• Title/Summary/Keyword: Array Probe

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High-Resolution Microarrays for Mapping Promoter Binding sites and Copy Number Variation in the Human Genome

  • Albert Thomas
    • 한국생물정보학회:학술대회논문집
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    • 한국생물정보시스템생물학회 2006년도 Principles and Practice of Microarray for Biomedical Researchers
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    • pp.125-126
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    • 2006
  • NimbleGen has developed strategies to use its high-density oligonucleotide microarray platform (385,000 probes per array) to map both promoter binding sites and copy number variation at very high-resolution in the human genome. Here we describe a genome-wide map of active promoters determined by experimentally locating the sites of transcription imitation complex binding throughout the human genome using microarrays combined with chromatin immunoprecipitation. This map defines 10,567 active promoters corresponding to 6,763 known genes and at least 1,196 un-annotated transcriptional units. Microarray-based comparative genomic hybridisation (CGH) is animportant research tool for investigating chromosomal aberrations frequently associated with complex diseases such as cancer, neuropsychiatric disorders, and congenital developmental disorders. NimbleGen array CGH is an ultra-high resolution (0.5-50 Kb) oligo array platform that can be used to detect amplifications and deletions and map the associated breakpoints on the whole-genome level or with custom fine-tiling arrays. For whole-genome array CGH, probes are tiled through genic and intergenic regions with a median probe spacing of 6 Kb, which provides a comprehensive, unbiased analysis of the genome.

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1차원 배열 탐촉자의 방사빔추적기법을 이용한 정적 3차원 초음파진단영상 구성 (Construction of Static 3D Ultrasonography Image by Radiation Beam Tracking Method from 1D Array Probe)

  • 김용태;도일;안봉영;김광연
    • 비파괴검사학회지
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    • 제35권2호
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    • pp.128-133
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    • 2015
  • 원격진료를 요하는 응급현장에서 사용을 위하여 1차원 배열 탐촉자를 손으로 조작하는 동안 변하는 방사빔의 위치를 추적하여 정적인 3차원 초음파영상을 구성하였다. 탐촉자에 고정된 모션센서의 병진운동 및 회전운동에 대한 정보를 기준직교좌표계로 변환하는 이론적 모델을 제시하였으며, 신호 증폭과 시리얼 통신을 위한 인터페이스 용도의 모듈을 상용의 센서를 사용하여 제작하였다. 실리콘 퍼티로 제작된 시험용 팬텀에 대한 B-모드의 동영상과 센서의 신호를 동기화하여 기록하였다. 동영상으로부터 주기적으로 추출한 B-모드 영상과 각 영상내의 픽셀 각각의 그레이 레벨을 이용하여 3차원 복셀의 그레이 레벨을 재구성하였다. 이 복셀의 데이터를 이용하여 3차원 영상과 임의단면의 B-모드 방식의 2차원 영상을 구성하였으며, 이 영상들은 시험용 팬텀의 형상과 잘 일치하였다.

무선랜용 U-Slot $2{\times}2$ 배열 마이크로스트립 광대역 안테나 설계 (Design of U-Slot $2{\times}2$ array microstrip wideband antenna for wireless LAN)

  • 주성남;김갑기
    • 한국정보통신학회논문지
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    • 제10권2호
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    • pp.374-379
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    • 2006
  • 본 논문에서는 5 GHz 대역 무선랜용 광대역, 고이득 패치 안테나를 설계 제작하였다. 마이크로스트립 안테나의 대역폭을 개선하기 위해서 첫 번째 직사각형 패치에 U-Slot을 삽입하여 마이크로스트립 라인-동축 프로브 급전방식으로 급전시켰으며, 두 번째 안테나를 $2{\times}2$ 배열 형태로 구현하여 이득을 개선하였다. 따라서 결과적으로 본 연구에서는 5 GHz 대역 광대역 U-Slot $2{\times}2$ 배열 패치 안테나를 설계 제작한다. 제작된 안테나는 Anritsu 37169A VNA(Vector Network Analyzer)를 사용하여 측정한 결과 입력 반사손실 VSWR 2:1인 범위가 $5.110 GHz{\sim} 6.142 GHz$까지 약 1 GHz라는 광대역 특성을 나타내었다. 또한 5.15 GHz, 5.35 GHz, 5.50 GHz, 5.85 GHz에 대하여 방사패턴을 측정한 결과 E-평면과 H-평면에서 안테나 이득 13 dBi 이상,3 dB 빔폭 $30^{\circ}$이상이라는 특성을 나타내었다.

수직형 MEMS 프로브 팁의 신뢰성 설계 및 전기적 특성평가 (Reliable design and electrical characteristics of vertical MEMS probe tip)

  • 이승훈;추성일;김진혁;한동철;문성욱
    • 한국신뢰성학회지:신뢰성응용연구
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    • 제7권1호
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    • pp.23-29
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    • 2007
  • Probe card is a test component which is to classify the known good die with electrical contact before the packaging in the ATE (automatic testing equipment). Conventional probe tip was mostly needle type, it has been difficult to meet with conventional type, because of decreasing chip size, pad to pad pitch and pads size increasingly. For that reason, probe cards using MEMS (micro electro mechanical system) technology have been developed for various semiconductor chips. In this paper, Area Array type MEMS Probe tip was designed,, fabricated, and characterized its mechanical and electrical properties. The authors found that good electrical characteristics under $1{\Omega}$ were acquired with gold (Au) and aluminium (Al) pad contact test over 0.5gf and 4gf respectively. And, contact resistance variation under $0.1{\Omega}$ were achieved with 100,000 times of repetition test. And, insertion loss (IS) for high frequency operation was ascertained over 300MHz at -3dB loss.

