was conducted using them. The results showed that the accuracy rate of newly designed icon has been improved. Also there is significant difference of reaction time between current icons and newly designed icons. Well-designed icon is confirmed that the strength of association relationship arises symmetrically rather than asymmetrically between the two pairs. User centered icons could be designed by improving the strength of association between the two pairs. Asymmetric SAT evaluates the strength of the association between the visual image and the verbal meanings to contribute to the development of icon which it related to human's association structure.

• Membrane Journal
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• v.22 no.2
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• pp.104-112
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• 2012

Chemically stable Polyvinylidene fluoride-hexa-fluoropropane (PVDF-HFP) copolymer asymmetric membranes were prepared by the conventional phase inversion process, using Dimethyacetamide (DMAc) as a solvent and water as a non-solvent. To control the pore size and porosity of the PVDF-HFP membranes, tetra-ethoxysilane (TEOS) was used as a pore-forming agent. The prepared membranes were characterized, using several analytical methods such as Fourier Transform Infrared spectroscopy (FTIR), Thermo-gravimetric analyzer (TGA), Field Emission Scanning Electronic Microscopy (FESEM). TEOS turned out to increase porosity and make homogeneous pores on the membranes. Depending on the composition of the dope solutions, the pore size was ranged from 0.1 to 1.0 ${\mu}m$. The flux of the PVDF-HFP membranes prepared by using TEOS as a pore forming agent was increased substantially without much decrease in the rejection. When 15 wt% PVDF-HFP solution was blended with 13 wt% TEOS solution at composition ratio of 70/30 in wt%, the water flux at 2 bars was about 2 $m^3/m^2day$.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.04a
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• pp.1237-1240
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• 2009

인터넷의 발달로 금융기관의 일반업무도 인터넷을 사용하여 수행되는 비중이 커짐에 따라 이를 수용하기 위한 대역폭이 확보되어야 한다. 그러나 늘어나는 트래픽을 수용하기 위한 금융권 본-지점의 통신을 위한 전용회선 등은 상대적으로 비용이 많이 들기 때문에 금융기관 본-지점간의 네트워크 구성을 위하여 물리적인 회선의 증설 대신 현재 사용중인 회선의 트래픽을 효율적으로 운영하는 등의 새로운 기법이 필요하기에 이르렀다. 이에 본 연구에서는 계속적으로 증가되고 있는 금융기관의 웹 기반의 각종 트랜잭션 트래픽을 원활하게 수용하기 위한 방안으로써 비대칭 라우팅의 개선을 통하여 영업점 네트워크 OSPF 라우팅에 대한 변형 수용으로 대역폭 Load Sharing 개선에 관한 방안을 제안하였다. 새로운 라우팅 기법을 실제환경에 적용하여 회선의 사용률이 적절하게 분산되어 사용되고 Load Sharing 성능이 향상됨을 증명하였다.

• Bulletin of the Korean Chemical Society
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• v.27 no.3
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• pp.423-425
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• 2006

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.7
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• pp.747-749
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• 2016

We consider a time-division multiple-access relay channel (MARC), in which two source nodes (SNs) transmit data with different data rate to a destination node (DN) with the help of a relay node (RN) using network coding (NC). However, due to its asymmetric data rate, the RN cannot combine the received bits by XOR NC. In this paper, we compare with the problem of asymmetric data rates by using zero padding and hierarchical 16QAM.

• Korean Journal of Metals and Materials
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• v.49 no.3
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• pp.243-249
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• 2011

This study describes the feasibility of producing high-strength Al alloy sheet with a high solute content using a combined technique of twin-roll strip casting and asymmetric rolling. The Al sheet produced in this study exhibited excellent formability ($\overline{r}$ =1.0, $\Delta$r=0.16) and mechanical properties ($\sigma_{TS}$~305 MPa, $\epsilon$~33%), that, cannot be feasibly obtained via the conventional technique based on ingot casting and rolling. The structural origin of the observed properties, especially enhanced formability, was clarified by examining the evolution of textures associated with strip casting and subsequent thermo-mechanical treatments. Our evaluation of the mechanical properties and formability leads us to conclude that the combination of strip casting and asymmetric rolling is a feasible process for enhancing the formability of Al alloy sheets to the level beyond what the conventional techniques can reach.