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위상배열 탐상검사법을 이용한 풍력발전용 블레이드의 일정가압 메커니즘 신뢰성 평가 (Reliability Evaluation of Constant Pressure Mechanism on Phased Array Ultrasonic Testing for Wind Turbine Blade)

  • 남문호;지수정;임선;임승환;정예찬
    • 한국신뢰성학회지:신뢰성응용연구
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    • 제17권3호
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    • pp.236-245
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    • 2017
  • Purpose: There is no established inspection system for composite wind blade during the fabrication stage even though the blades are one of the most important part at wind generation system, but phased array ultrasonic testing method has been continuously studied about wind turbine blade with composite. When wind turbine blade with complex shape by phased array probe is inspected, it is necessary to study for system keeping constant pressure using pressure device. Methods: In this paper, we propose constant pressure device for inspecting wind turbine blade by phased array ultrasonic test method. Design of the device controller is based on Hunt-Crossley model. We evaluate reliability of phased array ultrasonic inspection result that applicated constant pressure device. Result: Defect indication is precise and its error is small when constant pressure mechanism based on Hunt-Crossley model was used. Conclusion: When inspection is progressed using constant pressure mechanism, the reliability of composite wind blade inspection can be improved.

Electrochemical Characterization of Nanosized Electrode Arrays Prepared from Nanoporous Self-Assembled Monolayers

  • Choi, Shin-Jung;Park, Su-Moon
    • Bulletin of the Korean Chemical Society
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    • 제23권5호
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    • pp.699-704
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    • 2002
  • We characterized nanoelectrode arrays prepared from self-assembled monolayers (SAMs) by adsorption from a solution containing thiolated $\beta$-cyclodextrin ($\beta$-CD) and n-alkanethiol on the gold electrode surface, using electrochemical methods. While the framework, the n-hexadecanethiol SAM, effectively blocked electron transfer between the electrode surface and solution-phase redox probe molecules, the $\beta$-CD cavities isolated in the forests of n-hexadecanethiol molecules were shown to act as an ultramicroelectrode array. The shapes of cyclic voltammograms of probe molecules were related to the number densities of $\beta$-CD molecules within the monolayer films. Probe molecules that have the correct combination of physical and chemical characteristics were shown to effectively penetrate the framework through the $\beta$-CD pores and exchange electrons with the electrode surface.

BeCu 금속박판을 이용한 테스트 소켓 제작 (Fabrication of Test Socket from BeCu Metal Sheet)

  • 김봉환
    • 센서학회지
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    • 제21권1호
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    • pp.34-38
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    • 2012
  • We have developed a cost effective test socket for ball grid array(BGA) integrated circuit(IC) packages using BeCu metal sheet as a test probe. The BeCu furnishes the best combination of electrical conductivity and corrosion resistance. The probe of the test socket was designed with a BeCu cantilever. The cantilever was designed with a length of 450 ${\mu}m$, a width of 200 ${\mu}m$, a thickness of 10 ${\mu}m$, and a pitch of 650 ${\mu}m$ for $11{\times}11$ BGA. The fabrication of the test socket used techniques such as through-silicon-via filling, bonding silicon wafer and BeCu metal sheet with dry film resist(DFR). The test socket is applicable for BGA IC chip.

Measurement Data Comparison of Fast SAR Measurement System by Probe Arrays with Robot Scanning SAR Measurement System

  • Kim, Jun Hee;Gimm, Yoon-Myoung
    • Journal of electromagnetic engineering and science
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    • 제14권4호
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    • pp.336-341
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    • 2014
  • Dosimetry of radiating electromagnetic wave from mobile devices to human body has been evaluated by measuring Specific Absorption Rate (SAR). Usual SAR measurement system scans the volume by robot arm to evaluate RF power absorption to human body from wireless devices. It is possible to fast estimate the volume SAR by software deleting robot moving time with the 2D surface SAR data acquired by arrayed probes. This paper shows the principle of fast SAR measurement and the measured data comparison between the fast SAR system and the robot scanning system. Data of the fast SAR is well corresponding with data of robot scanning SAR within ${\pm}3$ dB, and its dynamic range covers from 10 mW/kg to 30 W/kg with 4.8 mm probe diameter.

최신특허 동향 바이오칩

  • 이한영
    • 한국생물공학회소식지
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    • 제11권2호
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    • pp.35-40
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    • 2004
  • ‘바이오칩(biochip)’ 이란 컴퓨터 칩(computer chip)에서 유래되어 바이오(bio)와 관련된 어떤 집적회로의 요소와 관련된 용어로 지칭되어 왔으나, 최근 몇년 동안 기술개발이 구체으로 이루어 지면서, DNA를 포함한 생체분자(biomolecule)에 대하여 생화학적 분석에 사용되는 프로브(probe)를 정렬(array)시킨 물질 및 장치라고 정의되고있다.(중략)

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